List of works - Susana de la Luna

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response

scientific article published on 12 April 2019

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

scientific article

A new member of the DP family, DP-3, with distinct protein products suggests a regulatory role for alternative splicing in the cell cycle transcription factor DRTF1/E2F.

scientific article published in October 1995

Alu-splice cloning of human Intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome

scientific article

Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2.

scientific article published on 22 September 2009

Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase.

scientific article

Cold shock induces the insertion of a cryptic exon in the neurofibromatosis type 1 (NF1) mRNA

scientific article published on March 2000

Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit

scientific article published in January 1994

Construction of cell lines that regulate by temperature the amplification and expression of influenza virus non-structural protein genes

scientific article published on September 1986

Cooperation to amplify gene-dosage-imbalance effects

scientific article published on 17 August 2006

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

scientific article

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells.

scientific article

DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly

scientific article

DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding

scientific article

DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumour growth

scientific article published on 20 October 2018

DYRK1A overexpression in pancreatic ductal adenocarcinoma contributes to tumor growth

scholarly article by Jeroni Luna et al published June 2015 in Pancreatology

DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors

scientific article

Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain

scientific article published on 01 September 2007

Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors ⬇️

scientific article published on November 1, 1997

Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system

scientific article (publication date: 28 February 2003)

Efficient transformation of mammalian cells with constructs containing a puromycin-resistance marker

article

Epitope mapping of cross-reactive monoclonal antibodies specific for the influenza A virus PA and PB2 polypeptides

scientific article published in August 1995

Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus

scientific article

Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment

scientific article

Identification of PatL1, a human homolog to yeast P body component Pat1

scientific article published on 06 September 2007

Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome

scientific article published on 01 March 2019

Individual expression of influenza virus PA protein induces degradation of coexpressed proteins.

scientific article published in April 1995

Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo

scientific article published in October 1997

Influenza virus naked RNA can be expressed upon transfection into cells co-expressing the three subunits of the polymerase and the nucleoprotein from simian virus 40 recombinant viruses.

scientific article published on March 1993

Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor

scientific article

Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation

scientific article

Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis

scientific article

Key Role of Amino Acid Repeat Expansions in the Functional Diversification of Duplicated Transcription Factors

scientific article

Molecular cloning and sequencing of influenza virus A/Victoria/3/75 polymerase genes: sequence evolution and prediction of possible functional domains

scientific article

Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro

scientific article published on November 1994

Mutational analysis of the influenza virus A/Victoria/3/75 PA protein: studies of interaction with PB1 protein and identification of a dominant negative mutant

scientific article published on August 1996

Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal

article

Nuclear transport of influenza virus polymerase PA protein.

scientific article

Overexpression of tau protein in COS-1 cells results in the stabilization of centrosome-independent microtubules and extension of cytoplasmic processes

scientific article published on January 1994

Permanent cell lines established from ts-COS cells that regulate by temperature the amplification and expression of cloned genes

scientific article

Permanent cell lines that show temperature-dependent expression of adenovirus virus-associated RNA.

scientific article

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life

scientific article

Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling.

scientific article published in September 2010

Regulation of gene amplification and expression in cells that constitutively express a temperature sensitive SV40 T-antigen.

scientific article

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

scientific article published on 26 June 2007

Resistance to foot-and-mouth disease virus mediated by trans-acting cellular products

scientific article

Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity

scientific article published on 2 December 2010

Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A.

scientific article

Structural determinants of KvLQT1 control by the KCNE family of proteins

scientific article (publication date: 2 March 2001)

Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system

scientific article published in August 1994

TFIIIC Binding to Alu Elements Controls Gene Expression via Chromatin Looping and Histone Acetylation

scientific article published on 20 November 2019

TFIIIC dynamically binds Alu elements to control gene expression through chromatin looping

article

The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities

scientific article published on 29 July 2020

The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators.

scholarly article

The molecular basis of glutamate formiminotransferase deficiency

scientific journal article

The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development

scientific article published in December 2008

pac Gene as Efficient Dominant Marker and Reporter Gene in Mammalian Cells

article

pac gene as efficient dominant marker and reporter gene in mammalian cells

scientific article published on January 1992

List of works by Susana de la Luna

A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response

A new aspartyl protease on 21q22.3, BACE2, is highly similar to Alzheimer's amyloid precursor protein beta-secretase

A new member of the DP family, DP-3, with distinct protein products suggests a regulatory role for alternative splicing in the cell cycle transcription factor DRTF1/E2F.

Alu-splice cloning of human Intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome

Characterization of a mouse model overexpressing beta-site APP-cleaving enzyme 2 reveals a new role for BACE2.

Chromatin-wide profiling of DYRK1A reveals a role as a gene-specific RNA polymerase II CTD kinase.

Cold shock induces the insertion of a cryptic exon in the neurofibromatosis type 1 (NF1) mRNA

Complex structure of the nuclear translocation signal of influenza virus polymerase PA subunit

Construction of cell lines that regulate by temperature the amplification and expression of influenza virus non-structural protein genes

Cooperation to amplify gene-dosage-imbalance effects

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

DYRK1A Kinase Positively Regulates Angiogenic Responses in Endothelial Cells.

DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly

DYRK1A autophosphorylation on serine residue 520 modulates its kinase activity via 14-3-3 binding

DYRK1A modulates c-MET in pancreatic ductal adenocarcinoma to drive tumour growth

DYRK1A overexpression in pancreatic ductal adenocarcinoma contributes to tumor growth

DYRK1A-mediated phosphorylation of GluN2A at Ser(1048) regulates the surface expression and channel activity of GluN1/GluN2A receptors

Differential expression of members of the RCAN family of calcineurin regulators suggests selective functions for these proteins in the brain

Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors ⬇️

Dyrk1A expression pattern supports specific roles of this kinase in the adult central nervous system

Efficient transformation of mammalian cells with constructs containing a puromycin-resistance marker

Epitope mapping of cross-reactive monoclonal antibodies specific for the influenza A virus PA and PB2 polypeptides

Eukaryotic translation initiation factor 4GI is a cellular target for NS1 protein, a translational activator of influenza virus

Genome-wide analysis of histidine repeats reveals their role in the localization of human proteins to the nuclear speckles compartment

Identification of PatL1, a human homolog to yeast P body component Pat1

Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndrome

Individual expression of influenza virus PA protein induces degradation of coexpressed proteins.

Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo

Influenza virus naked RNA can be expressed upon transfection into cells co-expressing the three subunits of the polymerase and the nucleoprotein from simian virus 40 recombinant viruses.

Integration of a growth-suppressing BTB/POZ domain protein with the DP component of the E2F transcription factor

Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation

Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis

Key Role of Amino Acid Repeat Expansions in the Functional Diversification of Duplicated Transcription Factors

Molecular cloning and sequencing of influenza virus A/Victoria/3/75 polymerase genes: sequence evolution and prediction of possible functional domains

Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro

Mutational analysis of the influenza virus A/Victoria/3/75 PA protein: studies of interaction with PB1 protein and identification of a dominant negative mutant

Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal

Nuclear transport of influenza virus polymerase PA protein.

Overexpression of tau protein in COS-1 cells results in the stabilization of centrosome-independent microtubules and extension of cytoplasmic processes

Permanent cell lines established from ts-COS cells that regulate by temperature the amplification and expression of cloned genes

Permanent cell lines that show temperature-dependent expression of adenovirus virus-associated RNA.

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life

Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling.

Regulation of gene amplification and expression in cells that constitutively express a temperature sensitive SV40 T-antigen.

Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin.

Resistance to foot-and-mouth disease virus mediated by trans-acting cellular products

Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity

Sprouty2-mediated inhibition of fibroblast growth factor signaling is modulated by the protein kinase DYRK1A.

Structural determinants of KvLQT1 control by the KCNE family of proteins

Synthesis of biologically active influenza virus core proteins using a vaccinia virus-T7 RNA polymerase expression system

TFIIIC Binding to Alu Elements Controls Gene Expression via Chromatin Looping and Histone Acetylation

TFIIIC dynamically binds Alu elements to control gene expression through chromatin looping

The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic Opportunities

The RCAN carboxyl end mediates calcineurin docking-dependent inhibition via a site that dictates binding to substrates and regulators.

The molecular basis of glutamate formiminotransferase deficiency

The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development

pac Gene as Efficient Dominant Marker and Reporter Gene in Mammalian Cells

pac gene as efficient dominant marker and reporter gene in mammalian cells