List of works - Angel R de Lera

9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice

scientific article published in June 2015

9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists

scientific article published in December 2004

A DFT Study of the Effect of the Ligands in the Reductive Elimination from Palladium Bis(allyl) Complexes†

A unifying mechanism for the rearrangement of vinyl allene oxide geometric isomers to cyclopentenones

scientific article published on 19 June 2014

A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor

scientific article

Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels

scientific article published on 25 October 2008

An Endogenous Mammalian Retinoid X Receptor Ligand, At Last!

scientific article

Apo-14´-Carotenoic Acid Is a Novel Endogenous and Bioactive Apo-Carotenoid

scientific article published on 04 September 2019

Bidirectional Hiyama-Denmark Cross-Coupling Reactions of Bissilyldeca-1,3,5,7,9-pentaenes for the Synthesis of Symmetrical and Non-Symmetrical Carotenoids

scientific article published on 15 October 2019

Bispyridinium dienes: histone deacetylase inhibitors with selective activities

scientific article published on 21 April 2007

Bispyrrolidinoindoline Epi(poly)thiodioxopiperazines (BPI-ETPs) and Simplified Mimetics: Structural Characterization, Bioactivities, and Total Synthesis

scientific article published in 2022

C-C reductive elimination in palladium complexes, and the role of coupling additives. A DFT study supported by experiment

scientific article published in March 2009

C3 halogen and c8'' substituents on stilbene arotinoids modulate retinoic Acid receptor subtype function

scientific article published in October 2009

Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies

scientific article published on 4 November 2004

Characterization of the switch in the mechanism of an intramolecular Diels-Alder reaction

scientific article

Competing thermal electrocyclic ring-closure reactions of (2Z)-hexa-2,4,5-trienals and their Schiff bases. Structural, kinetic, and computational studies

scientific article published in July 2010

Cycloisomerization of activated (2E,4Z)-heptatrienoate and its relevance to crispatene (bio)synthesis. A case of concerted and stepwise uncertainty

scientific article published in June 2006

Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008

article

Deciphering the Origin of Enantioselectivity on the Cis-Cyclopropanation of Styrene with Enantiopure Di-chloro,Di-gold(I)-SEGPHOS Carbenoids Generated from Propargylic Esters

scientific article published on 31 May 2019

Design of selective nuclear receptor modulators: RAR and RXR as a case study

scientific article published on October 2007

Dual RXR Agonists and RAR Antagonists Based on the Stilbene Retinoid Scaffold

scientific article

Electrocyclic ring opening of charged cis-bicyclo[3.2.0]heptadiene and heterocyclic derivatives. The anti-Woodward-Hoffmann quest (II).

scientific article published in March 2009

Ellipticity: a convenient tool to characterize electrocyclic reactions

scientific article published on 01 March 2005

Epigenetic multiple modulators

scientific article

Epigenetic profiling of the antitumor natural product psammaplin A and its analogues

scientific article published on 15 December 2010

Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities

scientific article published on 25 May 2007

Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO.

scientific article

Highly potent naphthofuran-based retinoic acid receptor agonists

scientific article published on May 2009

Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles

scientific article

Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities

scientific article

Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids

scientific article

International Union of Pharmacology. LX. Retinoic acid receptors

scientific article

International Union of Pharmacology. LXIII. Retinoid X receptors

scientific article

Inverse agonists and antagonists of retinoid receptors

scientific article published on January 2010

Ligand recognition by RAR and RXR receptors: binding and selectivity

scientific article

Low-lying excited-states of 5-benzyluracil

scientific article published on 01 May 2013

Macroscale plasmonic substrates for highly sensitive surface-enhanced Raman scattering

scientific article published on 29 April 2013

Mechanistic insights into the stereocontrolled synthesis of hexahydropyrrolo[2,3-b]indoles by electrophilic activation of tryptophan derivatives

scientific article published on 11 December 2007

Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers

scientific article

Modulation of RXR function through ligand design

scientific article published on 16 April 2011

Modulation of Retinoic Acid Receptor Subtypes by 5- and 8-Substituted (Naphthalen-2-yl)-based Arotinoids

scientific article published on 26 May 2015

Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

scientific article

Natural polyenic macrolactams and polycyclic derivatives generated by transannular pericyclic reactions: optimized biogenesis challenging chemical synthesis

scientific article published on 07 December 2020

New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators

scientific article published on September 2010

New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists

scientific article

Probing a polar cluster in the retinal binding pocket of bacteriorhodopsin by a chemical design approach

scientific article

Pseudorotation barriers of biological oxyphosphoranes: a challenge for simulations of ribozyme catalysis

scientific article published on 01 March 2005

Pseudorotation of Natural and Chemically Modified Biological Phosphoranes: Implications for RNA Catalysis

Pseudorotation of natural and chemically modified biological phosphoranes: implications for RNA catalysis

scientific article published on 01 July 2004

Pyrazine arotinoids with inverse agonist activities on the retinoid and rexinoid receptors

scientific article

RAR and RXR modulation in cancer and metabolic disease

scientific article published on October 2007

Rational design of RAR-selective ligands revealed by RARbeta crystal structure

scientific article

Rearrangement of vinyl allene oxide geometric isomers to cyclopentenones. Further computational insights with biologically relevant model systems.

scientific article published on 13 March 2017

Regulation of Hoxb4 induction after neurulation by somite signal and neural competence

scientific article

Retinoic acid receptor modulators: a perspective on recent advances and promises

scientific article

Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: insights into early anterior-posterior patterning of the chordate body plan

scientific article published on 13 November 2009

Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists.

scientific article published on 18 May 2009

Retinoid receptors and therapeutic applications of RAR/RXR modulators

scientific article published on January 2012

Selective, potent PPARgamma agonists with cyclopentenone core structure.

scientific article published on 23 February 2009

Silicon particles as trojan horses for potential cancer therapy.

scientific article

Simple diastereoselectivity of the BF3.OEt2-catalyzed vinylogous Mukaiyama aldol reaction of 2-(trimethylsiloxy)furans with aldehydes

scientific article published in April 2005

Stereocontrolled and versatile total synthesis of bispyrrolidinoindoline diketopiperazine alkaloids: structural revision of the fungal isolate (+)-asperdimin

scientific article published in September 2009

Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10

scientific article

Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor

scientific article published on 22 February 2007

Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1-Dichloromethylinden-1-ol Analogues

scientific article published on 21 August 2018

Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues

scientific article published in June 2010

Synthesis of C11-to-C14 methyl-shifted all-trans-retinal analogues and their activities on human aldo-keto reductases

scientific article published on 12 June 2020

Synthesis of N-heteroaryl retinals and their artificial bacteriorhodopsins.

scientific article published in November 2005

Synthesis of benzamides related to anacardic acid and their histone acetyltransferase (HAT) inhibitory activities

scientific article published in September 2008

Synthesis of diverse indole-containing scaffolds by gold(I)-catalyzed tandem reactions of 3-propargylindoles initiated by 1,2-indole migrations: scope and computational studies

scientific article published on August 2010

Synthesis of enantiopure C3- and C4-hydroxyretinals and their enzymatic reduction by ADH8 from Xenopus laevis

scientific article published on 30 November 2005

Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs

scientific article published on 18 October 2005

Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line

scientific article published on 30 January 2013

The specificity of alcohol dehydrogenase with cis-retinoids. Activity with 11-cis-retinol and localization in retina

scientific article published in May 2004

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

scientific article published on 26 December 2004

Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia.

scientific article published on 15 May 2009

List of works by Angel R de Lera

9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice

9-cis-retinoic acid analogues with bulky hydrophobic rings: new RXR-selective agonists

A DFT Study of the Effect of the Ligands in the Reductive Elimination from Palladium Bis(allyl) Complexes†

A unifying mechanism for the rearrangement of vinyl allene oxide geometric isomers to cyclopentenones

A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor

Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels

An Endogenous Mammalian Retinoid X Receptor Ligand, At Last!

Apo-14´-Carotenoic Acid Is a Novel Endogenous and Bioactive Apo-Carotenoid

Bidirectional Hiyama-Denmark Cross-Coupling Reactions of Bissilyldeca-1,3,5,7,9-pentaenes for the Synthesis of Symmetrical and Non-Symmetrical Carotenoids

Bispyridinium dienes: histone deacetylase inhibitors with selective activities

Bispyrrolidinoindoline Epi(poly)thiodioxopiperazines (BPI-ETPs) and Simplified Mimetics: Structural Characterization, Bioactivities, and Total Synthesis

C-C reductive elimination in palladium complexes, and the role of coupling additives. A DFT study supported by experiment

C3 halogen and c8'' substituents on stilbene arotinoids modulate retinoic Acid receptor subtype function

Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies

Characterization of the switch in the mechanism of an intramolecular Diels-Alder reaction

Competing thermal electrocyclic ring-closure reactions of (2Z)-hexa-2,4,5-trienals and their Schiff bases. Structural, kinetic, and computational studies

Cycloisomerization of activated (2E,4Z)-heptatrienoate and its relevance to crispatene (bio)synthesis. A case of concerted and stepwise uncertainty

Death Receptor Pathway Activation and Increase of ROS Production by the Triple Epigenetic Inhibitor UVI5008

Deciphering the Origin of Enantioselectivity on the Cis-Cyclopropanation of Styrene with Enantiopure Di-chloro,Di-gold(I)-SEGPHOS Carbenoids Generated from Propargylic Esters

Design of selective nuclear receptor modulators: RAR and RXR as a case study

Dual RXR Agonists and RAR Antagonists Based on the Stilbene Retinoid Scaffold

Electrocyclic ring opening of charged cis-bicyclo[3.2.0]heptadiene and heterocyclic derivatives. The anti-Woodward-Hoffmann quest (II).

Ellipticity: a convenient tool to characterize electrocyclic reactions

Epigenetic multiple modulators

Epigenetic profiling of the antitumor natural product psammaplin A and its analogues

Feijoa sellowiana derived natural Flavone exerts anti-cancer action displaying HDAC inhibitory activities

Growth factor-antagonized rexinoid apoptosis involves permissive PPARgamma/RXR heterodimers to activate the intrinsic death pathway by NO.

Highly potent naphthofuran-based retinoic acid receptor agonists

Highly twisted adamantyl arotinoids: synthesis, antiproliferative effects and RXR transactivation profiles

Indole-derived psammaplin A analogues as epigenetic modulators with multiple inhibitory activities

Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids

International Union of Pharmacology. LX. Retinoic acid receptors

International Union of Pharmacology. LXIII. Retinoid X receptors

Inverse agonists and antagonists of retinoid receptors

Ligand recognition by RAR and RXR receptors: binding and selectivity

Low-lying excited-states of 5-benzyluracil

Macroscale plasmonic substrates for highly sensitive surface-enhanced Raman scattering

Mechanistic insights into the stereocontrolled synthesis of hexahydropyrrolo[2,3-b]indoles by electrophilic activation of tryptophan derivatives

Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers

Modulation of RXR function through ligand design

Modulation of Retinoic Acid Receptor Subtypes by 5- and 8-Substituted (Naphthalen-2-yl)-based Arotinoids

Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

Natural polyenic macrolactams and polycyclic derivatives generated by transannular pericyclic reactions: optimized biogenesis challenging chemical synthesis

New anacardic acid-inspired benzamides: histone lysine acetyltransferase activators

New retinoid chemotypes: 9-cis-retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists

Probing a polar cluster in the retinal binding pocket of bacteriorhodopsin by a chemical design approach

Pseudorotation barriers of biological oxyphosphoranes: a challenge for simulations of ribozyme catalysis

Pseudorotation of Natural and Chemically Modified Biological Phosphoranes: Implications for RNA Catalysis

Pseudorotation of natural and chemically modified biological phosphoranes: implications for RNA catalysis

Pyrazine arotinoids with inverse agonist activities on the retinoid and rexinoid receptors

RAR and RXR modulation in cancer and metabolic disease

Rational design of RAR-selective ligands revealed by RARbeta crystal structure

Rearrangement of vinyl allene oxide geometric isomers to cyclopentenones. Further computational insights with biologically relevant model systems.

Regulation of Hoxb4 induction after neurulation by somite signal and neural competence

Retinoic acid receptor modulators: a perspective on recent advances and promises

Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: insights into early anterior-posterior patterning of the chordate body plan

Retinoid receptor subtype-selective modulators through synthetic modifications of RARgamma agonists.

Retinoid receptors and therapeutic applications of RAR/RXR modulators

Selective, potent PPARgamma agonists with cyclopentenone core structure.

Silicon particles as trojan horses for potential cancer therapy.

Simple diastereoselectivity of the BF3.OEt2-catalyzed vinylogous Mukaiyama aldol reaction of 2-(trimethylsiloxy)furans with aldehydes

Stereocontrolled and versatile total synthesis of bispyrrolidinoindoline diketopiperazine alkaloids: structural revision of the fungal isolate (+)-asperdimin

Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10

Structure, function and modulation of retinoic acid receptor beta, a tumor suppressor

Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1-Dichloromethylinden-1-ol Analogues

Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues

Synthesis of C11-to-C14 methyl-shifted all-trans-retinal analogues and their activities on human aldo-keto reductases

Synthesis of N-heteroaryl retinals and their artificial bacteriorhodopsins.

Synthesis of benzamides related to anacardic acid and their histone acetyltransferase (HAT) inhibitory activities

Synthesis of diverse indole-containing scaffolds by gold(I)-catalyzed tandem reactions of 3-propargylindoles initiated by 1,2-indole migrations: scope and computational studies

Synthesis of enantiopure C3- and C4-hydroxyretinals and their enzymatic reduction by ADH8 from Xenopus laevis

Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs

Synthetic approaches to DNMT inhibitor SGI-1027 and effects on the U937 leukemia cell line

The specificity of alcohol dehydrogenase with cis-retinoids. Activity with 11-cis-retinol and localization in retina

Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells

Understanding abnormal retinoid signaling as a causative mechanism in congenital diaphragmatic hernia.

Vitamin A5/X, a New Food to Lipid Hormone Concept for a Nutritional Ligand to Control RXR-Mediated Signaling