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List of works by Gideon M. Hirschfield

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

scientific article published in August 2016

A comparison of depression screening instruments in hepatitis C and the impact of depression on somatic symptoms

scientific article published in September 2011

A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease.

scientific article

A liver mass post-Fontan operation

scientific article published on 11 March 2014

A massive haematemesis

scientific article published in the British Medical Journal

A validated clinical tool for the prediction of varices in PBC: the Newcastle Varices in PBC Score.

scientific article published on 19 April 2013

Adult liver transplantation: what non-specialists need to know.

scientific article published on 22 May 2009

Amyloidosis: a clinico-pathophysiological synopsis.

scientific article published on February 2004

Amyloidosis: new strategies for treatment.

scientific article

An overview of the diagnosis and management of immunoglobulin G4-related disease

scientific article published on 20 June 2016

Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis

scientific article published on 10 October 2014

Apical Sodium-Dependent Transporter Inhibitors in Primary Biliary Cholangitis and Primary Sclerosing Cholangitis.

scientific article published on March 2017

Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes.

scientific article published on 19 January 2012

Autoantibodies and liver disease: uses and abuses.

scientific article

Autoimmune hepatitis – learning about your patients from their autoantibody profiles ⬇️

scientific article published on January 1, 2012

Autoimmune hepatitis: an approach to disease understanding and management

scientific article published on 20 May 2015

BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial

scientific article

Biliary atresia and survival into adulthood without transplantation: a collaborative multicentre clinic review

scientific article

C-reactive protein and its role in the pathogenesis of myocardial infarction.

scientific article published on November 2001

C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease

scientific article

C-reactive protein: a critical update

scientific article

C-reactive protein: a critical update

CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population

scientific article published on April 2009

Carriage of a tumor necrosis factor polymorphism amplifies the cytotoxic T-lymphocyte antigen 4 attributed risk of primary biliary cirrhosis: evidence for a gene-gene interaction

scientific article

Characterization of animal models for primary sclerosing cholangitis (PSC).

scientific article published on 19 February 2014

Cholestasis and cholestatic syndromes

scientific article published on 01 May 2009

Cirrhosis-associated immune dysfunction: Novel insights in impaired adaptive immunity

scientific article published on 11 November 2019

Clinical outcomes of donation after circulatory death liver transplantation in primary sclerosing cholangitis

scientific article published on 6 July 2017

Combined ursodeoxycholic acid (UDCA) and fenofibrate in primary biliary cholangitis patients with incomplete UDCA response may improve outcomes.

scientific article

Comparative MRI analysis of morphologic patterns of bile duct disease in IgG4-related systemic disease versus primary sclerosing cholangitis

article

Comparative analysis of portal cell infiltrates in antimitochondrial autoantibody-positive versus antimitochondrial autoantibody-negative primary biliary cirrhosis

scientific article published on 4 April 2012

Daclatasvir plus peginterferon alfa and ribavirin for treatment-naive chronic hepatitis C genotype 1 or 4 infection: a randomised study

scientific article published on 30 July 2014

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

scientific article

Development and Validation of a Scoring System to Predict Outcomes of Patients With Primary Biliary Cirrhosis Receiving Ursodeoxycholic Acid Therapy.

scientific article published on 07 August 2015

Diagnosis of primary biliary cirrhosis ⬇️

scientific article published on December 1, 2011

Donor factor V leiden mutation and vascular thrombosis following liver transplantation

scientific article published on 01 January 1998

Editorial: The Etiology of Intrahepatic Cholestasis of Pregnancy: Towards Solving a Monkey Puzzle

scientific article published on 01 January 2014

Editorial: autoimmune hepatitis - identifying options for treatment

scientific article published on 01 June 2016

Effect of NGM282, a FGF19 analogue, in Primary Sclerosing Cholangitis: a Multicentre, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial

scientific article published on 09 November 2018

Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study.

scientific article published on 7 February 2017

Effects of fluvastatin and bezafibrate combination on plasma fibrinogen, t-plasminogen activator inhibitor and C reactive protein levels in coronary artery disease patients with mixed hyperlipidaemia (FACT Study)--a rebuttal

scientific article published on 01 January 2001

Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid.

scientific article

Factors that Influence Health-Related Quality of Life in Patients with Primary Sclerosing Cholangitis.

scientific article published on 7 January 2016

Fatal reactivation of hepatitis B after chemotherapy for lymphoma.

scientific article

Fibrosis stage is an independent predictor of outcome in primary biliary cholangitis despite biochemical treatment response

scientific article published on 17 October 2019

Follicles, germinal centers, and immune mechanisms in primary biliary cirrhosis

scientific article published on 01 February 2015

Frequency and significance of IgG4 immunohistochemical staining in liver explants from patients with primary sclerosing cholangitis.

scientific article

Genetic Determinants of Cholestasis ⬇️

scientific article published on May 1, 2013

Genetic Distinctions in Patients With Primary Sclerosing Cholangitis: Immunoglobulin G4 Elevations and HLA Risk

scientific article published on 21 March 2015

Genetic Risks Link Autoimmune Hepatitis to Other Autoimmune Liver Disease

scientific article published on 25 June 2014

Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals

scientific article

Genetics in PBC: what do the "risk genes" teach us?

scientific article published on June 2015

Genetics of autoimmune liver disease: a brief summary for clinicians

scientific article

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

scientific article published on 16 October 2011

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

scientific article

Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis

scientific journal article

Good maternal and fetal outcomes for pregnant women with primary biliary cirrhosis.

scientific article published on 7 December 2013

Grand round: Autoimmune hepatitis

scientific article published on 20 November 2018

Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease

scientific article

HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry.

scientific article published on 11 July 2017

Hepatocellular carcinoma for the non-specialist.

scientific article published on 04 December 2009

High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires

scientific article published on 7 August 2015

Human C-reactive protein does not protect against acute lipopolysaccharide challenge in mice

scientific article published in December 2003

Identifying opportunities to improve management of autoimmune hepatitis: evaluation of drug adherence and psychosocial factors

scientific article published on 4 August 2012

IgG4 related disease - a retrospective descriptive study highlighting Canadian experiences in diagnosis and management.

scientific article

IgG4-related sclerosing disease: autoimmune pancreatitis and extrapancreatic manifestations

scientific article published on September 2011

Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants

scientific article

Immunogenetics in primary sclerosing cholangitis.

scientific article published on March 2017

Improvement of ischemic cholangiopathy in three patients with hereditary hemorrhagic telangiectasia following treatment with bevacizumab

scientific article

In Vitro and Ex Vivo Models to Study T Cell Migration Through the Human Liver Parenchyma

scientific article published in January 2017

Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability

scientific article

Insights into the management of Wilson's disease

scientific article published on 3 October 2017

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

scientific article

Intestinal CCL25 expression is increased in colitis and correlates with inflammatory activity

scientific article published on 9 February 2016

Investigating the safety and activity of the use of BTT1023 (Timolumab), in the treatment of patients with primary sclerosing cholangitis (BUTEO): A single-arm, two-stage, open-label, multi-centre, phase II clinical trial protocol

scientific article

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome

scientific article published on 21 April 2016

Levels of alkaline phosphatase and bilirubin are surrogate end points of outcomes of patients with primary biliary cirrhosis: an international follow-up study

scientific article published on 23 August 2014

Liver disease in the UK.

scientific article

Long-term follow-up of patients with difficult to treat type 1 autoimmune hepatitis on Tacrolimus therapy.

scientific article

Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis

scientific article published on 12 April 2014

Low-dose interleukin-2 promotes STAT-5 phosphorylation, Treg survival and CTLA-4-dependent function in autoimmune liver diseases

scientific article published on 8 February 2017

Making the most of new genetic risk factors – genetic and epigenetic fine mapping of causal autoimmune disease variants

scientific article published on 06 July 2015

Management of Primary Sclerosing Cholangitis: Conventions and Controversies ⬇️

scientific article published on May 1, 2012

Mechanisms of tissue injury in autoimmune liver diseases

scientific article published on August 2014

Mesenchymal stromal cells and liver fibrosis: a complicated relationship.

scientific article published on 6 September 2016

Metagenomics and autoimmune liver disease: searching for the unknown

scientific article published on 01 March 2009

NOTCH2 mutations in Alagille syndrome

scientific article

Navigating the road to personalized medicine: can we believe?

scientific article published on 6 April 2010

New Approaches to Investigate Drug-Induced Hypersensitivity

scientific article published on 2 November 2016

New insights into autoimmune liver diseases

scientific article published on 07 May 2008

Novel therapeutic targets in primary biliary cirrhosis

scientific article

OX40, OX40L and Autoimmunity: a Comprehensive Review.

scientific article published on 28 July 2015

Optimising risk stratification in primary biliary cirrhosis: AST/platelet ratio index predicts outcome independent of ursodeoxycholic acid response.

scientific article

Overlap syndrome: A real syndrome?

scientific article published on 01 March 2014

Overlap syndromes: the International Autoimmune Hepatitis Group (IAIHG) position statement on a controversial issue

scientific article published on 18 September 2010

PBC Screen: An IgG/IgA dual isotype ELISA detecting multiple mitochondrial and nuclear autoantibodies specific for primary biliary cirrhosis

scientific article published in December 2010

PR3-ANCA: a promising biomarker in primary sclerosing cholangitis (PSC).

scientific article

Pathogenesis of Cholestatic Liver Disease and Therapeutic Approaches ⬇️

scientific article published on September 16, 2010

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis

scientific article published on 5 March 2017

Patients With Autoimmune Hepatitis Who Have Antimitochondrial Antibodies Need Long-term Follow-up to Detect Late Development of Primary Biliary Cirrhosis

article

Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis

scientific article published on 24 October 2016

Portal hypertension in polycystic liver disease patients does not affect wait-list or immediate post-liver transplantation outcomes

scientific article

Post-prophylaxis Toxoplasma chorioretinitis following donor-recipient mismatched liver transplantation

scientific article published on 08 August 2016

Preface

scientific article published on 03 May 2017

Preprocedural inflammatory markers do not predict restenosis after successful coronary stenting

scientific article published in June 2004

Prevalence and risk factors for liver biochemical abnormalities in Canadian patients with systemic lupus erythematosus

scientific article published on 15 December 2011

Preventative hepatology: minimising symptoms and optimising care.

scientific article published on August 2008

Primary biliary cholangitis in 2016: High-definition PBC: biology, models and therapeutic advances

scientific article published on 11 January 2017

Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants

scientific article

Primary biliary cirrhosis: one disease with many faces.

scientific article published on January 2011

Primary biliary cirrhosis: the future

scientific article published on May 2008

Primary sclerosing cholangitis

scientific article published in The Lancet

Primary sclerosing cholangitis and the management of uncertainty and complexity

scientific article published on 25 July 2017

Progress in the genetics of primary biliary cirrhosis

scientific article published on 02 May 2011

Prospective evaluation of ursodeoxycholic acid withdrawal in patients with primary sclerosing cholangitis

scientific article published on 30 July 2014

Rare X chromosome abnormalities in systemic lupus erythematosus and Sjögren's syndrome

scientific article published on 10 July 2017

Recipient HLA-DR3, tumour necrosis factor-α promoter allele-2 (tumour necrosis factor-2) and cytomegalovirus infection are inter-related risk factors for chronic rejection of liver grafts

scientific article published on 01 May 2001

Renaming primary biliary cirrhosis—clarity or confusion?

scientific article published on 10 November 2015

Reply

scientific article published on 06 May 2016

Reply

scientific article published on 29 June 2015

Reply to: “AST/platelet ratio index associates with progression to hepatic failure and correlates with histological fibrosis stage in Japanese patients with primary biliary cirrhosis”

scientific article published on 23 August 2014

Reply: To PMID 25160979.

scientific article

Review article: overlap syndromes and autoimmune liver disease

scientific article published on 22 July 2012

Review article: pathophysiology and management of primary biliary cholangitis

scientific article published on 19 August 2020

Risk stratification in autoimmune cholestatic liver diseases: Opportunities for clinicians and trialists

scientific article

Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline

scientific article published on 18 April 2017

Seladelpar (MBX-8025), a selective PPAR-δ agonist, in patients with primary biliary cholangitis with an inadequate response to ursodeoxycholic acid: a double-blind, randomised, placebo-controlled, phase 2, proof-of-concept study

scientific article

Serum alkaline phosphatase in multidrug resistance 2 (Mdr2-/- ) knockout mice is strain specific

scientific article published on 26 June 2015

Should we screen for cirrhosis?

scientific article published on 12 July 2017

Simeprevir increases rate of sustained virologic response among treatment-experienced patients with HCV genotype-1 infection: a phase IIb trial

scientific article published on November 2013

Single-gene association between GATA-2 and autoimmune hepatitis: A novel genetic insight highlighting immunologic pathways to disease

scientific article published on 23 January 2016

Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study

scientific article

Surrogate endpoints for clinical trials in primary sclerosing cholangitis: Review and results from an International PSC Study Group consensus process

scientific article published on 29 September 2015

T regulatory cells and autoimmune liver disease

scientific article published on 01 February 2008

Targeting C-reactive protein for the treatment of cardiovascular disease.

scientific article

The 6 C's of Primary Sclerosing Cholangitis

scientific article published on 07 July 2020

The Genetics of Complex Cholestatic Disorders ⬇️

scientific article published on April 10, 2013

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share

scientific article

The Immunobiology and Pathophysiology of Primary Biliary Cirrhosis ⬇️

scientific article published on January 24, 2013

The Immunogenetics of Autoimmune Cholestasis

scientific article

The Pathogenesis of Autoimmune Liver Disease

scientific article published on 11 May 2016

The Pathogenesis of Primary Biliary Cholangitis: A Comprehensive Review

scientific article published on 19 September 2019

The Spectrum of Sclerosing Cholangitis and the Relevance of IgG4 Elevations in Routine Practice

scientific article published on 08 November 2011

The UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitis.

scientific article published on 29 July 2015

The evolution of cellular deficiency in GATA2 mutation

scientific article published on 17 December 2013

The genetic study of primary biliary cirrhosis: great hope, some caution.

scientific article published on June 2008

The gut microbiota and host health: a new clinical frontier

scientific article

The gut-adherent microbiota of PSC-IBD is distinct to that of IBD.

scientific article

The immunogenetics of primary biliary cirrhosis: A comprehensive review

scientific article

The impact of ileal pouch-anal anastomosis on graft survival following liver transplantation for primary sclerosing cholangitis

scientific article published on 08 June 2018

The inter-relationship of symptom severity and quality of life in 2055 patients with primary biliary cholangitis. ⬇️

scientific article published on 19 September 2016

The phenotypic expression of inflammatory bowel disease in patients with primary sclerosing cholangitis differs in the distribution of colitis

scientific article published on 14 May 2013

The role of attachment style and depression in patients with hepatitis C.

scientific article published in June 2013

The specificity of fatigue in primary biliary cirrhosis: evaluation of a large clinic practice

scientific article published in August 2010

Toronto HCC Risk Index: A validated scoring system to predict 10-year risk of HCC in patients with cirrhosis

scientific article

Toward the molecular dissection of primary biliary cirrhosis

scientific article published on 01 November 2009

Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice.

scientific article

Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE-/- mice

scientific article

Transient development of anti-mitochondrial antibodies accompanies autoimmune hepatitis-sclerosing cholangitis overlap

scientific article published on 01 January 2009

Treatment of autoimmune liver disease: current and future therapeutic options

scientific article

Unmet clinical need in autoimmune liver diseases

scientific article

Using GWAS to identify genetic predisposition in hepatic autoimmunity

scientific article

Utility and cost evaluation of multiparametric magnetic resonance imaging for the assessment of non-alcoholic fatty liver disease.

scientific article published on 22 December 2017

Validation of the prognostic value of histologic scoring systems in primary sclerosing cholangitis: An international cohort study.

scientific article published on 23 November 2016

Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis

scientific article

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome

scientific article published on 29 December 2015

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