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List of works by David R Poyner

A Polymorphism in the Growth Hormone (GH)-Releasing Hormone (GHRH) Receptor Gene Is Associated with Elevated Response to GHRH by Human Pituitary Somatotrophinomas in Vitro

scientific article published in August 2000

A comparison of the actions of BIBN4096BS and CGRP(8-37) on CGRP and adrenomedullin receptors expressed on SK-N-MC, L6, Col 29 and Rat 2 cells

scientific article published on September 2002

A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.

scientific article published in January 2005

A nonantisense sequence-selective effect of a phosphorothioate oligodeoxynucleotide directed against the epidermal growth factor receptor in A431 cells

scientific article

A polymorphism in the growth hormone-releasing hormone receptor gene: Clinical significance?

scientific article published in October 2002

Activation of Calcium-Sensitive Potassium Channels in L6 Skeletal Myocytes by Arginine Vasopressin Requires Extracellular Calcium

scientific article published in December 1995

Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: opportunities and challenges ⬇️

scientific article published on December 13, 2010

Altering the ribosomal subunit ratio in yeast maximizes recombinant protein yield

scientific article

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

scientific article published on 17 May 2016

CGRP receptor antagonists: design and screening.

scientific article published on December 2009

CGRP receptor heterogeneity: a role for receptor component protein?

scientific article published in January 2003

CGRP receptors: a headache to study, but will antagonists prove therapeutic in migraine?

scientific article published in February 2002

CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells

scientific article published on 23 June 2021

CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS.

scientific article published on 26 August 2003

Calcitonin Receptor N-Glycosylation Enhances Peptide Hormone Affinity by Controlling Receptor Dynamics

scientific article published on 06 February 2020

Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?

scientific article published in May 2012

Calcitonin gene-related peptide, adrenomedullin and flushing

scientific article published on 16 September 2009

Characterization and effects on cAMP accumulation of adrenomedullin and calcitonin gene-related peptide (CGRP) receptors in dissociated rat spinal cord cell culture.

scientific article published on 15 May 2006

Characterization of CGRP receptor binding

scientific article published on 01 September 2004

Characterization of a volume-sensitive chloride current in rat osteoblast-like (ROS 17/2.8) cells

scientific article published on June 1995

Characterization of metal ion-induced [3H]inositol hexakisphosphate binding to rat cerebellar membranes

scientific article published in January 1993

Characterization of receptors for calcitonin gene-related peptide and adrenomedullin on the guinea-pig vas deferens

scientific article published in March 1999

Characterization of the structure of RAMP1 by mutagenesis and molecular modeling

scientific article published on 21 April 2006

Combinatorial solid phase synthesis of multiply substituted 1,4-benzodiazepines and affinity studies on the CCK2 receptor (part 1).

scientific article published in January 2002

Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines

scientific article published in July 2002

Desensitisation of adrenomedullin and CGRP receptors

scientific article published in April 2003

Direct inhibitory effects of an antisense oligodeoxynucleotide upon the volume-sensitive chloride current in rat osteoblast-like (ROS 17/2.8) cells

scientific article published on October 1996

Diverse Functional Motifs within the Three Intracellular Loops of the CGRP1Receptor†

scientific article published in October 2006

Evidence that interaction between conserved residues in transmembrane helices 2, 3, and 7 are crucial for human VPAC1 receptor activation

scientific article published on 23 June 2010

Expression and purification of recombinant G protein-coupled receptors: A review

scientific article published on 31 October 2019

Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function

scientific article published on 16 June 2011

FITC-lectin avidity of Cryptococcus neoformans cell wall and capsular components

scientific article published on January 2004

Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR.

scientific article published on 18 July 2008

Functional characterisation of G protein-coupled receptors

scientific article published in September 2018

Functional characterization of two human receptor activity-modifying protein 3 variants

scientific article published on 23 December 2009

Functional recombinant protein is present in the pre-induction phases of Pichia pastoris cultures when grown in bioreactors, but not shake-flasks

scientific article published on 4 September 2014

G-protein coupled receptor solubilization and purification for biophysical analysis and functional studies, in the total absence of detergent.

scientific article published on 16 April 2015

G-protein-coupled receptors: from structural insights to functional mechanisms

scientific article published on February 2013

GPCR modulation by RAMPs

scientific article published in January 2006

GPCR-styrene maleic acid lipid particles (GPCR-SMALPs): their nature and potential.

scientific article published on April 2016

Identification of a novel inositol phosphate recognition site: specific [3H]inositol hexakisphosphate binding to brain regions and cerebellar membranes

scientific article published in March 1990

Inhibition of iron-catalysed hydroxyl radical formation by inositol polyphosphates: a possible physiological function for myo-inositol hexakisphosphate.

scientific article published on September 1993

Inositol phospholipids and phosphates for investigation of intact cell phospholipase C substrates and products

scientific article published on January 1991

Inositol polyphosphate-mediated iron transport in Pseudomonas aeruginosa

scientific article published in March 1999

Interactions between RAMP2 and CRF receptors: The effect of receptor subtypes, splice variants and cell context

scientific article published in May 2019

International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor

scientific article published on 13 June 2008

International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors

scientific article (publication date: June 2002)

Investigating G protein signalling bias at the glucagon-like peptide-1 receptor in yeast

scientific article published on August 2014

Lifting the lid on GPCRs: the role of extracellular loops

scientific article published on March 2012

Ligand Binding and Activation of the CGRP Receptor

scientific article published on 4 September 2009

Ligand binding and activation of the CGRP receptor.

scientific article

Ligand-induced conformational changes in a SMALP-encapsulated GPCR

scientific article published on 29 February 2020

Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor

scientific article published on 11 November 2009

Metabolism of myo-inositol pentakisphosphates in mammalian brain

scientific article

Microbial expression systems for membrane proteins ⬇️

scientific article published on 12 April 2018

Modulating receptor function through RAMPs: can they represent drug targets in themselves?

scientific article published on 16 January 2009

Modulation of Glucagon Receptor Pharmacology by Receptor Activity-modifying Protein-2 (RAMP2).

scientific article published on 21 July 2015

Molecular modelling of the human formyl peptide receptor

scientific article published in February 1995

Molecular pharmacology of receptors for calcitonin-gene-related peptide, amylin and adrenomedullin ⬇️

scientific article published on August 1, 1997

Multiple receptors for calcitonin gene-related peptide and amylin on guinea-pig ileum and vas deferens

scientific article published on March 1996

Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74.

scientific article published on 13 November 2009

Novel Peptide Antagonists of Adrenomedullin and Calcitonin Gene-Related Peptide Receptors: Identification, Pharmacological Characterization, and Interactions with Position 74 in Receptor Activity-Modifying Protein 1/3

article

Pharmacological characterization of a receptor for calcitonin gene-related peptide on rat, L6 myocytes

scientific article published on February 1992

Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes

scientific article published on 3 February 2005

Phosphatidylinositol-3-phosphate and inositol phosphates in mitogenesis

scientific article published in June 1990

Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex

scientific article published on 13 July 2018

Propylbenzilylcholine mustard labels an acidic residue in transmembrane helix 3 of the muscarinic receptor

scientific article published on 5 January 1989

RAMPs and CGRP receptors

scientific article published on January 2012

RAMPs as Drug Targets ⬇️

scientific article published on January 1, 2012

Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors

scientific article published on 14 October 2016

Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties

scientific article published on 24 March 2016

Receptor activity modifying proteins (RAMPs) interact with the VPAC2 receptor and CRF1 receptors and modulate their function

scientific article published in February 2013

Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.

scientific article published on 10 July 2017

Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.

scientific article published on February 2014

Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins.

scientific article published on April 2016

Receptor component protein, an endogenous allosteric modulator of family B G protein coupled receptors

scientific article published on 27 December 2019

Regulation of membrane potential by G-protein-coupled receptors in L6 skeletal myocytes: the role of second messengers

scientific article published on November 1993

Regulation of signal transduction by calcitonin gene-related peptide receptors

scientific article published on 13 July 2010

Relative Antagonism of Mutants of the CGRP Receptor Extracellular Loop 2 Domain (ECL2) Using a Truncated Competitive Antagonist (CGRP8-37): Evidence for the Dual Involvement of ECL2 in the Two-Domain Binding Model

scientific article published on 10 July 2017

Secretin family (Class B) G protein‐coupled receptors – from molecular to clinical perspectives ⬇️

scientific article published on May 1, 2012

Sequence and chemistry requirements for a novel aptameric oligonucleotide inhibitor of EGF receptor tyrosine kinase activity

scientific article published in June 2002

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies

scientific article published on 12 December 2012

Single molecule binding of a ligand to a G-protein-coupled receptor in real time using fluorescence correlation spectroscopy, rendered possible by nano-encapsulation in styrene maleic acid lipid particles

scientific article published on 19 May 2020

Stimulation of phosphatidylinositol-3-kinase by insulin-like growth factor 1 and other agonists

scientific article published on May 1992

Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor

scientific article published on 14 May 2015

Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides

scientific article published on August 1998

Structure-activity relationships for α-calcitonin gene-related peptide.

scientific article published on December 2013

Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation

scientific article published on January 2014

Structure-function analysis of RAMP1 by alanine mutagenesis

scientific article published in January 2009

Structure-function analysis of RAMP1-RAMP3 chimeras.

scientific article published in January 2010

Structure–function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors

scientific article published in May 2011

Surfactant-free purification of membrane proteins with intact native membrane environment

scientific article published on June 2011

Synthesis and evaluation of N1-substituted-3-propyl-1,4-benzodiazepine-2-ones as cholecystokinin (CCK2) receptor ligands

scientific article

Synthesis and iron binding studies of myo-inositol 1,2,3-trisphosphate and (±)-myo-inositol 1,2-bisphosphate, and iron binding studies of all myo-inositol tetrakisphosphates

scientific article published in February 1996

The Structure of the CGRP and Related Receptors

scientific article published on 01 January 2019

The activation of the CGRP receptor

scientific article published on February 2013

The effects of RAMPs upon cell signalling

scientific article published on 5 April 2017

The perils of using the human genome sequence: lessons from CALCRL

scientific article published in June 2001

The pharmacology of adrenomedullin 2/intermedin

scientific article published on May 2012

The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors

scientific article published on January 2004

The preclinical pharmacology of BIBN4096BS, a CGRP antagonist

scientific article published in January 2005

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach

scientific article published on 18 September 2013

The role of the 8-18 helix of CGRP8-37 in mediating high affinity binding to CGRP receptors; coulombic and steric interactions

scientific article published on January 2003

The role of the extracellular loops of the CGRP receptor, a family B GPCR.

scientific article published on April 2012

The second intracellular loop of the calcitonin gene-related peptide receptor provides molecular determinants for signal transduction and cell surface expression

scientific article published on 17 November 2005

The selectivity and structural determinants of peptide antagonists at the CGRP receptor of rat, L6 myocytes

scientific article published on July 1997

Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach

scientific article published on 29 May 2017

Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25.

scientific article published on 23 October 2017

h mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia

scientific article published on 3 September 2018

myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate ⬇️

scientific article published on April 15, 1991

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