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List of works by Bradford C. Berk

14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange

scientific article (publication date: 11 May 2001)

14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function.

scientific article

A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis.

scientific article

Acetylation of cyclophilin A is required for its secretion and vascular cell activation

scientific article

Activation of mitogen-activated protein kinases and p90 ribosomal S6 kinase in failing human hearts with dilated cardiomyopathy

scientific article published in January 2002

An epidermal growth factor (EGF) -dependent interaction between GIT1 and sorting nexin 6 promotes degradation of the EGF receptor.

scientific article published on 3 June 2008

Angiotensin II Induces Transactivation of Two Different Populations of the Platelet-derived Growth Factor β Receptor

scientific article published on 01 May 2000

Angiotensin II mediated signal transduction. Important role of tyrosine kinases.

scientific article

Angiotensin II signal transduction: Stimulation of multiple mitogen-activated protein kinase pathways.

scientific article published on September 1997

Angiotensin II signaling pathways mediated by tyrosine kinases.

scientific article

Angiotensin II stimulates the pp44 and pp42 mitogen-activated protein kinases in cultured rat aortic smooth muscle cells

scientific article published on 01 October 1992

Angiotensin II stimulation of vascular smooth muscle cells. Secondary signalling mechanisms.

scientific article

Angiotensin II type 2 receptor expression after vascular injury: differing effects of angiotensin-converting enzyme inhibition and angiotensin receptor blockade

scientific article published on 18 September 2006

Angiotensin II-mediated signal transduction pathways.

scientific article

Angiotensin II: a devious activator of mineralocorticoid receptor-dependent gene expression

scientific article published in April 2005

Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro

scientific journal article

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

scientific article

Atheroprone flow activation of the sterol regulatory element binding protein 2 and nod-like receptor protein 3 inflammasome mediates focal atherosclerosis

scientific article published on 9 July 2013

Axl mediates vascular remodeling induced by deoxycorticosterone acetate-salt hypertension

scientific article published on 8 October 2007

BMK1/ERK5 is a novel regulator of angiogenesis by destabilizing hypoxia inducible factor 1alpha

scientific article published on 05 May 2005

Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis

scientific article published on 11 December 2003

Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase

scientific journal article

Cezanne paints inflammation by regulating ubiquitination

scientific article published on June 2013

Chronic physiological shear stress inhibits tumor necrosis factor-induced proinflammatory responses in rabbit aorta perfused ex vivo

scientific article published on 08 September 2003

Circulating smooth muscle progenitor cells: novel players in plaque stability

scientific article published on 04 December 2007

Comparison of simultaneous measurements of blood pressure by tail-cuff and carotid arterial methods in conscious spontaneously hypertensive and Wistar-Kyoto rats.

scientific article

Contrasting effects of urokinase and tissue-type plasminogen activators on neointima formation and vessel remodelling after arterial injury

scientific article published in May 2004

Cyclophilin A - Promising New Target in Cardiovascular Therapy - ⬇️

scientific article published on October 15, 2010

Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms

scientific article published in June 2009

Cyclophilin A is a proinflammatory cytokine that activates endothelial cells

scientific article

Cyclophilin A is an important mediator of platelet function by regulating integrin αIIbβ3 bidirectional signalling

scientific article published on 16 January 2014

Cyclophilin A is required for angiotensin II-induced p47phox translocation to caveolae in vascular smooth muscle cells.

scientific article published on 11 July 2013

Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells.

scientific article

Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation.

scientific article published on 9 June 2008

Cyclophilin A modulates bone marrow-derived CD117(+) cells and enhances ischemia-induced angiogenesis via the SDF-1/CXCR4 axis.

scientific article published on 24 March 2016

Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice

scientific article published on 17 February 2011

Cyclosporin A inhibits flow-mediated activation of endothelial nitric-oxide synthase by altering cholesterol content in caveolae

scientific article published on 20 September 2004

Decreased BMP2 signal in GIT1 knockout mice slows bone healing.

scientific article published on 20 August 2014

ERK1/2 associates with the c-Met-binding domain of growth factor receptor-bound protein 2 (Grb2)-associated binder-1 (Gab1): role in ERK1/2 and early growth response factor-1 (Egr-1) nuclear accumulation

scientific article

Elevation of C-reactive protein in "active" coronary artery disease

scientific article published on 01 January 1990

Epidermal growth factor receptor transactivation is regulated by glucose in vascular smooth muscle cells

scientific article

Flow activates ERK1/2 and endothelial nitric oxide synthase via a pathway involving PECAM1, SHP2, and Tie2.

scientific article published on 28 June 2005

Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing

scientific article published on 24 May 2007

Flow shear stress and atherosclerosis: a matter of site specificity

scientific article published on 08 April 2011

Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening

scientific article published on 23 October 2003

Flow-mediated signaling modulates endothelial cell phenotype.

scientific article published on November 2006

Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway

scientific article published in November 2002

Fluid shear stress attenuates hydrogen peroxide-induced c-Jun NH2-terminal kinase activation via a glutathione reductase-mediated mechanism

scientific article published in October 2002

Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells

scientific article

Fluid shear stress inhibits vascular inflammation by decreasing thioredoxin-interacting protein in endothelial cells

scientific article

Fluid shear stress stimulates big mitogen-activated protein kinase 1 (BMK1) activity in endothelial cells. Dependence on tyrosine kinases and intracellular calcium

scientific article published on 01 January 1999

Fluid shear stress-mediated signal transduction: how do endothelial cells transduce mechanical force into biological responses?

scientific article published on April 1997

Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure

scientific journal article

Fyn and JAK2 mediate Ras activation by reactive oxygen species

scientific article published on 01 July 1999

G protein coupled receptor kinase 2 interacting protein 1 (GIT1) is a novel regulator of mitochondrial biogenesis in heart

scientific article

G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development

scientific article published on 9 March 2009

G-protein-coupled receptor kinase interacting protein-1 mediates intima formation by regulating vascular smooth muscle proliferation, apoptosis, and migration

scientific article published on 21 February 2013

G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation

scientific article

GIT1 Mediates Src-dependent Activation of Phospholipase Cγ by Angiotensin II and Epidermal Growth Factor ⬇️

scientific article (publication date: 12 December 2003)

GIT1 is a novel MEK1-ERK1/2 scaffold that localizes to focal adhesions

scientific article

GIT1 is a scaffold for ERK1/2 activation in focal adhesions

scientific article

GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells

scientific article

GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma

scientific article

GIT1 mediates thrombin signaling in endothelial cells: role in turnover of RhoA-type focal adhesions

scientific article (publication date: 30 April 2004)

GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass

scientific article

Gas6-axl receptor signaling is regulated by glucose in vascular smooth muscle cells

scientific journal article

Genetic modifier loci linked to intima formation induced by low flow in the mouse carotid.

scientific article published on 23 October 2008

Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells

scientific article published on 9 April 2009

Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner

scientific article published on 12 April 2007

Glutathiolation regulates tumor necrosis factor-alpha-induced caspase-3 cleavage and apoptosis: key role for glutaredoxin in the death pathway.

scientific article published on 21 December 2006

HDAC7 supports vascular integrity

scientific article published on 01 September 2006

Hydrogen peroxide activates the Gas6-Axl pathway in vascular smooth muscle cells

scientific article

Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C.

scientific article published on March 1993

Hypoxia and HIF-1alpha stability: another stress-sensing mechanism for Shc.

scientific article published in July 2002

Identification of a genetic locus on chromosome 11 that regulates leukocyte infiltration in mouse carotid artery.

scientific article published on 28 February 2013

Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002

scientific article published on 01 October 1999

Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice

scientific article

Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways

scientific article published on 30 July 2007

Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury

scientific article

Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation

scientific article published on 28 August 2003

Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression

scientific article

Interleukin-18 and interleukin-18 binding protein levels before and after percutaneous coronary intervention in patients with and without recent myocardial infarction

scientific article published on 01 November 2004

Interleukin-18 and macrophage migration inhibitory factor are associated with increased carotid intima-media thickening.

scientific article

Intima modifier locus 2 controls endothelial cell activation and vascular permeability.

scientific article

Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthase

scientific article published on 31 July 2003

Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179.

scientific article published in September 2005

Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains

scientific journal article

NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation

scientific article

Novel mechanisms of endothelial mechanotransduction

scientific article

Oligonucleotide microarrays reveal regulated genes related to inward arterial remodeling induced by urokinase plasminogen activator

scientific article published on 24 September 2008

PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2.

scientific article published on 31 January 2008

PKC-epsilon is required for mechano-sensitive activation of ERK1/2 in endothelial cells

scientific article published on 01 December 1997

PKCζ mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation

scientific article

Pharmacologic roles of heparin and glucocorticoids to prevent restenosis after coronary angioplasty.

scientific article published on May 1991

Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells.

scientific article

Physiologic stress-mediated signaling in the endothelium

scientific article published in January 2008

Plasminogen activator expression correlates with genetic differences in vascular remodeling.

scientific article

Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor

scientific article (publication date: 28 June 2002)

Protein kinase C-mediated intracellular alkalinization in rat and rabbit aortic smooth muscle cells

scientific article published on 01 September 1987

Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells

scientific article published on March 1997

Protein kinases as mediators of fluid shear stress stimulated signal transduction in endothelial cells: a hypothesis for calcium-dependent and calcium-independent events activated by flow

scientific article published on 01 December 1995

Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells

scientific article

Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice

scientific article

Reactive Oxygen Species as Mediators of Signal Transduction in Cardiovascular Disease ⬇️

scientific article published on February 1, 1998

Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras

scientific article published on 01 January 2000

Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation

scientific article published on October 2001

Redox redux: protecting the ischemic myocardium ⬇️

scientific article published on December 27, 2011

Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69.

scientific article

Regulation of sodium-hydrogen exchange in vascular smooth muscle

scientific article published on February 1995

Restenosis following coronary balloon angioplasty Role of smooth muscle cell proliferation

scientific article published on April 1991

Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation

scientific journal article

Role of Angiotensin-converting enzyme and neutral endopeptidase in flow-dependent remodeling

scientific article published on 3 March 2004

Role of hypertension in the metabolic syndrome: who is affected?

scientific article

Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival

scientific journal article

Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium

scientific journal article

Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells

scientific article published on 14 August 2003

Scaffolds direct Src-specific signaling in response to angiotensin II: new roles for Cas and GIT1.

scientific article published on April 2004

Shear stress is differentially regulated among inbred rat strains

scientific article published on 03 April 2003

Shear stress stimulation of p130(cas) tyrosine phosphorylation requires calcium-dependent c-Src activation

scientific article published on 01 September 1999

Shear stress-mediated extracellular signal-regulated kinase activation is regulated by sodium in endothelial cells. Potential role for a voltage-dependent sodium channel

scientific article

Smooth muscle apoptosis and vascular remodeling.

scientific article published on May 2008

Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells

scientific journal article

Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch

scientific article

Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning

scientific article published in November 2001

State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization: A Scientific Statement From the American Heart Association

scientific article

Strain-dependent differences in responses to exercise training in inbred and hybrid mice

scientific article published on 23 December 2004

Strain-dependent vascular remodeling: the "Glagov phenomenon" is genetically determined

scientific article published on 28 June 2004

TR4 nuclear receptor functions as a fatty acid sensor to modulate CD36 expression and foam cell formation.

scientific article published on 28 July 2009

The Angiotensin II AT1 Receptor Is Tyrosine and Serine Phosphorylated and can Serve as a Substrate for the SRC Family of Tyrosine Kinases

scientific article published on 01 April 1994

The Role of PB1 Domain Proteins in Endothelial Cell Dysfunction and Disease

scientific article

The hinge-helix 1 region of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) mediates interaction with extracellular signal-regulated kinase 5 and PPARgamma1 transcriptional activation: involvement in flow-induced PPARgamma activation

scientific article published on 01 October 2004

The role of MAP kinases in endothelial activation.

scientific article

Thioredoxin interacting protein promotes endothelial cell inflammation in response to disturbed flow by increasing leukocyte adhesion and repressing Kruppel-like factor 2

scientific article published on 19 January 2012

Thioredoxin interacting protein: redox dependent and independent regulatory mechanisms

scientific article published on 20 December 2011

Thioredoxin-interacting protein is a biomechanical regulator of Src activity: key role in endothelial cell stress fiber formation

scientific article published on 10 February 2014

Thioredoxin-interacting protein mediates TRX1 translocation to the plasma membrane in response to tumor necrosis factor-α: a key mechanism for vascular endothelial growth factor receptor-2 transactivation by reactive oxygen species

scientific article published on 02 June 2011

Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis

scientific article published on 7 February 2013

Thioredoxin: a key regulator of cardiovascular homeostasis

scientific article published on November 2003

Tissue-resident bone marrow-derived progenitor cells: key players in hypoxia-induced angiogenesis

scientific article published on 01 November 2005

Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS).

scientific article

Urokinase induces ROS production in vascular smooth muscle cells

scientific article published on 01 September 2006

Urokinase induces matrix metalloproteinase-9/gelatinase B expression in THP-1 monocytes via ERK1/2 and cytosolic phospholipase A2 activation and eicosanoid production

scientific article published on 22 August 2006

Vascular remodeling: hemodynamic and biochemical mechanisms underlying Glagov's phenomenon.

scientific article published on 31 May 2007

Vascular shear stress and activation of inflammatory genes.

scientific article

Vascular-derived reactive oxygen species for homeostasis and diseases

scientific article published on 03 May 2011

Vasoactive effects of growth factors

scientific article published on January 1989

c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation

scientific article published on 27 February 2001

c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1.

scientific article published on August 1997

p62 binding to protein kinase C ζ regulates tumor necrosis factor α-induced apoptotic pathway in endothelial cells

scientific article

p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1

scientific article published on 01 July 1999

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