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List of works by Luciano Pirola

118th ENMC International Workshop on Advances in Myotubular Myopathy. 26-28 September 2003, Naarden, The Netherlands. (5th Workshop of the International Consortium on Myotubular Myopathy).

scientific article

A special BioFactors issue dedicated to resveratrol ⬇️

scientific article published on September 1, 2010

Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.

scientific article published on 13 February 2001

Adipocytes, like their progenitors, contribute to inflammation of adipose tissues through promotion of Th-17 cells and activation of monocytes, in obese subjects

scientific article published on 25 January 2016

Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation.

scientific article published on 12 March 2015

Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans

scientific article

Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats.

scientific article published on 30 March 2017

Bifurcation of lipid and protein kinase signals of PI3Kgamma to the protein kinases PKB and MAPK

scientific article published on 01 October 1998

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

scientific article

Dietary polyphenols and their effects on cell biochemistry and pathophysiology

scientific article published on 6 November 2012

Dysregulation of sirtuins and key metabolic genes in skeletal muscle of pigs with spontaneous intrauterine growth restriction is associated with alterations of circulating IGF-1.

scientific article

Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the ADRB3 gene, lipid profile and oxidative stress in overweight or obese women

scientific article published on 13 October 2017

Effects of maternal low-protein diet and spontaneous physical activity on the transcription of neurotrophic factors in the placenta and the brains of mothers and offspring rats

scientific article published on 17 August 2020

Epigenetic phenomena linked to diabetic complications.

scientific article

Epigenetics in transgenerational responses to environmental impacts: from facts and gaps

scientific article published in January 2016

Essential roles of four-carbon backbone chemicals in the control of metabolism

scientific article (publication date: 26 August 2015)

Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport

scientific article

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells

scientific article

Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases

scientific article published on 16 June 2019

Insights on the epigenetic mechanisms underlying pulmonary arterial hypertension

scientific article published on 18 October 2018

Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site

scientific journal article

Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients

scientific article

Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways

scientific article

Maternal physical activity-induced adaptive transcriptional response in brain and placenta of mothers and rat offspring

scientific article published on 17 June 2019

Maternal protein restriction induced-hypertension is associated to oxidative disruption at transcriptional and functional levels in the medulla oblongata

scientific article published on 9 September 2016

Maternal voluntary physical activity attenuates delayed neurodevelopment in malnourished rats

scientific article

Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States

scientific article published on 17 March 2020

Modulation of insulin action.

scientific article published on 13 January 2004

Modulation of the vascular endothelium functioning by dietary components, the role of epigenetics.

scientific article published on 29 June 2016

Modulators of insulin action and their role in insulin resistance

scientific article published on 01 December 2003

Pharmacological and transcriptional inhibition of the G9a histone methyltransferase suppresses proliferation and modulates redox homeostasis in human microvascular endothelial cells

scientific article

Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells.

scientific article published on 19 September 2016

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

scientific article

Phosphoinositide 3-kinase signalling: no lipids.

scientific article

Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

scientific article published on 18 February 2003

Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes

scientific article

Phospholipase D2 regulates endothelial permeability through cytoskeleton reorganization and occludin downregulation

scientific article published on 14 April 2009

Production of phosphatidylinositol 5-phosphate by the phosphoinositide 3-phosphatase myotubularin in mammalian cells

scientific article

Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

scientific article published in Scientific Reports

Protein acetylation mechanisms in the regulation of insulin and insulin-like growth factor 1 signalling

scientific article published on 06 June 2012

Resveratrol is a class IA phosphoinositide 3-kinase inhibitor

scientific article

Role of pro- and anti-inflammatory phenomena in the physiopathology of type 2 diabetes and obesity

scientific article

Structure and function of phosphoinositide 3-kinases.

scientific article published in December 1998

The DCCT/EDIC study: epigenetic clues after three decades

scientific article published on 01 May 2014

The Epigenetic Profile of Tumor Endothelial Cells. Effects of Combined Therapy with Antiangiogenic and Epigenetic Drugs on Cancer Progression

scientific article published on 09 April 2020

The Methylation Status of the Epigenome: Its Emerging Role in the Regulation of Tumor Angiogenesis and Tumor Growth, and Potential for Drug Targeting

scientific article published on 10 August 2018

The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes

scientific journal article

The direct effect of leptin on skeletal muscle thermogenesis is mediated by substrate cycling between de novo lipogenesis and lipid oxidation.

scientific article published in November 2004

The histone deacetylase inhibitor sodium butyrate improves insulin signalling in palmitate-induced insulin resistance in L6 rat muscle cells through epigenetically-mediated up-regulation of Irs1.

scientific article published on 9 September 2016

The new paradigm of the developmental origin of health and diseases (DOHaD)--Epigenetics and environment: evidence and missing links

scientific article published in January 2016

The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice

scientific article published on 9 September 2016

Therapeutic potential of activators and inhibitors of sirtuins ⬇️

scientific article published on September 1, 2010

Transcriptional response of skeletal muscle to a low protein perinatal diet in rat offspring at different ages: The role of key enzymes of glucose-fatty acid oxidation

scientific article published on 15 December 2016

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