Search filters

List of works by William Bourguet

A Novel Mutation in THRA Gene Associated With an Atypical Phenotype of Resistance to Thyroid Hormone

scientific article

A canonical structure for the ligand-binding domain of nuclear receptors

scientific article published on 01 February 1996

A mollusk retinoic acid receptor (RAR) ortholog sheds light on the evolution of ligand binding.

scientific article

A mutation mimicking ligand-induced conformational change yields a constitutive RXR that senses allosteric effects in heterodimers ⬇️

scientific article published on September 15, 1997

A new mutation of the androgen receptor, P817A, causing partial androgen insensitivity syndrome: in vitro and structural analysis

scientific article published in June 2004

A revisited version of the apo structure of the ligand-binding domain of the human nuclear receptor retinoic X receptor α

scientific article published on 23 January 2019

A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor

scientific article

Allosteric Effects Govern Nuclear Receptor Action: DNA Appears as a Player

scientific article published on 02 June 2009

An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist.

scientific article published on May 2015

An integrated structure- and system-based framework to identify new targets of metabolites and known drugs.

scientific article published on 18 August 2015

Androgen and estrogen receptors: potential of crystallography in the fight against cancer.

scientific article published on 20 January 2007

Characterization of novel ligands of ERα, Erβ, and PPARγ: the case of halogenated bisphenol A and their conjugated metabolites

scientific article

Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies

scientific article published on 4 November 2004

Combining 'dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography

scientific article

Design and in vitro characterization of RXR variants as tools to investigate the biological role of endogenous rexinoids

scientific article published in 2022

Design of selective nuclear receptor modulators: RAR and RXR as a case study

scientific article published on October 2007

Differential action on coregulator interaction defines inverse retinoid agonists and neutral antagonists

scientific article

Dimerization of nuclear receptors

scientific article published on January 2013

Discovery of a highly active ligand of human pregnane x receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity.

scientific article

Estrogen-related receptor γ is an in vivo receptor of bisphenol A.

scientific article published on 17 April 2014

Exploring hydrophobic sites in proteins with xenon or krypton ⬇️

scientific article published on January 1, 1998

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

scientific article

Functional and Structural Study of the Amino Acid Substitution in a Novel Familial Androgen Receptor Mutation (W752G) Responsible for Complete Androgen Insensitivity Syndrome

scientific article published on 01 August 2018

Glutamic acid 709 substitutions highlight the importance of the interaction between androgen receptor helices H3 and H12 for androgen and antiandrogen actions

scientific article published on 22 December 2005

Heterodimeric Complex of RAR and RXR Nuclear Receptor Ligand-Binding Domains: Purification, Crystallization, and Preliminary X-Ray Diffraction Analysis

scientific article published on 01 July 2000

High Content Screening Using New U2OS Reporter Cell Models Identifies Harmol Hydrochloride as a Selective and Competitive Antagonist of the Androgen Receptor

scientific article published on 16 June 2020

INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

scientific article

In Silico Predictions of Endocrine Disruptors Properties

scientific article published on 01 November 2019

Insights into the activation mechanism of human estrogen-related receptor γ by environmental endocrine disruptors

scientific article published on 24 May 2019

Interplay of Protein Disorder in Retinoic Acid Receptor Heterodimer and Its Corepressor Regulates Gene Expression

scientific article published on 06 June 2019

Inverse agonists and antagonists of retinoid receptors

scientific article published on January 2010

Ligand- and DNA-induced dissociation of RXR tetramers 1 1Edited by M. Yaniv

scientific article published on 01 January 1998

Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures

scientific article published on 01 January 2021

Meeting report: nuclear receptors: transcription factors and drug targets connecting basic research with translational medicine

scientific article

Modulating retinoid X receptor with a series of (E)-3-[4-hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic acids and their 4-alkoxy isomers

scientific article

Modulation of RXR function through ligand design

scientific article published on 16 April 2011

Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function

scientific article

Monitoring ligand-mediated nuclear receptor-coregulator interactions by noncovalent mass spectrometry

scientific article published in December 2004

Mutation of the androgen receptor at amino acid 708 (Gly-->Ala) abolishes partial agonist activity of steroidal antiandrogens

scientific article published in April 2003

N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.

scientific article

Nuclear receptor ligand-binding domains: reduction of helix H12 dynamics to favour crystallization.

scientific article published on 11 June 2008

Nuclear receptor profiling of bisphenol-A and its halogenated analogues

scientific article published on January 2014

Pathological Interactions Between Mutant Thyroid Hormone Receptors and Corepressors and Their Modulation by a Thyroid Hormone Analogue with Therapeutic Potential

scientific article published on 16 October 2018

Pathophysiology of androgen insensitivity syndromes: molecular and structural approaches of natural and engineered androgen receptor mutations at amino acid 743.

scientific article published in December 2002

Protein-protein interactions in the regulation of RAR-RXR heterodimers transcriptional activity

scientific article published on 28 March 2020

Purification and crystallization of the heterodimeric complex of RARbeta and RXRalpha ligand-binding domains in the active conformation

scientific article published on 21 May 2004

Purification, Functional Characterization, and Crystallization of the Ligand Binding Domain of the Retinoid X Receptor

scientific article published on 01 October 1995

Pyrazine arotinoids with inverse agonist activities on the retinoid and rexinoid receptors

scientific article

RAR-RXR selectivity and biological activity of new retinoic acid analogues with heterocyclic or polycyclic aromatic systems

scientific article published in July 2002

Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations

scientific article published on 05 November 2019

Reporter Cell Lines for the Characterization of the Interactions between Human Nuclear Receptors and Endocrine Disruptors.

scientific article published on 11 May 2015

Reporter cell lines to evaluate the selectivity of chemicals for human and zebrafish estrogen and peroxysome proliferator activated γ receptors

scientific article published on 9 June 2015

Retinoic acid receptor modulators: a perspective on recent advances and promises

scientific article

Retinoic acid receptors: structural basis for coregulator interaction and exchange.

scientific article published on January 2014

Retinoid receptors and therapeutic applications of RAR/RXR modulators

scientific article published on January 2012

Selectivity of natural, synthetic and environmental estrogens for zebrafish estrogen receptors.

scientific article published on 8 August 2014

Separation of retinoid X receptor homo- and heterodimerization functions

scientific article

Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3

scientific article

Structural and functional evidences for the interactions between nuclear hormone receptors and endocrine disruptors at low doses

scientific article

Structural and functional profiling of environmental ligands for estrogen receptors.

scientific article

Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes

scientific article

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors

scientific article

Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR.

scientific article published on 12 March 2009

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds

scientific article

Synthesis of a biospecific adsorbent for the purification of the three human retinoic acid receptors by affinity chromatography

scientific article published on 01 September 1992

The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity.

scientific article

The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation.

scientific article published on 21 February 2018

The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice

article

Towards accurate high-throughput ligand affinity prediction by exploiting structural ensembles, docking metrics and ligand similarity

scientific article published on 01 January 2020

[The association makes the poison: new perspective on the cocktail effect of xenobiotics and drug interactions]

scientific article published on 01 April 2016

[Towards bisphenols without hormonal effects]

scientific article published on 25 January 2013

Paulina is supported by:

About Paulina

Help