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List of works by John B. Porter

6-Alkoxymethyl-3-hydroxy-4H-pyranones: potential ligands for cell-labelling with indium

scientific article published on 01 November 1999

A direct method for quantification of non-transferrin-bound iron

scientific article published on 01 May 1990

A novel method for non-transferrin-bound iron quantification by chelatable fluorescent beads based on flow cytometry

scientific article published on November 2014

A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload.

scientific article

A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease.

scientific article

A retrospective observational study of pre-operative sickle cell screening

scientific article published in April 2002

A trial to investigate the relationship between DFO pharmacokinetics and metabolism and DFO-related toxicity

scientific article published on June 1998

Animal toxicology of iron chelator L1

scientific article published on 01 July 1989

Approaching low liver iron burden in chelated patients with non-transfusion-dependent thalassemia: the safety profile of deferasirox

scientific article

Biopsy-based calibration of T2* magnetic resonance for estimation of liver iron concentration and comparison with R2 Ferriscan

scientific article

Blood transfusion: quality and safety issues in thalassemia, basic requirements and new trends

scientific article

Calibration of myocardial T2 and T1 against iron concentration.

scientific article

Cardiovascular T2-star (T2*) magnetic resonance for the early diagnosis of myocardial iron overload

scientific article published on 01 December 2001

Cardiovascular function and treatment in β-thalassemia major: a consensus statement from the American Heart Association

scientific article published on 17 June 2013

Cellular zinc content is a major determinant of iron chelator-induced apoptosis of thymocytes

scientific article published in December 2001

Challenges of adherence and persistence with iron chelation therapy

scientific article published on 13 October 2011

Clinical and methodological factors affecting non-transferrin-bound iron values using a novel fluorescent bead assay

scientific article published on 07 June 2016

Clinical management of gastrointestinal disturbances in patients with myelodysplastic syndromes receiving iron chelation treatment with deferasirox

scientific article published on 6 July 2011

Combined chelation therapy with deferasirox and deferoxamine in thalassemia ⬇️

scientific article published on November 11, 2012

Concepts and goals in the management of transfusional iron overload.

scientific article published on December 2007

Continued improvement in myocardial T2* over two years of deferasirox therapy in β-thalassemia major patients with cardiac iron overload

scientific article

Coronary artery bypass graft surgery in a patient with haemoglobin SC disease

scientific article published in July 2001

Cross-talk between available guidelines for the management of patients with beta-thalassemia major

scientific article published on 13 March 2013

Curcumin contributes to in vitro removal of non-transferrin bound iron by deferiprone and desferrioxamine in thalassemic plasma

scientific article published in September 2007

Deferasirox demonstrates a dose‐dependent reduction in liver iron concentration and consistent efficacy across subgroups of non‐transfusion‐dependent thalassemia patients ⬇️

scientific article published on May 13, 2013

Deferasirox effectively reduces iron overload in non-transfusion-dependent thalassemia (NTDT) patients: 1-year extension results from the THALASSA study.

scientific article published on 18 June 2013

Deferasirox for up to 3 years leads to continued improvement of myocardial T2* in patients with β-thalassemia major.

scientific article

Deferasirox reduces iron overload significantly in nontransfusion-dependent thalassemia: 1-year results from a prospective, randomized, double-blind, placebo-controlled study

scientific article published on 15 May 2012

Deferasirox--current knowledge and future challenges

scientific article

Defining serum ferritin thresholds to predict clinically relevant liver iron concentrations for guiding deferasirox therapy when MRI is unavailable in patients with non-transfusion-dependent thalassaemia.

scientific article published on 12 September 2014

Degenerative disc disease as a cause of back pain in the thalassaemic population: a case-control study using MRI and plain radiographs

scientific article published on 28 September 2005

Design, synthesis, and evaluation of novel 2-substituted 3-hydroxypyridin-4-ones: structure-activity investigation of metalloenzyme inhibition by iron chelators

scientific article published in January 2002

Detection of metallic cobalt and chromium liver deposition following failed hip replacement using T2* and R2 magnetic resonance

scientific article published on 6 May 2016

Determination of non-transferrin-bound iron in genetic hemochromatosis using a new HPLC-based method

scientific article published on 01 May 2000

Development of a new disease severity scoring system for patients with non-transfusion-dependent thalassemia.

scientific article

Effect of a novel oral active iron chelator: 1-(N-acetyl-6-aminohexyl)-3-hydroxy-2-methylpyridin-4-one (CM1) in iron-overloaded and non-overloaded mice

scientific article published on 01 September 2014

Effect of green tea on iron status and oxidative stress in iron-loaded rats.

scientific article published in July 2008

Effect of transfusional iron intake on response to chelation therapy in beta-thalassemia major

scientific article published on 19 October 2007

Effects of deferasirox-deferoxamine on myocardial and liver iron in patients with severe transfusional iron overload

scientific article published on May 2015

Effects of green tea on iron accumulation and oxidative stress in livers of iron-challenged thalassemic mice

scientific article published in March 2010

Efficacy and safety of deferasirox at low and high iron burdens: results from the EPIC magnetic resonance imaging substudy.

scientific article published on 21 October 2012

Efficacy of curcuminoids in alleviation of iron overload and lipid peroxidation in thalassemic mice.

scientific article

Efficacy of deferasirox in reducing and preventing cardiac iron overload in beta-thalassemia

scientific article published on 8 December 2009

Endothelial activation in patients with chronic venous disease

scientific article published on April 1998

Endothelial activation response to oral micronised flavonoid therapy in patients with chronic venous disease--a prospective study

scientific article published on 01 April 1999

Epigallocatechin-3-gallate and epicatechin-3-gallate from green tea decrease plasma non-transferrin bound iron and erythrocyte oxidative stress

scientific article published in May 2007

Ethical issues and risk/benefit assessment of iron chelation therapy: advances with deferiprone/deferoxamine combinations and concerns about the safety, efficacy and costs of deferasirox [Kontoghiorghes GJ, Hemoglobin 2008; 32(1-2):1-15.].

scientific article

Facilitated uptake of zinc into human erythrocytes. Relevance to the treatment of sickle-cell anaemia

scientific article published on 01 March 1990

Flow cytometric method for simultaneous assay of foetal haemoglobin containing red cells, reticulocytes and foetal haemoglobin containing reticulocytes

scientific article

Geographical variations in current clinical practice on transfusions and iron chelation therapy across various transfusion-dependent anaemias

scientific article published on 12 July 2012

Granulocytic sarcomas of small intestine and brain are associated with acute myelomonocytic leukaemia with abnormal eosinophils and inversion of chromosome 16.

scientific article published on November 1992

HPLC determination of 1,2-diethyl-3-hydroxypyridin-4-one (CP94), its iron complex [Fe(III) (CP94)3] and glucuronide conjugate [CP94-GLUC] in serum and urine of thalassaemic patients

scientific article published on 01 July 1994

Health-Related Quality of Life, Treatment Satisfaction, Adherence and Persistence in β-Thalassemia and Myelodysplastic Syndrome Patients with Iron Overload Receiving Deferasirox: Results from the EPIC Clinical Trial

scientific article published on 12 August 2012

Hematologic responses in patients with aplastic anemia treated with deferasirox: a post hoc analysis from the EPIC study

scientific article published on 12 April 2013

Hepcidin and iron species distribution inside the first-trimester human gestational sac ⬇️

scientific article published on December 22, 2010

Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait.

scientific article

High index of suspicion for early diagnosis of alendronate-induced stage zero osteonecrosis of jaw in thalassaemia major

scientific article published on 14 March 2014

Images in cardiovascular medicine. Superior vena cava occlusion by cardiovascular magnetic resonance.

scientific article published on August 2010

Improvement in liver pathology of patients with β-thalassemia treated with deferasirox for at least 3 years

scientific article

Increased leucocyte apoptosis in transfused β‐thalassaemia patients ⬇️

scientific article published on December 6, 2012

Inhibition of the hepatocyte uptake of radiolabelled monoclonal antibodies by chelating agents

scientific article published on January 1990

Iron chelation therapy for non-transfusion-dependent thalassemia (NTDT): a status quo.

scientific article

Iron chelation therapy in thalassemia major: a systematic review with meta-analyses of 1520 patients included on randomized clinical trials

scientific article published on 16 August 2011

Iron chelation therapy with deferasirox in patients with aplastic anemia: a subgroup analysis of 116 patients from the EPIC trial

scientific article published on 21 June 2010

Iron chelation with deferasirox in adult and pediatric patients with thalassemia major: efficacy and safety during 5 years' follow-up.

scientific article

Iron overload in thalassemia and related conditions: therapeutic goals and assessment of response to chelation therapies

scientific article published on December 2010

Iron toxicity: optimizing chelation therapy across transfusion-dependent anaemias. Introduction

scientific article published in December 2009

Left ventricular diastolic function compared with T2* cardiovascular magnetic resonance for early detection of myocardial iron overload in thalassemia major

scientific article published on 01 August 2005

Leukocyte activity in the microcirculation of the leg in patients with chronic venous disease

scientific article published on 01 August 1997

Long-term safety and efficacy of deferasirox (Exjade) for up to 5 years in transfusional iron-overloaded patients with sickle cell disease

scientific article

Mechanisms for the shuttling of plasma non-transferrin-bound iron (NTBI) onto deferoxamine by deferiprone.

scientific article

Mechanisms of plasma non-transferrin bound iron generation: insights from comparing transfused diamond blackfan anaemia with sickle cell and thalassaemia patients.

scientific article

Microvesicles in haemoglobinopathies offer insights into mechanisms of hypercoagulability, haemolysis and the effects of therapy

scientific article published on 17 April 2008

Monitoring and treatment of iron overload: state of the art and new approaches.

scientific article

Myocardial iron clearance during reversal of siderotic cardiomyopathy with intravenous desferrioxamine: a prospective study using T2* cardiovascular magnetic resonance

scientific article published in November 2004

Myocardial iron quantification using T2* and native T1mapping - a 250 patient study

Myocardial tissue characterization and the role of chronic anemia in sickle cell cardiomyopathy

scientific article published on 01 September 2007

Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera

scientific article published on 29 September 2007

New insights into transfusion-related iron toxicity: Implications for the oncologist

scientific article

Noncontrast myocardial T1 mapping using cardiovascular magnetic resonance for iron overload.

scientific article published on 08 August 2014

Normalized left ventricular volumes and function in thalassemia major patients with normal myocardial iron

scientific article published on 01 June 2007

On T2* magnetic resonance and cardiac iron

scientific article

On myocardial siderosis and left ventricular dysfunction in hemochromatosis.

scientific article published on 19 March 2013

Optimising iron chelation therapy with deferasirox for non-transfusion-dependent thalassaemia patients: 1-year results from the THETIS study

scientific article published on 11 November 2015

Optimizing iron chelation strategies in beta-thalassaemia major.

scientific article published on December 2009

Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease.

scientific article

Pathophysiology of transfusional iron overload: contrasting patterns in thalassemia major and sickle cell disease.

scientific article published on January 2009

Patient-reported outcomes of deferasirox (Exjade, ICL670) versus deferoxamine in sickle cell disease patients with transfusional hemosiderosis. Substudy of a randomized open-label phase II trial

scientific article

Perforation of superior vena cava by indwelling central venous catheters

scientific article published on 01 March 1987

Pharmacokinetics, metabolism, and disposition of deferasirox in beta-thalassemic patients with transfusion-dependent iron overload who are at pharmacokinetic steady state

scientific article published on 22 January 2010

Platelet labelling with indium-hydroxypyridinone and indium-hydroxypyranone complexes

scientific article published on 01 October 1994

Practical management of iron overload.

scientific article

Prevalence and distribution of iron overload in patients with transfusion-dependent anemias differs across geographic regions: results from the CORDELIA study

scientific article

Prospective evaluation of patient-reported outcomes during treatment with deferasirox or deferoxamine for iron overload in patients with beta-thalassemia

scientific article published on 01 May 2007

Prospective study of histomorphometry, biochemical bone markers and bone densitometric response to pamidronate in β-thalassaemia presenting with osteopenia-osteoporosis syndrome

scientific article published on 12 September 2012

Quantification of desferrioxamine and its iron chelating metabolites by high-performance liquid chromatography and simultaneous ultraviolet-visible/radioactive detection

scientific article published on 01 May 1992

Quantification of non-transferrin-bound iron in the presence of unsaturated transferrin

scientific article published on 01 September 1999

Raised haematocrit concentration and the risk of death and vascular complications after major surgery.

scientific article published in July 2013

Red blood cell-derived microparticles: An overview

scientific article published on 13 April 2016

Relation of myocardial T2* to right ventricular function in thalassaemia major

scientific article published on 22 April 2010

Response of iron overload to deferasirox in rare transfusion-dependent anaemias: equivalent effects on serum ferritin and labile plasma iron for haemolytic or production anaemias

scientific article published on 29 July 2011

Results of an international round robin for the quantification of serum non-transferrin-bound iron: Need for defining standardization and a clinically relevant isoform

scientific article published in June 2005

Reversal of cardiac iron loading and dysfunction in thalassemic mice by curcuminoids

scientific article published on 01 January 2011

Sample acceptance time criteria, electronic issue and alloimmunisation in thalassaemia.

scientific article

Second international round robin for the quantification of serum non-transferrin-bound iron and labile plasma iron in patients with iron-overload disorders.

scientific article

Secondary erythrocytosis due to compound homozygosity, but not compound heterozygosity, for Hb Luton and α-thalassemia: a family study.

scientific article published on 4 January 2012

Selection of hydroxypyridin-4-ones for the treatment of iron overload using in vitro and in vivo models

scientific article published on January 1988

Selective loss of anterior pituitary volume with severe pituitary-gonadal insufficiency in poorly compliant male thalassemic patients with pubertal arrest

scientific article published in June 1998

Separation and identification of desferrioxamine and its iron chelating metabolites by high-performance liquid chromatography and fast atom bombardment mass spectrometry: choice of complexing agent and application to biological fluids

scientific article published in June 1990

Structure-function investigation of the interaction of 1- and 2-substituted 3-hydroxypyridin-4-ones with 5-lipoxygenase and ribonucleotide reductase

scientific article

Sudden exertional death in sickle cell trait.

scientific article published on 30 September 2011

Sustained improvements in myocardial T2* over 2 years in severely iron-overloaded patients with beta thalassemia major treated with deferasirox or deferoxamine

scientific article

Symptomatic Erythrocytosis Due to Homozygosity for Hb Luton [HBA2: c.269A>T (or HBA1)] and α-Thalassemia: A Clinical Update.

scientific article published on 6 February 2016

Symptoms of depression and anxiety in patients with thalassemia: prevalence and correlates in the thalassemia longitudinal cohort.

scientific article

Synergistic intracellular iron chelation combinations: mechanisms and conditions for optimizing iron mobilization.

scientific article published on June 2015

Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias.

scientific article

The Iliad as Oral Formulaic Poetry

a book by John Porter

The development of hydroxypyridin-4-ones as orally active iron chelators

scientific article published on January 1990

The development of iron chelating drugs

scientific article

The efficacy of an iron chelator (CP94) in increasing cellular protoporphyrin IX following intravesical 5-aminolaevulinic acid administration: an in vivo study.

scientific article published on April 1997

The environment of the lipoxygenase iron binding site explored with novel hydroxypyridinone iron chelators

scientific article published on 01 April 1996

The pathophysiology of transfusional iron overload

scientific article

The relationship of intracellular iron chelation to the inhibition and regeneration of human ribonucleotide reductase

scientific article published on 01 August 1996

The toxic effects of desferrioxamine

scientific article

The use of skin Fe levels as a surrogate marker for organ Fe levels, to monitor treatment in cases of iron overload

scientific article published on 01 May 2000

Timed non-transferrin bound iron determinations probe the origin of chelatable iron pools during deferiprone regimens and predict chelation response

scientific article

Transfusion and chelation practices in sickle cell disease: a regional perspective

scientific article published on 30 July 2010

Treatment of heart failure in adults with thalassemia major: response in patients randomised to deferoxamine with or without deferiprone

scientific article published on 20 May 2013

Ultrafast Magnetic Resonance Imaging for Iron Quantification in Thalassemia Participants in the Developing World: The TIC-TOC Study (Thailand and UK International Collaboration in Thalassaemia Optimising Ultrafast CMR).

scientific article published on August 2016

Ultrashort echo time (UTE) MRI of the spine in thalassaemia

scientific article published on 01 February 2004

Utility of labile plasma iron and transferrin saturation in addition to serum ferritin as iron overload markers in different underlying anemias before and after deferasirox treatment.

scientific article published on 18 February 2015

Value of sequential monitoring of left ventricular ejection fraction in the management of thalassemia major

scientific article published on 4 March 2004

Which psychosocial factors are related to chelation adherence in thalassemia? A systematic review.

scientific article published on June 2010

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