List of works - Paul R. Crocker

A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration

scientific article published on 01 September 1994

A novel subset of murine B cells that expresses unmasked forms of CD22 is enriched in the bone marrow: implications for B-cell homing to the bone marrow

scientific article published on 01 November 2000

A small region of the natural killer cell receptor, Siglec-7, is responsible for its preferred binding to alpha 2,8-disialyl and branched alpha 2,6-sialyl residues. A comparison with Siglec-9.

scientific article published on 10 December 2001

A versatile gold surface approach for fabrication and interrogation of glycoarrays

scientific article

Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses

scientific article published on 01 June 2021

An expression system for screening of proteins for glycan and protein interactions

scientific article published on 04 January 2011

Analysis of lectin binding to glycolipid complexes using combinatorial glycoarrays

scientific article published on 6 April 2009

Analysis of sialoadhesin expression on mouse alveolar macrophages.

scientific article published on 3 May 2009

Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors

scientific article

Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin/CD169

scientific article

Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in P0.

scientific article published on 3 February 2006

Binding specificities of the sialoadhesin family of I-type lectins. Sialic acid linkage and substructure requirements for binding of myelin-associated glycoprotein, Schwann cell myelin protein, and sialoadhesin

scientific article published on July 1997

CD169 mediates the capture of exosomes in spleen and lymph node.

scientific article published on 19 November 2013

CD33-related siglecs as potential modulators of inflammatory responses

scientific article published on 21 February 2012

Campylobacter jejuni lipooligosaccharides modulate dendritic cell-mediated T cell polarization in a sialic acid linkage-dependent manner

scientific article

Carbohydrate microarrays reveal sulphation as a modulator of siglec binding

scientific article published on 19 April 2006

Carbohydrate recognition systems: functional triads in cell-cell interactions

scientific article

Cell-specific glycoforms of sialoadhesin and CD45 are counter-receptors for the cysteine-rich domain of the mannose receptor

scientific article

Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors

scientific journal article

Characterization of the mouse sialoadhesin gene, Sn.

scientific article published in December 1997

Characterization of the specific interaction between sialoadhesin and sialylated Campylobacter jejuni lipooligosaccharides

scientific article published on 26 April 2010

Chemoenzymatic synthesis of sialooligosaccharides on arrays for studies of cell surface adhesion

scientific article

Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.

scientific article published in May 2002

Complex of sialoadhesin with a glycopeptide ligand.

scientific article published in November 2004

Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin

scientific article

Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression

scientific article

Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E

scientific article

Enhancing the Receptor Affinity of the Sialic Acid-binding Domain of Vibrio cholerae Sialidase through Multivalency

scientific article

Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6'-sulfated sialyl Lewis x.

scientific article

Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?

scientific article

Expression of CD33-related siglecs on human mononuclear phagocytes, monocyte-derived dendritic cells and plasmacytoid dendritic cells

scientific article published on 01 January 2004

Fluorescent carbohydrate probes for cell lectins.

scientific article

Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue

scientific article

Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms

scientific article (publication date: June 2003)

Ganglioside binding pattern of CD33-related siglecs

scientific article published on 01 February 2003

Glycoimmunology: ignore at your peril!

scientific article published on 01 July 2009

Glycopeptides as oligosaccharide mimics: high affinity sialopeptide ligands for sialoadhesin from combinatorial libraries.

scientific article

High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family

scientific article

Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate

scientific article

Identification and characterization of adsorbed serum sialoglycans on Leishmania donovani promastigotes

scientific article

Individual plasmacytoid dendritic cells are major contributors to the production of multiple innate cytokines in an organ-specific manner during viral infection

article

Intravenous immunoglobulin preparations contain anti–Siglec-8 autoantibodies

scientific article published in April 2007

Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs

scientific article published on March 2000

MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion

scientific article published on November 2007

Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin

scientific article published on 01 October 1999

Maintenance of granulocyte numbers during acute peritonitis is defective in galectin-3-null mutant mice

scientific article published on 01 July 1998

Modifications of cell surface sialic acids modulate cell adhesion mediated by sialoadhesin and CD22.

scientific article published on December 1994

Molecular analysis of sialoside binding to sialoadhesin by NMR and site-directed mutagenesis

scientific article

Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6'-sulfo-sialyl Lewis X as a preferred glycan ligand

scientific article

Myelin-associated glycoprotein binding to gangliosides. Structural specificity and functional implications.

scientific article

Myelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition site

scientific journal article

Negative regulation of leucocyte functions by CD33-related siglecs

scientific article published on 01 December 2006

Neoglycolipid probes prepared via oxime ligation for microarray analysis of oligosaccharide-protein interactions

scientific article published on July 2007

New functions for the sialic acid-binding adhesion molecule CD22, a member of the growing family of Siglecs.

scientific article

Overexpression of MUC1 reconfigures the binding properties of tumor cells

scientific article published on 01 December 2001

PEGylation of anti-sialoadhesin monoclonal antibodies enhances their inhibitory potencies without impairing endocytosis in mouse peritoneal macrophages

scientific article published in February 2009

Porcine arterivirus attachment to the macrophage-specific receptor sialoadhesin is dependent on the sialic acid-binding activity of the N-terminal immunoglobulin domain of sialoadhesin

scientific article published on 13 June 2007

Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides

scientific article (publication date: May 2006)

Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression

scientific article

SOCS3 targets Siglec 7 for proteasomal degradation and blocks Siglec 7-mediated responses.

scientific article published on 30 November 2006

Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition

scientific article published on 27 November 2009

Sialoadhesin (Sn) maps to mouse chromosome 2 and human chromosome 20 and is not linked to the other members of the sialoadhesin family, CD22, MAG, and CD33

scientific article published on 01 July 1995

Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice

scientific article published on 24 October 2006

Sialoadhesin deficiency does not influence the severity of lupus nephritis in New Zealand black x New Zealand white F1 mice.

scientific article

Sialoadhesin expression in intact degenerating retinas and following transplantation

scientific article published on 18 July 2008

Sialoadhesin in recognition of self and non-self.

scientific article published on 27 March 2012

Sialoadhesin-deficient mice exhibit subtle changes in B- and T-cell populations and reduced immunoglobulin M levels.

scientific article

Sialoside specificity of the siglec family assessed using novel multivalent probes: identification of potent inhibitors of myelin-associated glycoprotein.

scientific article

Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation.

scientific article

Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b

scientific article published on 08 August 2006

Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer

scientific article

Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes.

scientific article

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling

scientific article published on 11 January 2013

Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils

scientific article

Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population

scientific article

Siglecs and their roles in the immune system

scientific article

Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.

scientific article

Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling.

scientific article

Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin

scientific article (publication date: May 2003)

Surface plasmon resonance imaging for real-time, label-free analysis of protein interactions with carbohydrate microarrays

article

The M/GP(5) glycoprotein complex of porcine reproductive and respiratory syndrome virus binds the sialoadhesin receptor in a sialic acid-dependent manner

scientific article

The amino-terminal immunoglobulin-like domain of sialoadhesin contains the sialic acid binding site. Comparison with CD22.

scientific article

The antigen recognized by MOMA-I is sialoadhesin

scientific article published on 8 May 2006

The potential role of sialoadhesin as a macrophage recognition molecule in health and disease

scientific article published on August 1997

The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design

scientific article

List of works by Paul R. Crocker

A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration

A novel subset of murine B cells that expresses unmasked forms of CD22 is enriched in the bone marrow: implications for B-cell homing to the bone marrow

A small region of the natural killer cell receptor, Siglec-7, is responsible for its preferred binding to alpha 2,8-disialyl and branched alpha 2,6-sialyl residues. A comparison with Siglec-9.

A versatile gold surface approach for fabrication and interrogation of glycoarrays

Activation of regulatory T cells triggers specific changes in glycosylation associated with Siglec-1-dependent inflammatory responses

An expression system for screening of proteins for glycan and protein interactions

Analysis of lectin binding to glycolipid complexes using combinatorial glycoarrays

Analysis of sialoadhesin expression on mouse alveolar macrophages.

Analysis of the CD33-related siglec family reveals that Siglec-9 is an endocytic receptor expressed on subsets of acute myeloid leukemia cells and absent from normal hematopoietic progenitors

Antigen delivery to macrophages using liposomal nanoparticles targeting sialoadhesin/CD169

Attenuated demyelination in the absence of the macrophage-restricted adhesion molecule sialoadhesin (Siglec-1) in mice heterozygously deficient in P0.

Binding specificities of the sialoadhesin family of I-type lectins. Sialic acid linkage and substructure requirements for binding of myelin-associated glycoprotein, Schwann cell myelin protein, and sialoadhesin

CD169 mediates the capture of exosomes in spleen and lymph node.

CD33-related siglecs as potential modulators of inflammatory responses

Campylobacter jejuni lipooligosaccharides modulate dendritic cell-mediated T cell polarization in a sialic acid linkage-dependent manner

Carbohydrate microarrays reveal sulphation as a modulator of siglec binding

Carbohydrate recognition systems: functional triads in cell-cell interactions

Cell-specific glycoforms of sialoadhesin and CD45 are counter-receptors for the cysteine-rich domain of the mannose receptor

Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors

Characterization of the mouse sialoadhesin gene, Sn.

Characterization of the specific interaction between sialoadhesin and sialylated Campylobacter jejuni lipooligosaccharides

Chemoenzymatic synthesis of sialooligosaccharides on arrays for studies of cell surface adhesion

Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia.

Complex of sialoadhesin with a glycopeptide ligand.

Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin

Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression

Early murine T-lymphocyte activation is accompanied by a switch from N-Glycolyl- to N-acetyl-neuraminic acid and generation of ligands for siglec-E

Enhancing the Receptor Affinity of the Sialic Acid-binding Domain of Vibrio cholerae Sialidase through Multivalency

Eosinophil-selective binding and proapoptotic effect in vitro of a synthetic Siglec-8 ligand, polymeric 6'-sulfated sialyl Lewis x.

Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation?

Expression of CD33-related siglecs on human mononuclear phagocytes, monocyte-derived dendritic cells and plasmacytoid dendritic cells

Fluorescent carbohydrate probes for cell lectins.

Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue

Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms

Ganglioside binding pattern of CD33-related siglecs

Glycoimmunology: ignore at your peril!

Glycopeptides as oligosaccharide mimics: high affinity sialopeptide ligands for sialoadhesin from combinatorial libraries.

High resolution crystal structures of Siglec-7. Insights into ligand specificity in the Siglec family

Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate

Identification and characterization of adsorbed serum sialoglycans on Leishmania donovani promastigotes

Individual plasmacytoid dendritic cells are major contributors to the production of multiple innate cytokines in an organ-specific manner during viral infection

Intravenous immunoglobulin preparations contain anti–Siglec-8 autoantibodies

Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs

MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion

Macrophage-tumour cell interactions: identification of MUC1 on breast cancer cells as a potential counter-receptor for the macrophage-restricted receptor, sialoadhesin

Maintenance of granulocyte numbers during acute peritonitis is defective in galectin-3-null mutant mice

Modifications of cell surface sialic acids modulate cell adhesion mediated by sialoadhesin and CD22.

Molecular analysis of sialoside binding to sialoadhesin by NMR and site-directed mutagenesis

Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6'-sulfo-sialyl Lewis X as a preferred glycan ligand

Myelin-associated glycoprotein binding to gangliosides. Structural specificity and functional implications.

Myelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition site

Negative regulation of leucocyte functions by CD33-related siglecs

Neoglycolipid probes prepared via oxime ligation for microarray analysis of oligosaccharide-protein interactions

New functions for the sialic acid-binding adhesion molecule CD22, a member of the growing family of Siglecs.

Overexpression of MUC1 reconfigures the binding properties of tumor cells

PEGylation of anti-sialoadhesin monoclonal antibodies enhances their inhibitory potencies without impairing endocytosis in mouse peritoneal macrophages

Porcine arterivirus attachment to the macrophage-specific receptor sialoadhesin is dependent on the sialic acid-binding activity of the N-terminal immunoglobulin domain of sialoadhesin

Probing sialic acid binding Ig-like lectins (siglecs) with sulfated oligosaccharides

Probing the cis interactions of the inhibitory receptor Siglec-7 with alpha2,8-disialylated ligands on natural killer cells and other leukocytes using glycan-specific antibodies and by analysis of alpha2,8-sialyltransferase gene expression

SOCS3 targets Siglec 7 for proteasomal degradation and blocks Siglec 7-mediated responses.

Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell recognition

Sialoadhesin (Sn) maps to mouse chromosome 2 and human chromosome 20 and is not linked to the other members of the sialoadhesin family, CD22, MAG, and CD33

Sialoadhesin deficiency ameliorates myelin degeneration and axonopathic changes in the CNS of PLP overexpressing mice

Sialoadhesin deficiency does not influence the severity of lupus nephritis in New Zealand black x New Zealand white F1 mice.

Sialoadhesin expression in intact degenerating retinas and following transplantation

Sialoadhesin in recognition of self and non-self.

Sialoadhesin-deficient mice exhibit subtle changes in B- and T-cell populations and reduced immunoglobulin M levels.

Sialoside specificity of the siglec family assessed using novel multivalent probes: identification of potent inhibitors of myelin-associated glycoprotein.

Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation.

Siglec-7 undergoes a major conformational change when complexed with the alpha(2,8)-disialylganglioside GT1b

Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer

Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes.

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling

Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils

Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population

Siglecs and their roles in the immune system

Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.

Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling.

Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin