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List of works by Lorraine O'Driscoll

2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype

scientific article published on 07 March 2019

A microarray approach to translational medicine in breast cancer: how representative are cell line models of clinical conditions?

scientific article published on May 2007

A phase I clinical and pharmacokinetic study of the multi-drug resistance protein-1 (MRP-1) inhibitor sulindac, in combination with epirubicin in patients with advanced cancer.

scientific article published on 27 April 2006

Analysis of Gene Expression as Relevant to Cancer Cells and Circulating Tumour Cells

article

Analysis of changes in phosphorylation of receptor tyrosine kinases: antibody arrays

scientific article published on January 2015

Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.

scientific article

Biological properties of extracellular vesicles and their physiological functions.

scientific article published on 14 May 2015

Biomarkers and multiple drug resistance in breast cancer.

scientific article published on August 2006

Blood-Based Biomarkers for Metabolic Syndrome

scientific article published on 14 April 2016

Breast cancer: understanding sensitivity and resistance to chemotherapy and targeted therapies to aid in personalised medicine.

scientific article published on May 2009

Challenges in molecular analysis for individualized cancer therapy

Characterisation and manipulation of docetaxel resistant prostate cancer cell lines

scientific article

Characterisation of BHK-21 cells engineered to secrete human insulin.

scientific article

Comparative antiproliferative effects of iniparib and olaparib on a panel of triple-negative and non-triple-negative breast cancer cell lines

scientific article published on June 2013

Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles

scientific article published on 01 August 2019

Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis

scientific article published on 5 June 2013

Dairy proteins, dairy lipids, and postprandial lipemia in persons with abdominal obesity (DairyHealth): a 12-wk, randomized, parallel-controlled, double-blinded, diet intervention study

scientific article published on 14 January 2015

Decreasing Txnip mRNA and protein levels in pancreatic MIN6 cells reduces reactive oxygen species and restores glucose regulated insulin secretion

scientific article

Detecting de novo insulin synthesis in embryonic stem cell-derived populations.

scientific article published on 30 December 2006

Detection of amplifiable mRNA extracellular to insulin-producing cells: potential for predicting beta cell mass and function

scientific article published on 23 August 2007

Directed differentiation of mouse embryonic stem cells into pancreatic-like or neuronal- and glial-like phenotypes.

scientific article

Docetaxel-resistance in prostate cancer: evaluating associated phenotypic changes and potential for resistance transfer via exosomes

scientific article

Drug metabolism-related genes as potential biomarkers: analysis of expression in normal and tumour breast tissue.

scientific article published on 27 September 2007

Drug resistance in cancer - searching for mechanisms, markers and therapeutic agents

scientific article published on December 2007

EGFR and HER2 inhibition in pancreatic cancer

scientific article

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research.

scientific article published on February 2017

Editorial [Hot Topic: Mechanisms of Drug Sensitivity and Resistance in Cancer (Guest Editor: Lorraine ODriscoll)]

Engineering Vero cells to secrete human insulin

scientific article

Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs.

scientific article published on September 2004

European Network on Microvesicles and Exosomes in Health and Disease (ME-HaD)

article

Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine

scientific article

Exosomes are involved in mediating radiation induced bystander signaling in human keratinocyte cells.

scientific article published on 6 February 2014

Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells

scientific article published on 27 February 2013

Expanding on exosomes and ectosomes in cancer

scientific article published on June 2015

Expression and prognostic relevance of Mcl-1 in breast cancer.

scientific article published on March 2004

Expression in murine teratocarcinoma F9 cells of transcription factors involved in pancreas development

scientific article

Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma

scientific article published on 24 June 2009

Extracellular vesicles from mesenchymal stem cells as a Covid-19 treatment

scientific article published on 06 May 2020

Extracellular vesicles in blood: are they viable as diagnostic and predictive tools in breast cancer?

scientific article published on 04 December 2020

Feasibility and relevance of global expression profiling of gene transcripts in serum from breast cancer patients using whole genome microarrays and quantitative RT-PCR.

scientific article published on March 2008

Galectin-3 expression alters adhesion, motility and invasion in a lung cell line (DLKP), in vitro.

scientific article published on November 2002

Global analysis of serum microRNAs as potential biomarkers for lung adenocarcinoma.

scientific article published on 04 September 2013

ISEV position paper: extracellular vesicle RNA analysis and bioinformatics.

scientific article

Identification of a novel, functional role for S100A13 in invasive lung cancer cell lines.

scientific article published on 3 December 2007

Identification of microRNAs with a role in glucose stimulated insulin secretion by expression profiling of MIN6 cells

scientific article published on 24 April 2010

Inhibiting extracellular vesicles formation and release: a review of EV inhibitors

scientific article published on 19 December 2019

Intracellular and extracellular microRNAs in breast cancer

scientific article

Investigation of MRP-1 protein and MDR-1 P-glycoprotein expression in invasive breast cancer: a prognostic study

scientific article

Investigation of the molecular profile of basal cell carcinoma using whole genome microarrays

scientific article published on 15 December 2006

Irish thoracic society

article

Isolation from a human MDR lung cell line of multiple clonal subpopulations which exhibit significantly different drug resistance

scientific article published on May 1997

Isolation of exosomes for subsequent mRNA, MicroRNA, and protein profiling.

scientific article

Isolation, structure elucidation, and cytotoxic evaluation of furanonaphthoquinones from in vitro plantlets and cultures of Streptocarpus dunnii

scientific article

Isosteviol has beneficial effects on palmitate-induced α-cell dysfunction and gene expression

scientific article

Lack of prognostic significance of survivin, survivin-deltaEx3, survivin-2B, galectin-3, bag-1, bax-alpha and MRP-1 mRNAs in breast cancer

scientific article

MAGE-D4B is a novel marker of poor prognosis and potential therapeutic target involved in breast cancer tumorigenesis

scientific article published on 8 August 2011

MDR1/P-glycoprotein and MRP-1 drug efflux pumps in pancreatic carcinoma

scientific article published on July 2007

MDR1/P-glycoprotein and MRP-1 mRNA and protein expression in non-small cell lung cancer

scientific article published on May 2007

Matrix Metalloproteinase Expression and Production by Alveolar Macrophages in Emphysema ⬇️

scientific article published on July 1, 1997

Mechanisms associated with loss of glucose responsiveness in beta cells

scientific article

Melanoma-associated antigen family protein-D4: clinical significance and functional relevance in breast cancer

scientific article published on 18 May 2010

Membrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis.

scientific article

Mesenchymal Stem Cell Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications

scientific article published on 16 April 2020

Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies

scientific article

Methods in Apoptosis

MicroRNA Profiling of Exosomes

scientific article published in January 2017

MicroRNA expression analysis: techniques suitable for studies of intercellular and extracellular microRNAs

scientific article

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

scientific article published on 23 November 2018

Molecular markers of multiple drug resistance in breast cancer

scientific article

Molecular medicine of microRNAs: structure, function and implications for diabetes.

scientific article published on 15 August 2008

Multiple drug resistance-related messenger RNA expression in archival formalin-fixed paraffin-embedded human breast tumour tissue

scientific article published on January 1996

Neratinib resistance and cross-resistance to other HER2-targeted drugs due to increased activity of metabolism enzyme cytochrome P4503A4.

scientific article published on 2 February 2017

Neuromedin U alters bioenergetics and expands the cancer stem cell phenotype in HER2-positive breast cancer.

scientific article published on 24 March 2017

Neuromedin U: a candidate biomarker and therapeutic target to predict and overcome resistance to HER-tyrosine kinase inhibitors

scientific article

Neuromedin U: a multifunctional neuropeptide with pleiotropic roles

scientific article

Phenotypic and global gene expression profile changes between low passage and high passage MIN-6 cells.

scientific article published on December 2006

Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance

scientific article published on October 2012

Predictive biomarkers for dasatinib treatment in melanoma

scientific article

Prevalence and prognostic and predictive relevance of PRAME in breast cancer

scientific article published on 12 July 2007

Profiling Circulating miRNAs from the Plasma of Individuals with Metabolic Syndrome

scientific article published in January 2017

Proteomic analysis of conditioned media from glucose responsive and glucose non-responsive phenotypes reveals a panel of secreted proteins associated with beta cell dysfunction

scientific article

Proteomic screening of glucose-responsive and glucose non-responsive MIN-6 beta cells reveals differential expression of proteins involved in protein folding, secretion and oxidative stress

scientific article published on December 2006

Receptor tyrosine kinase targeting in multicellular spheroids

scientific article published on January 2015

Receptor tyrosine kinases and drug resistance: development and characterization of in vitro models of resistance to RTK inhibitors

scientific article published on January 2015

Reverse-transcriptase polymerase chain reaction to detect extracellular mRNAs.

scientific article

SNIP/p140Cap mRNA expression is an unfavourable prognostic factor in breast cancer and is not expressed in normal breast tissue

scientific article published on 13 May 2008

Setting up a Cell Culture Laboratory

article

Survivin: role in normal cells and in pathological conditions

scientific article (publication date: April 2003)

TMEM25, REPS2 and Meis 1: favourable prognostic and predictive biomarkers for breast cancer

scientific article published on 21 September 2009

The Role of Exosomes in Breast Cancer

scientific article published on 14 October 2015

The development and validation of the Virtual Tissue Matrix, a software application that facilitates the review of tissue microarrays on line

scientific article published on 17 May 2006

The future of Extracellular Vesicles as Theranostics - an ISEV meeting report

scientific article published on 04 September 2020

The relevance of using 3D cell cultures, in addition to 2D monolayer cultures, when evaluating breast cancer drug sensitivity and resistance

scientific article published on 10 June 2016

The use of LC-MS to identify differentially expressed proteins in docetaxel-resistant prostate cancer cell lines

scientific article published on July 2012

The use of reverse transcriptase-polymerase chain reaction (RT-PCR) to investigate specific gene expression in multidrug-resistant cells

scientific article published on January 1993

Three-dimensional cell culture: the missing link in drug discovery

scientific article

Tyrosine kinase inhibitors potentiate the cytotoxicity of MDR-substrate anticancer agents independent of growth factor receptor status in lung cancer cell lines.

scientific article

Western blotting analysis as a tool to study receptor tyrosine kinases

scientific article

mdr1 ribozyme mediated reversal of the multi-drug resistant phenotype in human lung cell lines

scientific article published on 01 January 1996

miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity.

scientific article published on 24 September 2015

miR-34a is an intracellular and exosomal predictive biomarker for response to docetaxel with clinical relevance to prostate cancer progression

scientific article

miR-630 targets IGF1R to regulate response to HER-targeting drugs and overall cancer cell progression in HER2 over-expressing breast cancer.

scientific article

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