List of works - Vera Marisa Costa

"Ecstasy" toxicity to adolescent rats following an acute low binge dose

scientific article

A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B.

scientific article published on 18 September 2015

Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils

scientific article published on 18 March 2013

Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes

scientific article

Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes

scientific article published on 24 December 2008

Adverse outcome pathways induced by 3,4-dimethylmethcathinone and 4-methylmethcathinone in differentiated human SH-SY5Y neuronal cells

scientific article published on 07 May 2020

Aged rats are more vulnerable than adolescents to “ecstasy”-induced toxicity

article

Amanita phalloides poisoning: Mechanisms of toxicity and treatment

scientific article published on 12 September 2015

An effective antidotal combination of polymyxin B and methylprednisolone for α-amanitin intoxication

scientific article published on 19 March 2019

Biodistribution of polyacrylic acid-coated iron oxide nanoparticles is associated with proinflammatory activation and liver toxicity

scientific article

Chemical characterization and protective effect of the Bactris setosa Mart. fruit against oxidative/nitrosative stress

scientific article published on 30 September 2016

Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report

scientific article published on 16 June 2015

Combination of Cl‑IB‑MECA with paclitaxel is a highly effective cytotoxic therapy causing mTOR‑dependent autophagy and mitotic catastrophe on human melanoma cells

scientific article

Comprehensive review of cardiovascular toxicity of drugs and related agents.

scientific article published on 5 January 2018

Correction to: In vitro mechanistic studies on α-amanitin and its putative antidotes

scientific article published on 17 April 2020

Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes

scientific journal article

Cumulative mitoxantrone-induced haematological and hepatic adverse effects in a subchronic in vivo study

scientific article published in November 2013

Development and validation of a GC/IT-MS method for simultaneous quantitation of para and meta-synephrine in biological samples

scientific article published on 23 February 2010

Doxorubicin Is Key for the Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Combination in Differentiated H9c2 Cells

scientific article published on 10 January 2019

ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity

scientific article

Evaluation of GSH adducts of adrenaline in biological samples

scientific article published in July 2007

Flavonoids as antiobesity agents: A review

scientific article published on 20 October 2020

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study

scientific article published on 27 September 2019

Histological and toxicological evaluation, in rat, of a P-glycoprotein inducer and activator: 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5)

scientific article published on 27 August 2019

In vitro mechanistic studies on α-amanitin and its putative antidotes

scientific article published on 19 March 2020

In vivo toxicometabolomics reveals multi-organ and urine metabolic changes in mice upon acute exposure to human-relevant doses of 3,4-methylenedioxypyrovalerone (MDPV)

scientific article published on 19 November 2020

Inosine strongly enhances proliferation of human C32 melanoma cells through PLC-PKC-MEK1/2-ERK1/2 and PI3K pathways

scientific article

Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

scientific article published on 16 October 2019

Methods for the analysis of transcriptome dynamics

scientific article published on 26 July 2019

Methylphenidate clinically oral doses improved brain and heart glutathione redox status and evoked renal and cardiac tissue injury in rats

scientific article published on 23 February 2018

Methylphenidate effects in the young brain: friend or foe?

scientific article published on 12 April 2017

Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Energetic Impairment

Mitoxantrone impairs proteasome activity and prompts early energetic and proteomic changes in HL-1 cardiomyocytes at clinically relevant concentrations

scientific article published on 07 September 2020

Mitoxantrone is More Toxic than Doxorubicin in SH-SY5Y Human Cells: A 'Chemobrain' In Vitro Study.

scientific article published on 5 May 2018

Modeling chronic brain exposure to amphetamines using primary rat neuronal cortical cultures.

scientific article published on 15 July 2014

Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy

scientific article published on 14 September 2016

Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells

scientific article published on 27 November 2012

Oxidation Process of Adrenaline in Freshly Isolated Rat Cardiomyocytes: Formation of Adrenochrome, Quinoproteins, and GSH Adduct

scientific article published on 13 July 2007

Pixantrone, a new anticancer drug with the same old cardiac problems? An in vitro study with differentiated and non-differentiated H9c2 cells

scientific article published on 01 May 2018

Potentiation of cytotoxicity of paclitaxel in combination with Cl-IB-MECA in human C32 metastatic melanoma cells: A new possible therapeutic strategy for melanoma

scientific article published on 23 August 2013

Quantification of alpha-amanitin in biological samples by HPLC using simultaneous UV- diode array and electrochemical detection

scientific article published on 10 June 2015

Quantitative histochemistry for macrophage biodistribution on mice liver and spleen after the administration of a pharmacological-relevant dose of polyacrylic acid-coated iron oxide nanoparticles

scientific article published on 6 February 2017

Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors

Structural isomerization of synephrine influences its uptake and ensuing glutathione depletion in rat-isolated cardiomyocytes

scientific article published on 8 December 2010

Structure-cytotoxicity relationship profile of 13 synthetic cathinones in differentiated human SH-SY5Y neuronal cells

scientific article published on 29 August 2019

Synephrine: from trace concentrations to massive consumption in weight-loss

scientific article

The Heart As a Target for Xenobiotic Toxicity: The Cardiac Susceptibility to Oxidative Stress ⬇️

scientific article published on August 23, 2013

The Main Metabolites of Fluorouracil + Adriamycin + Cyclophosphamide (FAC) Are Not Major Contributors to FAC Toxicity in H9c2 Cardiac Differentiated Cells ⬇️

article

The Role of the Metabolism of Anticancer Drugs in Their Induced-Cardiotoxicity

scientific article

The Secretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-Induced Cytotoxicity: Impact in Non-Tumor Cells

scientific article published on 3 December 2021

The age factor for mitoxantrone's cardiotoxicity: multiple doses render the adult mouse heart more susceptible to injury

scientific article published on 9 January 2015

The combination of Cl-IB-MECA with paclitaxel: a new anti-metastatic therapeutic strategy for melanoma

scientific article published on 14 August 2014

The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs

scientific article published on 10 April 2017

The metabolic profile of mitoxantrone and its relation with mitoxantrone-induced cardiotoxicity

scientific article published on 02 April 2013

The neurotoxicity of amphetamines during the adolescent period

scientific article

The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons

scientific article

Therapeutic concentrations of mitoxantrone elicit energetic imbalance in H9c2 cells as an earlier event

scientific article published on December 2013

Toxicity of amphetamines: an update

scientific article

Toxicity of the amphetamine metabolites 4-hydroxyamphetamine and 4-hydroxynorephedrine in human dopaminergic differentiated SH-SY5Y cells.

scientific article published on 20 January 2017

List of works by Vera Marisa Costa

"Ecstasy" toxicity to adolescent rats following an acute low binge dose

A breakthrough on Amanita phalloides poisoning: an effective antidotal effect by polymyxin B.

Acetaminophen prevents oxidative burst and delays apoptosis in human neutrophils

Adrenaline and reactive oxygen species elicit proteome and energetic metabolism modifications in freshly isolated rat cardiomyocytes

Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes

Adverse outcome pathways induced by 3,4-dimethylmethcathinone and 4-methylmethcathinone in differentiated human SH-SY5Y neuronal cells

Aged rats are more vulnerable than adolescents to “ecstasy”-induced toxicity

Amanita phalloides poisoning: Mechanisms of toxicity and treatment

An effective antidotal combination of polymyxin B and methylprednisolone for α-amanitin intoxication

Biodistribution of polyacrylic acid-coated iron oxide nanoparticles is associated with proinflammatory activation and liver toxicity

Chemical characterization and protective effect of the Bactris setosa Mart. fruit against oxidative/nitrosative stress

Co-ingestion of amatoxins and isoxazoles-containing mushrooms and successful treatment: A case report

Combination of Cl‑IB‑MECA with paclitaxel is a highly effective cytotoxic therapy causing mTOR‑dependent autophagy and mitotic catastrophe on human melanoma cells

Comprehensive review of cardiovascular toxicity of drugs and related agents.

Correction to: In vitro mechanistic studies on α-amanitin and its putative antidotes

Cross-functioning between the extraneuronal monoamine transporter and multidrug resistance protein 1 in the uptake of adrenaline and export of 5-(glutathion-S-yl)adrenaline in rat cardiomyocytes

Cumulative mitoxantrone-induced haematological and hepatic adverse effects in a subchronic in vivo study

Development and validation of a GC/IT-MS method for simultaneous quantitation of para and meta-synephrine in biological samples

Doxorubicin Is Key for the Cardiotoxicity of FAC (5-Fluorouracil + Adriamycin + Cyclophosphamide) Combination in Differentiated H9c2 Cells

ER stress-inducible factor CHOP affects the expression of hepcidin by modulating C/EBPalpha activity

Evaluation of GSH adducts of adrenaline in biological samples

Flavonoids as antiobesity agents: A review

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study

Histological and toxicological evaluation, in rat, of a P-glycoprotein inducer and activator: 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5)

In vitro mechanistic studies on α-amanitin and its putative antidotes

In vivo toxicometabolomics reveals multi-organ and urine metabolic changes in mice upon acute exposure to human-relevant doses of 3,4-methylenedioxypyrovalerone (MDPV)

Inosine strongly enhances proliferation of human C32 melanoma cells through PLC-PKC-MEK1/2-ERK1/2 and PI3K pathways

Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

Methods for the analysis of transcriptome dynamics

Methylphenidate clinically oral doses improved brain and heart glutathione redox status and evoked renal and cardiac tissue injury in rats

Methylphenidate effects in the young brain: friend or foe?

Mitochondrial Cumulative Damage Induced by Mitoxantrone: Late Onset Cardiac Energetic Impairment

Mitoxantrone impairs proteasome activity and prompts early energetic and proteomic changes in HL-1 cardiomyocytes at clinically relevant concentrations

Mitoxantrone is More Toxic than Doxorubicin in SH-SY5Y Human Cells: A 'Chemobrain' In Vitro Study.

Modeling chronic brain exposure to amphetamines using primary rat neuronal cortical cultures.

Naphthoquinoxaline metabolite of mitoxantrone is less cardiotoxic than the parent compound and it can be a more cardiosafe drug in anticancer therapy

Neurotoxicity of "ecstasy" and its metabolites in human dopaminergic differentiated SH-SY5Y cells

Oxidation Process of Adrenaline in Freshly Isolated Rat Cardiomyocytes: Formation of Adrenochrome, Quinoproteins, and GSH Adduct

Pixantrone, a new anticancer drug with the same old cardiac problems? An in vitro study with differentiated and non-differentiated H9c2 cells

Potentiation of cytotoxicity of paclitaxel in combination with Cl-IB-MECA in human C32 metastatic melanoma cells: A new possible therapeutic strategy for melanoma

Quantification of alpha-amanitin in biological samples by HPLC using simultaneous UV- diode array and electrochemical detection

Quantitative histochemistry for macrophage biodistribution on mice liver and spleen after the administration of a pharmacological-relevant dose of polyacrylic acid-coated iron oxide nanoparticles

Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors

Structural isomerization of synephrine influences its uptake and ensuing glutathione depletion in rat-isolated cardiomyocytes

Structure-cytotoxicity relationship profile of 13 synthetic cathinones in differentiated human SH-SY5Y neuronal cells

Synephrine: from trace concentrations to massive consumption in weight-loss

The Heart As a Target for Xenobiotic Toxicity: The Cardiac Susceptibility to Oxidative Stress ⬇️

The Main Metabolites of Fluorouracil + Adriamycin + Cyclophosphamide (FAC) Are Not Major Contributors to FAC Toxicity in H9c2 Cardiac Differentiated Cells ⬇️

The Role of the Metabolism of Anticancer Drugs in Their Induced-Cardiotoxicity

The Secretome of Human Neonatal Mesenchymal Stem Cells Modulates Doxorubicin-Induced Cytotoxicity: Impact in Non-Tumor Cells

The age factor for mitoxantrone's cardiotoxicity: multiple doses render the adult mouse heart more susceptible to injury

The combination of Cl-IB-MECA with paclitaxel: a new anti-metastatic therapeutic strategy for melanoma

The importance of drug metabolites synthesis: the case-study of cardiotoxic anticancer drugs

The metabolic profile of mitoxantrone and its relation with mitoxantrone-induced cardiotoxicity

The neurotoxicity of amphetamines during the adolescent period

The neurotoxicity of hallucinogenic amphetamines in primary cultures of hippocampal neurons

Therapeutic concentrations of mitoxantrone elicit energetic imbalance in H9c2 cells as an earlier event

Toxicity of amphetamines: an update

Toxicity of the amphetamine metabolites 4-hydroxyamphetamine and 4-hydroxynorephedrine in human dopaminergic differentiated SH-SY5Y cells.