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List of works by Hidde J. Haisma

18F-FEAnGA for PET of β-glucuronidase activity in neuroinflammation

scientific article published on 8 February 2012

6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site ⬇️

scientific article published on November 10, 2011

A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices

scientific article published on 16 March 2017

A comparative study on the immunotherapeutic efficacy of recombinant Semliki Forest virus and adenovirus vector systems in a murine model for cervical cancer.

scientific article published on 11 October 2007

A conditionally replicating adenovirus with strict selectivity in killing cells expressing epidermal growth factor receptor.

scientific article published on 19 December 2006

A facile method for the labeling of proteins with zirconium isotopes

scientific article published on 01 May 1996

A fully human anti-Ep-CAM scFv-beta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug.

scientific article

A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy

scientific article published on 01 December 2004

A monoclonal antibody against human beta-glucuronidase for application in antibody-directed enzyme prodrug therapy

scientific article published on 01 August 1995

A monoclonal antibody-beta-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer.

scientific article

A new application for liposomes in cancer therapy. Immunoliposomes bearing enzymes (immuno-enzymosomes) for site-specific activation of prodrugs

scientific article published on December 1993

A next-generation sequencing method for gene doping detection that distinguishes low levels of plasmid DNA against a background of genomic DNA

scientific article published on 11 July 2019

A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity

scientific article

A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo

scientific article

A rapid and versatile method for harnessing scFv antibody fragments with various biological effector functions

scientific article published on 01 April 2000

Adenovirus retargeting to surface expressed antigens on oral mucosa

scientific article published on April 2010

An assay for the detection of human anti-murine immunoglobulins in the presence of CA125 antigen

scientific article published on 01 January 1988

Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases

scientific article published on 21 June 2012

Analysis of a conjugate between anti-carcinoembryonic antigen monoclonal antibody and alkaline phosphatase for specific activation of the prodrug etoposide phosphate.

scientific article published on January 1992

Antibody-Free Detection of Protein Tyrosine Nitration in Tissue Sections

scientific article published on 11 July 2011

CD40-targeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation

article

CX Chemokine Receptor 7 Contributes to Survival of KRAS-Mutant Non-Small Cell Lung Cancer upon Loss of Epidermal Growth Factor Receptor

scientific article published on 30 March 2019

Cationic polymeric gene delivery of beta-glucuronidase for doxorubicin prodrug therapy

scientific article published in November 1999

Characterization of novel anthracycline prodrugs activated by human beta-glucuronidase for use in antibody-directed enzyme prodrug therapy

scientific article published on 01 August 1996

Cloning and characterization of human liver cytosolic beta-glycosidase

scientific article published in June 2001

Conditionally replicative adenovirus expressing a targeting adapter molecule exhibits enhanced oncolytic potency on CAR-deficient tumors.

scientific article published on November 2003

Construction and characterization of a fusion protein of single-chain anti-carcinoma antibody 323/A3 and human beta-glucuronidase

scientific article published on 01 January 1998

Cytosolic beta-glycosidases for activation of glycoside prodrugs of daunorubicin.

scientific article

Design of immuno-enzymosomes with maximum enzyme targeting capability: effect of the enzyme density on the enzyme targeting capability and cell binding properties

scientific article published on 01 July 1999

Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies directed against intracellular antigens

scientific article published on 01 September 1992

Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection.

scientific article

Distribution and pharmacokinetics of the prodrug daunorubicin-GA3 in nude mice bearing human ovarian cancer xenografts

scientific article published on 01 March 1999

Efficient and selective gene transfer into primary human brain tumors by using single-chain antibody-targeted adenoviral vectors with native tropism abolished

scientific article published on March 2002

Employment of liver tissue slice analysis to assay hepatotoxicity linked to replicative and nonreplicative adenoviral agents

scientific article published in June 2006

Endosomal escape pathways for delivery of biologicals

scientific article

Engineering zinc finger protein transcription factors to downregulate the epithelial glycoprotein-2 promoter as a novel anti-cancer treatment

scientific article published on May 2007

Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89

scientific article published on 01 December 1992

Functional inhibition of NF-kappaB signal transduction in alphavbeta3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IkappaB gene

scientific article published on 13 January 2006

Gene doping.

scientific article

Gene doping: an overview and current implications for athletes.

scientific article

Gene therapy for meningioma: improved gene delivery with targeted adenoviruses

scientific article published in August 2002

HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity.

scientific article published on 15 March 2016

Higher ADCC of murine peritoneal cells after immunization with allogenic tumor cells as compared with stimulation by adriamycin, BCG, and thioglycolate

scientific article published on 01 September 1986

Highly efficient and carcinoma-specific adenoviral replication restricted by the EGP-2 promoter.

scientific article published on 28 November 2006

Histone acetyl transferases as emerging drug targets.

scientific article published on 02 July 2009

Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation.

scientific article

Human IgM monoclonal antibody 16.88: pharmacokinetics and immunogenicity in colorectal cancer patients

scientific article

Immunoliposomes as enzyme-carriers (immuno-enzymosomes) for antibody-directed enzyme prodrug therapy (ADEPT): optimization of prodrug activating capacity

scientific article published on 01 April 1996

Improved characteristics of a human beta-glucuronidase-antibody conjugate after deglycosylation for use in antibody-directed enzyme prodrug therapy

scientific article published on 01 September 1996

Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative

scientific article published on 3 July 2010

In vivo evaluation of [18F]FEAnGA-Me: a PET tracer for imaging β-glucuronidase (β-GUS) activity in a tumor/inflammation rodent model

scientific article

Induction of β-glucuronidase release by cytostatic agents in small tumors

scientific article published on 11 October 2012

Inhibition of melanoma growth by targeting of antigen to dendritic cells via an anti-DEC-205 single-chain fragment variable molecule

scientific article published on 01 December 2008

Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones.

scientific article

Isothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF

scientific article published on 25 January 2011

Liposome-mediated targeting of enzymes to cancer cells for site-specific activation of prodrugs: comparison with the corresponding antibody-enzyme conjugate

scientific article published on March 2003

Localization of radiolabelled F(ab')2 fragments of monoclonal antibodies in nude mice bearing intraperitoneally growing human ovarian cancer xenografts.

scientific article

Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation

scientific article published on August 2006

Minor human antibody response to a mouse and chimeric monoclonal antibody after a single i.v. infusion in ovarian carcinoma patients: a comparison of five assays

scientific article published on 01 January 1995

Novel anthracycline-spacer-beta-glucuronide,-beta-glucoside, and -beta-galactoside prodrugs for application in selective chemotherapy

scientific article published on 01 August 1999

Ovarian cancer targeted adenoviral-mediated mda-7/IL-24 gene therapy

scientific article published on 12 October 2005

PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells

scientific article published on 25 January 2008

Pharmacological interventions for improving adenovirus usage in gene therapy.

scientific article

Polyinosinic acid blocks adeno-associated virus macrophage endocytosis in vitro and enhances adeno-associated virus liver-directed gene therapy in vivo

scientific article published on September 2013

Polyinosinic acid enhances delivery of adenovirus vectors in vivo by preventing sequestration in liver macrophages

scientific article

Potent systemic anticancer activity of adenovirally expressed EGFR-selective TRAIL fusion protein

scientific article published on 23 September 2008

Pronounced antitumor efficacy by extracellular activation of a doxorubicin-glucuronide prodrug after adenoviral vector-mediated expression of a human antibody-enzyme fusion protein

scientific article published on March 2004

Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate

scientific article published on February 2001

Prostate specific membrane antigen (PSMA) is a tissue-specific target for adenoviral transduction of prostate cancer in vitro

scientific article

Protein transduction domains and their utility in gene therapy.

scientific article published on October 2003

Receptor-specific TRAIL as a means to achieve targeted elimination of activated hepatic stellate cells

scientific article published on 25 November 2016

Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation

scientific article published in August 2003

Secreted and tumour targeted human carboxylesterase for activation of irinotecan

scientific article published on September 2002

Secretion of thymidine kinase to increase the effectivity of suicide gene therapy results in the loss of enzymatic activity

article

Selective targeting of adenovirus to alphavbeta3 integrins, VEGFR2 and Tie2 endothelial receptors by angio-adenobodies

scientific article

Specific localization of In-111-labeled monoclonal antibody versus 67-Ga-labeled immunoglobulin in mice bearing human breast carcinoma xenografts

scientific article published on 01 January 1984

Step into the groove: engineered transcription factors as modulators of gene expression.

scientific article

Synthesis and biological activity of beta-glucuronyl carbamate-based prodrugs of paclitaxel as potential candidates for ADEPT

scientific article published on 01 February 1997

Synthesis and evaluation of [18F]-FEAnGA as a PET Tracer for beta-glucuronidase activity

scientific article published on May 2010

Targeted adenovirus mediated inhibition of NF-κB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo

scientific article

Targeted cancer gene therapy: the flexibility of adenoviral gene therapy vectors

scientific article

Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways

scientific article

The effects of γ-interferon combined with 5-fluorouracil or 5-fluoro-2′-deoxyuridine on proliferation and antigen expression in a panel of human colorectal cancer cell lines ⬇️

scientific article published on July 9, 1991

The efficacy of the anthracycline prodrug daunorubicin-GA3 in human ovarian cancer xenografts.

scientific article

Transductional targeting of adenoviral vectors to prostate cancer in vitro

scientific article published on 01 November 1999

Tumor-specific activation of prodrugs: is there a role for nuclear medicine?

scientific article published in October 2008

Tumour localisation with 131I-labelled human IgM monoclonal antibody 16.88 in advanced colorectal cancer patients

scientific article published on 01 January 1991

Use of monoclonal antibodies for detection and therapy of carcinomas.

scientific article

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