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List of works by Debbie Hay

"Just Because It's Out There, People Aren't Going to Use It." HIV Self-Testing Among Young, Black MSM, and Transgender Women.

scientific article published on 16 September 2015

A Single Pseudoproline and Microwave Solid Phase Peptide Synthesis Facilitates an Efficient Synthesis of Human Amylin 1–37

A comparison of the actions of BIBN4096BS and CGRP(8-37) on CGRP and adrenomedullin receptors expressed on SK-N-MC, L6, Col 29 and Rat 2 cells

scientific article published on September 2002

A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.

scientific article published in January 2005

A key role for tryptophan 84 in receptor activity-modifying protein 1 in the amylin 1 receptor

scientific article published on 27 March 2010

A second trigeminal CGRP receptor: function and expression of the AMY1 receptor.

scientific article published on April 2015

Activity of Pramlintide, Rat and Human Amylin but not Aβ1–42at Human Amylin Receptors

scientific article published in January 2014

Adrenomedullin and calcitonin gene-related peptide receptors in endocrine-related cancers: opportunities and challenges ⬇️

scientific article published on December 13, 2010

Adrenomedullin receptors: molecular identity and function.

scientific article

Adrenomedullin: receptor and signal transduction

scientific article

Agonist bias and agonist-dependent antagonism at corticotrophin releasing factor receptors

scientific article published on 01 June 2020

Agonist-dependent consequences of proline to alanine substitution in the transmembrane helices of the calcitonin receptor

scientific article published on 8 May 2007

Amylin

scientific article published on May 2017

Amylin Receptor*

scientific article published in 2007

Amylin receptors: molecular composition and pharmacology

scientific article

Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development

scientific article published on 08 April 2016

Amylin: Pharmacology, Physiology, and Clinical Potential

scientific article published on July 2015

Amyloidogenicity, Cytotoxicity, and Receptor Activity of Bovine Amylin: Implications for Xenobiotic Transplantation and the Design of Nontoxic Amylin Variants

scientific article published on 22 August 2018

An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

scientific article published on 17 May 2016

Analysis of Amylin Consensus Sequences Suggests that Human Amylin is Not Optimized to Minimize Amyloid Formation and Provides Clues to Factors that Modulate Amyloidogenicity

scientific article published on 04 May 2020

Antagonism of CGRP Signaling by Rimegepant at Two Receptors

scientific article published on 20 August 2020

Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14.

scientific article published on 10 August 2015

CGRP Receptor Biology: Is There More Than One Receptor?

scientific article published on 01 January 2019

CGRP and its receptors

scientific article

CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons

scientific article published on 10 May 2022

CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors?

scientific article published on December 2013

CGRP receptor antagonist activity of olcegepant depends on the signalling pathway measured

scientific article published in January 2017

CGRP receptor antagonists: design and screening.

scientific article published on December 2009

CGRP receptor heterogeneity: a role for receptor component protein?

scientific article published in January 2003

CL/RAMP2 and CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS.

scientific article published on 26 August 2003

Calcitonin Gene-Related Peptide Receptor*

scientific article published in 2007

Calcitonin Receptor

scientific article published in 2007

Calcitonin and Amylin Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.

scientific article published on 19 February 2016

Calcitonin and amylin receptor peptide interaction mechanisms. INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS.

scientific article published on July 2016

Calcitonin and calcitonin receptor-like receptors: common themes with family B GPCRs?

scientific article published in May 2012

Calcitonin gene-related peptide, adrenomedullin and flushing

scientific article published on 16 September 2009

Calcitonin-Type Receptors

scientific article published in 2007

Characterization of CGRP receptor binding

scientific article published on 01 September 2004

Characterization of the structure of RAMP1 by mutagenesis and molecular modeling

scientific article published on 21 April 2006

Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines

scientific article published in July 2002

Complexing receptor pharmacology: modulation of family B G protein-coupled receptor function by RAMPs

scientific article

Conclusions and Future Perspectives

Convergent chemoenzymatic synthesis of a library of glycosylated analogues of pramlintide: structure-activity relationships for amylin receptor agonism

scientific article published on 17 July 2014

Correlates of anal intercourse vary by partner type among substance-using women: baseline data from the UNITY study.

scientific article

Corrigendum to “The structure of secretin family GPCR peptide ligands: implications for receptor pharmacology and drug development” [Drug Discov. Today 17 (17–18) (2012) 1006–1014]

article

Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor

scientific article published on 18 March 2019

Desensitisation of adrenomedullin and CGRP receptors

scientific article published in April 2003

Determinants of 1-piperidinecarboxamide, N-[2-[[5-amino-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl) (BIBN4096BS) affinity for calcitonin gene-r

scientific article published on 29 August 2006

Differential activation of G-proteins by mu-opioid receptor agonists

scientific article published on March 2006

Distinct Patterns of Internalization of Different Calcitonin Gene-Related Peptide Receptors

scientific article published on 26 February 2020

Do Sexual Networks of Men Who Have Sex with Men in New York City Differ by Race/Ethnicity?

scientific article

Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors

scientific article

Erratum: An allosteric role for receptor activity-modifying proteins in defining GPCR pharmacology

scientific article published on 21 June 2016

Evidence that α-Calcitonin Gene-Related Peptide Is a Neurohormone that Controls Systemic Lipid Availability and Utilization

article

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy.

scientific article published on 15 February 2018

Functional characterization of two human receptor activity-modifying protein 3 variants

scientific article published on 23 December 2009

Functions of third extracellular loop and helix 8 of Family B GPCRs complexed with RAMPs and characteristics of their receptor trafficking

scientific article published on August 2013

GPCR modulation by RAMPs

scientific article published in January 2006

Glicentin-related pancreatic polypeptide inhibits glucose-stimulated insulin secretion from the isolated pancreas of adult male rats

scientific article published on December 2015

HIV Sexual Risk and Syndemics among Women in Three Urban Areas in the United States: Analysis from HVTN 906

scientific article published on June 2015

Heterodimers and family-B GPCRs: RAMPs, CGRP and adrenomedullin

scientific article published in November 2004

Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function

scientific article published in October 2008

Identification of Small-Molecule Positive Modulators of Calcitonin-like Receptor-Based Receptors

scientific article published on 12 March 2020

Identification of a pathway by which glucose regulates β-catenin signalling via the cAMP/protein kinase A pathway in β-cell models

scientific article published on February 2013

Identification of key residues involved in adrenomedullin binding to the AM1 receptor

scientific article

Immunohistochemical detection of the calcitonin receptor-like receptor protein in the microvasculature of rat endothelium

scientific article published on November 2003

Interaction of calcitonin-gene-related peptide with its receptors

scientific article

International Union of Pharmacology. LXIX. Status of the calcitonin gene-related peptide subtype 2 receptor

scientific article published on 13 June 2008

Knockouts and transgenics confirm the importance of adrenomedullin in the vasculature.

scientific article

Knowing is not enough: a qualitative report on HIV testing among heterosexual African-American men

scientific article

Ligand Binding and Activation of the CGRP Receptor

scientific article published on 4 September 2009

Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding

scientific article published on 24 February 2010

Mapping the calcitonin receptor in human brain stem

scientific article

Measurement of cAMP in an Undergraduate Teaching Laboratory, Using ALPHAscreen Technology

scientific article published on 14 February 2012

Measurement of phosphorylated extracellular signal-regulated kinase 1 and 2 in an undergraduate teaching laboratory with ALPHAscreen technology

scientific article published on 17 March 2009

Mice lacking the neuropeptide alpha-calcitonin gene-related peptide are protected against diet-induced obesity

scientific article published on 7 July 2010

Modulating receptor function through RAMPs: can they represent drug targets in themselves?

scientific article published on 16 January 2009

Molecular Mechanisms of Class B GPCR Activation: Insights from Adrenomedullin Receptors

scientific article published on 26 February 2020

Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin

scientific article published on 23 April 2018

Molecular studies of CGRP and the CGRP family of peptides in the central nervous system

scientific article published in January 2018

N-Glycosylation of Asparagine 130 in the Extracellular Domain of the Human Calcitonin Receptor Significantly Increases Peptide Hormone Affinity

scientific article published on 14 June 2017

New Insights into the Regulation of CGRP-Family Receptors

scientific article published on 04 December 2018

Novel Peptide Antagonists of Adrenomedullin and Calcitonin Gene-Related Peptide Receptors: Identification, Pharmacological Characterization, and Interactions with Position 74 in Receptor Activity-Modifying Protein 1/3

article

Oxyntomodulin inhibits food intake in the rat

scientific article published on 01 October 2001

PACAP receptor pharmacology and agonist bias: analysis in primary neurons and glia from the trigeminal ganglia and transfected cells

scientific article

Pharmacological Characterization and Investigation of N-Terminal Loop Amino Acids of Adrenomedullin 2 That Are Important for Receptor Activation

scientific article published on 29 July 2019

Pharmacological characterization of rat amylin receptors: implications for the identification of amylin receptor subtypes.

scientific article

Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes

scientific article published on 3 February 2005

Pharmacology of the human CGRP1 receptor in Cos 7 cells

scientific article published on 20 December 2005

Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex

scientific article published on 13 July 2018

Post-exposure Prophylaxis Awareness, Knowledge, Access and Use Among Three Populations in New York City, 2016-17

scientific article published on 01 August 2018

Preferences for HIV test characteristics among young, Black Men Who Have Sex With Men (MSM) and transgender women: Implications for consistent HIV testing.

scientific article published on 20 February 2018

Probing the mechanism of receptor activity-modifying protein modulation of GPCR ligand selectivity through rational design of potent adrenomedullin and calcitonin gene-related peptide antagonists

scientific article published on 23 January 2018

RAMPs and CGRP receptors

scientific article published on January 2012

RAMPs as Drug Targets ⬇️

scientific article published on January 1, 2012

Recent progress in unraveling the complexities of receptor biology: towards new therapeutics

scientific article

Receptor Activity-Modifying Proteins (RAMPs): New Insights and Roles

scientific article

Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties

scientific article published on 24 March 2016

Receptor activity modifying proteins and their potential as drug targets

scientific article published on January 2010

Receptor activity-modifying protein dependent and independent activation mechanisms in the coupling of calcitonin gene-related peptide and adrenomedullin receptors to Gs.

scientific article published on 10 July 2017

Receptor activity-modifying protein-dependent effects of mutations in the calcitonin receptor-like receptor: implications for adrenomedullin and calcitonin gene-related peptide pharmacology.

scientific article published on February 2014

Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Δ(1-47)hCT((a)) function

scientific article published on February 2013

Receptor activity-modifying proteins have limited effects on the class B G protein-coupled receptor calcitonin receptor-like receptor stalk

scientific article published in February 2018

Receptor activity-modifying proteins; multifunctional G protein-coupled receptor accessory proteins.

scientific article published on April 2016

Regulation of signal transduction by calcitonin gene-related peptide receptors

scientific article published on 13 July 2010

Reply to comment on: A second trigeminal CGRP receptor: function and expression of the AMY1 receptor

scientific article

Secretin family (Class B) G protein‐coupled receptors – from molecular to clinical perspectives ⬇️

scientific article published on May 1, 2012

Sexual orientation- and race-based discrimination and sexual HIV risk behavior among urban MSM.

scientific article

Similarity between class A and class B G-protein-coupled receptors exemplified through calcitonin gene-related peptide receptor modelling and mutagenesis studies

scientific article published on 12 December 2012

Solid-Phase Thiol-Ene Lipidation of Peptides for the Synthesis of a Potent CGRP Receptor Antagonist

scholarly article

Solid-Phase Thiol-Ene Lipidation of Peptides for the Synthesis of a Potent CGRP Receptor Antagonist

scientific article published on 06 August 2018

Stimulation of Posterior Thalamic Nuclei Induces Photophobic Behavior in Mice

scientific article published on 04 August 2020

Structural Basis for Receptor Activity-Modifying Protein-Dependent Selective Peptide Recognition by a G Protein-Coupled Receptor

scientific article published on 14 May 2015

Structural insights into RAMP modification of secretin family G protein-coupled receptors: implications for drug development

scientific article published on 29 June 2011

Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins

scientific article published on 20 March 2020

Structure-activity relationships for α-calcitonin gene-related peptide.

scientific article published on December 2013

Structure-activity relationships of the N-terminus of calcitonin gene-related peptide: key roles of alanine-5 and threonine-6 in receptor activation

scientific article published on January 2014

Structure-function analysis of RAMP1 by alanine mutagenesis

scientific article published in January 2009

Structure-function analysis of RAMP1-RAMP3 chimeras.

scientific article published in January 2010

Structure-function relationships of the N-terminus of receptor activity-modifying proteins

scientific article published on 10 December 2009

Structure–function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors

scientific article published in May 2011

Synthesis and amylin receptor activity of glycomimetics of pramlintide using click chemistry

scientific article published on 03 May 2016

Synthesis of isotopically labelled αCGRP8-37 and its lipidated analogue

scientific article published on 25 March 2020

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors ⬇️

journal article from 'British Journal of Pharmacology' published in 2021

The Molecular Control of Calcitonin Receptor Signaling

scientific article published on 11 January 2019

The calcitonin gene-related peptide family

article

The pharmacology of adrenomedullin 2/intermedin

scientific article published on May 2012

The pharmacology of adrenomedullin receptors and their relationship to CGRP receptors

scientific article published on January 2004

The preclinical pharmacology of BIBN4096BS, a CGRP antagonist

scientific article published in January 2005

The receptor activity modifying protein family of G protein coupled receptor accessory proteins

scientific article published on June 2004

The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach

scientific article published on 18 September 2013

The role of glutamic acid 73 in adrenomedullin interactions with rodent AM2 receptors

scientific article published on 21 April 2012

The structure of secretin family GPCR peptide ligands: implications for receptor pharmacology and drug development

scientific article published on 11 May 2012

The third extracellular loop of the human calcitonin receptor-like receptor is crucial for the activation of adrenomedullin signalling

scientific article published on May 2012

Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25.

scientific article published on 23 October 2017

Vasopressin-oxytocin-type signaling is ancient and has a conserved water homeostasis role in euryhaline marine planarians

scientific article published on 04 March 2022

What makes a CGRP2 receptor?

scientific article published on October 2007

Who is Using the HIV Self-Test among Young Black Men Who Have Sex With Men (MSM) and Transwomen in New York City?

scientific article published on 09 April 2020

α-Calcitonin gene related peptide (α-CGRP) mediated lipid mobilization in 3T3-L1 adipocytes

scientific article published on 2 June 2014

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