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List of works by Aaron B. Bowman

A novel manganese-dependent ATM-p53 signaling pathway is selectively impaired in patient-based neuroprogenitor and murine striatal models of Huntington's disease

scientific article

ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology

scientific article published in December 2006

Age- and manganese-dependent modulation of dopaminergic phenotypes in a C. elegans DJ-1 genetic model of Parkinson's disease

scientific article published on February 2015

Allosteric activation of M4 muscarinic receptors improve behavioral and physiological alterations in early symptomatic YAC128 mice.

scientific article

Altered manganese homeostasis and manganese toxicity in a Huntington's disease striatal cell model are not explained by defects in the iron transport system.

scientific article

Animal models of autism spectrum disorders: information for neurotoxicologists

scientific article

BDNF and Huntingtin protein modifications by manganese: implications for striatal medium spiny neuron pathology in manganese neurotoxicity.

scientific article

Brain Manganese and the Balance between Essential Roles and Neurotoxicity

scientific article published on 18 March 2020

Cellular fura-2 manganese extraction assay (CFMEA).

scientific article published on May 2011

Cellular manganese content is developmentally regulated in human dopaminergic neurons

scientific article

Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese

scientific article

Chronic exposure to methylmercury induces puncta formation in cephalic dopaminergic neurons in Caenorhabditis elegans

scientific article published on 11 January 2020

Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes

scientific article

Combined exposure to methylmercury and manganese during L1 larval stage causes motor dysfunction, cholinergic and monoaminergic up-regulation and oxidative stress in L4 Caenorhabditis elegans

scholarly article by Maria Rosa C Schetinger et al published 15 October 2018 in Toxicology

DHCEO accumulation is a critical mediator of pathophysiology in a Smith–Lemli–Opitz syndrome model ⬇️

scientific article published on December 11, 2011

DMH1, a highly selective small molecule BMP inhibitor promotes neurogenesis of hiPSCs: comparison of PAX6 and SOX1 expression during neural induction.

scientific article

Disease-toxicant interactions in manganese exposed Huntington disease mice: early changes in striatal neuron morphology and dopamine metabolism

scientific article (publication date: 2012)

Disease-toxicant screen reveals a neuroprotective interaction between Huntington's disease and manganese exposure

scientific article published on 21 October 2009

Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes

scientific article published on 18 February 2007

Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation

scientific article

Functional characterization of a testis-specific DNA binding activity at the H19/Igf2 imprinting control region.

scientific article

Gammaretroviral vector encoding a fluorescent marker to facilitate detection of reprogrammed human fibroblasts during iPSC generation

scientific article published on 10 December 2013

Gender and manganese exposure interactions on mouse striatal neuron morphology

scientific article

Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects

scientific article

Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.

scientific article

Huntington's disease associated resistance to Mn neurotoxicity is neurodevelopmental stage and neuronal lineage dependent

scientific article published on 20 September 2019

Huntington's disease genotype suppresses global manganese-responsive processes in pre-manifest and manifest YAC128 mice

scientific article published on 18 May 2020

Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension.

scientific article

Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganese

scientific article published on 11 February 2020

Lipid modifications of Sonic hedgehog ligand dictate cellular reception and signal response.

scientific article

Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C. elegans

scientific article published on 13 March 2015

Manganese Acts upon Insulin/IGF Receptors to Phosphorylate AKT and Increase Glucose Uptake in Huntington's Disease Cells

scientific article published on 04 December 2019

Manganese Is Essential for Neuronal Health

scientific article published on 13 May 2015

Manganese homeostasis in the nervous system

scientific article

Manganese-Induced Parkinsonism and Parkinson's Disease: Shared and Distinguishable Features

scientific article

Manganese-induced Neurotoxicity: From C. elegans to Humans

scientific article

Morphometric analysis in neurodegenerative disorders

scientific article

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

scientific article published on 20 January 2005

Novel high-throughput assay to assess cellular manganese levels in a striatal cell line model of Huntington's disease confirms a deficit in manganese accumulation

scientific article published on 14 January 2011

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

scientific article

Optimization of Fluorescence Assay of Cellular Manganese Status for High Throughput Screening ⬇️

scientific article published on November 20, 2012

PARK2 patient neuroprogenitors show increased mitochondrial sensitivity to copper

scientific article

Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor ⬇️

scientific article published on September 2015

Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.

scientific article

Role of astrocytes in brain function and disease

scientific article

Role of manganese in neurodegenerative diseases

scientific article published on October 2011

SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity

scientific journal article

Sex- and structure-specific differences in antioxidant responses to methylmercury during early development

scientific article published on 22 July 2016

The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans

scientific article published on 22 January 2014

The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk ⬇️

scientific article published on February 11, 2012

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