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List of works by Robert B. Clarke

17β-estradiol regulates giant vesicle formation via estrogen receptor-alpha in human breast cancer cells

scientific article

A Role for Notch Signalling in Breast Cancer and Endocrine Resistance

scientific article

A detailed mammosphere assay protocol for the quantification of breast stem cell activity.

scientific article published on 05 June 2012

A differential role for CXCR4 in the regulation of normal versus malignant breast stem cell activity.

scientific article published on February 2014

Aberrant activation of notch signaling in human breast cancer

scientific article published on February 2006

Acquired resistance of ER- positive breast cancer to endocrine treatment confers an adaptive sensitivity to TRAIL through post-translational downregulation of c-FLIP.

scientific article published on 23 January 2018

Activated c-SRC in ductal carcinoma in situ correlates with high tumour grade, high proliferation and HER2 positivity

scientific article published on 24 October 2006

An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiation

scientific article published on 22 November 2015

Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity

scientific article

Biomarkers of dietary energy restriction in women at increased risk of breast cancer.

scientific article

Breast cancer stem cells and their role in resistance to endocrine therapy

scientific article published on April 2011

Breast cancer stem cells: something out of notching?

scientific article

Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling.

scientific article published on 20 April 2016

Combined inhibition of ErbB1/2 and Notch receptors effectively targets breast ductal carcinoma in situ (DCIS) stem/progenitor cell activity regardless of ErbB2 status

scientific article

Combining Notch inhibition with current therapies for breast cancer treatment

scientific article published on January 2013

Complementary yet distinct roles for oestrogen receptor-alpha and oestrogen receptor-beta in mouse mammary epithelial proliferation

scientific article

Complexity galore: 3D cultures, biomechanics and systems medicine at the eighth ENBDC workshop "Methods in Mammary Gland Development and Cancer".

scientific article published on 25 November 2016

Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy

scientific article published on September 2010

Contrasting hypoxic effects on breast cancer stem cell hierarchy is dependent on ER-α status

scientific article published on 17 December 2012

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

scientific article published on October 2013

Cyclin-dependent kinase inhibitors and basement membrane interact to regulate breast epithelial cell differentiation and acinar morphogenesis.

scientific article

Development of clinically relevant in vivo metastasis models using human bone discs and breast cancer patient-derived xenografts

scientific article published on 29 November 2019

Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: an experimentally supported mathematical model

scientific article

Disruption of a Quorum Sensing mechanism triggers tumorigenesis: a simple discrete model corroborated by experiments in mammary cancer stem cells

scientific article published on 20 April 2010

Dissecting tumor metabolic heterogeneity: Telomerase and large cell size metabolically define a sub-population of stem-like, mitochondrial-rich, cancer cells

scientific article

Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy

scientific article

Effect of a farnesyl transferase inhibitor (R115777) on ductal carcinoma in situ of the breast in a human xenograft model and on breast and ovarian cancer cell growth in vitro and in vivo.

scientific article

Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue

scientific article published in June 2006

Effects of oestrogens and anti-oestrogens on normal breast tissue from women bearing BRCA1 and BRCA2 mutations.

scientific article published on April 2006

Effects of short-term antiestrogen treatment of primary breast cancer on estrogen receptor mRNA and protein expression and on estrogen-regulated genes

article

Enrichment of human osteosarcoma stem cells based on hTERT transcriptional activity

scientific article published on December 2013

Epithelial stem cells in the mammary gland: casting light into dark corners

scientific article

Erratum to: Patient-Derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis.

scientific article published on 4 November 2016

Estrogen sensitivity of normal human breast tissue in vivo and implanted into athymic nude mice: analysis of the relationship between estrogen-induced proliferation and progesterone receptor expression

scientific article published on September 1997

Estrogenicity of essential oils is not required to relieve symptoms of urogenital atrophy in breast cancer survivors.

scientific article published on 2 April 2018

Ethnicity influences breast cancer stem cells' drug resistance

scientific article published on 2 March 2018

FAK inhibition alone or in combination with adjuvant therapies reduces cancer stem cell activity

scientific article published on 28 May 2021

FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4

scientific article published on 11 April 2019

Focal adhesion kinase and Wnt signaling regulate human ductal carcinoma in situ stem cell activity and response to radiotherapy

scientific article published on February 2015

G Protein-Coupled Receptors at the Crossroad between Physiologic and Pathologic Angiogenesis: Old Paradigms and Emerging Concepts

scientific article published on 14 December 2017

GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment

scientific article published on 6 December 2017

High-throughput genomic technology in research and clinical management of breast cancer. Exploiting the potential of gene expression profiling: is it ready for the clinic?

scientific article published on January 2006

Hormones and cancer: update from Tokyo 2010

scientific article published on 01 January 2011

Human breast cell proliferation and its relationship to steroid receptor expression.

scientific article published in June 2004

Human breast epithelial stem cells and their regulation.

scientific article

Identification of a putative intestinal stem cell and early lineage marker; musashi-1.

scientific article

Induction of apoptosis by tamoxifen and ICI 182780 in primary breast cancer

scientific article published on 01 August 1997

Intermittent energy restriction induces changes in breast gene expression and systemic metabolism

scientific article published on 28 May 2016

Interrogating open issues in cancer precision medicine with patient-derived xenografts.

scientific article published on 20 January 2017

Isolation and characterization of human mammary stem cells.

scientific article published in December 2005

It's all in the details: methods in breast development and cancer

scientific article published on 14 August 2009

Lack of caveolin-1 (P132L) somatic mutations in breast cancer

article

Lapatinib inhibits stem/progenitor proliferation in preclinical in vitro models of ductal carcinoma in situ (DCIS).

scientific article

Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity.

scientific article published on 27 October 2015

Mammary development, carcinomas and progesterone: role of Wnt signalling

scientific article published on 01 January 2007

Mammary stem cells and breast cancer--role of Notch signalling.

scientific article published on June 2007

Mechanisms of Disease: prediction and prevention of breast cancer--cellular and molecular interactions

scientific article

Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling

scientific article published on 01 November 2019

Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells

scientific article published on 12 January 2016

Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen

scientific article published on 03 March 2009

Novel cell culture technique for primary ductal carcinoma in situ: role of Notch and epidermal growth factor receptor signaling pathways

scientific article published on 01 April 2007

Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling.

scientific article published on 8 March 2013

Origins of breast cancer subtypes and therapeutic implications

scientific article published on September 2007

P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer.

scientific article

PAK4 regulates stemness and progression in endocrine resistant ER-positive metastatic breast cancer

article

Patient-derived Mammosphere and Xenograft Tumour Initiation Correlates with Progression to Metastasis

scientific article published on 28 September 2016

Patient-derived xenograft (PDX) models in basic and translational breast cancer research.

scientific article published on 27 December 2016

Patient-derived xenograft models: an emerging platform for translational cancer research

scientific article

Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells.

scientific article published on January 2013

Reduction in apoptosis relative to mitosis in histologically normal epithelium accompanies fibrocystic change and carcinoma of the premenopausal human breast

article

Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

scientific article

Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch

scientific article (publication date: 2006)

Resistance to endocrine therapy: are breast cancer stem cells the culprits?

scientific article published on 28 February 2009

Risk determination and prevention of breast cancer

scientific article

SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling.

scientific article published on 12 September 2016

Stem cells and tissue homeostasis in mammary glands

scientific article published on 01 January 2005

Stem cells in breast tumours: are they ready for the clinic?

scientific article published on 26 April 2012

Steroid receptors and cell cycle in normal mammary epithelium.

scientific article published on January 2004

Steroid receptors and proliferation in the human breast.

scientific article published on November 2003

TPD52 and NFKB1 gene expression levels correlate with G2 chromosomal radiosensitivity in lymphocytes of women with and at risk of hereditary breast cancer

scientific article

Tailored Functionalized Magnetic Nanoparticles to Target Breast Cancer Cells Including Cancer Stem-Like Cells

scientific article published on 29 May 2020

Targeting Endometrial Cancer Stem Cell Activity with Metformin Is Inhibited by Patient-Derived Adipocyte-Secreted Factors

scientific article published on 11 May 2019

Targeting IL-8 signalling to inhibit breast cancer stem cell activity

scientific article published on 14 September 2013

Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer

scientific article published on 30 May 2020

Targeting treatment-resistant breast cancer stem cells with FKBPL and its peptide derivative, AD-01, via the CD44 pathway

scientific article published on 5 June 2013

The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts

scientific article published on 12 September 2019

The Notch Pathway Promotes Osteosarcoma Progression through Activation of Ephrin Reverse Signaling

scientific article published on 30 September 2019

The Role of Steroid Hormones in Breast and Effects on Cancer Stem Cells.

scientific article published on 13 March 2018

The centrosomal kinase Nek2 displays elevated levels of protein expression in human breast cancer

scientific article

The embryonic transcription cofactor LBH is a direct target of the Wnt signaling pathway in epithelial development and in aggressive basal subtype breast cancers

scientific article

The mammary gland "side population": a putative stem/progenitor cell marker?

scientific article

The origin of estrogen receptor alpha-positive and alpha-negative breast cancer

scientific article published on January 2008

The role of steroid hormones in breast cancer stem cells

scientific article

The seventh ENBDC workshop on methods in mammary gland development and cancer

scientific article

Tissue Factor promotes breast cancer stem cell activity in vitro.

scientific article

Tumour-promoting activity of altered WWP1 expression in breast cancer and its utility as a prognostic indicator

scientific article published on 01 September 2008

Wnt pathway activity in breast cancer sub-types and stem-like cells

scientific article

p27KIP1 phosphorylation by PKB/Akt leads to poor breast cancer prognosis

scientific article

‘The charmingest place’: non-coding RNA, lineage tracing, tumor heterogeneity, metastasis and metabolism--new methods in mammary gland development and cancer: the fifth ENBDC Workshop

scientific article published on January 2013

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