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List of works by Heidrun Potschka

(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.

scientific article published on 28 May 2014

2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches

scientific article published on 14 May 2019

A comparison of extracellular levels of phenytoin in amygdala and hippocampus of kindled and non-kindled rats

scientific article

A microdialysis study of striatal dopamine release in the circling rat, a genetic animal model with spontaneous lateralized rotational behavior

scientific article published on 01 January 2000

A retrospective evaluation of species-specific sensitivity for neurological signs in toxicological studies: Is the dog more sensitive than the non-human primate?

scientific article published on 27 December 2015

A safe bet? Inter-laboratory variability in behaviour-based severity assessment

scientific article published on 07 November 2019

Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus

scientific article

Add-on treatment with verapamil in pharmacoresistant canine epilepsy

scientific article published on 10 January 2011

Age-dependent decline of blood-brain barrier P-glycoprotein expression in the canine brain

scientific article published on 16 October 2009

Allele-specific polymerase chain reaction diagnostic test for the functional MDR1 polymorphism in dogs

scientific article

Amygdala-kindling does not induce a persistent loss of GABA neurons in the substantia nigra pars reticulata of rats

scientific article published in October 2004

Analysis in conditional cannabinoid 1 receptor-knockout mice reveals neuronal subpopulation-specific effects on epileptogenesis in the kindling paradigm

scientific article published on 11 August 2014

Animal and human data: where are our concepts for drug-resistant epilepsy going?

scientific article

Animal models of drug‐resistant epilepsy* ⬇️

scientific article published on 01 September 2012

Anticonvulsant effects of transcranial direct-current stimulation (tDCS) in the rat cortical ramp model of focal epilepsy

scientific article published in July 2006

Are neuronal nicotinic receptors a target for antiepileptic drug development? Studies in different seizure models in mice and rats

scientific article published in April 2003

Brain access and anticonvulsant efficacy of carbamazepine, lamotrigine, and felbamate in ABCC2/MRP2-deficient TR- rats

scientific article published on December 2003

Brain penetration and anticonvulsant efficacy of intranasal phenobarbital in rats

scientific article published on 01 July 2008

Brivaracetam does not alter spatial learning and memory in both normal and amygdala-kindled rats

scientific article published on August 2010

CNS transporters and drug delivery in epilepsy

scientific article published on January 2014

COVID-19 and seizures: Is there a link?

scientific article published on 17 September 2020

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

scientific article published on 26 September 2009

Canine epilepsy as a translational model?

scientific article published on 18 March 2013

Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy.

scientific article

Cellular localization of Y-box binding protein 1 in brain tissue of rats, macaques, and humans

scientific article

Controlled multiplex PCR of enterotoxigenic Clostridium perfringens strains in food samples

scientific article

Corneal kindling in mice: behavioral and pharmacological differences to conventional kindling

scientific article

Deficiency of neural cell adhesion molecule or its polysialylation modulates pharmacological effects of the AMPA receptor antagonist NBQX.

scientific article published on 20 September 2007

Defining body-weight reduction as a humane endpoint: a critical appraisal

scientific article published on 30 October 2019

Design of composite measure schemes for comparative severity assessment in animal-based neuroscience research: A case study focussed on rat epilepsy models

scientific article published on 15 May 2020

Development of kindling and spontaneous seizures after massed stimulation of different loci in the rat piriform cortex

article

Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein

scientific article published on 10 October 2006

Distemper virus encephalitis exerts detrimental effects on hippocampal neurogenesis

scientific article

Drug Resistance

Drug resistance in brain diseases and the role of drug efflux transporters.

scientific article

Dynamic regulation of P-glycoprotein in human brain capillaries.

scientific article published on 7 August 2013

Effect of aging on neurogenesis in the canine brain

scientific article

Effect of eslicarbazepine acetate in the corneal kindling progression and the amygdala kindling model of temporal lobe epilepsy

scientific article published on December 2013

Effect of low-intensity 50-Hz magnetic fields on kindling acquisition and fully kindled seizures in rats

scientific article published in November 1998

Effect of phenytoin on sodium and calcium currents in hippocampal CA1 neurons of phenytoin-resistant kindled rats

scientific article published in January 2002

Effects of the NMDA receptor antagonist D-CPPene on extracellular levels of dopamine and dopamine and serotonin metabolites in striatum of kindled and non-kindled rats

scientific article

Effects of the novel antiepileptic drug lacosamide on the development of amygdala kindling in rats

scientific article published in November 2006

Effects of the novel antiepileptic drug levetiracetam on spontaneous recurrent seizures in the rat pilocarpine model of temporal lobe epilepsy

scientific article published in April 2002

Electrical but not chemical kindling increases sensitivity to some phencyclidine-like behavioral effects induced by the competitive NMDA receptor antagonist D-CPPene in rats

scientific article published in July 1998

Epileptogenesis and neuropathology after different types of status epilepticus induced by prolonged electrical stimulation of the basolateral amygdala in rats

scientific article published in June 2003

Expression of the multidrug transporter P-glycoprotein in brain capillary endothelial cells and brain parenchyma of amygdala-kindled rats

scientific article published in July 2002

Expression regulation and targeting of the peroxisome proliferator-activated receptor γ following electrically-induced status epilepticus

scientific article published on 7 August 2015

Finding a better drug for epilepsy: antiepileptogenesis targets.

scientific article published on 12 October 2012

Frontal versus transcorneal stimulation to induce maximal electroshock seizures or kindling in mice and rats

scientific article published in May 1998

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon

scientific article published in March 2003

Gabapentin-lactam, a close analogue of the anticonvulsant gabapentin, exerts convulsant activity in amygdala kindled rats

scientific article published on 01 February 2000

Genetic and pharmacological targeting of heat shock protein 70 in the mouse amygdala-kindling model

scientific article published on 16 November 2018

Glutamate-Mediated Down-Regulation of the Multidrug-Resistance Protein BCRP/ABCG2 in Porcine and Human Brain Capillaries

scientific article published on 30 April 2015

Glutamate-mediated upregulation of the multidrug resistance protein 2 in porcine and human brain capillaries

scientific article published on 12 December 2014

Hydantoin-substituted 4,6-dichloroindole-2-carboxylic acids as ligands with high affinity for the glycine binding site of the NMDA receptor

scientific article published on January 2003

Identification and characterization of outcome measures reported in animal models of epilepsy: Protocol for a systematic review of the literature-A TASK2 report of the AES/ILAE Translational Task Force of the ILAE.

scientific article published in November 2017

Identification of brain regions predicting epileptogenesis by serial [18F]GE-180 positron emission tomography imaging of neuroinflammation in a rat model of temporal lobe epilepsy

scientific article

Imaging biomarkers of behavioral impairments: A pilot micro-positron emission tomographic study in a rat electrical post-status epilepticus model

scientific article published on 28 October 2018

Imaging correlates of behavioral impairments: An experimental PET study in the rat pilocarpine epilepsy model

scientific article published on 20 June 2018

Imaging of P-glycoprotein-mediated pharmacoresistance in the hippocampus: proof-of-concept in a chronic rat model of temporal lobe epilepsy.

scientific article published on 14 July 2010

Immunohistochemical localization of P-glycoprotein in rat brain and detection of its increased expression by seizures are sensitive to fixation and staining variables

scientific article

Impact of Theiler's virus infection on hippocampal neuronal progenitor cells: differential effects in two mouse strains

scientific article published in December 2012

Impact of seizure activity on free extracellular phenytoin concentrations in amygdala-kindled rats.

scientific article published on 29 June 2011

Impact of the NCAM derived mimetic peptide plannexin on the acute cellular consequences of a status epilepticus

scientific article published on 20 July 2011

Impact of the PSA-NCAM system on pathophysiology in a chronic rodent model of temporal lobe epilepsy

scientific article

Impact of the erythropoietin-derived peptide mimetic Epotris on the histopathological consequences of status epilepticus

scientific article

Impact of the neural cell adhesion molecule-derived peptide FGL on seizure progression and cellular alterations in the mouse kindling model

scientific article published on 23 January 2014

In vivo down-regulation of mouse brain capillary P-glycoprotein: a preliminary investigation

scientific article published on 11 August 2009

In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats

scientific article published in October 2001

In vivo imaging of dopamine receptors in a model of temporal lobe epilepsy.

scientific article published on 19 August 2009

Increased expression of the multidrug transporter P-glycoprotein in limbic brain regions after amygdala-kindled seizures in rats

scientific article published in January 2004

Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice

scientific article published on 18 March 2015

Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats

scientific article published in February 2004

International Veterinary Epilepsy Task Force consensus proposal: medical treatment of canine epilepsy in Europe

scientific article published on 28 August 2015

International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol

scientific article published on 28 August 2015

International veterinary epilepsy task force consensus proposal: diagnostic approach to epilepsy in dogs

scientific article

International veterinary epilepsy task force consensus proposal: outcome of therapeutic interventions in canine and feline epilepsy

scientific article published on 28 August 2015

International veterinary epilepsy task force consensus report on epilepsy definition, classification and terminology in companion animals

scientific article published on 28 August 2015

International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats

scientific article published on 28 August 2015

Introduction to the EQIPD quality system

scientific article published on 24 May 2021

Kindling-induced overexpression of Homer 1A and its functional implications for epileptogenesis

scientific article published in December 2002

LU 73068, a new non-NMDA and glycine/NMDA receptor antagonist: pharmacological characterization and comparison with NBQX and L-701,324 in the kindling model of epilepsy.

scientific article

Lack of effects of prolonged treatment with phenobarbital or phenytoin on the expression of P-glycoprotein in various rat brain regions

scientific article published in September 2002

Lacosamide treatment following status epilepticus attenuates neuronal cell loss and alterations in hippocampal neurogenesis in a rat electrical status epilepticus model

scientific article

Long-term genetic fate mapping of adult generated neurons in a mouse temporal lobe epilepsy model

scientific article published on 30 June 2012

MAP-kinase-activated protein kinase 2 expression and activity is induced after neuronal depolarization.

scientific article

Michael Foundation Forum 2010

scientific article published on 01 February 2011

Microglial ROS production in an electrical rat post-status epilepticus model of epileptogenesis

scientific article

Minocycline fails to exert antiepileptogenic effects in a rat status epilepticus model

scientific article

Modulating P-glycoprotein regulation: future perspectives for pharmacoresistant epilepsies?

scientific article published on 30 April 2010

Modulation of neurogenesis by targeted hippocampal irradiation fails to affect kindling progression

scientific article published on June 2010

Molecular alterations of the TLR4-signaling cascade in canine epilepsy

scientific article published on 20 January 2020

Multidrug resistance protein MRP2 contributes to blood-brain barrier function and restricts antiepileptic drug activity

scientific article published on 27 March 2003

Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain

scientific article published in August 2001

N-acetyl-L-leucine accelerates vestibular compensation after unilateral labyrinthectomy by action in the cerebellum and thalamus

scientific article

N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy

scientific article published in January 2003

Naturally occurring Clostridium perfringens nontoxic alpha-toxin variant as a potential vaccine candidate against alpha-toxin-associated diseases.

scientific article

Nest-building performance in rats: impact of vendor, experience, and sex

scientific article published on 23 July 2019

Neurogenesis in the adult rat piriform cortex

scientific article published in April 2006

Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures.

scientific article

Neutralization of hemolytic and mouse lethal activities of C. perfringens alpha-toxin need simultaneous blockade of two epitopes by monoclonal antibodies.

scientific article published in July 1997

Newborn neurons with hilar basal dendrites hallmark epileptogenic networks

scientific article

Over-expression of P-glycoprotein in the canine brain following spontaneous status epilepticus

scientific article published on 6 December 2008

P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats

scientific article

P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain

scientific article published in November 2001

Perampanel: Does it have broad-spectrum potential?

scientific article published on 28 June 2018

Pharmacoresistance

scientific article published on January 2012

Pharmacoresistance and expression of multidrug transporter P-glycoprotein in kindled rats

scientific article

Polymorphic variants of the multidrug resistance gene Mdr1a and response to antiepileptic drug treatment in the kindling model of epilepsy

scientific article published on 06 September 2006

Polysialic acid affects pathophysiological consequences of status epilepticus

scientific article published in June 2010

Pre-treatment with the NMDA receptor glycine-binding site antagonist L-701,324 improves pharmacosensitivity in a mouse kindling model

scientific article published on 2 March 2014

Prevention of seizure-induced up-regulation of endothelial P-glycoprotein by COX-2 inhibition

scientific article

Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats

scientific article published on 18 May 2007

Proteomic profiling of epileptogenesis in a rat model: Focus on inflammation

scientific article published on 11 December 2015

Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model

scientific article

Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy

scientific article published in August 2001

Retarded kindling progression in mice deficient in the extracellular matrix glycoprotein tenascin-R.

scientific article published on 30 October 2008

Role of CNS efflux drug transporters in antiepileptic drug delivery: Overcoming CNS efflux drug transport ⬇️

scientific article published on December 20, 2011

Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling

scientific article

Semi-automated generation of pictures for the Mouse Grimace Scale: A multi-laboratory analysis (Part 2)

scientific article published on 29 October 2019

Synergism of perampanel and zonisamide in the rat amygdala kindling model of temporal lobe epilepsy

scientific article published on 8 February 2016

Targeting epileptogenesis-associated induction of neurogenesis by enzymatic depolysialylation of NCAM counteracts spatial learning dysfunction but fails to impact epilepsy development

scientific journal article

Targeting of microglial KCa3.1 channels by TRAM-34 exacerbates hippocampal neurodegeneration and does not affect ictogenesis and epileptogenesis in chronic temporal lobe epilepsy models

scientific article published on 10 July 2014

Targeting prostaglandin E2 EP1 receptors prevents seizure-associated P-glycoprotein up-regulation

scientific article

Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach.

scientific article

Targeting the endocannabinoid system in the amygdala kindling model of temporal lobe epilepsy in mice

scientific article

Targeting the prostaglandin E2 EP1 receptor and cyclooxygenase-2 in the amygdala kindling model in mice

scientific article published on 24 July 2010

The CNTF-derived peptide mimetic Cintrofin attenuates spatial-learning deficits in a rat post-status epilepticus model

scientific article published on 11 October 2013

The antiepileptic drug levetiracetam selectively modifies kindling-induced alterations in gene expression in the temporal lobe of rats

scientific article

The erythropoietin-derived peptide mimetic pHBSP affects cellular and cognitive consequences in a rat post-status epilepticus model

scientific article published on 2 November 2011

The mixed blessing of treating symptoms in acute vestibular failure--evidence from a 4-aminopyridine experiment

scientific article

The novel antiepileptic drug imepitoin compares favourably to other GABA-mimetic drugs in a seizure threshold model in mice and dogs

scientific article published on 18 September 2013

The role of p-glycoprotein in psychiatric disorders: a reliable guard of the brain?

scientific article published on September 2011

Toward evidence-based severity assessment in rat models with repeated seizures: I. Electrical kindling.

scientific article published on 26 February 2018

Toward evidence-based severity assessment in rat models with repeated seizures: II. Chemical post-status epilepticus model

scientific article published on 31 August 2019

Toward evidence-based severity assessment in rat models with repeated seizures: III. Electrical post-status epilepticus model

scientific article published on 27 June 2019

Transient increase of P-glycoprotein expression in endothelium and parenchyma of limbic brain regions in the kainate model of temporal lobe epilepsy

scientific article published in October 2002

Transporter Hypothesis of Drug-Resistant Epilepsy: Challenges for Pharmacogenetic Approaches ⬇️

scientific article published on October 1, 2010

Uptake and binding of the serotonin 5-HT1A antagonist [18F]-MPPF in brain of rats: effects of the novel P-glycoprotein inhibitor tariquidar

scientific article published on 28 September 2009

Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays

scientific article published on 16 October 2006

Where are we heading? Challenges in evidence-based severity assessment

scientific article published on 13 November 2019

[11C]quinidine and [11C]laniquidar PET imaging in a chronic rodent epilepsy model: impact of epilepsy and drug-responsiveness

scientific article

[18F]MPPF and [18F]FDG μPET imaging in rats: impact of transport and restraint stress

scientific article published on 29 September 2020

mGlu1 and mGlu5 receptor antagonists lack anticonvulsant efficacy in rodent models of difficult-to-treat partial epilepsy

scientific article published on 24 March 2006

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