List of works - Nigel Mackman

2011 Nobel Prize in Physiology or Medicine: Toll-like receptors, dendritic cells, and their roles in atherosclerosis

scientific article

A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult mice

scientific article published on 14 December 2004

Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-α-induced apoptosis.

scientific article published on 31 January 2012

Anthracycline treatment of the human monocytic leukemia cell line THP-1 increases phosphatidylserine exposure and tissue factor activity

scientific article

Blood coagulation and blood vessel development: is tissue factor the missing link?

scientific article published on November 2011

Circulating microparticle tissue factor activity is increased in patients with cirrhosis

scientific article

Circulating microparticle tissue factor, thromboembolism and survival in pancreaticobiliary cancers.

scientific article published on 13 July 2013

Coagulation activation and microparticle-associated coagulant activity in cancer patients

scientific article published on 26 April 2012

Coagulation, protease-activated receptors, and viral myocarditis.

scientific article

Comment on "tissue factor expressed by microparticles is associated with mortality but not with thrombosis in cancer patients".

scientific article

Comment on "tissue factor-dependent chemokine production aggravates experimental colitis"

scientific article published on 18 October 2011

Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice

scientific article published on January 2014

Critical Review of Mouse Models of Venous Thrombosis ⬇️

scientific article published on March 1, 2012

Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis

scientific article

Del-etion of Microvesicles From the Circulation ⬇️

scientific article published on 02 March 2012

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease.

scientific article published on 21 January 2014

Dysregulated coagulation associated with hypofibrinogenaemia and plasma hypercoagulability: implications for identifying coagulopathic mechanisms in humans

scientific article published on 26 July 2012

Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH independent of its effects on hemolysis and microparticle formation

scientific article

Effect of PAR-2 Deficiency in Mice on KC Expression after Intratracheal LPS Administration

scientific article

Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet

scientific article published on October 2010

Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis

scientific article

Functional characterization of a cloned haemolysin determinant from E. coli of human origin, encoding information for the secretion of a 107K polypeptide

scientific article published on 01 January 1984

Hepatocyte tissue factor activates the coagulation cascade in mice

scientific article published on 10 January 2013

Human pancreatic tumors grown in mice release tissue factor-positive microvesicles that increase venous clot size

scientific article published on 22 August 2017

Hyperlipidemia, tissue factor, coagulation, and simvastatin

scientific article

Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites ⬇️

scientific article published on December 1, 1991

Low levels of tissue factor are compatible with development and hemostasis in mice.

scientific article published on February 1998

Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress

scientific article published on 2 October 2012

MP's and VTE's: Fact or fiction

scientific article published on 25 September 2011

MPs or ICs?

scientific article published on 01 January 2011

Microparticle-associated tissue factor activity in patients with pancreatic cancer: correlation with clinicopathological features.

scientific article

Microparticle-associated tissue factor activity, venous thromboembolism and mortality in pancreatic, gastric, colorectal and brain cancer patients.

scientific article published on July 2012

Microparticles in hemostasis and thrombosis.

scientific article

Microvesicles as risk markers for venous thrombosis

scientific article published on February 2013

Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

scientific article published on 3 January 2012

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.

scientific article published on 26 March 2012

Monocytic microparticles activate endothelial cells in an IL-1β–dependent manner ⬇️

scientific article published on June 23, 2011

Mouse Models, Risk Factors, and Treatments of Venous Thrombosis ⬇️

scientific article published on 01 March 2012

Multiple roles of the coagulation protease cascade during virus infection

scientific article published on 14 March 2014

Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model.

scientific article published on 20 December 2011

Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors

scientific article published on 02 May 2019

Neutrophils, NETs, and immunothrombosis

scientific article published on 01 September 2018

New insights into the mechanisms of venous thrombosis

scholarly article by Nigel Mackman published 1 September 2012 in Journal of Clinical Investigation

New players in haemostasis and thrombosis.

scientific article published on 27 February 2014

P2X7 regulation of macrophage tissue factor activity and microparticle generation ⬇️

scientific article published on September 1, 2012

PAR-1 contributes to the innate immune response during viral infection.

scientific article published on 8 February 2013

PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI.

scientific article

Platelet ITAM signaling is critical for vascular integrity in inflammation

scientific article

Platelet tissue factor: to be or not to be.

scientific article published on 31 May 2013

Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activity.

scientific article published on 6 July 2011

Protease activated receptor-2 contributes to heart failure

scientific article

Protease-Activated Receptor 1 Enhances Poly I:C Induction of the Antiviral Response in Macrophages and Mice.

scientific article published on 8 November 2016

Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet.

scientific article

Protease-activated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury.

scientific article

Protease-activated receptors and myocardial infarction

scientific article

Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica

scientific article published on July 2011

Prothrombotic mechanisms and anticoagulant therapy in dogs with immune-mediated hemolytic anemia

scientific article published on January 2013

Regulation of thrombin-induced plasminogen activator inhibitor-1 in 4T1 murine breast cancer cells

scientific article

Regulation of tissue factor gene expression in monocytes and endothelial cells: Thromboxane A2 as a new player

scientific article

Role of cardiac myocyte tissue factor in heart hemostasis

scientific article published on 01 August 2007

Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury.

scientific article

Role of tissue factor in atherothrombosis

scientific article published on October 2012

Role of tissue factor in embryonic blood vessel development.

scientific article

Role of tissue factor in venous thrombosis.

scientific article

Roles of PAR1 and PAR2 in viral myocarditis.

scientific article

Safety and efficacy of thrombin-JMI: a multidisciplinary expert group consensus

scientific article

Sources of tissue factor that contribute to thrombosis after rupture of an atherosclerotic plaque

scientific article published on 22 March 2012

Strengths and weaknesses of a new mouse model of thrombosis induced by inferior vena cava stenosis: communication from the SSC of the ISTH.

scientific article published on April 2014

The antithrombotic effects of statins

scientific article published on January 2014

The septic milieu triggers expression of spliced tissue factor mRNA in human platelets.

scientific article

Therapeutic strategies for thrombosis: new targets and approaches

scientific article published on 04 March 2020

Tissue factor and its measurement in whole blood, plasma, and microparticles

scientific article

Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice

scientific article

Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus-infected mice.

scientific article

Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations

scientific article published on 11 February 2014

Tissue factor in health and disease

scientific article published on January 2012

Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease

scientific article

Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy

scientific article published on 31 August 2011

Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice.

scientific article

Towards a standardization of the murine ferric chloride-induced carotid arterial thrombosis model

scientific article published on 01 September 2011

Tumor-derived tissue factor activates coagulation and enhances thrombosis in a mouse xenograft model of human pancreatic cancer ⬇️

scientific article published on April 30, 2012

Uremic Serum and Ubiquitylation of Tissue Factor ⬇️

scientific article published on December 25, 2012

Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes

scientific article published on 2 February 2024

Web of Science’s Citation Median Metrics Overcome the Major Constraints of the Journal Impact Factor

scientific article published in 2022

β-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells.

scientific article published on 18 May 2012

List of works by Nigel Mackman

2011 Nobel Prize in Physiology or Medicine: Toll-like receptors, dendritic cells, and their roles in atherosclerosis

A balance between tissue factor and tissue factor pathway inhibitor is required for embryonic development and hemostasis in adult mice

Alternatively spliced tissue factor and full-length tissue factor protect cardiomyocytes against TNF-α-induced apoptosis.

Anthracycline treatment of the human monocytic leukemia cell line THP-1 increases phosphatidylserine exposure and tissue factor activity

Blood coagulation and blood vessel development: is tissue factor the missing link?

Circulating microparticle tissue factor activity is increased in patients with cirrhosis

Circulating microparticle tissue factor, thromboembolism and survival in pancreaticobiliary cancers.

Coagulation activation and microparticle-associated coagulant activity in cancer patients

Coagulation, protease-activated receptors, and viral myocarditis.

Comment on "tissue factor expressed by microparticles is associated with mortality but not with thrombosis in cancer patients".

Comment on "tissue factor-dependent chemokine production aggravates experimental colitis"

Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice

Critical Review of Mouse Models of Venous Thrombosis ⬇️

Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis

Del-etion of Microvesicles From the Circulation ⬇️

Differential contribution of FXa and thrombin to vascular inflammation in a mouse model of sickle cell disease.

Dysregulated coagulation associated with hypofibrinogenaemia and plasma hypercoagulability: implications for identifying coagulopathic mechanisms in humans

Eculizumab therapy results in rapid and sustained decreases in markers of thrombin generation and inflammation in patients with PNH independent of its effects on hemolysis and microparticle formation

Effect of PAR-2 Deficiency in Mice on KC Expression after Intratracheal LPS Administration

Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet

Fibrin facilitates both innate and T cell-mediated defense against Yersinia pestis

Functional characterization of a cloned haemolysin determinant from E. coli of human origin, encoding information for the secretion of a 107K polypeptide

Hepatocyte tissue factor activates the coagulation cascade in mice

Human pancreatic tumors grown in mice release tissue factor-positive microvesicles that increase venous clot size

Hyperlipidemia, tissue factor, coagulation, and simvastatin

Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in THP-1 monocytic cells requires both activator protein 1 and nuclear factor kappa B binding sites ⬇️

Low levels of tissue factor are compatible with development and hemostasis in mice.

Low levels of tissue factor lead to alveolar haemorrhage, potentiating murine acute lung injury and oxidative stress

MP's and VTE's: Fact or fiction

MPs or ICs?

Microparticle-associated tissue factor activity in patients with pancreatic cancer: correlation with clinicopathological features.

Microparticle-associated tissue factor activity, venous thromboembolism and mortality in pancreatic, gastric, colorectal and brain cancer patients.

Microparticles in hemostasis and thrombosis.

Microvesicles as risk markers for venous thrombosis

Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.

Monocytic microparticles activate endothelial cells in an IL-1β–dependent manner ⬇️

Mouse Models, Risk Factors, and Treatments of Venous Thrombosis ⬇️

Multiple roles of the coagulation protease cascade during virus infection

Myeloid cell tissue factor does not contribute to venous thrombogenesis in an electrolytic injury model.

Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors

Neutrophils, NETs, and immunothrombosis

New insights into the mechanisms of venous thrombosis

New players in haemostasis and thrombosis.

P2X7 regulation of macrophage tissue factor activity and microparticle generation ⬇️

PAR-1 contributes to the innate immune response during viral infection.

PF4/heparin-antibody complex induces monocyte tissue factor expression and release of tissue factor positive microparticles by activation of FcγRI.

Platelet ITAM signaling is critical for vascular integrity in inflammation

Platelet tissue factor: to be or not to be.

Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activity.

Protease activated receptor-2 contributes to heart failure

Protease-Activated Receptor 1 Enhances Poly I:C Induction of the Antiviral Response in Macrophages and Mice.

Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet.

Protease-activated receptor 2 deficiency reduces cardiac ischemia/reperfusion injury.

Protease-activated receptors and myocardial infarction

Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica

Prothrombotic mechanisms and anticoagulant therapy in dogs with immune-mediated hemolytic anemia

Regulation of thrombin-induced plasminogen activator inhibitor-1 in 4T1 murine breast cancer cells

Regulation of tissue factor gene expression in monocytes and endothelial cells: Thromboxane A2 as a new player

Role of cardiac myocyte tissue factor in heart hemostasis

Role of fibrinogen and protease-activated receptors in acute xenobiotic-induced cholestatic liver injury.

Role of tissue factor in atherothrombosis

Role of tissue factor in embryonic blood vessel development.

Role of tissue factor in venous thrombosis.

Roles of PAR1 and PAR2 in viral myocarditis.

Safety and efficacy of thrombin-JMI: a multidisciplinary expert group consensus

Sources of tissue factor that contribute to thrombosis after rupture of an atherosclerotic plaque

Strengths and weaknesses of a new mouse model of thrombosis induced by inferior vena cava stenosis: communication from the SSC of the ISTH.

The antithrombotic effects of statins

The septic milieu triggers expression of spliced tissue factor mRNA in human platelets.

Therapeutic strategies for thrombosis: new targets and approaches

Tissue factor and its measurement in whole blood, plasma, and microparticles

Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice

Tissue factor deficiency increases alveolar hemorrhage and death in influenza A virus-infected mice.

Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations

Tissue factor in health and disease

Tissue factor promotes activation of coagulation and inflammation in a mouse model of sickle cell disease

Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy

Tissue factor-positive tumor microvesicles activate platelets and enhance thrombosis in mice.