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List of works by Heiko Herwald

A Farewell to Arms: Streptococcal Strategies to Cope with Innate Immunity

scientific article published on 25 June 2014

A fibrin biofilm covers the blood clot and protects from microbial invasion. ⬇️

scientific article

A human antithrombin isoform dampens inflammatory responses and protects from organ damage during bacterial infection

scientific article published on 23 September 2019

A novel role for pro-coagulant microvesicles in the early host defense against streptococcus pyogenes.

scientific article

A rapid method for selecting suitable animal species for studying pathogen interactions with plasma protein ligands in vivo.

scientific article published on 7 February 2017

Aberrant inflammatory response to Streptococcus pyogenes in mice lacking myeloid differentiation factor 88.

scientific article published on 17 December 2009

Absorption of kininogen from human plasma by Streptococcus pyogenes is followed by the release of bradykinin

scientific article

Activation of TAFI on the Surface of Streptococcus pyogenes Evokes Inflammatory Reactions by Modulating the Kallikrein/Kinin System

scientific article published on 12 July 2008

Activation of human polymorphonuclear neutrophils by streptolysin O from Streptococcus pyogenes leads to the release of proinflammatory mediators

scientific article published in June 2006

Activation of the contact-phase system on bacterial surfaces--a clue to serious complications in infectious diseases

scientific article published on March 1998

Activation of the human contact system on neutrophil extracellular traps.

scientific article published on 20 February 2009

Active but inoperable thrombin is accumulated in a plasma protein layer surrounding Streptococcus pyogenes

article

Adsorption of components of the plasma kinin-forming system on the surface of Porphyromonas gingivalis involves gingipains as the major docking platforms.

scientific article

All That Glisters Is Not Gold - Staphylococcus aureus and Innate Immunity

scientific article published on 12 January 2015

Alteration of Leukocyte Count Correlates With Increased Pulmonary Vascular Permeability and Decreased PaO2:FiO2 Ratio Early After Major Burns

scientific article published on July 2015

An ecoimmunological approach to study evolutionary and ancient links between coagulation, complement and Innate immunity.

scientific article

Another Brick in the Wall

scientific article published on 26 February 2019

Anti-inflammatory, anti-coagulant, anti-biotic?

scientific article published on 14 February 2013

Antibodies against a surface protein of Streptococcus pyogenes promote a pathological inflammatory response

scientific article

Antimicrobial activity of fibrinogen and fibrinogen-derived peptides – a novel link between coagulation and innate immunity

scientific article published on 07 March 2013

Back to the Present

scientific article published on 30 June 2015

Bacterial Proteases Disarming Host Defense

scientific article published on 02 December 2008

Binding characteristics of thrombin-activatable fibrinolysis inhibitor to streptococcal surface collagen-like proteins A and B

scientific article published on 28 July 2011

Catch Me if You Can or Actors on the Run

scientific article published on 11 December 2018

Cells of Innate and Adaptive Immunity: A Matter of Class?

scientific article published on 02 February 2017

Chasing Flies because Time Flies

scientific article published on 25 October 2014

Coagulation systems of invertebrates and vertebrates and their roles in innate immunity: the same side of two coins?

scientific article

Coagulation, an ancestral serine protease cascade, exerts a novel function in early immune defense

scientific article published on 25 May 2011

Cold Atmospheric Plasma Disarms M1 Protein, an Important Streptococcal Virulence Factor

scientific article published on 27 September 2019

Comprehensive Mass Spectrometric Survey of Streptococcus pyogenes Subcellular Proteomes

scientific article published on 21 November 2017

Contact activation by pathogenic bacteria: a virulence mechanism contributing to the pathophysiology of sepsis.

scientific article published on January 2003

Contact system activation in severe infectious diseases

scientific article

Contact-system activation in children with vasculitis

scientific article published in The Lancet

DNA-fragmentation is a source of bactericidal activity against Pseudomonas aeruginosa.

scientific article

Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release

scientific article published on 18 February 2016

Early depletion of contact system in patients with sepsis: a prospective matched control observational study

scientific article published on 05 November 2018

Editorial

scientific article published on 19 August 2011

Elevated Plasma Levels of Antimicrobial Polypeptides in Patients with Severe Sepsis

scientific article published on 23 June 2010

Evaluation of potential biomarkers for the discrimination of bacterial and viral infections

scientific article

Extracellular Histones Induce Chemokine Production in Whole Blood Ex Vivo and Leukocyte Recruitment In Vivo.

scientific article published on 8 December 2015

Foodies of Innate Immunity

scientific article published on 13 May 2015

Geranylgeranyl transferase regulates streptococcal M1 protein-induced CXC chemokine formation and neutrophil recruitment in the lung

scientific article

Globular C1 q receptor (p33) binds and stabilizes pro-inflammatory MCP-1: a novel mechanism for regulation of MCP-1 production and function.

scientific article published on 22 January 2018

Gone with the Wind--Innate Immunity and Airway Inflammation.

scientific article published in March 2016

Hemostasis in Invertebrates and Vertebrates: An Evolutionary Excursion

article

Heparin binding protein in patients with acute respiratory failure treated with granulocyte colony-stimulating factor (filgrastim) – a prospective, placebo-controlled, double-blind study ⬇️

scientific article published on January 30, 2013

Heparin binding protein is increased in chronic leg ulcer fluid and released from granulocytes by secreted products of Pseudomonas aeruginosa

scientific article published in August 2004

Heparin-binding protein (HBP) in critically ill patients with influenza A(H1N1) infection

scientific article

Heparin-binding protein (HBP): an early marker of respiratory failure after trauma?

scientific article published on 16 January 2013

Heparin-binding protein (HBP/CAP37) - a link to endothelin-1 in endotoxemia-induced pulmonary oedema?

scientific article published on 11 March 2014

Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability

scientific article published on 01 October 2001

Heparin-binding protein as a biomarker of acute kidney injury in critical illness

scientific article

Heparin-binding protein as a biomarker of circulatory failure during severe infections: a report of three cases.

scientific article

Heparin-binding protein as a biomarker of post-injury sepsis in trauma patients.

scientific article published on 22 March 2018

Heparin-binding protein release is strongly induced by Leptospira spp. and is a candidate for an early diagnostic marker of human leptospirosis

scientific article published on 01 February 2019

Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis

scientific article

Heparin-binding protein: an early marker of circulatory failure in sepsis

scientific article

Human endogenous peptide p33 inhibits detrimental effects of LL-37 on osteoblast viability

scientific article

Human kininogens interact with M protein, a bacterial surface protein and virulence determinant

scientific article published on January 1995

Identification of Two Protein-binding and Functional Regions of Curli, a Surface Organelle and Virulence Determinant of Escherichia coli

scientific article published in Journal of Biological Chemistry

Identification of an endothelial cell binding site on kininogen domain D3

scientific article published in Journal of Biological Chemistry

Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model

scientific article

Immunoregulation of Neutrophil Extracellular Trap Formation by Endothelial-Derived p33 (gC1q Receptor).

scientific article published on 17 October 2017

Increased Plasma Levels of Heparin-Binding Protein on Admission to Intensive Care Are Associated with Respiratory and Circulatory Failure

scientific article

Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study

scientific article published on 30 December 2011

Induction of anti-β2-glycoprotein I autoantibodies in mice by protein H of Streptococcus pyogenes

scientific article published on 01 December 2011

Inflammatory role and prognostic value of platelet chemokines in acute coronary syndrome

article published in 2014

Innate immunity - a clinical perspective

scientific article published on 16 April 2019

Interactions between surface proteins of Streptococcus pyogenes and coagulation factors modulate clotting of human plasma

scientific article published on 01 February 2003

Interferon-λ: Inters Ferocity or Inter-Ferocities?

scientific article published on 24 March 2015

Intracellular Clearance by Nobel Laureates.

scientific article

Isolation and characterization of the kininogen-binding protein p33 from endothelial cells. Identity with the gC1q receptor

scientific article

Journal of Innate Immunity Ten Years Later

scientific article published on 25 October 2018

Kinin B2 receptor-mediated bradykinin internalization and metalloendopeptidase EP24.15-dependent intracellular bradykinin degradation

scientific article

Kinin receptor expression during Staphylococcus aureus infection

scientific article published on 30 May 2006

LL-37-induced host cell cytotoxicity depends on cellular expression of the globular C1q receptor (p33).

scientific article published on 27 October 2015

Leptospira interrogans outer membrane protein LipL21 is a potent inhibitor of neutrophil myeloperoxidase.

scientific article published on 13 December 2017

Leucocyte recruitment and molecular fortification of keratinocytes triggered by streptococcal M1 protein.

scientific article published on 3 October 2017

M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes

scientific article

M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage

scientific article published in February 2004

M1 protein from streptococcus pyogenes induces nitric oxide-mediated vascular hyporesponsiveness to phenylephrine: involvement of toll-like receptor activation

scientific article published in July 2010

Macrophages: past, present and future.

scientific article published on 26 October 2013

Mapping of the H-kininogen binding site exposed by the prekallikrein heavy chain

scientific article published on January 1, 1992

Mapping of the discontinuous kininogen binding site of prekallikrein. A distal binding segment is located in the heavy chain domain A4.

scientific article

Mapping of the high molecular weight kininogen binding site of prekallikrein. Evidence for a discontinuous epitope formed by distinct segments of the prekallikrein heavy chain ⬇️

scientific article published on July 5, 1993

Mapping the cell binding site on high molecular weight kininogen domain 5.

scientific article published in August 1995

Modulation of Hemostatic and Inflammatory Responses by Leptospira Spp

scientific article

Modulation of membrane traffic by microorganisms.

scientific article

Modulation of the coagulation system during severe streptococcal disease.

scientific article published on January 2013

Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein

scientific article published on 05 March 2008

Neutrophil extracellular trap-microparticle complexes enhance thrombin generation via the intrinsic pathway of coagulation in mice

scientific article published on 5 March 2018

Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages

scientific article

Neutrophil secretion products pave the way for inflammatory monocytes

scientific article

Neutrophil-Derived Hyperresistinemia in Severe Acute Streptococcal Infections

scientific article published on 28 August 2009

Neutrophil-derived heparin binding protein--a mediator of increased vascular permeability after burns?

scientific article published on 27 May 2009

Neutrophils engage the kallikrein-kinin system to open up the endothelial barrier in acute inflammation

article

Nobel Parasites in the Kingdom of Invertebrates.

scientific article published on 23 December 2015

Of DAMPs and macrophages.

scientific article published on 6 December 2012

On PAMPs and DAMPs

scientific article published on 13 August 2016

Osteopontin That Is Elevated in the Airways during COPD Impairs the Antibacterial Activity of Common Innate Antibiotics.

scientific article published on 5 January 2016

Osteopontin protects against lung injury caused by extracellular histones

scientific article published on 16 August 2018

Osteopontin protects against pneumococcal infection in a murine model of allergic airway inflammation

scientific article published on 19 November 2018

Paracelsus, poison, and colistin

scientific article published on 11 August 2017

Pathogen entrapment by transglutaminase--a conserved early innate immune mechanism

scientific article

Peptidoglycan from Staphylococcus aureus induces tissue factor expression and procoagulant activity in human monocytes

scientific article published on June 2002

Plasma Levels of Hepcidin and Reticulocyte Haemoglobin during Septic Shock

scientific article published on 18 September 2020

Protein C inhibitor.

scientific article published on June 2011

Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production

scientific article published on 22 February 2018

Ras regulates alveolar macrophage formation of CXC chemokines and neutrophil activation in streptococcal M1 protein-induced lung injury

scientific article published on 01 April 2014

Regulation of kinin B(2) receptors by bradykinin in human lung cells

scientific article published on November 2008

Renal clearance of heparin-binding protein and elimination during renal replacement therapy: Studies in ICU patients and healthy volunteers

scientific article published on 29 August 2019

STAT3-dependent CXC chemokine formation and neutrophil migration in streptococcal M1 protein-induced acute lung inflammation

scientific article published on 3 April 2015

Selected Biomarkers Correlate with the Origin and Severity of Sepsis.

scientific article published on 27 March 2018

Sepsis--the unknown public disease of our time

scientific article published on 17 November 2015

Serious, Severe, Sepsis

scientific article published on 31 January 2020

Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system.

scientific article published on November 2000

Signaling via beta(2) integrins triggers neutrophil-dependent alteration in endothelial barrier function.

scientific article

Simvastatin decreases the level of heparin-binding protein in patients with acute lung injury.

scientific article

Simvastatin regulates CXC chemokine formation in streptococcal M1 protein-induced neutrophil infiltration in the lung.

scientific article published on 25 March 2011

Soluble M1 protein of Streptococcus pyogenes triggers potent T cell activation

scientific article

Staphylococcus aureus induces release of bradykinin in human plasma

scientific article published on June 2001

Staphylococcus aureus-induced clotting of plasma is an immune evasion mechanism for persistence within the fibrin network

scientific article published on 22 December 2014

Stimulation of blood mononuclear cells with bacterial virulence factors leads to the release of pro-coagulant and pro-inflammatory microparticles

scientific article published on 10 November 2011

Streptococcal M protein: a multipotent and powerful inducer of inflammation

scientific article published on July 2006

Streptococcal M proteins and their role as virulence determinants.

scientific article published on 07 May 2010

Streptococcal M1 Protein-Induced Lung Injury is Independent of Platelets in Mice

scientific article published on 01 January 2011

Streptococcal M1 protein triggers chemokine formation, neutrophil infiltration, and lung injury in an NFAT-dependent manner

scientific article

Streptococcal M1 protein-provoked CXC chemokine formation, neutrophil recruitment and lung damage are regulated by Rho-kinase signaling.

scientific article

Streptococcal cysteine proteinase releases kinins: a virulence mechanism

scientific article published on August 1996

Streptococcal inhibitor of complement-mediated lysis (SIC): an anti-inflammatory virulence determinant.

scientific article

Streptococcal m1 protein triggers farnesyltransferase-dependent formation of CXC chemokines in alveolar macrophages and neutrophil infiltration of the lungs

scientific article published on 4 September 2012

Superantigens from Staphylococcus aureus induce procoagulant activity and monocyte tissue factor expression in whole blood and mononuclear cells via IL-1beta

article

Surveillance and Countermeasures in Innate Immunity

scientific article published on 17 December 2013

TFPI-2 Protects Against Gram-Negative Bacterial Infection

scientific article published on 11 September 2018

Tackling the Pros and Cons of Inflammation

scientific article published on 30 August 2019

Targeted mass spectrometry analysis of neutrophil-derived proteins released during sepsis progression

scientific article published on 7 August 2014

Targeting Rac1 signaling inhibits streptococcal M1 protein-induced CXC chemokine formation, neutrophil infiltration and lung injury

scientific article

The Extracellular Matrix: Reloaded Revolutions

scientific article published on 05 June 2019

The Janus Face of Macrophages in Immunity

article

The Neutrophil: A Beautiful Beast or a Beastly Beauty?

scientific article published on 08 September 2015

The Nonantibiotic Macrolide EM703 Improves Survival in a Model of Quinolone-Treated Pseudomonas aeruginosa Airway Infection.

scientific article published on 26 June 2017

The Origin of a Paradigm

scientific article published on 28 April 2016

The antibacterial activity of peptides derived from human beta-2 glycoprotein I is inhibited by protein H and M1 protein from Streptococcus pyogenes

scientific article published on 18 December 2007

The coagulation system and its function in early immune defense

scientific article published on 3 April 2014

The conversion of fibrinogen to fibrin at the surface of curliated Escherichia coli bacteria leads to the generation of proinflammatory fibrinopeptides

scientific article published on 12 June 2003

The dual role of the contact system in bacterial infectious disease

article

The interplay between host haemostatic systems and Leptospira spp. infections

scientific article published on 06 March 2020

Thrombin-activatable fibrinolysis inhibitor binds to Streptococcus pyogenes by interacting with collagen-like proteins A and B.

scientific article published on 6 June 2007

Treatment of invasive streptococcal infection with a peptide derived from human high-molecular weight kininogen.

scientific article published on 11 May 2009

Treatment with p33 curtails morbidity and mortality in a histone-induced murine shock model.

scientific article

Unexpected and Novel Functions of Complement Proteins

scientific article published on 20 May 2014

Vigilant keratinocytes trigger pathogen-associated molecular pattern signaling in response to streptococcal M1 protein.

scientific article published on 28 September 2015

Visions and the Progress of Science.

scientific article

Zinc-dependent conformational changes in domain D5 of high molecular mass kininogen modulate contact activation

scientific article published on 01 January 2001

p33 (gC1q receptor) prevents cell damage by blocking the cytolytic activity of antimicrobial peptides.

scientific article published on 30 October 2013

β₂-glycoprotein I: a novel component of innate immunity.

scientific article published on 31 March 2011

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