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List of works by Matthias Bureik

A common polymorphic variant of UGT1A5 displays increased activity due to optimized cofactor binding

scientific article published on 30 April 2018

A comprehensive overview of common polymorphic variants that cause missense mutations in human CYPs and UGTs

scientific article published on 09 January 2019

A convenient new method for reproducible fed-batch fermentation of fission yeast Schizosaccharomyces pombe

scientific article published on 17 February 2020

A fission yeast-based test system for the determination of IC50 values of anti-prostate tumor drugs acting on CYP21

A fluorimetric assay for cortisol

scientific article

Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria

scientific article

Anti-CYP4Z1 autoantibodies detected in breast cancer patients

scientific article

Biotechnological production of 20-alpha-dihydrodydrogesterone at pilot scale

scientific article published on 15 April 2011

Biotechnological synthesis of drug metabolites using human cytochrome P450 2D6 heterologously expressed in fission yeast exemplified for the designer drug metabolite 4'-hydroxymethyl-alpha-pyrrolidinobutyrophenone

scientific article published on 18 May 2007

Biotechnological synthesis of drug metabolites using human cytochrome P450 isozymes heterologously expressed in fission yeast

scientific article published on July 2009

Biotechnological synthesis of the designer drug metabolite 4'-hydroxymethyl-alpha-pyrrolidinohexanophenone in fission yeast heterologously expressing human cytochrome P450 2D6--a versatile alternative to multistep chemical synthesis

scientific article

Bystander signaling via oxidative metabolism

scientific article published on 4 August 2017

CYP21-catalyzed production of the long-term urinary metandienone metabolite 17beta-hydroxymethyl-17 alpha-methyl-18-norandrosta-1,4,13-trien-3-one: a contribution to the fight against doping.

scientific article published in January 2010

CYP4Z1 - A Human Cytochrome P450 Enzyme that Might Hold the Key to Curing Breast Cancer

scientific article published on 7 February 2017

Challenges of steroid biotransformation with human cytochrome P450 monooxygenase CYP21 using resting cells of recombinant Schizosaccharomyces pombe

scientific article published on 2 February 2010

Coexpression of CPR from various origins enhances biotransformation activity of human CYPs in S. pombe.

scientific article published on 6 June 2013

Coexpression of redox partners increases the hydrocortisone (cortisol) production efficiency in CYP11B1 expressing fission yeast Schizosaccharomyces pombe

scientific article

Combined chemical and biotechnological production of 20βOH-NorDHCMT, a long-term metabolite of Oral-Turinabol (DHCMT).

scientific article published on 26 February 2018

Comparative Proteome Analysis in Schizosaccharomyces pombe Identifies Metabolic Targets to Improve Protein Production and Secretion.

scientific article

Comparison of cytochrome P450 expression in four different human osteoblast models

scientific article

Convenient gram-scale metabolite synthesis by engineered fission yeast strains expressing functional human P450 systems

scientific article published on 07 October 2010

Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1

scientific article published on 01 April 2019

Cytochrome P450 expression patterns in human osteoblasts during osteogenic differentiation with or without TNFα treatment

scientific article published on 04 April 2020

Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells

scientific article published on June 2002

Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) inhibitors. Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypert

scientific article

Efficient conversion of 11-deoxycortisol to cortisol (hydrocortisone) by recombinant fission yeast Schizosaccharomyces pombe.

scientific article

Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast

scientific article published on 23 September 2017

Engineering of human CYP3A enzymes by combination of activating polymorphic variants.

scientific article

Expression and secretion of a CB4-1 scFv-GFP fusion protein by fission yeast

scientific article published on 10 July 2010

Functional Expression of All Human Sulfotransferases in Fission Yeast, Assay Development, and Structural Models for Isoforms SULT4A1 and SULT6B1

scientific article published on 06 November 2020

Functional characterization and mechanistic modeling of the human cytochrome P450 enzyme CYP4A22

scientific article published on 07 July 2019

Functional expression and activity screening of all human cytochrome P450 enzymes in fission yeast

scientific article published on 21 May 2019

Functional expression of human mitochondrial CYP11B2 in fission yeast and identification of a new internal electron transfer protein, etp1.

scientific article published in February 2002

Glucuronide production by whole-cell biotransformation using genetically engineered fission yeast Schizosaccharomyces pombe

scientific article published on 11 December 2009

Human 20α-hydroxysteroid dehydrogenase (AKR1C1)-dependent biotransformation with recombinant fission yeast Schizosaccharomyces pombe

scientific article published on 19 August 2010

Human CYP4Z1 catalyzes the in-chain hydroxylation of lauric acid and myristic acid.

scientific article

Human p53 restores DNA synthesis control in fission yeast

scientific article

Increased TCA cycle activity and reduced oxygen consumption during cytochrome P450-dependent biotransformation in fission yeast

scientific article published on 01 August 2006

Inhibition of aldosterone biosynthesis by staurosporine

scientific article

Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors

scientific article published on November 2002

New Proluciferin Substrates for Human CYP4 Family Enzymes

scientific article published on 01 September 2020

Overcoming the metabolic burden of protein secretion in Schizosaccharomyces pombe – A quantitative approach using 13C-based metabolic flux analysis

scientific article published on 19 November 2013

Phosphorylation of bovine adrenodoxin by protein kinase CK2 affects the interaction with its redox partner cytochrome P450scc (CYP11A1).

scientific article

Plasma membrane localization of CYP4Z1 and CYP19A1 and the detection of anti-CYP19A1 autoantibodies in humans

scientific article published on 10 May 2019

Production and NMR analysis of the human ibuprofen metabolite 3-hydroxyibuprofen

scientific article published on 27 December 2011

Production of human phase 1 and 2 metabolites by whole-cell biotransformation with recombinant microbes.

scientific article published on July 2010

Production of ibuprofen acyl glucosides by human UGT2B7

scientific article published on 23 August 2011

ROS production by adrenodoxin does not cause apoptosis in fission yeast

scientific article

S-Glucuronidation of 7-mercapto-4-methylcoumarin by human UDP glycosyltransferases in genetically engineered fission yeast cells ⬇️

scientific article published on December 1, 2011

Selective oxidation of UDP-glucose to UDP-glucuronic acid using permeabilized Schizosaccharomyces pombe expressing human UDP-glucose 6-dehydrogenase

scientific article published on 18 November 2015

Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase

scientific article

The "Bringer" strategy: a very fast and highly efficient method for construction of mutant libraries by error-prone polymerase chain reaction of ring-closed plasmids

scientific article

The adrenodoxin-like ferredoxin of Schizosaccharomyces pombe mitochondria

scientific article

The human mineralocorticoid receptor only partially differentiates between different ligands after expression in fission yeast

scientific article

The human steroid hydroxylases CYP1B1 and CYP11B2

scientific article

Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination - insights from metandienone metabolism

scientific article

Use of fission yeast heterologously expressing human cytochrome P450 2B6 in biotechnological synthesis of the designer drug metabolite N-(1-phenylcyclohexyl)-2-hydroxyethanamine.

scientific article published on 9 January 2009

Vitamin D(3) metabolism in human glioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol

scientific article

Whole-cell biotransformation assay for investigation of the human drug metabolizing enzyme CYP3A7

scientific article published on 13 July 2010

p53 antibodies: Call for quality ⬇️

scientific article published on November 14, 1997

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