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List of works by Wolfgang H Sommer

A cluster of differentially expressed signal transduction genes identified by microarray analysis in a rat genetic model of alcoholism

scientific article published on 01 January 2004

A common functional allele of the Nogo receptor gene, reticulon 4 receptor (RTN4R), is associated with sporadic amyotrophic lateral sclerosis in a French population

scientific article published on 17 June 2015

A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology.

scientific article published on 26 July 2016

A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice.

scientific article published on 8 September 2014

A systems medicine research approach for studying alcohol addiction

scientific article published in November 2013

A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males.

scientific article published on 11 December 2015

Acute ethanol challenge inhibits glycogen synthase kinase-3beta in the rat prefrontal cortex

scientific article

Addiction Research Consortium: Losing and regaining control over drug intake (ReCoDe)-From trajectories to mechanisms and interventions

scientific article published on 20 December 2019

An integrated genome research network for studying the genetics of alcohol addiction

scientific article published on October 2010

Anterior insula stimulation suppresses appetitive behavior while inducing forebrain activation in alcohol-preferring rats

scientific article published on 18 May 2020

Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test

scientific article published in January 2002

Anxiogenic-like action of galanin after intra-amygdala administration in the rat.

scientific article

Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis

scientific article published on 18 May 2015

Brain activation induced by voluntary alcohol and saccharin drinking in rats assessed with manganese-enhanced magnetic resonance imaging

scientific article

Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system

scientific article

Cannabinoid CB1 receptor antagonism reduces conditioned reinstatement of ethanol-seeking behavior in rats

scientific article published in April 2005

Choice for drug or natural reward engages largely overlapping neuronal ensembles in the infralimbic prefrontal cortex.

scientific article published on 24 February 2018

Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain

scientific article published on 24 June 2020

Comparison of gene expression profiles in the blood, hippocampus and prefrontal cortex of rats

scientific article

Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence

scientific article published on 22 February 2016

Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence

scientific article

Corticosterone actions on the hippocampal brain-derived neurotrophic factor expression are mediated by exon IV promoter.

scientific article published in February 2006

DNA microarrays and expression profiling in drug abuse research

scientific article published on 01 March 2005

Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions

scientific article published in June 1997

Deep grey matter iron accumulation in alcohol use disorder

scientific article published on 5 January 2017

Developing neuroscience-based treatments for alcohol addiction: A matter of choice?

scientific article published on 08 October 2019

Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence

scientific article published on December 2016

Differential expression of NPY and its receptors in alcohol-preferring AA and alcohol-avoiding ANA rats

scientific article published in November 2001

Differential expression of diacylglycerol kinase iota and L18A mRNAs in the brains of alcohol-preferring AA and alcohol-avoiding ANA rats.

scientific article published in January 2001

Dissociation of antidepressant-like activity of escitalopram and nortriptyline on behaviour and hippocampal BDNF expression in female rats

scientific article published on 24 January 2011

Dopamine systems adaptation during acquisition and consolidation of a skill

scientific article

Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics

scientific article published on 30 January 2018

Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat.

scientific article

Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques.

scientific article published on 16 October 2017

Ethanol-induced activation of AKT and DARPP-32 in the mouse striatum mediated by opioid receptors

scientific article

Evaluating network brain connectivity in alcohol postdependent state using Network-Based Statistic.

scientific article published in July 2017

Existence of striatal nerve cells coexpressing CCK(B) and D2 receptor mRNAs

scientific article

Exposure of rat brain to 915 MHz GSM microwaves induces changes in gene expression but not double stranded DNA breaks or effects on chromatin conformation

scientific article published in May 2006

Expression Profiling in Alcoholism Research

scientific article

Functional CRH variation increases stress-induced alcohol consumption in primates

scholarly article

Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques

scientific article

Functional genomics strategies to identify susceptibility genes and treatment targets in alcohol dependence

scientific article

Gene discovery in neuropharmacological and behavioral studies using Affymetrix microarray data

scientific article

Gene expression in brain: a window on ethanol dependence, neuroadaptation, and preference

scientific article published in February 2003

Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis

scientific article published on 17 July 2017

Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference

scientific article published on 8 February 2006

Genetic variation and brain gene expression in rodent models of alcoholism implications for medication development

scientific article published on January 2010

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

scientific journal article

Genome-wide association study of alcohol dependence

scientific journal article

Gluco- and mineralocorticoid receptor-mediated regulation of neurotrophic factor gene expression in the dorsal hippocampus and the neocortex of the rat.

scientific article published in August 2000

Glutathione-S-transferase expression in the brain: possible role in ethanol preference and longevity

scientific article published in September 2006

Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats

scientific article

High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats

scientific article

Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect

scientific article

Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1

scientific article published on 21 April 2020

Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

scientific article

Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinking outcome: a functional imaging study in alcohol dependent subjects

scientific article published on 18 April 2015

Incubation of neural alcohol cue reactivity after withdrawal and its blockade by naltrexone

scientific article published on 12 February 2019

Induction of hippocampal glial cells expressing basic fibroblast growth factor RNA by corticosterone

scientific article

Local 5,7-dihydroxytryptamine lesions of rat amygdala: release of punished drinking, unaffected plus-maze behavior and ethanol consumption

scientific article

Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol

scientific article published in January 2002

Long-lasting tolerance to alcohol following a history of dependence.

scientific article

Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats

scientific article published on 25 March 2010

Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex.

scientific article published on July 2015

Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis.

scientific article

Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents

scientific article

Modulation of nucleus accumbens connectivity by alcohol drinking and naltrexone in alcohol-preferring rats: A manganese-enhanced magnetic resonance imaging study

scientific article

Modulation of voluntary ethanol consumption by beta-arrestin 2.

scientific article published on 26 March 2008

Multi-modal MRI classifiers identify excessive alcohol consumption and treatment effects in the brain.

scientific article published on 8 June 2016

Negative Association Between MR-Spectroscopic Glutamate Markers and Gray Matter Volume After Alcohol Withdrawal in the Hippocampus: A Translational Study in Humans and Rats

scientific article published on 18 January 2017

Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking

scientific article published on 10 December 2009

Neuroplasticity in brain reward circuitry following a history of ethanol dependence

scientific article published on April 2008

On the role of c-fos expression in striatal transmission. The antisense oligonucleotide approach ⬇️

scientific article published on September 1, 1997

Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol-Dependent Rats and Humans

scientific article published in November 2017

Persistent behavioral and autonomic supersensitivity to stress following prenatal stress exposure in rats

scientific article published in March 2003

Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons

scientific article

Plasticity and impact of the central renin–angiotensin system during development of ethanol dependence

article

Postdependent state in rats as a model for medication development in alcoholism

scientific article

RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release

scientific article

Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol

scientific article published in March 2007

Repetitive Transcranial Magnetic Stimulation in Alcohol Dependence: A Randomized, Double-Blind, Sham-Controlled Proof-of-Concept Trial Targeting the Medial Prefrontal and Anterior Cingulate Cortices

scientific article published in 2022

Reprogramming of mPFC transcriptome and function in alcohol dependence

scientific article published on 22 September 2016

Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence

scientific article published on February 2013

Site-specific administration of antisense oligonucleotides using biodegradable polymer microspheres provides sustained delivery and improved subcellular biodistribution in the neostriatum of the rat brain

scientific article published in January 2000

Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress.

scientific article

Targeting brain angiotensin and corticotrophin-releasing hormone systems interaction for the treatment of mood and alcohol use disorders

scientific article published on May 2008

The Calpain Inhibitor A-705253 Attenuates Alcohol-Seeking and Relapse with Low Side-Effect Profile.

scientific article published on 28 July 2015

The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus

scientific article

The Need for Treatment Responsive Translational Biomarkers in Alcoholism Research

scientific article published on 31 May 2016

The SyBil-AA real-time fMRI neurofeedback study: protocol of a single-blind randomized controlled trial in alcohol use disorder

scientific article published on 17 January 2018

The alcohol-preferring AA and alcohol-avoiding ANA rats: neurobiology of the regulation of alcohol drinking

scientific article published on September 2006

The neurometabolic fingerprint of excessive alcohol drinking

scientific article published on 13 March 2015

The search for candidate genes of alcoholism: evidence from expression profiling studies.

scientific article

The spread and uptake pattern of intracerebrally administered oligonucleotides in nerve and glial cell populations of the rat brain

scientific article published in April 1998

Transcription factor gene expression profiling after acute intermittent nicotine treatment in the rat cerebral cortex.

scientific article published in January 2005

Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues

scientific article

Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats

scientific article published on 10 September 2011

Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence

scientific article published on 21 June 2007

Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress

scientific journal article

XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans

scientific article

[19] Pharmacokinetic properties of oligonucleotides in brain

scientific article published on 01 January 2000

c-fos antisense oligonucleotides increase firing rate of striatal neurons in the anaesthetized rat.

scientific article published on March 2004

mRNA GPR162 changes are associated with decreased food intake in rat, and its human genetic variants with impairments in glucose homeostasis in two Swedish cohorts

scientific article published on 28 January 2016

β-Arrestin 2 knockout mice exhibit sensitized dopamine release and increased reward in response to a low dose of alcohol

scientific article published on 19 June 2013

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