List of works - Stefano Rivella

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction

scientific article published on 31 March 2012

Changes in bone microarchitecture and biomechanical properties in the th3 thalassemia mouse are associated with decreased bone turnover and occur during the period of bone accrual.

scientific article

Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice

scientific article

Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis

scientific article

Progress toward the genetic treatment of the beta-thalassemias.

scientific article

Lack of hepcidin ameliorates anemia and improves growth in an adenine-induced mouse model of chronic kidney disease

scientific article published on 20 July 2016

Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation

scientific article

Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt.

scientific article published on 22 December 2016

Future alternative therapies for β-thalassemia

scientific article published on December 1, 2009

Development of K562 cell clones expressing beta-globin mRNA carrying the beta039 thalassaemia mutation for the screening of correctors of stop-codon mutations

scientific article published on 9 July 2009

A preclinical approach for gene therapy of beta-thalassemia.

scientific article published on August 2010

Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models

scientific article

Gene therapy in thalassemia and hemoglobinopathies.

scientific article

Probes for CpG islands on the distal long arm of the human X chromosome are clustered in Xq24 and Xq28.

scientific article published on December 1990

Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia

scientific article published on October 2010

Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease.

scientific article

Comparative mapping of the actin-binding protein 280 genes in human and mouse

scientific article published on 01 May 1994

Altered erythropoiesis and iron metabolism in carriers of thalassemia

scientific article

Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia

scientific article published on January 2005

Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome

scientific article published on 20 July 2017

Prospects for a hepcidin mimic to treat β-thalassemia and hemochromatosis

scientific article published on 01 June 2011

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.

scientific article published on September 2017

Combining gene therapy and fetal hemoglobin induction for treatment of β-thalassemia

scientific article published on June 1, 2013

Lack of Gdf11 does not improve anemia or prevent the activity of RAP-536 in a mouse model of β-thalassemia

scientific article published on 31 May 2019

β-Thalassemia and Polycythemia vera: targeting chronic stress erythropoiesis.

scientific article

What can we learn from ineffective erythropoiesis in thalassemia?

scientific article published on 3 October 2017

Iron age: novel targets for iron overload

scientific article

Protective role of calreticulin in HFE hemochromatosis

scientific article published on 4 October 2007

Polycythemia is associated with bone loss and reduced osteoblast activity in mice.

scientific article published on 09 December 2015

RBCs Homeostatically Bind mtDNA Through TLR9 to Maintain Quiescence and Prevent Lung Injury

scientific article

Selection and mapping of replication origins from a 500-kb region of the human X chromosome and their relationship to gene expression

scientific article published in November 1999

Identification of novel RFLPs in the vicinity of CpG islands in Xq28: application to the analysis of the pattern of X chromosome inactivation

scientific article published on January 1, 1992

New strategies to target iron metabolism for the treatment of beta thalassemia

scientific article published on 25 February 2016

Therapeutic globin gene delivery using lentiviral vectors.

scientific article

Efficacy and safety of ruxolitinib in regularly transfused patients with thalassemia: results from a phase 2a study

scientific article published on 2 November 2017

A validated cellular biobank for β-thalassemia

scientific article published on 02 September 2016

Iron metabolism under conditions of ineffective erythropoiesis in beta-thalassemia

scientific article published on 06 November 2018

Crosstalk between Erythropoiesis and Iron Metabolism

scientific article

In vivo gene transfer strategies to achieve partial correction of von Willebrand disease.

scientific article

Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major

scientific article published on 2 November 2017

Do not super-excess me!

scientific article published on May 2012

Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues

scientific article

Selection and fine mapping of chromosome-specific cDNAs: application to human chromosome 1.

scientific article published on December 1996

Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.

scientific article published on 4 May 2015

Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis

scientific article published on 01 October 2019

Basic principles of gene transfer in hematopoietic stem cells.

scientific article published on 01 January 1999

Gene Addition Strategies for β-Thalassemia and Sickle Cell Anemia

scientific article published in January 2017

Enucleate or replicate? Ask the cytoskeleton.

scientific article published on January 2014

In vivo hematopoietic stem cell modification by mRNA delivery

scientific article published on 27 July 2023

List of works by Stefano Rivella

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction

Changes in bone microarchitecture and biomechanical properties in the th3 thalassemia mouse are associated with decreased bone turnover and occur during the period of bone accrual.

Decreasing TfR1 expression reverses anemia and hepcidin suppression in β-thalassemic mice

Id1 represses osteoclast-dependent transcription and affects bone formation and hematopoiesis

Progress toward the genetic treatment of the beta-thalassemias.

Lack of hepcidin ameliorates anemia and improves growth in an adenine-induced mouse model of chronic kidney disease

Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation

Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt.

Future alternative therapies for β-thalassemia

Development of K562 cell clones expressing beta-globin mRNA carrying the beta039 thalassaemia mutation for the screening of correctors of stop-codon mutations

A preclinical approach for gene therapy of beta-thalassemia.

Iron metabolism and ineffective erythropoiesis in beta-thalassemia mouse models

Gene therapy in thalassemia and hemoglobinopathies.

Probes for CpG islands on the distal long arm of the human X chromosome are clustered in Xq24 and Xq28.

Analysis of alpha hemoglobin stabilizing protein overexpression in murine β-thalassemia

Intestine-specific Disruption of Hypoxia-inducible Factor (HIF)-2α Improves Anemia in Sickle Cell Disease.

Comparative mapping of the actin-binding protein 280 genes in human and mouse

Altered erythropoiesis and iron metabolism in carriers of thalassemia

Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia

Tropomodulin 1 controls erythroblast enucleation via regulation of F-actin in the enucleosome

Prospects for a hepcidin mimic to treat β-thalassemia and hemochromatosis

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.

Combining gene therapy and fetal hemoglobin induction for treatment of β-thalassemia

Lack of Gdf11 does not improve anemia or prevent the activity of RAP-536 in a mouse model of β-thalassemia

β-Thalassemia and Polycythemia vera: targeting chronic stress erythropoiesis.

What can we learn from ineffective erythropoiesis in thalassemia?

Iron age: novel targets for iron overload

Protective role of calreticulin in HFE hemochromatosis

Polycythemia is associated with bone loss and reduced osteoblast activity in mice.

RBCs Homeostatically Bind mtDNA Through TLR9 to Maintain Quiescence and Prevent Lung Injury

Selection and mapping of replication origins from a 500-kb region of the human X chromosome and their relationship to gene expression

Identification of novel RFLPs in the vicinity of CpG islands in Xq28: application to the analysis of the pattern of X chromosome inactivation

New strategies to target iron metabolism for the treatment of beta thalassemia

Therapeutic globin gene delivery using lentiviral vectors.

Efficacy and safety of ruxolitinib in regularly transfused patients with thalassemia: results from a phase 2a study

A validated cellular biobank for β-thalassemia

Iron metabolism under conditions of ineffective erythropoiesis in beta-thalassemia

Crosstalk between Erythropoiesis and Iron Metabolism

In vivo gene transfer strategies to achieve partial correction of von Willebrand disease.

Short-term administration of JAK2 inhibitors reduces splenomegaly in mouse models of β-thalassemia intermedia and major

Do not super-excess me!

Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues

Selection and fine mapping of chromosome-specific cDNAs: application to human chromosome 1.

Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β -Globin Gene with the IVSI-6 Thalassemia Mutation.

Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis

Basic principles of gene transfer in hematopoietic stem cells.

Gene Addition Strategies for β-Thalassemia and Sickle Cell Anemia

Enucleate or replicate? Ask the cytoskeleton.

In vivo hematopoietic stem cell modification by mRNA delivery