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List of works by Rienk Nieuwland

A Systematic Approach to Improve Scatter Sensitivity of a Flow Cytometer for Detection of Extracellular Vesicles

scientific article published on 04 February 2020

A standardized method to determine the concentration of extracellular vesicles using tunable resistive pulse sensing

scientific article published on 27 September 2016

Absolute sizing and label-free identification of extracellular vesicles by flow cytometry

scientific article published on 4 January 2018

Accumulation of bioactive lipids during storage of blood products is not cell but plasma derived and temperature dependent

scientific article published on 16 May 2011

Acetylsalicylic acid prevents platelet-induced proarrhythmic effects on intracellular Ca2+ homeostasis in ventricular myocytes

scientific article published on 16 October 2012

Activated complement components and complement activator molecules on the surface of cell-derived microparticles in patients with rheumatoid arthritis and healthy individuals

scientific article

Activated human platelet products induce proarrhythmic effects in ventricular myocytes

scientific article published on 30 May 2011

Activated platelets in patients with severe hypertriglyceridemia: effects of triglyceride-lowering therapy

scientific article published on 01 October 2000

Activated protein C inhibits neutrophil migration in allergic asthma: a randomised trial.

scientific article published on 17 September 2015

Altered platelet contents in survivors of early ischemic ventricular fibrillation: Preliminary findings ⬇️

scientific article published on January 9, 2013

Antigenic characterization of endothelial cell-derived microparticles and their detection ex vivo

scientific article published on 01 November 2003

Apheresis platelet concentrates contain platelet-derived and endothelial cell-derived microparticles

scientific article published on 01 February 2011

Bulk immunoassays for analysis of extracellular vesicles

scientific article published on 19 January 2017

C-reactive protein in myocardial infarction binds to circulating microparticles but is not associated with complement activation

article

CEA-, Her2/neu-, BCRP- and Hsp27-positive microparticles in breast cancer patients.

scientific article

Cell Saver device efficiently removes cell-derived microparticles during cardiac surgery

scientific article published in September 2007

Cell-Derived Microparticles and Complement Activation in Preeclampsia Versus Normal Pregnancy

scientific article published on 12 April 2007

Cell-derived microparticles contain caspase 3 in vitro and in vivo

scientific article published in May 2005

Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism

scientific article published on 01 November 2002

Cell-derived microparticles in the pathogenesis of cardiovascular disease: friend or foe?

scientific article published on January 2011

Cell-derived vesicles exposing coagulant tissue factor in saliva

article by R. J. Berckmans et al published 19 January 2011 in Blood

Cellular microparticles: new players in the field of vascular disease?

scientific article published on June 2004

Cellular origin of microparticles exposing tissue factor in cancer: a mixed double?

scientific article published on 04 July 2008

Cellular origin of platelet-derived microparticles in vivo.

scientific article published on 8 August 2010

Centrifugation affects the purity of liquid biopsy-based tumor biomarkers

scientific article published on 01 December 2018

Changes in Microparticle Numbers and Cellular Origin During Pregnancy and Preeclampsia

scientific article published on 01 January 2008

Circulating Platelet-derived and Placenta-derived Microparticles Expose Flt-1 in Preeclampsia

scientific article published on 20 October 2008

Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease

scientific article published on 08 October 2009

Circulating microparticles in breast cancer patients: a comparative analysis with established biomarkers

scientific article published on 01 March 2008

Circulating microparticles remain associated with complement activation despite intensive anti-inflammatory therapy in early rheumatoid arthritis

scientific article published on 16 November 2009

Classification, functions, and clinical relevance of extracellular vesicles

scientific article

Clearance and phenotype of extracellular vesicles after red blood cell transfusion in a human endotoxemia model

scientific article published on 22 June 2019

Clearance of platelet microparticles in vivo

scientific article published on 13 January 2011

Climacteric lowers plasma levels of platelet-derived microparticles: a pilot study in pre- versus postmenopausal women

scientific article published on 23 May 2012

Clinical Significance of Tissue Factor-Exposing Microparticles in Arterial and Venous Thrombosis

scientific article published on 26 September 2015

Clinical requirements for extracellular vesicle assays

article by Lisa Ayers et al published 2019 in Journal of extracellular vesicles

Co-isolation of extracellular vesicles and high-density lipoproteins using density gradient ultracentrifugation

scientific article published on 8 July 2014

Coagulation activation and microparticle-associated coagulant activity in cancer patients

scientific article published on 26 April 2012

Comparison of Generic Fluorescent Markers for Detection of Extracellular Vesicles by Flow Cytometry

scientific article published on 16 February 2018

Comparison of risk prediction scores for venous thromboembolism in cancer patients: a prospective cohort study

scientific article published on 26 May 2017

Complement activation on the surface of cell-derived microparticles during cardiac surgery with cardiopulmonary bypass - is retransfusion of pericardial blood harmful?

scientific article published on 21 October 2010

Congenital deficiency of factor XIII caused by two missense mutations in a Dutch family

scientific article

Considerations towards a roadmap for collection, handling and storage of blood extracellular vesicles

scientific article published on 01 August 2019

Deriving Extracellular Vesicle Size From Scatter Intensities Measured by Flow Cytometry

scientific article published on 31 August 2018

Detailed analysis of the plasma extracellular vesicle proteome after separation from lipoproteins

scientific article published on 13 February 2018

Detection of extracellular vesicles in plasma and urine of prostate cancer patients by flow cytometry and surface plasmon resonance imaging

scientific article published on 04 June 2020

Development of Peritoneal Carcinomatosis in Epithelial Ovarian Cancer: A Review.

scientific article published in November 2017

Diabetic Nephropathy Alters the Distribution of Circulating Angiogenic MicroRNAs Among Extracellular Vesicles, HDL, and Ago-2

scientific article published on 10 September 2019

Differential Effects of Nonselective Versus Selective β-Blockers on Cardiac Sympathetic Activity and Hemostasis in Patients with Heart Failure ⬇️

scientific article published on August 22, 2013

Direct binding of C1q to apoptotic cells and cell blebs induces complement activation

scientific article published on 01 June 2002

Disappearance of glycoprotein Ib from the platelet surface in pericardial blood during cardiopulmonary bypass

scientific article published in May 1998

Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms

scientific article published on December 2015

EVpedia: a community web portal for extracellular vesicles research

scientific article

Effects of cancer on platelets

scientific article published on 24 April 2014

Effects of helium on inflammatory and oxidative stress-induced endothelial cell damage

scientific article published on 18 June 2015

Elevated Endothelial Microparticles Following Consecutive Meals Are Associated With Vascular Endothelial Dysfunction in Type 2 Diabetes

scientific article published on 01 March 2007

Elevated levels of platelet microparticles are associated with disease activity in rheumatoid arthritis

scientific article published on 01 June 2002

Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus

scientific article published in November 2002

Elevated platelet and leukocyte response to oral bacteria in periodontitis

scientific article

Embryology, anatomy, physiology and pathophysiology of the peritoneum and the peritoneal vasculature

scientific article published on 09 October 2018

Endogenous microparticles drive the proinflammatory host immune response in severely injured trauma patients

scientific article published on 01 April 2015

Enhanced coagulation activation in preeclampsia: the role of APC resistance, microparticles and other plasma constituents.

scientific article published in September 2002

Erratum. Diabetic Nephropathy Alters the Distribution of Circulating Angiogenic MicroRNAs Among Extracellular Vesicles, HDL, and Ago-2. Diabetes 2019;68:2287-2300

scientific article published on 10 June 2020

Essentials of extracellular vesicles: posters on basic and clinical aspects of extracellular vesicles

scientific article published on 30 November 2018

Evaluation of coagulation activation after rhinovirus infection in patients with asthma and healthy control subjects: an observational study.

scientific article published on 07 February 2014

Expression of inflammation-related genes in endothelial cells is not directly affected by microparticles from preeclamptic patients

article

Extracellular Vesicles from Red Blood Cell Products Induce a Strong Pro-Inflammatory Host Response, Dependent on Both Numbers and Storage Duration

scientific article

Extracellular vesicles and coagulation in blood from healthy humans revisited

scientific article published on 08 November 2019

Extracellular vesicles exposing tissue factor for the prediction of venous thromboembolism in patients with cancer: A prospective cohort study

scientific article published on 10 April 2018

Extracellular vesicles from human plasma and serum are carriers of extravesicular cargo-Implications for biomarker discovery

scientific article published on 19 August 2020

Extracellular vesicles in human follicular fluid do not promote coagulation.

scientific article published on 22 August 2016

Extracellular vesicles in physiological and pathological conditions

scientific article published on 20 December 2012

Extracellular vesicles in post-infarct ventricular remodelling.

scientific article published on 5 October 2017

Extracellular vesicles, tissue factor, cancer and thrombosis - discussion themes of the ISEV 2014 Educational Day

scientific article published on 13 March 2015

FLow-Induced PRotrusions (FLIPRs)

FLow-induced PRotrusions (FLIPRs): a platelet-derived platform for the retrieval of microparticles by monocytes and neutrophils

Gender-specific and menstrual cycle dependent differences in circulating microparticles

scientific article published on 01 November 2007

Generation of platelet-derived microparticles in patients undergoing cardiac surgery is not affected by complement activation

scientific article

Glycan modification of glioblastoma-derived extracellular vesicles enhances receptor-mediated targeting of dendritic cells

scientific article published on 09 August 2019

Glycan-Modified Apoptotic Melanoma-Derived Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination

scientific article published on 28 August 2019

Handling and storage of human body fluids for analysis of extracellular vesicles

scientific article

Helium alters the cytoskeleton and decreases permeability in endothelial cells cultured in vitro through a pathway involving Caveolin-1.

scientific article published on 19 March 2018

Helium induces preconditioning in human endothelium in vivo

scientific article published in January 2013

Hormone replacement therapy leads to increased plasma levels of platelet derived microparticles in postmenopausal women

scientific article published on 11 October 2011

Human alternatively spliced tissue factor is not secreted and does not trigger coagulation.

scientific article published on 22 June 2009

Human bone marrow contains high levels of extracellular vesicles with a tissue-specific subtype distribution

scientific article published in PLoS ONE

Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner.

scientific article

Human milk triggers coagulation via tissue factor-exposing extracellular vesicles

scientific article published on 01 December 2020

ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19

scientific article published on 16 May 2020

Improvement of cognitive test performance in patients undergoing primary CABG and other CPB-assisted cardiac procedures

scientific article published on 01 September 2008

Inhibition of microparticle release triggers endothelial cell apoptosis and detachment

scientific article published on 01 November 2007

Insulin inhibits tissue factor expression in monocytes

scientific article

Isolated microparticles, but not whole plasma, from women with preeclampsia impair endothelium-dependent relaxation in isolated myometrial arteries from healthy pregnant women

scientific article published on 01 December 2002

Isolation of Platelet-Derived Extracellular Vesicles

scientific article published in January 2017

Label-free identification and chemical characterisation of single extracellular vesicles and lipoproteins by synchronous Rayleigh and Raman scattering

scientific article published on 19 February 2020

Lamin A/C mutation is independently associated with an increased risk of arterial and venous thromboembolic complications

scientific article published on 14 October 2012

Leukocyte activation and circulating leukocyte-derived microparticles in preeclampsia

scientific article published in May 2009

MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments

scientific article published on 03 February 2020

Measurement of circulating cell-derived microparticles by flow cytometry: Sources of variability within the assay

scientific article published on 22 January 2011

Measuring circulating cell-derived microparticles

scientific article published on 01 October 2004

Method to traceably determine the refractive index by measuring the angle of minimum deviation

scientific article published in 2022

Methodological Guidelines to Study Extracellular Vesicles

scientific article

Methods for Separation and Characterization of Extracellular Vesicles: Results of a Worldwide Survey Performed by the ISEV Rigor and Standardization Subcommittee

scientific article published on 25 August 2020

Microparticle subpopulations are increased in preeclampsia: Possible involvement in vascular dysfunction?

scientific article published on 01 August 2002

Microparticle-associated P-selectin reflects platelet activation in preeclampsia

scientific article

Microparticles and Exosomes in Gynecologic Neoplasias

scholarly article by Rienk Nieuwland et al published February 2011 in Seminars in Thrombosis and Hemostasis

Microparticles and exosomes in gynecologic neoplasias

scientific article

Microparticles and exosomes: impact on normal and complicated pregnancy

scientific article published on November 2007

Microparticles for Diagnosis of Graft-Versus-Host Disease After Allogeneic Stem Transplantation

scientific article published on 01 July 2011

Microparticles in cardiovascular diseases.

scientific article

Microparticles in vascular disorders: how tissue factor-exposing vesicles contribute to pathology and physiology

scientific article published on October 2012

Microparticles of pregnant women and preeclamptic patients activate endothelial cells in the presence of monocytes

scientific article

Microvesicles in vascular homeostasis and diseases. Position Paper of the European Society of Cardiology (ESC) Working Group on Atherosclerosis and Vascular Biology

scientific article published in June 2017

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

scientific article published on 23 November 2018

Monocyte-mediated activation of endothelial cells occurs only after binding to extracellular vesicles from red blood cell products, a process mediated by β-integrin

scientific article published on 7 November 2016

Na+/H+ Exchange in Platelets

Negative regulation of the platelet Na+/H+exchanger by trimeric G-proteins

scientific article published on 01 December 2000

ORIGINAL ARTICLE: Systemic Changes in Haemostatic Balance are not Associated with Increased Levels of Circulating Microparticles in Women with Recurrent Spontaneous Abortion

scientific article published on 01 February 2008

Optical and non-optical methods for detection and characterization of microparticles and exosomes

scientific article

P-Selectin- and CD63-Exposing Platelet Microparticles Reflect Platelet Activation in Peripheral Arterial Disease and Myocardial Infarction

scientific article published on 26 January 2006

P2Y12 antagonist ticagrelor inhibits the release of procoagulant extracellular vesicles from activated platelets

scientific article published on 19 April 2018

Periodontitis is associated with platelet activation.

scientific article published on 28 May 2008

Phospholipid composition of cell-derived microparticles determined by one-dimensional high-performance thin-layer chromatography

scientific article published in March 2002

Phospholipid composition of in vitro endothelial microparticles and their in vivo thrombogenic properties

scientific article published on 21 September 2007

Placental corticotrophin-releasing hormone mRNA and microparticles in maternal plasma are not measures of placental shedding of debris: a rebuttal

scientific article published on 26 July 2008

Plasma Concentrations of Extracellular Vesicles Are Decreased in Patients with Post-Infarct Cardiac Remodelling

Plasma markers of coagulation and endothelial activation in Fabry disease: impact of renal impairment.

scientific article

Plasma vesicle miRNAs for therapy response monitoring in Hodgkin lymphoma patients.

scientific article

Platelet extracellular vesicles as biomarkers for arterial thrombosis

scientific article

Platelet microparticles contain active caspase 3.

scientific article

Platelet removal by single-step centrifugation

scientific article published on 17 June 2020

Platelets are hyperactivated but show reduced glycoprotein VI reactivity in COVID-19 patients

scientific article published on 07 January 2021

Poor perfusion of the microvasculature in peritoneal metastases of ovarian cancer

scientific article published on 01 February 2020

Postprandial changes in the phospholipid composition of circulating microparticles are not associated with coagulation activation

scientific article published on 2 October 2011

Predilution Versus Postdilution During Continuous Venovenous Hemofiltration: A Comparison of Circuit Thrombogenesis

scientific article published on 01 July 2006

Pro- and non-coagulant forms of non-cell-bound tissue factor in vivo

scientific article published on 01 September 2003

Prolactin does not affect human platelet aggregation or secretion

scientific article published in June 2009

Randomized controlled trial protocol to investigate the antiplatelet therapy effect on extracellular vesicles (AFFECT EV) in acute myocardial infarction

scientific article published on 26 December 2018

Rate zonal centrifugation can partially separate platelets from platelet-derived vesicles

scientific article published on 10 July 2020

Reduced complement activation during cardiopulmonary bypass does not affect the postoperative acute phase response

scientific article published in November 2004

Refractive index determination of nanoparticles in suspension using nanoparticle tracking analysis

scientific article published on 2 October 2014

Reliable measurements of extracellular vesicles by clinical flow cytometry

scientific article published on 23 September 2020

Reproducible extracellular vesicle size and concentration determination with tunable resistive pulse sensing

scientific article published on 10 December 2014

Retransfusion of pericardial blood does not trigger systemic coagulation during cardiopulmonary bypass

scientific article published on 12 March 2007

Rigor and standardization of extracellular vesicle research: Paving the road towards robustness

scientific article published on 14 December 2020

Role of P2Y Receptors in Platelet Extracellular Vesicle Release

scientific article published on 23 August 2020

Routine platelet aggregation inhibition not useful when using acetylsalicylic acid or clopidogrel

scientific article published in January 2009

Saccharomyces cerevisiae-derived HBsAg preparations differ in their attachment to monocytes, immune-suppressive potential, and T-cell immunogenicity

scientific article published in August 2003

Schistosoma mansoni infection affects the proteome and lipidome of circulating extracellular vesicles in the host

scientific article published on 27 June 2020

Simvastatin-induced endothelial cell detachment and microparticle release are prenylation dependent

scientific article published on 01 September 2008

Single vs. swarm detection of microparticles and exosomes by flow cytometry

scientific article

Single-step isolation of extracellular vesicles by size-exclusion chromatography

scientific article (publication date: 2014)

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017.

scientific article

Supernatant of Aged Erythrocytes Causes Lung Inflammation and Coagulopathy in a “Two-Hit” In Vivo Syngeneic Transfusion Model

scientific article published on 01 July 2010

Supernatant of stored platelets causes lung inflammation and coagulopathy in a novel in vivo transfusion model

scientific article published on 17 May 2010

Surface Plasmon Resonance is an Analytically Sensitive Method for Antigen Profiling of Extracellular Vesicles.

scientific article published on 7 August 2017

Surveillance of megakaryocytic function by measurement of CD61-exposing microparticles in allogeneic hematopoietic stem cell recipients

scientific article published on 09 February 2011

Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes

scientific article

The Ability of Extracellular Vesicles to Induce a Pro-Inflammatory Host Response

scientific article

The Clinics and Etiology of Preeclampsia

The P4-ATPase ATP9A is a novel determinant of exosome release

scientific article published on 04 April 2019

The acute effect of beta-guanidinopropionic acid versus creatine or placebo in healthy men (ABC-Trial): A randomized controlled first-in-human trial.

scientific article

The effect of red blood cell transfusion on platelet function in critically ill patients

scientific article published on 01 November 2019

The functions of microparticles in pre-eclampsia

scientific article published on 02 March 2011

The functions of microparticles in preeclampsia

scientific article

The generation and use of recombinant extracellular vesicles as biological reference material

scientific article published on 23 July 2019

The high alkaline fraction on isoelectric focusing of cerebrospinal fluid is cystatin C

scientific article published on 01 April 1998

The influence of aspirin dose and glycemic control on platelet inhibition in patients with type 2 diabetes mellitus

scientific article published on 01 April 2012

The phospholipid composition and cholesterol content of platelet-derived microparticles: a comparison with platelet membrane fractions

scientific article published in December 2005

Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome).

scientific article published in September 2015

Ticagrelor attenuates the increase of extracellular vesicle concentrations in plasma after acute myocardial infarction compared to clopidogrel

scientific article published on 09 January 2020

Tissue Factor Coagulant Activity is Regulated by the Plasma Membrane Microenvironment

scientific article published on 21 April 2018

Toll-Like Receptor Signalling Is Not Involved in Platelet Response to Streptococcus pneumoniae In Vitro or In Vivo

scientific article

Toward standardization of assays measuring extracellular vesicle-associated tissue factor activity

scientific article published on 23 June 2019

Towards defining reference materials for measuring extracellular vesicle refractive index, epitope abundance, size and concentration

scientific article published on 24 September 2020

Towards traceable size determination of extracellular vesicles.

scientific article published on 04 February 2014

Transfusion of autologous extracellular vesicles from stored red blood cells does not affect coagulation in a model of human endotoxemia

scientific article published on 25 March 2018

Transfusion-related risk of secondary bacterial infections in sepsis patients: a retrospective cohort study

scientific article published in April 2011

Transglutaminase 2 is secreted from smooth muscle cells by transamidation-dependent microparticle formation

scientific article published on 10 August 2011

Two consecutive high-fat meals affect endothelial-dependent vasodilation, oxidative stress and cellular microparticles in healthy men.

scientific article published in May 2006

Updating the MISEV minimal requirements for extracellular vesicle studies: building bridges to reproducibility.

scientific article

Urinary mitochondrial deoxyribonucleic acid associates with delayed graft function following renal transplantation

scientific article published on 24 December 2018

Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

scientific article

Why do cells release vesicles?

scientific article published on 11 February 2010

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