List of works - Valentín Ceña

Acetaminophen induces apoptosis in rat cortical neurons

scientific article

Acetaminophen induces human neuroblastoma cell death through NFKB activation

scientific article

Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line.

scientific article published on 22 January 2007

Acetylcholinesterase activation in organotypic rat hippocampal slice cultures deprived of oxygen and glucose.

scientific article published in September 2003

Acetylcholinesterase activity and molecular isoform distribution are altered after focal cerebral ischemia

scientific article published in October 2003

Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission.

scientific article published in January 2007

Adrenal medulla calcium channel population is not conserved in bovine chromaffin cells in culture.

scientific article published in January 2004

Aliskiren prevents the toxic effects of peritoneal dialysis fluids during chronic dialysis in rats

scientific article (publication date: 2012)

Aminophosphine ligands as a privileged platform for development of antitumoral ruthenium(ii) arene complexes

scientific article published on 10 November 2017

An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors

scientific article published in April 2001

Assessment of doxorubicin delivery devices based on tailored bare polycaprolactone against glioblastoma

scientific article published on 09 January 2019

Atorvastatin reduces high glucose toxicity in rat peritoneal mesothelial cells

scientific article published on 28 February 2011

Axoplasmic transport of [3H]ouabain binding sites and catecholamine secretion from an adrenergic nerve trunk.

scientific article published in July 1992

Barriers to non-viral vector-mediated gene delivery in the nervous system

scientific article published on 12 January 2011

Bcl-x L blocks mitochondrial multiple conductance channel activation and inhibits 6-OHDA-induced death in SH-SY5Y cells

scientific article published on April 2004

Bcl-x(L) blocks a mitochondrial inner membrane channel and prevents Ca2+ overload-mediated cell death

scientific article

Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression

scientific article

Cardiac glycosides stimulate phospholipase C activity in rat pinealocytes

scientific article published on 01 February 1987

Catecholamine secretion induced by tetraethylammonium from cultured bovine adrenal chromaffin cells

scientific article published on 01 May 1993

Catecholamine secretion, calcium levels and calcium influx in response to membrane depolarization in bovine chromaffin cells

scientific article published on 01 September 1995

Characteristics of receptor-operated and membrane potential-dependent ATP secretion from adrenal medullary chromaffin cells

scientific article published on January 1990

Characterization of the alpha +-like Na+,K+-ATPase which mediates ouabain inhibition of adrenergic induction of N-acetyltransferase (EC 2.3.1.87) activity: studies with isolated pinealocytes

scientific article

Cholinergic modulation of status epilepticus in the rat barrel field region of primary somatosensory cortex

scientific article published on 16 August 2005

Chromaffin cell death induced by 6-hydroxydopamine is independent of mitochondrial swelling and caspase activation.

scientific article published in March 2003

Chromostatin receptors control calcium channel activity in adrenal chromaffin cells

scientific article published on 01 January 1992

Click Synthesis of Size- and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery

scientific article published on 21 October 2020

Cofilin activation mediates Bax translocation to mitochondria during excitotoxic neuronal death

scientific journal article

Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis

scientific article published on 06 December 2020

D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-Induced arc and zif268 expression in the hippocampus

scientific article published on 29 March 2007

Dendrimer- and polymeric nanoparticle-aptamer bioconjugates as nonviral delivery systems: a new approach in medicine

scientific article published on 10 April 2020

Dendrimer-mediated siRNA delivery knocks down Beclin 1 and potentiates NMDA-mediated toxicity in rat cortical neurons.

scientific article

Dendrimers as vectors for genetic material delivery to the nervous system

scientific article published on January 2012

Developmental study of ouabain inhibition of adrenergic induction of rat pineal serotonin N-acetyltransferase (EC 2.3.1.87).

scientific article

Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine

scientific article

Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells

scientific article published on 8 May 2017

Effect of the dihydropyridine Bay K 8644 on the release of [3H]-noradrenaline from the rat isolated vas deferens

scientific article

Effects of calcium and Bay K-8644 on calcium currents in adrenal medullary chromaffin cells

scientific article published on 01 December 1989

Effects of the cardiotonic drug ARL-115 on the release of noradrenaline from the cat atrium, the binding of 3H-ouabain to plasma membranes and the movements of calcium in mitochondria

scientific article published on 01 September 1982

Efficient, non-toxic hybrid PPV-PAMAM dendrimer as a gene carrier for neuronal cells

scientific article published on 10 March 2011

Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell

scientific article published on 17 April 2020

Enhanced docetaxel-mediated cytotoxicity in human prostate cancer cells through knockdown of cofilin-1 by carbon nanohorn delivered siRNA.

scientific article

Evaluation of Amino-Functional Polyester Dendrimers Based on Bis-MPA as Nonviral Vectors for siRNA Delivery

scientific article published on 14 August 2018

Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1)

scientific article published on 18 March 2019

Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: Key factor analysis (Part 2)

scientific article published on 21 March 2019

Extracellular calcium has distinct effects on fast and slow components of the depolarization-induced secretory response from chromaffin cells.

scientific article published in September 1996

G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel

scientific article published on 13 November 2006

Gas1 is induced during and participates in excitotoxic neuronal death

scientific article (publication date: March 2002)

Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway.

scientific article published on 20 November 2003

Glitazones differentially regulate primary astrocyte and glioma cell survival. Involvement of reactive oxygen species and peroxisome proliferator-activated receptor-gamma.

scientific article published on 29 December 2003

Glutamate N-methyl-D-aspartate receptor blockade prevents induction of GAP-43 after focal ischemia in rats

scientific article published in June 2001

Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons.

scientific article

Highly efficient transfection of rat cortical neurons using carbosilane dendrimers unveils a neuroprotective role for HIF-1alpha in early chemical hypoxia-mediated neurotoxicity

scientific article

Hydroxyindole O-methyltransferase

scientific article published in January 1987

In vivo therapeutic applications of phosphorus dendrimers: state of the art

scientific article published on 04 December 2020

Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome.

scientific article

Inhibition of adrenomedullary catecholamine release by propranolol isomers and clonidine involving mechanisms unrelated to adrenoceptors.

scientific article published on December 1987

Inhibition of p42 MAPK using a nonviral vector-delivered siRNA potentiates the anti-tumor effect of metformin in prostate cancer cells.

scientific article published on 13 October 2011

Inhibition of the canonical Wnt pathway by high glucose can be reversed by parathyroid hormone-related protein in osteoblastic cells

scientific article published on August 2013

Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria

scientific article

Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions

scientific article published on January 2005

Ion dependence of the release of noradrenaline by tetraethylammonium and 4-aminopyridine from cat splenic slices

scientific article published on February 1985

Kinetic characteristics of calcium-dependent, cholinergic receptor controlled ATP secretion from adrenal medullary chromaffin cells

scientific article published in April 1990

Knocking down HMGB1 using dendrimer-delivered siRNA unveils its key role in NMDA-induced autophagy in rat cortical neurons

scientific journal article

Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment

scientific article

Mechanisms of action of Methylthioadenosine: pathways implicated in neuroprotection in models of Multiple Sclerosis and other neurological diseases.

scientific article published on 25 November 2010

Mitochondrial control of neuron death and its role in neurodegenerative disorders.

scientific article published on June 2003

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

scientific article published on January 2003

Molecular bases of neuroprotection in brain ischemia

scientific article published on 01 January 1997

Molecular cloning and permanent expression in a neuroblastoma cell line of a fast inactivating potassium channel from bovine adrenal medulla.

scientific article published in August 1992

Molecular determinants for cyclo-oligosaccharide-based nanoparticle-mediated effective siRNA transfection.

scientific article

Naloxone inhibits nicotine-induced receptor current and catecholamine secretion in bovine chromaffin cells

scientific article

Nanoparticle crossing of blood-brain barrier: a road to new therapeutic approaches to central nervous system diseases

scientific article published on 12 July 2018

Nanoparticles for brain-specific drug and genetic material delivery, imaging and diagnosis

scientific article

Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo.

scientific article published on 28 August 2017

Nicotinic receptors in neurodegeneration

scientific article published on May 2013

Nonviral vectors for the delivery of small interfering RNAs to the CNS.

scientific article published on October 2010

Norepinephrine stimulates potassium efflux from pinealocytes: evidence for involvement of biochemical "AND" gate operated by calcium and adenosine 3',5'-monophosphate.

scientific article

Orthograde and retrograde axonal transport of calmodulin in a cat noradrenergic neurone.

scientific article

Ouabain induces acetylcholine release from pure cholinergic synaptosomes independently of extracellular calcium concentration

scientific article published in November 1988

Peptides, proteins and nanotechnology: A promising synergy for breast cancer targeting and treatment

scientific article published on 22 August 2020

Pertussis toxin stimulation of catecholamine release from adrenal medullary chromaffin cells: mechanism may be by direct activation of L-type and G-type calcium channels

scientific article

Pharmacological dissection of receptor-associated and voltage-sensitive ionic channels involved in catecholamine release

scientific article published in December 1983

Pharmacological targets in neurodegenerative diseases

scientific article

Potential advancements in the treatment of difficult-to-treat glioblastoma through nanoparticle drug delivery

scientific article published on 13 August 2020

Presence and axonal transport of cholinoceptor, but not adrenoceptor sites on a cat noradrenergic neurone

scientific article published on December 1982

Presence of a noradrenaline uptake system on a ligated cat sympathetic nerve

scientific article published in March 1986

Reactive oxygen species induce swelling and cytochrome c release but not transmembrane depolarization in isolated rat brain mitochondria

scientific article published in June 2003

Release of noradrenaline from the ligated cat hypogastric nerve

scientific article published on 01 January 1980

Retinal S-antigen: immunocytochemical and immunochemical studies on distribution in animal photoreceptors and pineal organs

scientific article published in January 1986

Role and regulation of p53 in depolarization-induced neuronal death.

scientific article published in January 2003

Role of generation, architecture, pH and ionic strength on successful siRNA delivery and transfection by hybrid PPV-PAMAM dendrimers

scientific article

Second Generation Amphiphilic Poly-Lysine Dendrons Inhibit Glioblastoma Cell Proliferation without Toxicity for Neurons or Astrocytes

scientific article

Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells

scientific article published on September 2000

Stressor-related impairment of synaptic transmission in hippocampal slices from alpha-synuclein knockout mice

scientific journal article

Superoxide anions mediate veratridine-induced cytochrome c release and caspase activity in bovine chromaffin cells

scientific article published on December 2002

Synthesis, characterization, DNA interactions and antiproliferative activity on glioblastoma of iminopyridine platinum(II) chelate complexes.

scientific article

The Delivery Challenge in Neurodegenerative Disorders: The Nanoparticles Role in Alzheimer's Disease Therapeutics and Diagnostics

scientific article published on 17 October 2018

The endoplasmic reticulum stress and the HIF-1 signalling pathways are involved in the neuronal damage caused by chemical hypoxia.

scientific article published on 24 March 2015

The use of nanoparticles for gene therapy in the nervous system

scientific article published on January 2012

Tricyclic antidepressants block cholinergic nicotinic receptors and ATP secretion in bovine chromaffin cells

scientific article published on 01 November 1997

Unbinding forces and energies between a siRNA molecule and a dendrimer measured by force spectroscopy

scientific article published on 18 November 2015

Uptake of [3H]-nicotine and [3H]-noradrenaline by cultured chromaffin cells

scientific article published on January 1984

Use of nanoparticles for glioblastoma treatment: a new approach

scientific article published on 27 September 2017

Veratridine induces apoptotic death in bovine chromaffin cells through superoxide production

scientific article published on August 2000

[Cysteine proteinase and neurodegeneration]

scientific article published on 01 August 2000

[The role of the mitochondrial permeability transition pore in neurodegenerative processes]

scientific article published in August 2002

[The serine proteases and their function in neuronal death processes]

scientific article published in March 2004

omega-Agatoxin IVA blocks nicotinic receptor channels in bovine chromaffin cells

scientific article published on 01 March 1995

omega-Conotoxin GVIA blocks nicotine-induced catecholamine secretion by blocking the nicotinic receptor-activated inward currents in bovine chromaffin cells

scientific article published on 01 May 1995

List of works by Valentín Ceña

Acetaminophen induces apoptosis in rat cortical neurons

Acetaminophen induces human neuroblastoma cell death through NFKB activation

Acetaminophen potentiates staurosporine-induced death in a human neuroblastoma cell line.

Acetylcholinesterase activation in organotypic rat hippocampal slice cultures deprived of oxygen and glucose.

Acetylcholinesterase activity and molecular isoform distribution are altered after focal cerebral ischemia

Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission.

Adrenal medulla calcium channel population is not conserved in bovine chromaffin cells in culture.

Aliskiren prevents the toxic effects of peritoneal dialysis fluids during chronic dialysis in rats

Aminophosphine ligands as a privileged platform for development of antitumoral ruthenium(ii) arene complexes

An activity-dependent switch from facilitation to inhibition in the control of excitotoxicity by group I metabotropic glutamate receptors

Assessment of doxorubicin delivery devices based on tailored bare polycaprolactone against glioblastoma

Atorvastatin reduces high glucose toxicity in rat peritoneal mesothelial cells

Axoplasmic transport of [3H]ouabain binding sites and catecholamine secretion from an adrenergic nerve trunk.

Barriers to non-viral vector-mediated gene delivery in the nervous system

Bcl-x L blocks mitochondrial multiple conductance channel activation and inhibits 6-OHDA-induced death in SH-SY5Y cells

Bcl-x(L) blocks a mitochondrial inner membrane channel and prevents Ca2+ overload-mediated cell death

Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseCgamma activity and glutamate receptor expression

Cardiac glycosides stimulate phospholipase C activity in rat pinealocytes

Catecholamine secretion induced by tetraethylammonium from cultured bovine adrenal chromaffin cells

Catecholamine secretion, calcium levels and calcium influx in response to membrane depolarization in bovine chromaffin cells

Characteristics of receptor-operated and membrane potential-dependent ATP secretion from adrenal medullary chromaffin cells

Characterization of the alpha +-like Na+,K+-ATPase which mediates ouabain inhibition of adrenergic induction of N-acetyltransferase (EC 2.3.1.87) activity: studies with isolated pinealocytes

Cholinergic modulation of status epilepticus in the rat barrel field region of primary somatosensory cortex

Chromaffin cell death induced by 6-hydroxydopamine is independent of mitochondrial swelling and caspase activation.

Chromostatin receptors control calcium channel activity in adrenal chromaffin cells

Click Synthesis of Size- and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery

Cofilin activation mediates Bax translocation to mitochondria during excitotoxic neuronal death

Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis

D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-Induced arc and zif268 expression in the hippocampus

Dendrimer- and polymeric nanoparticle-aptamer bioconjugates as nonviral delivery systems: a new approach in medicine

Dendrimer-mediated siRNA delivery knocks down Beclin 1 and potentiates NMDA-mediated toxicity in rat cortical neurons.

Dendrimers as vectors for genetic material delivery to the nervous system

Developmental study of ouabain inhibition of adrenergic induction of rat pineal serotonin N-acetyltransferase (EC 2.3.1.87).

Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine

Docetaxel-Loaded Nanoparticles Assembled from β-Cyclodextrin/Calixarene Giant Surfactants: Physicochemical Properties and Cytotoxic Effect in Prostate Cancer and Glioblastoma Cells

Effect of the dihydropyridine Bay K 8644 on the release of [3H]-noradrenaline from the rat isolated vas deferens

Effects of calcium and Bay K-8644 on calcium currents in adrenal medullary chromaffin cells

Effects of the cardiotonic drug ARL-115 on the release of noradrenaline from the cat atrium, the binding of 3H-ouabain to plasma membranes and the movements of calcium in mitochondria

Efficient, non-toxic hybrid PPV-PAMAM dendrimer as a gene carrier for neuronal cells

Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell

Enhanced docetaxel-mediated cytotoxicity in human prostate cancer cells through knockdown of cofilin-1 by carbon nanohorn delivered siRNA.

Evaluation of Amino-Functional Polyester Dendrimers Based on Bis-MPA as Nonviral Vectors for siRNA Delivery

Exploration of biomedical dendrimer space based on in-vitro physicochemical parameters: key factor analysis (Part 1)

Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: Key factor analysis (Part 2)

Extracellular calcium has distinct effects on fast and slow components of the depolarization-induced secretory response from chromaffin cells.

G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel

Gas1 is induced during and participates in excitotoxic neuronal death

Glial cell line-derived neurotrophic factor increases intracellular calcium concentration. Role of calcium/calmodulin in the activation of the phosphatidylinositol 3-kinase pathway.

Glitazones differentially regulate primary astrocyte and glioma cell survival. Involvement of reactive oxygen species and peroxisome proliferator-activated receptor-gamma.

Glutamate N-methyl-D-aspartate receptor blockade prevents induction of GAP-43 after focal ischemia in rats

Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons.

Highly efficient transfection of rat cortical neurons using carbosilane dendrimers unveils a neuroprotective role for HIF-1alpha in early chemical hypoxia-mediated neurotoxicity

Hydroxyindole O-methyltransferase

In vivo therapeutic applications of phosphorus dendrimers: state of the art

Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome.

Inhibition of adrenomedullary catecholamine release by propranolol isomers and clonidine involving mechanisms unrelated to adrenoceptors.

Inhibition of p42 MAPK using a nonviral vector-delivered siRNA potentiates the anti-tumor effect of metformin in prostate cancer cells.

Inhibition of the canonical Wnt pathway by high glucose can be reversed by parathyroid hormone-related protein in osteoblastic cells

Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria

Involvement of mitochondrial potential and calcium buffering capacity in minocycline cytoprotective actions

Ion dependence of the release of noradrenaline by tetraethylammonium and 4-aminopyridine from cat splenic slices

Kinetic characteristics of calcium-dependent, cholinergic receptor controlled ATP secretion from adrenal medullary chromaffin cells

Knocking down HMGB1 using dendrimer-delivered siRNA unveils its key role in NMDA-induced autophagy in rat cortical neurons

Lifeguard/neuronal membrane protein 35 regulates Fas ligand-mediated apoptosis in neurons via microdomain recruitment

Mechanisms of action of Methylthioadenosine: pathways implicated in neuroprotection in models of Multiple Sclerosis and other neurological diseases.

Mitochondrial control of neuron death and its role in neurodegenerative disorders.

Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1.

Molecular bases of neuroprotection in brain ischemia

Molecular cloning and permanent expression in a neuroblastoma cell line of a fast inactivating potassium channel from bovine adrenal medulla.

Molecular determinants for cyclo-oligosaccharide-based nanoparticle-mediated effective siRNA transfection.

Naloxone inhibits nicotine-induced receptor current and catecholamine secretion in bovine chromaffin cells

Nanoparticle crossing of blood-brain barrier: a road to new therapeutic approaches to central nervous system diseases

Nanoparticles for brain-specific drug and genetic material delivery, imaging and diagnosis

Neutral high-generation phosphorus dendrimers inhibit macrophage-mediated inflammatory response in vitro and in vivo.

Nicotinic receptors in neurodegeneration

Nonviral vectors for the delivery of small interfering RNAs to the CNS.

Norepinephrine stimulates potassium efflux from pinealocytes: evidence for involvement of biochemical "AND" gate operated by calcium and adenosine 3',5'-monophosphate.