List of works - Ciro Isidoro

A fast and simple method for simultaneous mixed site-specific mutagenesis of a wide coding sequence

scientific article

A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29.

scientific article published on January 1995

Agonist monoclonal antibodies against HGF receptor protect cardiac muscle cells from apoptosis.

scientific article

Akt induces apoptosis in neuroblastoma cells expressing a C98X vasopressin mutant following autophagy suppression.

scientific article

Altered intracellular processing and enhanced secretion of procathepsin D in a highly deviated rat hepatoma

article

Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

scientific article published on 02 May 2019

Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro

scientific article published on February 2004

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

scientific article

Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium

scientific article published on 17 March 2008

Autophagy and thyroid carcinogenesis: genetic and epigenetic links

scientific article published on 16 December 2013

Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells

scientific article published on 19 August 2019

Autophagy is a prosurvival mechanism in cells expressing an autosomal dominant familial neurohypophyseal diabetes insipidus mutant vasopressin transgene.

scientific article

Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas

scientific article published on 14 May 2010

Autophagy-dependent cell survival and cell death in an autosomal dominant familial neurohypophyseal diabetes insipidus in vitro model.

scientific article

Autophagy-dependent toxicity of amino-functionalized nanoparticles in ovarian cancer cells

scientific article published on 01 September 2019

Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome.

scientific article published on 28 April 2015

Biocompatibility, endocytosis, and intracellular trafficking of mesoporous silica and polystyrene nanoparticles in ovarian cancer cells: effects of size and surface charge groups

scientific article

Brefeldin A prevents uncovering but not phosphorylation of the recognition marker in cathepsin D

scientific article published on 01 July 1990

Butyrate Inhibits Colorectal Cancer Cell Proliferation through Autophagy Degradation of β-Catenin Regardless of <i>APC</i> and β-Catenin Mutational Status

scientific article published on 13 May 2022

Cathepsin D-Bax death pathway in oxidative stressed neuroblastoma cells

scientific article published on 8 January 2007

Cell-free Lactiplantibacillus plantarum OC01 supernatant suppresses IL-6-induced proliferation and invasion of human colorectal cancer cells: Effect on β-Catenin degradation and induction of autophagy

scientific article published in 2023

Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation

scientific article published on 8 July 2011

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

scientific article published on 01 September 2020

Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression.

scientific article

Comparative studies on protein turnover regulations in tumor cells and host tissues: development and analysis of an experimental model

scientific article

Coordinated Metabolic Changes and Modulation of Autophagy during Myogenesis

scientific article published on 16 June 2016

DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity

scientific article published on 15 June 2012

Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated with Estrogen Receptor-Negative Subtypes and Poor Prognosis.

scientific article

Defective autophagy in Parkinson's disease: role of oxidative stress.

scientific article published on 17 August 2012

Destination 'lysosome': a target organelle for tumour cell killing?

scientific article published on September 2003

Determination of the phosphorylation, uncovering of mannose 6-phosphate groups and targeting of lysosomal enzymes

scientific article published on March 1991

Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells

scientific article published on May 2010

Differential segregation of human and hamster cathepsin D in transfected baby-hamster kidney cells

scientific article published on January 1991

Differential targeting and processing of procathepsin D in normal and transformed murine 3T3 fibroblasts.

scientific article published on January 1997

Differentiation-dependent autophagy controls the fate of newly synthesized N-linked glycoproteins in the colon adenocarcinoma HT-29 cell line.

scientific article published on July 1995

Differentiation-induced changes in the content, secretion, and subcellular distribution of lysosomal cathepsins in the human colon cancer HT-29 cell line

scientific article published on July 1997

Dihydroartemisinin induces apoptosis and autophagy-dependent cell death in cholangiocarcinoma through a DAPK1-BECLIN1 pathway

scientific article published on 05 September 2018

Dopamine exacerbates mutant Huntingtin toxicity via oxidative-mediated inhibition of autophagy in SH-SY5Y neuroblastoma cells: Beneficial effects of anti-oxidant therapeutics

scientific article published on 10 November 2016

Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments

scientific article

Effects of calcitriol on the biogenesis of a lysosomal protease in monocytes from patients with renal failure

scientific article published on 01 January 1994

Endosomal-lysosomal proteolysis mediates death signalling by TNFalpha, not by etoposide, in L929 fibrosarcoma cells: evidence for an active role of cathepsin D.

scientific article published in July 2002

Epigenetic control of autophagy by microRNAs in ovarian cancer

scientific article

Exposed Thiols Confer Localization in the Endoplasmic Reticulum by Retention Rather than Retrieval

scientific article published in Journal of Biological Chemistry

Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer

scientific article (publication date: 2014)

Expression and posttranslational fate of cathepsin D in HT-29 tumor cells depend on their enterocytic differentiation state.

scientific article published on September 1997

Expression of protein kinase C beta1 confers resistance to TNFalpha- and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells

scientific article

Folding, activity and targeting of mutated human cathepsin D that cannot be processed into the double-chain form

scientific article published on 25 November 2006

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

High Expression of the Lysosomal Protease Cathepsin D Confers Better Prognosis in Neuroblastoma Patients by Contrasting EGF-Induced Neuroblastoma Cell Growth

scientific article published on 26 April 2022

High expression of cathepsin D in non-Hodgkin's lymphomas negatively impacts on clinical outcome.

scientific article published on January 2010

High levels of proteolytic enzymes in the ascitic fluid and plasma of rats bearing the Yoshida AH-130 hepatoma

scientific article published on 01 January 1995

High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells

scientific article published on 19 August 2005

Human and hamster procathepsin D, although equally tagged with mannose-6-phosphate, are differentially targeted to lysosomes in transfected BHK cells

scientific article published on May 1998

Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells

scientific article published in June 2002

Induced autophagy reduces virus output in dengue infected monocytic cells

scientific article

Induction of mRNA for tumor necrosis factor alpha in hemodialysis

scientific article published on 01 January 1993

Inhibition of PI3k class III-dependent autophagy prevents apoptosis and necrosis by oxidative stress in dopaminergic neuroblastoma cells.

scientific article

Involvement of autophagy in ovarian cancer: a working hypothesis

scientific article

Kinetics and fate of IgA-IgG aggregates as a model of naturally occurring immune complexes in IgA nephropathy

article

Knockdown of cathepsin D in zebrafish fertilized eggs determines congenital myopathy.

scientific article published on 4 April 2013

Labeling and exocytosis of secretory compartments in RBL mastocytes by polystyrene and mesoporous silica nanoparticles

scientific article

Lithium delays progression of amyotrophic lateral sclerosis

scholarly article

Localization and Processing of Glycosylphosphatidylinositol-Anchored Cathepsin D

scientific article published on 01 June 1995

Loss of expression of the oncosuppressor PTEN in thyroid incidentalomas associates with GLUT1 plasmamembrane expression.

scientific article

Lysophosphatidic Acid Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response

scientific article published on 31 January 2018

Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas

scientific article published in February 2002

Lysosomal segregation of a mannose-rich glycoprotein imparted by the prosequence of myeloperoxidase

scientific article published on November 1998

Mis-sorting of procathepsin D in metastogenic tumor cells is not due to impaired synthesis of the phosphomannosyl signal

scientific article published on 01 March 1997

NaGdF4Nanoparticles Coated with Functionalised Ethylenediaminetetraacetic Acid as Versatile Probes for Dual Optical and Magnetic Resonance Imaging

scientific article published on 16 October 2014

On a case of "Macrodystrophia lipomatosa"

scientific article published on 01 September 1997

Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts

scientific article published on 29 November 2018

Ovarian mitochondrial dynamics and cell fate regulation in an androgen-induced rat model of polycystic ovarian syndrome

scientific article published on 23 January 2020

PI3K-dependent lysosome exocytosis in nitric oxide-preconditioned hepatocytes

scientific article published on 07 February 2006

PTEN deficiency and mutant p53 confer glucose-addiction to thyroid cancer cells: impact of glucose depletion on cell proliferation, cell survival, autophagy and cell migration.

scientific article

PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells

scientific article published on 4 November 2016

PTEN regulates plasma membrane expression of glucose transporter 1 and glucose uptake in thyroid cancer cells.

scientific article published on 14 August 2014

Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection.

scientific article published on July 2015

Photoactive hybrid nanomaterials: indocyanine immobilized in mesoporous MCM-41 for "in-cell" bioimaging

scientific article published on March 2009

Preconditioning-induced cytoprotection in hepatocytes requires Ca(2+)-dependent exocytosis of lysosomes

scientific article published on 17 February 2004

Prognostic significance of microvessel density and vascular endothelial growth factor expression in sinonasal carcinomas☆

scientific article published on 08 February 2006

Protection from UVB Toxicity in Human Keratinocytes by Thailand Native Herbs Extracts.

scientific article published on 12 August 2013

Protein turnover states of tumour cells and host tissues in an experimental model

article

Publishing scientifically sound papers in Traditional and Complementary Medicine.

scientific article published on 16 January 2016

Purification and properties of cathepsin D from rat Yoshida ascites hepatoma AH-130

scientific article published on 01 May 1988

Raman Spectrometric Detection Methods for Early and Non-Invasive Diagnosis of Alzheimer's Disease

scientific article

Regulation of protein sorting at the TGN by plasma membrane receptor activation.

scientific article

Regulation of rat hepatocyte protein kinase C ? isoenzymes by the lipid peroxidation product 4-hydroxy-2,3-nonenal: A signaling pathway to modulate vesicular transport of glycoproteins

scientific article published on 01 May 1999

Report from the Second International Conference of Traditional and Complementary Medicine on Health 2015

scientific article published on 16 January 2016

Resveratrol Contrasts IL-6 Pro-Growth Effects and Promotes Autophagy-Mediated Cancer Cell Dormancy in 3D Ovarian Cancer: Role of miR-1305 and of Its Target ARH-I

scientific article published on 25 April 2022

Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D.

scientific article published on 20 November 2006

Resveratrol inhibits IL-6-induced ovarian cancer cell migration through epigenetic up-regulation of autophagy

scientific article

Resveratrol interrupts the pro-invasive communication between cancer associated fibroblasts and cholangiocarcinoma cells

scientific article published on 23 May 2018

Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation.

scientific article published on 19 May 2017

Resveratrol reduces the invasive growth and promotes the acquisition of a long-lasting differentiated phenotype in human glioblastoma cells

scientific article published on 11 March 2011

Resveratrol-induced apoptosis depends on the lipid kinase activity of Vps34 and on the formation of autophagolysosomes

scientific article published on 28 November 2007

Role of monocytes in cryoglobulinemia-associated nephritis

scientific article published in May 1993

Serum and intracellular detection of cytokines in patients undergoing chronic hemodialysis

scientific article

Similarities and differences in the biogenesis, processing and lysosomal targeting between zebrafish and human pro-Cathepsin D: functional implications

scientific article

Single amino acid arginine deprivation triggers prosurvival autophagic response in ovarian carcinoma SKOV3

scientific article

Suppression of autophagy precipitates neuronal cell death following low doses of methamphetamine

scientific article

Suppression of the 'uncovering' of mannose-6-phosphate residues in lysosomal enzymes in the presence of NH4Cl

scientific article published on August 1990

Synthesis, maturation and extracellular release of procathepsin D as influenced by cell proliferation or transformation

scientific article published on December 1995

The Potential for Plant Derivatives against Acrylamide Neurotoxicity

scientific article

The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders.

scientific article published on 26 April 2016

The dilemma: does tissue expression of cathepsin D reflect tumor malignancy? The question: does the assay truly mirror cathepsin D mis-function in the tumor?

scientific article published on January 2010

The expression of prolactin and its cathepsin D-mediated cleavage in the bovine corpus luteum vary with the estrous cycle

scientific article published on 04 September 2007

The fine tuning of metabolism, autophagy and differentiation during in vitro myogenesis.

scientific article

The lysosomal protease cathepsin D is efficiently sorted to and secreted from regulated secretory compartments in the rat basophilic/mast cell line RBL.

scientific article published on September 2000

The metabolic cross-talk between epithelial cancer cells and stromal fibroblasts in ovarian cancer progression: Autophagy plays a role.

scientific article published on 19 September 2017

The protein restriction mimetic Resveratrol is an autophagy inducer stronger than amino acid starvation in ovarian cancer cells

scientific article published on 30 August 2017

The role of autophagy on the survival of dopamine neurons

scientific article published on January 2009

The second annual conference of International ovarian cancer consortium and the symposium on tumor microenvironment and therapeutic resistance.

scientific article

Thyroid incidentaloma identified by ¹⁸F-fluorodeoxyglucose positron emission tomography with CT (FDG-PET/CT): clinical and pathological relevance.

scientific article published in October 2011

Transcriptomic analysis of the autophagy machinery in crustaceans

scientific article

Transformation by oncogenic ras-p21 alters the processing and subcellular localization of the lysosomal protease cathepsin D.

scientific article published on June 1999

Turmeric toxicity in A431 epidermoid cancer cells associates with autophagy degradation of anti-apoptotic and anti-autophagic p53 mutant.

scientific article

Will Omics Biotechnologies Save Us from Future Pandemics? Lessons from COVID-19 for Vaccinomics and Adversomics

scientific article published in 2022

cFLIP expression correlates with tumour progression and patient outcome in non-Hodgkin lymphomas of low grade of malignancy

scientific article published on 01 March 2006

List of works by Ciro Isidoro

A fast and simple method for simultaneous mixed site-specific mutagenesis of a wide coding sequence

A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29.

Agonist monoclonal antibodies against HGF receptor protect cardiac muscle cells from apoptosis.

Akt induces apoptosis in neuroblastoma cells expressing a C98X vasopressin mutant following autophagy suppression.

Altered intracellular processing and enhanced secretion of procathepsin D in a highly deviated rat hepatoma

Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium

Autophagy and thyroid carcinogenesis: genetic and epigenetic links

Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells

Autophagy is a prosurvival mechanism in cells expressing an autosomal dominant familial neurohypophyseal diabetes insipidus mutant vasopressin transgene.

Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas

Autophagy-dependent cell survival and cell death in an autosomal dominant familial neurohypophyseal diabetes insipidus in vitro model.

Autophagy-dependent toxicity of amino-functionalized nanoparticles in ovarian cancer cells

Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome.

Biocompatibility, endocytosis, and intracellular trafficking of mesoporous silica and polystyrene nanoparticles in ovarian cancer cells: effects of size and surface charge groups

Brefeldin A prevents uncovering but not phosphorylation of the recognition marker in cathepsin D

Butyrate Inhibits Colorectal Cancer Cell Proliferation through Autophagy Degradation of β-Catenin Regardless of <i>APC</i> and β-Catenin Mutational Status

Cathepsin D-Bax death pathway in oxidative stressed neuroblastoma cells

Cell-free Lactiplantibacillus plantarum OC01 supernatant suppresses IL-6-induced proliferation and invasion of human colorectal cancer cells: Effect on β-Catenin degradation and induction of autophagy

Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation

Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets

Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression.

Comparative studies on protein turnover regulations in tumor cells and host tissues: development and analysis of an experimental model

Coordinated Metabolic Changes and Modulation of Autophagy during Myogenesis

DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity

Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated with Estrogen Receptor-Negative Subtypes and Poor Prognosis.

Defective autophagy in Parkinson's disease: role of oxidative stress.

Destination 'lysosome': a target organelle for tumour cell killing?

Determination of the phosphorylation, uncovering of mannose 6-phosphate groups and targeting of lysosomal enzymes

Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells

Differential segregation of human and hamster cathepsin D in transfected baby-hamster kidney cells

Differential targeting and processing of procathepsin D in normal and transformed murine 3T3 fibroblasts.

Differentiation-dependent autophagy controls the fate of newly synthesized N-linked glycoproteins in the colon adenocarcinoma HT-29 cell line.

Differentiation-induced changes in the content, secretion, and subcellular distribution of lysosomal cathepsins in the human colon cancer HT-29 cell line

Dihydroartemisinin induces apoptosis and autophagy-dependent cell death in cholangiocarcinoma through a DAPK1-BECLIN1 pathway

Dopamine exacerbates mutant Huntingtin toxicity via oxidative-mediated inhibition of autophagy in SH-SY5Y neuroblastoma cells: Beneficial effects of anti-oxidant therapeutics

Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments

Effects of calcitriol on the biogenesis of a lysosomal protease in monocytes from patients with renal failure

Endosomal-lysosomal proteolysis mediates death signalling by TNFalpha, not by etoposide, in L929 fibrosarcoma cells: evidence for an active role of cathepsin D.

Epigenetic control of autophagy by microRNAs in ovarian cancer

Exposed Thiols Confer Localization in the Endoplasmic Reticulum by Retention Rather than Retrieval

Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer

Expression and posttranslational fate of cathepsin D in HT-29 tumor cells depend on their enterocytic differentiation state.

Expression of protein kinase C beta1 confers resistance to TNFalpha- and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells

Folding, activity and targeting of mutated human cathepsin D that cannot be processed into the double-chain form

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

High Expression of the Lysosomal Protease Cathepsin D Confers Better Prognosis in Neuroblastoma Patients by Contrasting EGF-Induced Neuroblastoma Cell Growth

High expression of cathepsin D in non-Hodgkin's lymphomas negatively impacts on clinical outcome.

High levels of proteolytic enzymes in the ascitic fluid and plasma of rats bearing the Yoshida AH-130 hepatoma

High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells

Human and hamster procathepsin D, although equally tagged with mannose-6-phosphate, are differentially targeted to lysosomes in transfected BHK cells

Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells

Induced autophagy reduces virus output in dengue infected monocytic cells

Induction of mRNA for tumor necrosis factor alpha in hemodialysis

Inhibition of PI3k class III-dependent autophagy prevents apoptosis and necrosis by oxidative stress in dopaminergic neuroblastoma cells.

Involvement of autophagy in ovarian cancer: a working hypothesis

Kinetics and fate of IgA-IgG aggregates as a model of naturally occurring immune complexes in IgA nephropathy

Knockdown of cathepsin D in zebrafish fertilized eggs determines congenital myopathy.

Labeling and exocytosis of secretory compartments in RBL mastocytes by polystyrene and mesoporous silica nanoparticles

Lithium delays progression of amyotrophic lateral sclerosis

Localization and Processing of Glycosylphosphatidylinositol-Anchored Cathepsin D

Loss of expression of the oncosuppressor PTEN in thyroid incidentalomas associates with GLUT1 plasmamembrane expression.

Lysophosphatidic Acid Induces Metabolic Reprogramming in Ovarian Cancer via a Pseudohypoxic Response

Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas

Lysosomal segregation of a mannose-rich glycoprotein imparted by the prosequence of myeloperoxidase

Mis-sorting of procathepsin D in metastogenic tumor cells is not due to impaired synthesis of the phosphomannosyl signal

NaGdF4Nanoparticles Coated with Functionalised Ethylenediaminetetraacetic Acid as Versatile Probes for Dual Optical and Magnetic Resonance Imaging

On a case of "Macrodystrophia lipomatosa"

Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts

Ovarian mitochondrial dynamics and cell fate regulation in an androgen-induced rat model of polycystic ovarian syndrome

PI3K-dependent lysosome exocytosis in nitric oxide-preconditioned hepatocytes

PTEN deficiency and mutant p53 confer glucose-addiction to thyroid cancer cells: impact of glucose depletion on cell proliferation, cell survival, autophagy and cell migration.

PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells

PTEN regulates plasma membrane expression of glucose transporter 1 and glucose uptake in thyroid cancer cells.

Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection.

Photoactive hybrid nanomaterials: indocyanine immobilized in mesoporous MCM-41 for "in-cell" bioimaging