List of works - Douglas M. Noonan

A think tank of TINK/TANKs: tumor-infiltrating/tumor-associated natural killer cells in tumor progression and angiogenesis

scientific article

AAV-mediated gene transfer of tissue inhibitor of metalloproteinases-1 inhibits vascular tumor growth and angiogenesis in vivo

scientific article published on January 2004

Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis.

scientific article published on March 2004

Angiopoietin2 and Tie2: Tied to Lymphangiogenesis and Lung Metastasis. New Perspectives in Antimetastatic Antiangiogenic Therapy ⬇️

scientific article published on February 17, 2012

Angioprevention with fenretinide: targeting angiogenesis in prevention and therapeutic strategies

scientific article published on 19 January 2010

Angiostatin anti-angiogenesis requires IL-12: the innate immune system as a key target

scientific article

Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells

scientific article

Biological assays and genomic analysis reveal lipoic acid modulation of endothelial cell behavior and gene expression

scientific article published on 24 November 2006

Biosynthesis of heparan sulfate proteoglycans of developing chick breast skeletal muscle in vitro

scientific article published on 01 October 1986

Bringing new players into the field: onco-pharmacovigilance in the era of cardio-oncology

scientific article published on 22 January 2012

COVID-19 and Obesity: Dangerous Liaisons

scientific article published on 04 August 2020

Cancer prevention by targeting angiogenesis

scientific article published on 31 July 2012

Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity

scientific article

Capecitabine in breast cancer: the issue of cardiotoxicity during fluoropyrimidine treatment

scientific article published on September 2010

Cardio-oncology in targeting the HER receptor family: the puzzle of different cardiotoxicities of HER2 inhibitors

scientific article

Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention

scientific article

Cardiovascular Active Peptides of Marine Origin with ACE Inhibitory Activities: Potential Role as Anti-Hypertensive Drugs and in Prevention of SARS-CoV-2 Infection

scientific article published on 07 November 2020

Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth.

scientific article published on 5 July 2010

Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines

scientific article

Choking Hypoxia-Inducible Factor 1α: A Novel Mechanism for Connective Tissue Growth Factor Inhibition of Angiogenesis

scientific article published on 01 July 2006

Cytokine Loaded Biopolymers as a Novel Strategy to Study Stem Cells during Wound-Healing Processes

scientific article published on 11 March 2011

Diabetes mellitus induced inhibition of glucosaminyl N-deacetylase: effect of short-term blood glucose control in diabetic rats

scientific article published on 01 April 1993

Differential effects of angiostatin, endostatin and interferon-alpha(1) gene transfer on in vivo growth of human breast cancer cells.

scientific article published on July 2002

Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes

scientific article

Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors

scientific article published on 9 August 2007

Endocrine disruptor agent nonyl phenol exerts an estrogen-like transcriptional activity on estrogen receptor positive breast cancer cells.

scientific article published on January 2014

Endothelial cell aging and apoptosis in prevention and disease: E-selectin expression and modulation as a model

scientific article published on January 2008

Environmental impact of multi-wall carbon nanotubes in a novel model of exposure: systemic distribution, macrophage accumulation, and amyloid deposition

scientific article

Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells

scientific article published on August 2000

Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs

scientific article published on 10 April 2010

Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress

scientific article

Growth factor supplemented matrigel improves ectopic skeletal muscle formation--a cell therapy approach

scientific article

HIV Tat, its TARgets and the control of viral gene expression

scientific article

HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons.

scientific article

HIV-1 Tat protein mimicry of chemokines

scientific article

Highly stable oligomerization forms of HIV-1 Tat detected by monoclonal antibodies and requirement of monomeric forms for the transactivating function on the HIV-1 LTR.

scientific article

Human Chorionic Gonadotropin Inhibits Kaposi’s Sarcoma Associated Angiogenesis, Matrix Metalloprotease Activity, and Tumor Growth

scientific article published on 01 August 2002

Human immunodeficiency virus transactivator protein (Tat) stimulates chemotaxis, calcium mobilization, and activation of human polymorphonuclear leukocytes: implications for Tat-mediated pathogenesis.

scientific article published on 8 November 2000

Identification of a novel domain of HIV tat involved in monocyte chemotaxis

scientific article published in June 1998

Identification, isolation and expansion of myoendothelial cells involved in leech muscle regeneration

scientific article

In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16INK4A-defective, pRb-positive human melanoma cells.

scientific article published on March 2005

In vivo isolation and characterization of stem cells with diverse phenotypes using growth factor impregnated biomatrices

scientific article

Inflammation, inflammatory cells and angiogenesis: decisions and indecisions

scientific article published on March 2008

Inflammatory angiogenesis and the tumor microenvironment as targets for cancer therapy and prevention

scientific article published on January 2014

Inhibition of a vascular ocular tumor growth by IL-12 gene transfer

article

Inhibition of tumor angiogenesis by angiostatin: from recombinant protein to gene therapy

scientific article

Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size

scientific article (publication date: 25 April 1997)

Interactions of single-wall carbon nanotubes with endothelial cells

scientific article published on 20 August 2009

KSHV sequences in biopsies and cultured spindle cells of epidemic, iatrogenic and Mediterranean forms of Kaposi's sarcoma

scientific article published on 01 September 1996

Kaposi's Sarcoma Cells of Different Etiologic Origins Respond to HIV-Tat through the Flk-1/KDR (VEGFR-2): Relevance in AIDS-KS Pathology

article

Kaposi's sarcoma and human chorionic gonadotropin: mechanisms, moieties and mysteries

scientific article

Matrigel promotes retinoblastoma cell growth in vitro and in vivo

scientific article published in September 1992

Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent

scientific article

Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallocatechin-3-gallate

scientific article published on July 2004

Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets

scientific article

Metabolic regulation and redox activity as mechanisms for angioprevention by dietary phytochemicals

scientific article

Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase

scientific article

Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses

scientific article published on 5 August 2005

Molecular pathways for cancer angioprevention

scientific article published on August 2007

Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat RGD and basic peptides

article

N-(4-hydroxyphenyl)retinamide inhibits retinoblastoma growth through reactive oxygen species-mediated cell death

scientific article published in March 2003

NET amyloidogenic backbone in human activated neutrophils

scientific article published on 14 October 2015

Natural Killer Cells from Malignant Pleural Effusion Are Endowed with a Decidual-Like Proangiogenic Polarization.

scientific article

Novel cell death pathways induced by N-(4-hydroxyphenyl)retinamide: therapeutic implications.

scientific article published in January 2007

Orchestration of angiogenesis by immune cells

scientific article

Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection

scientific article published on 18 March 2020

Paradoxic effects of metformin on endothelial cells and angiogenesis

scientific article published on 13 January 2014

Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.

scientific article published in May 2003

Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent

scientific article published in April 2002

Prediction of breast cancer metastasis by genomic profiling: where do we stand?

scientific article published on 24 March 2009

Preliminary Evidence on the Diagnostic and Molecular Role of Circulating Soluble EGFR in Non-Small Cell Lung Cancer

scientific article

Prevention of angiogenesis by naked DNA IL-12 gene transfer: angioprevention by immunogene therapy.

scientific article published in February 2004

Renal dysfunction and increased risk of cardiotoxicity with trastuzumab therapy: a new challenge in cardio-oncology

scientific article published on 02 September 2012

Rescuing COX-2 inhibitors from the waste bin.

scientific article published in June 2005

Role of the alpha3beta1 and alpha6beta4 integrins in tumor invasion

scientific article

SANIST: a rapid mass spectrometric SACI/ESI data acquisition and elaboration platform for verifying potential candidate biomarkers

scientific article (publication date: 15 October 2015)

Skeletonema marinoi Extracts and Associated Carotenoid Fucoxanthin Downregulate Pro-Angiogenic Mediators on Prostate Cancer and Endothelial Cells

scientific article published in 2023

Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities.

scientific article published on April 2003

Strategies to Prevent "Bad Luck" in Cancer

scientific article

Suppression of invasive behavior of melanoma cells by stable expression of anti-sense perlecan cDNA.

scientific article

Suramin interferes with auto/paracrine insulin-like growth factor I-controlled proliferative loop on human lung cancer cell lines

scientific article published on October 1994

Surface-activated chemical ionization-electrospray ionization source improves biomarker discovery with mass spectrometry

scientific article published on May 2012

Surface-activated chemical ionization-electrospray mass spectrometry in the analysis of urinary thiodiglycolic acid

scientific article published on 01 February 2013

The "chemoinvasion assay": a tool to study tumor and endothelial cell invasion of basement membranes

scientific article published in January 2004

The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-kappaB pathway

scientific article published on 4 September 2006

The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells

scientific article (publication date: 26 September 2002)

The Microalgal Diatoxanthin Inflects the Cytokine Storm in SARS-CoV-2 Stimulated ACE2 Overexpressing Lung Cells

scientific article published in 2022

The Ovarian Cancer Tumor Immune Microenvironment (TIME) as Target for Therapy: A Focus on Innate Immunity Cells as Therapeutic Effectors

scientific article published on 28 April 2020

The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity

scientific article (publication date: August 2000)

The alpha 3 beta 1 integrin is involved in melanoma cell migration and invasion.

scientific article

The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells.

scientific article

The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells

scientific article published on 18 September 2014

The cAMP analog 8-Cl-cAMP inhibits growth and induces differentiation and apoptosis in retinoblastoma cells

scientific article published on September 1997

The in vitro invasiveness and interactions with laminin of K-1735 melanoma cells. Evidence for different laminin-binding affinities in high and low metastatic variants

scientific article published in July 1989

The leech: a novel invertebrate model for studying muscle regeneration and diseases.

scientific article published on January 2010

The proangiogenic phenotype of natural killer cells in patients with non-small cell lung cancer

scientific article published on February 2013

The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent

scientific article published on 7 December 2007

The three-dimensional microvascular architecture of the human Kaposi sarcoma implanted in nude mice: a SEM corrosion casting study

scientific article published on 22 August 2006

The transforming growth factor-beta family members bone morphogenetic protein-2 and macrophage inhibitory cytokine-1 as mediators of the antiangiogenic activity of N-(4-hydroxyphenyl)retinamide

scientific article published on June 2005

The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker

scientific article

The ‘chemoinvasion’ assay, 25 years and still going strong: the use of reconstituted basement membranes to study cell invasion and angiogenesis ⬇️

scientific article published on 06 September 2010

Tumor inflammatory angiogenesis and its chemoprevention

scientific article

Tumors and inflammatory infiltrates: friends or foes?

scientific article

Unsung Hero Robert C. Gallo

scientific article

miR181b is induced by the chemopreventive polyphenol curcumin and inhibits breast cancer metastasis via down-regulation of the inflammatory cytokines CXCL1 and -2.

scientific article published on 16 January 2014

List of works by Douglas M. Noonan

A think tank of TINK/TANKs: tumor-infiltrating/tumor-associated natural killer cells in tumor progression and angiogenesis

AAV-mediated gene transfer of tissue inhibitor of metalloproteinases-1 inhibits vascular tumor growth and angiogenesis in vivo

Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis.

Angiopoietin2 and Tie2: Tied to Lymphangiogenesis and Lung Metastasis. New Perspectives in Antimetastatic Antiangiogenic Therapy ⬇️

Angioprevention with fenretinide: targeting angiogenesis in prevention and therapeutic strategies

Angiostatin anti-angiogenesis requires IL-12: the innate immune system as a key target

Aspirin and atenolol enhance metformin activity against breast cancer by targeting both neoplastic and microenvironment cells

Biological assays and genomic analysis reveal lipoic acid modulation of endothelial cell behavior and gene expression

Biosynthesis of heparan sulfate proteoglycans of developing chick breast skeletal muscle in vitro

Bringing new players into the field: onco-pharmacovigilance in the era of cardio-oncology

COVID-19 and Obesity: Dangerous Liaisons

Cancer prevention by targeting angiogenesis

Cancer stem cells and the tumor microenvironment: interplay in tumor heterogeneity

Capecitabine in breast cancer: the issue of cardiotoxicity during fluoropyrimidine treatment

Cardio-oncology in targeting the HER receptor family: the puzzle of different cardiotoxicities of HER2 inhibitors

Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention

Cardiovascular Active Peptides of Marine Origin with ACE Inhibitory Activities: Potential Role as Anti-Hypertensive Drugs and in Prevention of SARS-CoV-2 Infection

Cell delivery of Met docking site peptides inhibit angiogenesis and vascular tumor growth.

Cell density-dependent regulation of matrix metalloproteinase and TIMP expression in differently tumorigenic breast cancer cell lines

Choking Hypoxia-Inducible Factor 1α: A Novel Mechanism for Connective Tissue Growth Factor Inhibition of Angiogenesis

Cytokine Loaded Biopolymers as a Novel Strategy to Study Stem Cells during Wound-Healing Processes

Diabetes mellitus induced inhibition of glucosaminyl N-deacetylase: effect of short-term blood glucose control in diabetic rats

Differential effects of angiostatin, endostatin and interferon-alpha(1) gene transfer on in vivo growth of human breast cancer cells.

Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes

Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors

Endocrine disruptor agent nonyl phenol exerts an estrogen-like transcriptional activity on estrogen receptor positive breast cancer cells.

Endothelial cell aging and apoptosis in prevention and disease: E-selectin expression and modulation as a model

Environmental impact of multi-wall carbon nanotubes in a novel model of exposure: systemic distribution, macrophage accumulation, and amyloid deposition

Expression of functional tyrosine kinases on immortalized Kaposi's sarcoma cells

Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs

Glycogen synthase kinase 3 regulates cell death and survival signaling in tumor cells under redox stress

Growth factor supplemented matrigel improves ectopic skeletal muscle formation--a cell therapy approach

HIV Tat, its TARgets and the control of viral gene expression

HIV-1 Tat causes apoptotic death and calcium homeostasis alterations in rat neurons.

HIV-1 Tat protein mimicry of chemokines

Highly stable oligomerization forms of HIV-1 Tat detected by monoclonal antibodies and requirement of monomeric forms for the transactivating function on the HIV-1 LTR.

Human Chorionic Gonadotropin Inhibits Kaposi’s Sarcoma Associated Angiogenesis, Matrix Metalloprotease Activity, and Tumor Growth

Human immunodeficiency virus transactivator protein (Tat) stimulates chemotaxis, calcium mobilization, and activation of human polymorphonuclear leukocytes: implications for Tat-mediated pathogenesis.

Identification of a novel domain of HIV tat involved in monocyte chemotaxis

Identification, isolation and expansion of myoendothelial cells involved in leech muscle regeneration

In vitro and in vivo tumor growth inhibition by a p16-mimicking peptide in p16INK4A-defective, pRb-positive human melanoma cells.

In vivo isolation and characterization of stem cells with diverse phenotypes using growth factor impregnated biomatrices

Inflammation, inflammatory cells and angiogenesis: decisions and indecisions

Inflammatory angiogenesis and the tumor microenvironment as targets for cancer therapy and prevention

Inhibition of a vascular ocular tumor growth by IL-12 gene transfer

Inhibition of tumor angiogenesis by angiostatin: from recombinant protein to gene therapy

Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size

Interactions of single-wall carbon nanotubes with endothelial cells

KSHV sequences in biopsies and cultured spindle cells of epidemic, iatrogenic and Mediterranean forms of Kaposi's sarcoma

Kaposi's Sarcoma Cells of Different Etiologic Origins Respond to HIV-Tat through the Flk-1/KDR (VEGFR-2): Relevance in AIDS-KS Pathology

Kaposi's sarcoma and human chorionic gonadotropin: mechanisms, moieties and mysteries

Matrigel promotes retinoblastoma cell growth in vitro and in vivo

Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent

Mechanisms of inhibition of tumor angiogenesis and vascular tumor growth by epigallocatechin-3-gallate

Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets

Metabolic regulation and redox activity as mechanisms for angioprevention by dietary phytochemicals

Microenvironmental control of malignancy exerted by RNASET2, a widely conserved extracellular RNase

Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses

Molecular pathways for cancer angioprevention

Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat RGD and basic peptides

N-(4-hydroxyphenyl)retinamide inhibits retinoblastoma growth through reactive oxygen species-mediated cell death

NET amyloidogenic backbone in human activated neutrophils

Natural Killer Cells from Malignant Pleural Effusion Are Endowed with a Decidual-Like Proangiogenic Polarization.

Novel cell death pathways induced by N-(4-hydroxyphenyl)retinamide: therapeutic implications.

Orchestration of angiogenesis by immune cells

Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection

Paradoxic effects of metformin on endothelial cells and angiogenesis

Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.

Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea as a candidate anti-HIV agent

Prediction of breast cancer metastasis by genomic profiling: where do we stand?

Preliminary Evidence on the Diagnostic and Molecular Role of Circulating Soluble EGFR in Non-Small Cell Lung Cancer

Prevention of angiogenesis by naked DNA IL-12 gene transfer: angioprevention by immunogene therapy.

Renal dysfunction and increased risk of cardiotoxicity with trastuzumab therapy: a new challenge in cardio-oncology

Rescuing COX-2 inhibitors from the waste bin.

Role of the alpha3beta1 and alpha6beta4 integrins in tumor invasion

SANIST: a rapid mass spectrometric SACI/ESI data acquisition and elaboration platform for verifying potential candidate biomarkers

Skeletonema marinoi Extracts and Associated Carotenoid Fucoxanthin Downregulate Pro-Angiogenic Mediators on Prostate Cancer and Endothelial Cells

Somatostatin inhibits tumor angiogenesis and growth via somatostatin receptor-3-mediated regulation of endothelial nitric oxide synthase and mitogen-activated protein kinase activities.

Strategies to Prevent "Bad Luck" in Cancer