List of works - Pierre-Hervé Luppi

A Particular Medullary-Spinal Inhibitory Pathway is Recruited for the Expression of Muscle Atonia During REM Sleep

scientific article published on 02 November 2018

A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep

scientific article

A very large number of GABAergic neurons are activated in the tuberal hypothalamus during paradoxical (REM) sleep hypersomnia

scientific article

Adrenergic input from medullary ventrolateral C1 cells to the nucleus raphe pallidus of the cat, as demonstrated by a double immunostaining technique

scientific article published on 01 November 1989

Afferent projections to the rat locus coeruleus demonstrated by retrograde and anterograde tracing with cholera-toxin B subunit and Phaseolus vulgaris leucoagglutinin

scientific article published on 01 March 1995

Afferent projections to the rat nuclei raphe magnus, raphe pallidus and reticularis gigantocellularis pars alpha demonstrated by iontophoretic application of choleratoxin (subunit b).

scientific article published in June 1997

Afferents to the nucleus reticularis parvicellularis of the cat medulla oblongata: a tract-tracing study with cholera toxin B subunit.

scientific article

Alterations in c-fos expression after different experimental procedures of sleep deprivation in the cat.

scientific article published in September 1996

Alternating vigilance states: new insights regarding neuronal networks and mechanisms.

scientific article published on 28 April 2009

Anatomical and electrophysiological evidence for a glycinergic inhibitory innervation of the rat locus coeruleus

scientific article published in July 1991

Anatomical demonstration of a medullary enkephalinergic pathway potentially implicated in the oro-facial muscle atonia of paradoxical sleep in the cat.

scientific article published in January 1998

Animal models of REM dysfunctions: what they tell us about the cause of narcolepsy and RBD?

scientific article published on September 2014

Both the hippocampus and striatum are involved in consolidation of motor sequence memory.

scientific article published in April 2008

Brainstem glycinergic neurons and their activation during active (rapid eye movement) sleep in the cat.

scientific article published on 7 August 2006

Brainstem mechanisms of paradoxical (REM) sleep generation.

scientific article

Brainstem structures responsible for paradoxical sleep onset and maintenance.

scientific article published in July 2004

Breakdown in REM sleep circuitry underlies REM sleep behavior disorder

scientific article published on 24 March 2014

Catecholaminergic afferents to the cat median eminence as determined by double-labelling methods

scientific article published on 01 January 1990

Characterization of the melanin-concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats

scientific article published in November 2007

Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recovery

scientific article published in May 2005

Differential origin of the activation of dorsal and ventral dentate gyrus granule cells during paradoxical (REM) sleep in the rat.

scientific article published on 18 August 2016

Distribution of enkephalin and its relation to serotonin in cat and monkey spinal cord and brain stem

scientific article published in June 1992

Distribution of glycine-immunoreactive cell bodies and fibers in the rat brain

scientific article published in December 1996

Dopaminergic neurons expressing Fos during waking and paradoxical sleep in the rat.

scientific article published on 6 March 2010

Effect of chronic treatment with milnacipran on sleep architecture in rats compared with paroxetine and imipramine

scientific article published in October 2002

Effect of strychnine on rat locus coeruleus neurones during sleep and wakefulness

scientific article published in December 1996

Effects of electrolytic lesion of hypothalamic paraventricular nucleus and its related areas on the sleep waking cycle in the cat.

scientific article published in October 1987

Electrophysiological Evidence That the Retrosplenial Cortex Displays a Strong and Specific Activation Phased with Hippocampal Theta during Paradoxical (REM) Sleep

scientific article published on 20 July 2017

Electrophysiological evidence that noradrenergic neurons of the rat locus coeruleus are tonically inhibited by GABA during sleep.

scientific article published in March 1998

Evidence for widespread afferents to Barrington's nucleus, a brainstem region rich in corticotropin-releasing hormone neurons

scientific article published in September 1994

Evidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergic.

scientific article published on April 2011

Forebrain afferents to the cat posterior hypothalamus: a double labeling study

scientific article published on 01 July 1989

Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods

scientific article published in January 1998

Forebrain projections of the rostral nucleus raphe magnus shown by iontophoretic application of choleratoxin b in rats

scientific article published in October 1996

Fos and serotonin immunoreactivity in the raphe nuclei of the cat during carbachol-induced active sleep: a double-labeling study.

scientific article published in July 1995

GABAergic control of hypothalamic melanin-concentrating hormone-containing neurons across the sleep-waking cycle.

scientific article published in July 2005

Genetic deletion of melanin-concentrating hormone neurons impairs hippocampal short-term synaptic plasticity and hippocampal-dependent forms of short-term memory.

scientific article published on 21 March 2015

Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder

scientific article published on 21 December 2016

Glycine-immunoreactive neurones in the cat brain stem reticular formation

scientific article

Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation ⬇️

scholarly article from 'Scientific Reports' published in 2021

Identification of sleep-promoting neurons in vitro.

scientific article published in April 2000

Jouvet's animal model of RBD, clinical RBD, and their relationships to REM sleep mechanisms

scientific article published on 06 June 2018

Levels of Interference in Long and Short-Term Memory Differentially Modulate Non-REM and REM Sleep

scientific article published on 10 October 2016

Localization of CRF-immunoreactive neurons in the cat medulla oblongata: their presence in the inferior olive

scientific article published in January 1988

Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset.

scientific article published in September 2003

Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep

scientific article (publication date: 2009)

Localization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the rat.

scientific article published in April 2006

Localization of tyrosine hydroxylase-immunoreactive neurons in the cat hypothalamus, with special reference to fluorescence histochemistry

scientific article published in August 1987

Lower brainstem afferents to the cat posterior hypothalamus: a double-labeling study

scientific article

Lower brainstem catecholamine afferents to the rat dorsal raphe nucleus

scientific article published on 01 January 1996

Major impairments of glutamatergic transmission and long-term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor-1

scientific article

Melanin concentrating hormone in central hypersomnia

scientific article

Monoaminergic, peptidergic, and cholinergic afferents to the cat facial nucleus as evidenced by a double immunostaining method with unconjugated cholera toxin as a retrograde tracer

scientific article published in May 1989

Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment

scientific article published on 19 July 2019

Neurochemical aspects of sleep regulation with specific focus on slow-wave sleep.

scientific article published on June 2010

Neurochemistry of sleep an overview of animal experimental work.

scientific article published on January 2011

Neurology and psychiatry: waking up to opportunities of sleep. : State of the art and clinical/research priorities for the next decade

scientific article published on 07 August 2015

New Breakthroughs in Understanding the Role of Functional Interactions between the Neocortex and the Claustrum

scientific article published in November 2017

New aspects in the pathophysiology of rapid eye movement sleep behavior disorder: the potential role of glutamate, gamma-aminobutyric acid, and glycine.

scientific article published on 19 June 2013

Noradrenergic neurons expressing Fos during waking and paradoxical sleep deprivation in the rat.

scientific article published on 27 December 2008

Not a single but multiple populations of GABAergic neurons control sleep.

scientific article published on 12 March 2016

ONEIROS, a new miniature standalone device for recording sleep electrophysiology, physiology, temperatures and behavior in the lab and field

scientific article published on 03 September 2018

Obituary: Michel Jouvet (1925-2017), The father of paradoxical sleep

scientific article

Origin of the dopaminergic innervation of the rat dorsal raphe nucleus

scientific article published on 01 December 1995

Origin of the glycinergic innervation of the rat trigeminal motor nucleus

scientific article published in November 1996

Origins of the glycinergic inputs to the rat locus coeruleus and dorsal raphe nuclei: a study combining retrograde tracing with glycine immunohistochemistry.

scientific article published in March 1999

Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus.

scientific article published on February 2009

Paradoxical (REM) sleep deprivation in mice using the small-platforms-over-water method: polysomnographic analyses and melanin-concentrating hormone and hypocretin/orexin neuronal activation before, during and after deprivation

scientific article published on 18 December 2014

Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control.

scientific article published on 13 March 2013

Paradoxical (REM) sleep genesis: the switch from an aminergic-cholinergic to a GABAergic-glutamatergic hypothesis.

scientific article published on November 2006

Paradoxical sleep in mice lacking M3 and M2/M4 muscarinic receptors.

scientific article published on 17 August 2005

Partial homologies between sleep states in lizards, mammals, and birds suggest a complex evolution of sleep states in amniotes

scientific article

Peptidergic hypothalamic afferents to the cat nucleus raphe pallidus as revealed by a double immunostaining technique using unconjugated cholera toxin as a retrograde tracer

scientific article published on 01 February 1987

Periventricular dopaminergic neurons terminating in the neuro-intermediate lobe of the cat hypophysis

scientific article published in February 1986

Progress in our understanding of the architecture of paradoxical sleep since William Dement and Michel Jouvet ⬇️

scientific article published on 01 October 2011

Projection from nucleus reuniens thalami to piriform cortex: a tracing study in the rat

scientific article published on 01 January 1995

Quantitative and qualitative aspects on the distribution of 5-HT and its coexistence with substance P and TRH in cat ventral medullary neurons

scientific article

REM sleep behaviour disorder

scientific article published on 30 August 2018

Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy--a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group.

scientific article published on 22 July 2013

Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons.

scientific article published in June 2000

Role of MCH neurons in paradoxical (REM) sleep control

scientific article

Role of the dorsal paragigantocellular reticular nucleus in paradoxical (rapid eye movement) sleep generation: a combined electrophysiological and anatomical study in the rat.

scientific article

Role of the lateral paragigantocellular nucleus in the network of paradoxical (REM) sleep: an electrophysiological and anatomical study in the rat.

scientific article

Role of the melanin-concentrating hormone neuropeptide in sleep regulation.

scientific article published on 04 August 2009

Selective activation of a few limbic structures during paradoxical (REM) sleep by the claustrum and the supramammillary nucleus: evidence and function

scientific article published on 24 March 2017

Serotonergic and non-serotonergic projections from the raphe nuclei to the piriform cortex in the rat: a cholera toxin B subunit (CTb) and 5-HT immunohistochemical study

scientific article published on 01 February 1995

Single-unit and polygraphic recordings associated with systemic or local pharmacology: a multi-purpose stereotaxic approach for the awake, anaesthetic-free, and head-restrained rat.

scientific article published in July 2000

Sleep architecture and homeostasis in mice with partial ablation of melanin-concentrating hormone neurons.

scientific article published on 31 October 2015

Sleep architecture of the melanin-concentrating hormone receptor 1-knockout mice.

scientific article published in April 2008

Sleep-wake physiology

scientific article published on 01 January 2019

Sub-regions of the dorsal raphé nucleus receive different inputs from the brainstem

scientific article published on 02 August 2018

Targeted recombination in active populations as a new mouse genetic model to study sleep-active neuronal populations: Demonstration that Lhx6+ neurons in the ventral zona incerta are activated during paradoxical sleep hypersomnia

scientific article published on 14 January 2020

The Inappropriate Occurrence of REM Sleep in Narcolepsy is not due to a Defect in Homeostatic Regulation of REM Sleep

scientific article published on 7 March 2018

The endogenous somnogen adenosine excites a subset of sleep-promoting neurons via A2A receptors in the ventrolateral preoptic nucleus.

scientific article

The inhibition of the dorsal paragigantocellular reticular nucleus induces waking and the activation of all adrenergic and noradrenergic neurons: a combined pharmacological and functional neuroanatomical study.

scientific article

The lateral hypothalamic area controls paradoxical (REM) sleep by means of descending projections to brainstem GABAergic neurons.

scientific article

The neuronal network responsible for paradoxical sleep and its dysfunctions causing narcolepsy and rapid eye movement (REM) behavior disorder.

scientific article

The nuclei of origin of monoaminergic, peptidergic, and cholinergic afferents to the cat nucleus reticularis magnocellularis: a double-labeling study with cholera toxin as a retrograde tracer

scientific article published on 01 November 1988

The rat ponto-medullary network responsible for paradoxical sleep onset and maintenance: a combined microinjection and functional neuroanatomical study

scientific article published in November 2002

The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat.

scientific article published on 5 June 2008

The supramammillary nucleus and the claustrum activate the cortex during REM sleep

scientific article

Topography of neurophysin-immunoreactive neurons projecting to the neurohypophysis: direct evidence as revealed by a double staining method

scientific article published in April 1988

Tuberal hypothalamic neurons secreting the satiety molecule Nesfatin-1 are critically involved in paradoxical (REM) sleep homeostasis

scientific article

Unrelated course of subthalamic nucleus and globus pallidus neuronal activities across vigilance states in the rat.

scientific article

Unsupervised online classifier in sleep scoring for sleep deprivation studies

scientific article

VIP-like immunoreactive projections from the dorsal raphe and caudal linear raphe nuclei to the bed nucleus of the stria terminalis demonstrated by a double immunohistochemical method in the rat

scientific article published on 01 June 1995

Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder

scientific article

[Demonstration of a different localization of perikarya immunoreactive to oxytocin and vasopressin in the cat hypothalamus]

scientific article published on 01 January 1984

[Glycine immunoreactive neurons in the medulla oblongata in cats]

scientific article published on 01 January 1990

[Histamine-immunoreactive neurons in the hypothalamus of cats]

scientific article published on 01 January 1986

[Localization of cholinergic neurons in the cat lower brain stem]

scientific article published on 01 January 1986

[Michel Jouvet, from the discovery of paradoxical sleep and muscle atonia to the role of neuropeptides]

scientific article published on 12 December 2019

List of works by Pierre-Hervé Luppi

A Particular Medullary-Spinal Inhibitory Pathway is Recruited for the Expression of Muscle Atonia During REM Sleep

A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep

A very large number of GABAergic neurons are activated in the tuberal hypothalamus during paradoxical (REM) sleep hypersomnia

Adrenergic input from medullary ventrolateral C1 cells to the nucleus raphe pallidus of the cat, as demonstrated by a double immunostaining technique

Afferent projections to the rat locus coeruleus demonstrated by retrograde and anterograde tracing with cholera-toxin B subunit and Phaseolus vulgaris leucoagglutinin

Afferent projections to the rat nuclei raphe magnus, raphe pallidus and reticularis gigantocellularis pars alpha demonstrated by iontophoretic application of choleratoxin (subunit b).

Afferents to the nucleus reticularis parvicellularis of the cat medulla oblongata: a tract-tracing study with cholera toxin B subunit.

Alterations in c-fos expression after different experimental procedures of sleep deprivation in the cat.

Alternating vigilance states: new insights regarding neuronal networks and mechanisms.

Anatomical and electrophysiological evidence for a glycinergic inhibitory innervation of the rat locus coeruleus

Anatomical demonstration of a medullary enkephalinergic pathway potentially implicated in the oro-facial muscle atonia of paradoxical sleep in the cat.

Animal models of REM dysfunctions: what they tell us about the cause of narcolepsy and RBD?

Both the hippocampus and striatum are involved in consolidation of motor sequence memory.

Brainstem glycinergic neurons and their activation during active (rapid eye movement) sleep in the cat.

Brainstem mechanisms of paradoxical (REM) sleep generation.

Brainstem structures responsible for paradoxical sleep onset and maintenance.

Breakdown in REM sleep circuitry underlies REM sleep behavior disorder

Catecholaminergic afferents to the cat median eminence as determined by double-labelling methods

Characterization of the melanin-concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats

Cholinergic and noncholinergic brainstem neurons expressing Fos after paradoxical (REM) sleep deprivation and recovery

Differential origin of the activation of dorsal and ventral dentate gyrus granule cells during paradoxical (REM) sleep in the rat.

Distribution of enkephalin and its relation to serotonin in cat and monkey spinal cord and brain stem

Distribution of glycine-immunoreactive cell bodies and fibers in the rat brain

Dopaminergic neurons expressing Fos during waking and paradoxical sleep in the rat.

Effect of chronic treatment with milnacipran on sleep architecture in rats compared with paroxetine and imipramine

Effect of strychnine on rat locus coeruleus neurones during sleep and wakefulness

Effects of electrolytic lesion of hypothalamic paraventricular nucleus and its related areas on the sleep waking cycle in the cat.

Electrophysiological Evidence That the Retrosplenial Cortex Displays a Strong and Specific Activation Phased with Hippocampal Theta during Paradoxical (REM) Sleep

Electrophysiological evidence that noradrenergic neurons of the rat locus coeruleus are tonically inhibited by GABA during sleep.

Evidence for widespread afferents to Barrington's nucleus, a brainstem region rich in corticotropin-releasing hormone neurons

Evidence that neurons of the sublaterodorsal tegmental nucleus triggering paradoxical (REM) sleep are glutamatergic.

Forebrain afferents to the cat posterior hypothalamus: a double labeling study

Forebrain afferents to the rat dorsal raphe nucleus demonstrated by retrograde and anterograde tracing methods

Forebrain projections of the rostral nucleus raphe magnus shown by iontophoretic application of choleratoxin b in rats

Fos and serotonin immunoreactivity in the raphe nuclei of the cat during carbachol-induced active sleep: a double-labeling study.

GABAergic control of hypothalamic melanin-concentrating hormone-containing neurons across the sleep-waking cycle.

Genetic deletion of melanin-concentrating hormone neurons impairs hippocampal short-term synaptic plasticity and hippocampal-dependent forms of short-term memory.

Genetic inactivation of glutamate neurons in the rat sublaterodorsal tegmental nucleus recapitulates REM sleep behaviour disorder

Glycine-immunoreactive neurones in the cat brain stem reticular formation

Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation ⬇️

Identification of sleep-promoting neurons in vitro.

Jouvet's animal model of RBD, clinical RBD, and their relationships to REM sleep mechanisms

Levels of Interference in Long and Short-Term Memory Differentially Modulate Non-REM and REM Sleep

Localization of CRF-immunoreactive neurons in the cat medulla oblongata: their presence in the inferior olive

Localization of the GABAergic and non-GABAergic neurons projecting to the sublaterodorsal nucleus and potentially gating paradoxical sleep onset.

Localization of the brainstem GABAergic neurons controlling paradoxical (REM) sleep

Localization of the neurons active during paradoxical (REM) sleep and projecting to the locus coeruleus noradrenergic neurons in the rat.

Localization of tyrosine hydroxylase-immunoreactive neurons in the cat hypothalamus, with special reference to fluorescence histochemistry

Lower brainstem afferents to the cat posterior hypothalamus: a double-labeling study

Lower brainstem catecholamine afferents to the rat dorsal raphe nucleus

Major impairments of glutamatergic transmission and long-term synaptic plasticity in the hippocampus of mice lacking the melanin-concentrating hormone receptor-1

Melanin concentrating hormone in central hypersomnia

Monoaminergic, peptidergic, and cholinergic afferents to the cat facial nucleus as evidenced by a double immunostaining method with unconjugated cholera toxin as a retrograde tracer

Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment

Neurochemical aspects of sleep regulation with specific focus on slow-wave sleep.

Neurochemistry of sleep an overview of animal experimental work.

Neurology and psychiatry: waking up to opportunities of sleep. : State of the art and clinical/research priorities for the next decade

New Breakthroughs in Understanding the Role of Functional Interactions between the Neocortex and the Claustrum

New aspects in the pathophysiology of rapid eye movement sleep behavior disorder: the potential role of glutamate, gamma-aminobutyric acid, and glycine.

Noradrenergic neurons expressing Fos during waking and paradoxical sleep deprivation in the rat.

Not a single but multiple populations of GABAergic neurons control sleep.

ONEIROS, a new miniature standalone device for recording sleep electrophysiology, physiology, temperatures and behavior in the lab and field

Obituary: Michel Jouvet (1925-2017), The father of paradoxical sleep

Origin of the dopaminergic innervation of the rat dorsal raphe nucleus

Origin of the glycinergic innervation of the rat trigeminal motor nucleus

Origins of the glycinergic inputs to the rat locus coeruleus and dorsal raphe nuclei: a study combining retrograde tracing with glycine immunohistochemistry.

Paradoxical (REM) sleep deprivation causes a large and rapidly reversible decrease in long-term potentiation, synaptic transmission, glutamate receptor protein levels, and ERK/MAPK activation in the dorsal hippocampus.

Paradoxical (REM) sleep deprivation in mice using the small-platforms-over-water method: polysomnographic analyses and melanin-concentrating hormone and hypocretin/orexin neuronal activation before, during and after deprivation

Paradoxical (REM) sleep genesis by the brainstem is under hypothalamic control.

Paradoxical (REM) sleep genesis: the switch from an aminergic-cholinergic to a GABAergic-glutamatergic hypothesis.

Paradoxical sleep in mice lacking M3 and M2/M4 muscarinic receptors.

Partial homologies between sleep states in lizards, mammals, and birds suggest a complex evolution of sleep states in amniotes

Peptidergic hypothalamic afferents to the cat nucleus raphe pallidus as revealed by a double immunostaining technique using unconjugated cholera toxin as a retrograde tracer

Periventricular dopaminergic neurons terminating in the neuro-intermediate lobe of the cat hypophysis

Progress in our understanding of the architecture of paradoxical sleep since William Dement and Michel Jouvet ⬇️

Projection from nucleus reuniens thalami to piriform cortex: a tracing study in the rat

Quantitative and qualitative aspects on the distribution of 5-HT and its coexistence with substance P and TRH in cat ventral medullary neurons

REM sleep behaviour disorder

Rapid eye movement sleep behavior disorder: devising controlled active treatment studies for symptomatic and neuroprotective therapy--a consensus statement from the International Rapid Eye Movement Sleep Behavior Disorder Study Group.