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List of works by Miia Turpeinen

A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes

scientific article published on 9 February 2009

A simple method for differentiation of monoisotopic drug metabolites with hydrogen-deuterium exchange liquid chromatography/electrospray mass spectrometry

scientific article published in May 2005

Adverse events due to unnecessary radiation exposure in medical imaging reported in Finland

scientific article published on 19 February 2020

An evaluation of the cytochrome P450 inhibition potential of selected pesticides in human hepatic microsomes.

scientific article published in August 2009

Analysis of nine drugs and their cytochrome P450-specific probe metabolites from urine by liquid chromatography-tandem mass spectrometry utilizing sub 2 microm particle size column

scientific article published on 7 November 2008

CYP2B6 and CYP2C19 as the major enzymes responsible for the metabolism of selegiline, a drug used in the treatment of Parkinson's disease, as revealed from experiments with recombinant enzymes

scientific article published in November 2001

Characterization of Diuron N-Demethylation by Mammalian Hepatic Microsomes and cDNA-Expressed Human Cytochrome P450 Enzymes

scientific article published on 18 June 2007

Comparison of anti-p53 antibodies in immunoblotting

scientific article published on 01 May 2002

Comparison of metabolic stability and metabolite identification of 55 ECVAM/ICCVAM validation compounds between human and rat liver homogenates and microsomes - a preliminary analysis.

scientific article published in January 2009

Cytochrome P450 (CYP) inhibition screening: comparison of three tests

scientific article published on 27 June 2006

Cytochrome P450 2B6: function, genetics, and clinical relevance

scientific article published on January 2012

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

scientific article

Drugs used for neurologic and psychiatric conditions increase the risk for bullous pemphigoid: A case-control study

scientific article published on 13 February 2019

Effect of Caffeine Intake 12 or 24 Hours Prior to Melatonin Intake and CYP1A2*1F Polymorphism on CYP1A2 Phenotyping by Melatonin

scientific article published on 01 October 2006

Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation

scientific article published in June 2005

Effect of renal impairment on the pharmacokinetics of bupropion and its metabolites

scientific article

Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene.

scientific article published on 15 August 2013

Effects of selective serotonin reuptake inhibitors on timolol metabolism in human liver microsomes and cryo-preserved hepatocytes

scientific article published on 11 November 2009

Estrogen receptor alpha genotype confers interindividual variability of response to estrogen and testosterone in mesenchymal-stem-cell-derived osteoblasts

scientific article

Exposure to oral S-ketamine is unaffected by itraconazole but greatly increased by ticlopidine

scientific article published on 29 June 2011

Formation of GSH-trapped reactive metabolites in human liver microsomes, S9 fraction, HepaRG-cells, and human hepatocytes

article

From known knowns to known unknowns: predicting in vivo drug metabolites

scientific article published on May 2009

Functional expression, inhibition and induction of CYP enzymes in HepaRG cells

scientific article published on 26 March 2009

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation

scientific article

Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites

scientific article published on 22 November 2011

Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts

scientific article published on 01 October 2015

Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts

scientific article published on 01 March 2015

Hospitalizations Due to Adverse Drug Events in the Elderly-A Retrospective Register Study

scientific article published on 05 October 2016

Identification of bupropion urinary metabolites by liquid chromatography/mass spectrometry

scientific article published on 01 January 2007

Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme--an in silico approach

scientific article published on 9 October 2007

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

scientific article

In vitro interaction cocktail assay for nine major cytochrome P450 enzymes with 13 probe reactions and a single LC/MSMS run: analytical validation and testing with monoclonal anti-CYP antibodies

scientific article published on 01 July 2007

In vitro-in vivo extrapolation of hepatic clearance: biological tools, scaling factors, model assumptions and correct concentrations

scientific article published on October 2007

In vivo-in vitro-in silico pharmacokinetic modelling in drug development: current status and future directions

scientific article

Inhibition and induction of CYP enzymes in humans: an update

scientific article published on 27 October 2020

Liquid chromatography-mass spectrometry in in vitro drug metabolite screening.

scientific article published on 26 December 2008

Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors

scientific article published on 09 August 2006

Metabolism and metabolite profiles in vitro and in vivo of ospemifene in humans and preclinical species

scientific article published on 18 November 2015

Metabolism of hyperforin, the active constituent of St. John's wort, in human liver microsomes

scientific article published on 17 December 2010

Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance.

scientific article published on January 2011

Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay

scientific article published in January 2005

New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis

scientific article published on 26 February 2007

New study designs in clinical drug development

scientific article published in January 2017

Oral diabetes medications other than dipeptidyl peptidase 4 inhibitors are not associated with bullous pemphigoid: A Finnish nationwide case-control study

scientific article published on 25 May 2018

Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations

scientific article published on January 2013

Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver.

scientific article

Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8.

scientific article published on 4 November 2015

PharmGKB summary: venlafaxine pathway

scientific article published on January 2014

Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

scientific article

Prediction of drug metabolism and interactions on the basis of in vitro investigations.

scientific article

Predictive value of animal models for human cytochrome P450 (CYP)-mediated metabolism: A comparative studyin vitro

article

Preservation, induction or incorporation of metabolism into the in vitro cellular system − Views to current opportunities and limitations

scientific article published on 19 June 2012

Quantitative analysis of 4β- and 4α‑hydroxycholesterol in human plasma and serum by UHPLC/ESI-HR-MS

scientific article published on 02 October 2018

Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro

scientific article

Stability of sufentanil and levobupivacaine solutions and a mixture in a 0.9% sodium chloride infusion stored in polypropylene syringes

scientific article published in May 2003

Stable expression, activity, and inducibility of cytochromes P450 in differentiated HepaRG cells

scientific article

Tandem mass spectrometric analysis of S- and N-linked glutathione conjugates of pulegone and menthofuran and identification of P450 enzymes mediating their formation

scientific article published in April 2016

The Risks and Outcomes Resulting From Medication Errors Reported in the Finnish Tertiary Care Units:: A Cross-Sectional Retrospective Register Study

scientific article published on 01 January 2019

The effect of oral contraceptives on the pharmacokinetics of melatonin in healthy subjects with CYP1A2 g.-163C>A polymorphism

scientific article published on 19 May 2008

The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico.

scientific article published on October 2006

The prevalence of medication-related adverse events in inpatients-a systematic review and meta-analysis

scientific article published on 5 September 2017

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction

scientific article published on 26 October 2012

Timolol Metabolism in Human Liver Microsomes Is Mediated Principally by CYP2D6

scientific article published on 12 April 2007

Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated

article

Transfer of repaglinide in the dually perfused human placenta and the role of organic anion transporting polypeptides (OATPs)

article

Vildagliptin significantly increases the risk of bullous pemphigoid: A Finnish nationwide registry study

scientific article published on 7 February 2018

Warfarin-induced calciphylaxis in patients with normal renal function

scientific article published on 19 June 2016

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