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List of works by Mark Arnold

2012 white paper on recent issues in bioanalysis and alignment of multiple guidelines

scientific article published on 01 September 2012

A convenient strategy for quantitative determination of drug concentrations in tissue homogenates using a liquid chromatography/tandem mass spectrometry assay for plasma samples

scientific article published on 21 July 2011

A rapid, accurate and robust UHPLC-MS/MS method for quantitative determination of BMS-927711, a CGRP receptor antagonist, in plasma in support of non-clinical toxicokinetic studies.

scientific article published on 20 May 2013

A rugged and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of BMS-790052 in plasma

scientific article published on 30 May 2011

A rugged and accurate liquid chromatography-tandem mass spectrometry method for the determination of asunaprevir, an NS3 protease inhibitor, in plasma

scientific article published on 4 February 2013

A sensitive and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of the novel hepatitis C NS5A inhibitor BMS-790052 (daclastasvir) in human plasma and urine

scientific article published on 14 May 2012

A sensitive method for the determination of entecavir at picogram per milliliter level in human plasma by solid phase extraction and high-pH LC-MS/MS.

scientific article published on 13 February 2009

A simple 96-well liquid-liquid extraction with a mixture of acetonitrile and methyl t-butyl ether for the determination of a drug in human plasma by high-performance liquid chromatography with tandem mass spectrometry

scientific article published in February 2004

A simplified and completely automated workflow for regulated LC-MS/MS bioanalysis using cap-piercing direct sampling and evaporation-free solid phase extraction.

scientific article published on 4 February 2013

A user-friendly robotic sample preparation program for fully automated biological sample pipetting and dilution to benefit the regulated bioanalysis.

scientific article published on 24 January 2012

A validated HPLC-MS/MS assay for quantifying unstable pharmacologically active metabolites of clopidogrel in human plasma: application to a clinical pharmacokinetic study

scientific article published on March 2013

Approach to evaluating dried blood spot sample stability during drying process and discovery of a treated card to maintain analyte stability by rapid on-card pH modification

scientific article published on 01 November 2011

Bioanalysis of propylparaben and p-hydroxybenzoic acid, and their sulfate conjugates in rat plasma by liquid chromatography-tandem mass spectrometry

scientific article published on 24 December 2013

Building the Global Bioanalysis Consortium - working towards a functional globally acceptable and harmonized guideline on bioanalytical method validation

scientific article published on 01 November 2010

Calculation and mitigation of isotopic interferences in liquid chromatography-mass spectrometry/mass spectrometry assays and its application in supporting microdose absolute bioavailability studies

scientific article published on 10 May 2012

Conference report: 12th Annual University of Wisconsin Land O'Lakes Bioanalytical Conference

scientific article published in October 2011

Determination of a neuroprotective agent (S)-(+)-BMS-204352 in human, rat and dog plasma by enantioselective liquid chromatography-tandem mass spectrometry

scientific article published in November 2004

Development and validation of sensitive and selective LC-MS/MS methods for the determination of BMS-708163, a gamma-secretase inhibitor, in plasma and cerebrospinal fluid using deprotonated or formate adduct ions as precursor ions

scientific article published on 6 July 2010

Disposition of radiolabeled BMS-204352 in rats and dogs

scientific article published on 01 January 2002

Effect of mobile phase pH, aqueous-organic ratio, and buffer concentration on electrospray ionization tandem mass spectrometric fragmentation patterns: implications in liquid chromatography/tandem mass spectrometric bioanalysis

scientific article published on 01 November 2010

Effective screening approach to select esterase inhibitors used for stabilizing ester-containing prodrugs analyzed by LC-MS/MS

scientific article published on 01 April 2010

Esterase inhibitors as ester-containing drug stabilizers and their hydrolytic products: potential contributors to the matrix effects on bioanalysis by liquid chromatography/tandem mass spectrometry.

scientific article published in June 2012

Evaluating and defining sample preparation procedures for DBS LC-MS/MS assays

scientific article published on 01 August 2010

Fit-for-purpose bioanalytical cross-validation for LC-MS/MS assays in clinical studies

scientific article

High performance liquid chromatographic-mass spectrometric assay for the quantitation of BMS-204352 in dog K(3)EDTA plasma.

scientific article

Identifying, evaluating, and controlling bioanalytical risks resulting from nonuniform matrix ion suppression/enhancement and nonlinear liquid chromatography-mass spectrometry assay response

scientific article published on November 2010

Impact of the implementation of a well-designed electronic laboratory notebook on bioanalytical laboratory function

scientific article published on July 2011

Implications of Differences in Bioanalytical Regulations Between Canada, USA and South America ⬇️

scientific article published on February 1, 2011

Increased productivity in quantitative bioanalysis using a monolithic column coupled with high-flow direct-injection liquid chromatography/tandem mass spectrometry

scientific article published on 01 January 2006

International harmonization of bioanalytical guidance.

scientific article published in April 2010

Liquid chromatography and tandem mass spectrometry for the quantitative determination of ixabepilone (BMS-247550, Ixempra) in human plasma: method validation, overcoming curve splitting issues and eliminating chromatographic interferences from degra

scientific article published on 16 December 2009

Liquid chromatography and tandem mass spectrometry method for the quantitative determination of saxagliptin and its major pharmacologically active 5-monohydroxy metabolite in human plasma: method validation and overcoming specific and non-specific b

scientific article published on 06 February 2012

Liquid chromatography coupled with tandem mass spectrometry for the bioanalysis of proteins in drug development: practical considerations in assay development and validation

scientific article published on 13 February 2013

Liquid-liquid extraction of strongly protein bound BMS-299897 from human plasma and cerebrospinal fluid, followed by high-performance liquid chromatography/tandem mass spectrometry

scientific article published on 03 January 2007

Novel MS solutions inspired by MIST.

scientific article published on July 2010

Overcoming bioanalytical challenges in an Onglyza(®) intravenous [(14)C]microdose absolute bioavailability study with accelerator MS.

scientific article published in August 2012

Pharmacokinetics of a newly identified active metabolite of buspirone after administration of buspirone over its therapeutic dose range.

scientific article

Practical and efficient strategy for evaluating oral absolute bioavailability with an intravenous microdose of a stable isotopically-labeled drug using a selected reaction monitoring mass spectrometry assay.

scientific article published on 6 November 2012

Quantitative determination of BMS-378806 in human plasma and urine by high-performance liquid chromatography/tandem mass spectrometry

scientific article published in June 2007

Quantitative determination of pioglitazone in human serum by direct-injection high-performance liquid chromatography mass spectrometry and its application to a bioequivalence study

scientific article published in October 2003

Simple and efficient digestion of a monoclonal antibody in serum using pellet digestion: comparison with traditional digestion methods in LC-MS/MS bioanalysis

scientific article published on 01 December 2012

Simultaneous determination of a selective adenosine 2A agonist, BMS-068645, and its acid metabolite in human plasma by liquid chromatography-tandem mass spectrometry--evaluation of the esterase inhibitor, diisopropyl fluorophosphate, in the stabiliz

scientific article published on 13 January 2007

Simultaneous oral therapeutic and intravenous ¹⁴C-microdoses to determine the absolute oral bioavailability of saxagliptin and dapagliflozin

scientific article published in March 2013

Sites of first-pass bioactivation (hydrolysis) of orally administered zofenopril calcium in dogs

scientific article

Strategy and its implications of protein bioanalysis utilizing high-resolution mass spectrometric detection of intact protein

scientific article published on 01 November 2011

Strategy of accelerated method development for high-throughput bioanalytical assays using ultra high-performance liquid chromatography coupled with mass spectrometry

scientific article published in November 2009

Summary of the Eleventh Annual University of Wisconsin Land O'Lakes Bioanalytical Conference

scientific article published in October 2010

The synthesis of a carbon-14 labeled pegylated Adnectin™ for placental transfer studies in guinea pigs

scientific article published on 16 July 2013

Theory-guided efficient strategy to maximize speed and resolution in rapid gradient LC-MS/MS bioanalysis

scientific article

Validated LC-MS/MS methods for the determination of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor in normal and ZDF rat plasma

scientific article published on December 2010

What is next for dried blood spots?

scientific article published on August 2012

When opportunity met aspirational goals: accelerator MS, microdosing and absolute bioavailability studies

scientific article published on 01 August 2012

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