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List of works by Anette Müllertz

A New Approach to Dissolution Testing by UV Imaging and Finite Element Simulations ⬇️

scientific article published on January 11, 2013

A comparison of the solubility of danazol in human and simulated gastrointestinal fluids

scientific article published on 01 July 2000

A dynamic in vitro lipolysis model

article

A dynamic in vitro lipolysis model. II: Evaluation of the model

scientific article

A fast and novel internal calibration method for quantitative Raman measurements on aqueous solutions

scholarly article by S. Duraipandian et al published 2018 in Analytical Methods

A novel excipient, 1-perfluorohexyloctane shows limited utility for the oral delivery of poorly water-soluble drugs

scientific article published on 21 January 2011

A slow cooling rate of indomethacin melt spatially confined in microcontainers increases the physical stability of the amorphous drug without influencing its biorelevant dissolution behaviour

article published in 2014

Absorption of triglycerides with defined or random structure by rats with biliary and pancreatic diversion

scientific article published on 01 June 1995

Adsorption of pharmaceutical excipients onto microcrystals of siramesine hydrochloride: effects on physicochemical properties

scientific article published on 24 June 2008

Amorphous is not always better—A dissolution study on solid state forms of carbamazepine

An updated and simplified method for bile duct cannulation of rats

scientific article published on 24 August 2010

Analysis of 3D Prints by X-ray Computed Microtomography and Terahertz Pulsed Imaging

scientific article

Anhydrate to hydrate solid-state transformations of carbamazepine and nitrofurantoin in biorelevant media studied in situ using time-resolved synchrotron X-ray diffraction

scientific article published on 13 January 2016

Apomorphine and its esters: Differences in Caco-2 cell permeability and chylomicron affinity

scientific article published on 6 June 2016

Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and l-Arginine

scientific article published on 9 April 2018

Are phytosomes a superior nanodelivery system for the antioxidant rutin?

Azone® decreases the buccal mucosal permeation of diazepam in a concentration-dependent manner via a reservoir effect

scientific article published on 15 February 2014

Bile salts and their importance for drug absorption

scientific article published on 15 April 2013

Bioavailability of Cinnarizine in Dogs: Effect of SNEDDS Loading Level and Correlation with Cinnarizine Solubilization During In Vitro Lipolysis

Bioavailability of Seocalcitol IV: Evaluation of Lymphatic Transport in Conscious Rats

Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state

scientific article

Bioavailability of seocalcitol I: Relating solubility in biorelevant media with oral bioavailability in rats--effect of medium and long chain triglycerides

scientific article published in August 2005

Bioavailability of seocalcitol II: development and characterisation of self-microemulsifying drug delivery systems (SMEDDS) for oral administration containing medium and long chain triglycerides

scientific article

Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state

scientific article

Bioinspired Layer-by-Layer Microcapsules Based on Cellulose Nanofibers with Switchable Permeability.

scientific article

Biorelevant characterisation of amorphous furosemide salt exhibits conversion to a furosemide hydrate during dissolution

scientific article published on 16 September 2013

Biorelevant dissolution media: aggregation of amphiphiles and solubility of estradiol

scientific article published in February 2006

Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity

scientific article published in August 2010

Buccal absorption of diazepam is improved when administered in bioadhesive tablets-An in vivo study in conscious Göttingen mini-pigs

scientific article

Cellulose Nanopaper and Nanofoam for Patient-Tailored Drug Delivery

Characterising lipid lipolysis and its implication in lipid-based formulation development

scientific article

Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies

scientific article

Characterization and Physical Stability of Spray Dried Solid Dispersions of Probucol and PVP-K30

Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities

scientific article published on 31 May 2013

Characterization of prototype self-nanoemulsifying formulations of lipophilic compounds

scientific article

Characterization of the Hydrodynamics in a Miniaturized Dissolution Apparatus

scientific article published on 9 December 2017

Cinnarizine food-effects in beagle dogs can be avoided by administration in a Self Nano Emulsifying Drug Delivery System (SNEDDS).

scientific article published on 15 November 2013

Clinical studies with oral lipid based formulations of poorly soluble compounds

scientific article

Colloidal structures in media simulating intestinal fed state conditions with and without lipolysis products

scientific article

Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example

scientific article published on 2 July 2014

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

scientific article

Comparison of induction methods for supersaturation: pH shift versus solvent shift

scientific article published on 20 November 2019

Comparison of lipases for in vitro models of gastric digestion: lipolysis using two infant formulas as model substrates

scientific article

Comparison of the lymphatic transport of a lipophilic drug from vehicles containing alpha-tocopherol and/or triglycerides in rats

scientific article published in November 2001

Comparison of the lymphatic transport of halofantrine administered in disperse systems containing three different unsaturated fatty acids

scientific article published in September 2001

Comparison of total oral bioavailability and the lymphatic transport of halofantrine from three different unsaturated triglycerides in lymph-cannulated conscious rats

scientific article published in December 2001

Corrigendum to "Formulation and characterization of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine" [Int. J. Pharm. 502 (1-2) (2016) 151-160]

scholarly article published in International Journal of Pharmaceutics

Determination of surface-adsorbed excipients of various types on drug particles prepared by antisolvent precipitation using HPLC with evaporative light scattering detection

Development and characterization of clove oil nanoemulsions and self-microemulsifying drug delivery systems

article

Development of Self-Emulsifying Drug Delivery Systems (SEDDS) for Oral Bioavailability Enhancement of Poorly Soluble Drugs

article

Development of a Video-Microscopic Tool To Evaluate the Precipitation Kinetics of Poorly Water Soluble Drugs: A Case Study with Tadalafil and HPMC.

scientific article

Development of a high-throughput in vitro intestinal lipolysis model for rapid screening of lipid-based drug delivery systems

Development of a μDissolution-Permeation model with in situ drug concentration monitoring

Development of simulated intestinal fluids containing nutrients as transport media in the Caco-2 cell culture model: assessment of cell viability, monolayer integrity and transport of a poorly aqueous soluble drug and a substrate of efflux mechanism

scientific article published on 10 August 2007

Dissolution Model Development: Formulation Effects and Filter Complications

article

Dissolution enhancement of griseofulvin from griseofulvin-sodium dodecyl sulfate discs investigated by UV imaging

Dissolution of hydrocortisone in human and simulated intestinal fluids

scientific article

Dissolution of solid lipid extrudates in biorelevant media

Early pharmaceutical profiling to predict oral drug absorption: current status and unmet needs.

scientific article

Effect of bile on the oral absorption of halofantrine in polyethylene glycol 400 and polysorbate 80 formulations dosed to bile duct cannulated rats

Effect of composition of simulated intestinal media on the solubility of poorly soluble compounds investigated by design of experiments

scientific article published on 3 October 2017

Effect of different surfactants in biorelevant medium on the secretion of a lipophilic compound in lipoproteins using Caco-2 cell culture

scientific article published in January 2006

Effect of food intake and co-administration of placebo self-nanoemulsifying drug delivery systems on the absorption of cinnarizine in healthy human volunteers

scientific article published on 14 January 2016

Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug

scientific article published on 5 January 2005

Effects of polysorbate 80 on the in-vitro precipitation and oral bioavailability of halofantrine from polyethylene glycol 400 formulations in rats

scientific article published on January 2010

Efficacy of oral lipid-based formulations of apomorphine and its diester in a Parkinson's disease rat model

scientific article published on 16 June 2017

Elucidating Pathway and Anesthetic Mechanism of Action of Clove Oil Nanoformulations in Fish

scientific article published on 22 April 2022

Elucidating the Molecular Interactions Occurring during Drug Precipitation of Weak Bases from Lipid-Based Formulations: A Case Study with Cinnarizine and a Long Chain Self-Nanoemulsifying Drug Delivery System

scientific article published on 22 September 2015

Enzymatic characterization of lipid-based drug delivery systems

scientific article

Evaluating side-by-side diffusion models for studying drug supersaturation in an absorptive environment: a case example of fenofibrate and felodipine

scientific article published on 26 December 2019

Evaluation of self-emulsifying drug delivery systems for oral insulin delivery using an in vitro model simulating the intestinal proteolysis

scientific article published on 19 February 2020

Evaluation of the use of Göttingen minipigs to predict food effects on the oral absorption of drugs in humans

scientific article

Ex vivo correlation of the permeability of metoprolol across human and porcine buccal mucosa

scientific article published on 13 May 2014

Examination of oral absorption and lymphatic transport of halofantrine in a triple-cannulated canine model after administration in self-microemulsifying drug delivery systems (SMEDDS) containing structured triglycerides.

scientific article

Exploring the fate of liposomes in the intestine by dynamic in vitro lipolysis

Exploring the utility of the Chasing Principle: influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspension

scientific article published on 07 July 2018

Fat emulsions based on structured lipids (1,3-specific triglycerides): an investigation of the in vivo fate

scientific article published on 01 May 1996

Feasibility of capsule endoscopy for direct imaging of drug delivery systems in the fasted upper-gastrointestinal tract.

scientific article published on 19 February 2014

Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS.

scientific article published on 18 September 2013

Floating solid cellulose nanofibre nanofoams for sustained release of the poorly soluble model drug furosemide

scientific article published on 15 August 2017

Formulation and characterization of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine

Formulation of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine and Kolliphor® RH40 using experimental design

scientific article published on 13 October 2017

From concept to in vivo testing: Microcontainers for oral drug delivery

scientific article published on October 2017

High-Throughput Lipolysis in 96-Well Plates for Rapid Screening of Lipid-Based Drug Delivery Systems

scientific article published on 2 January 2017

Hydrolysed pea proteins mitigate in vitro wheat starch digestibility

Image Analytical Approach for Needle-Shaped Crystal Counting and Length Estimation

Impact of Lipid-Based Drug Delivery Systems on the Transport and Uptake of Insulin Across Caco-2 Cell Monolayers

Impact of sodium dodecyl sulphate on the dissolution of poorly soluble drug into biorelevant medium from drug-surfactant discs

scientific article published on 02 March 2014

Improving the drug load and in vitro performance of supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS) using polymeric precipitation inhibitors

scientific article published on 14 December 2019

In Vitro Model Simulating Gastro-Intestinal Digestion in the Pediatric Population (Neonates and Young Infants).

scientific article published on 28 October 2016

In Vitro, Ex Vivo and In Vivo Evaluation of Microcontainers for Oral Delivery of Insulin

scientific article published on 07 January 2020

In Vivo Precipitation of Poorly Soluble Drugs from Lipid-Based Drug Delivery Systems.

scientific article

In vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systems

In vitro and in vivo performance of monoacyl phospholipid-based self-emulsifying drug delivery systems.

scientific article

In vitro and in vivo performance of novel supersaturated self-nanoemulsifying drug delivery systems (super-SNEDDS)

article published in 2012

In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products.

scientific article published on 23 November 2012

In vitro lipolysis data does not adequately predict the in vivo performance of lipid-based drug delivery systems containing fenofibrate

scientific article

In vitro lipolysis models as a tool for the characterization of oral lipid and surfactant based drug delivery systems

scientific article published on 15 March 2011

In vitro models for the prediction of in vivo performance of oral dosage forms

scientific article published on 27 August 2013

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

scientific article published on 20 December 2018

In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks.

scientific article

In vivo anesthetic effect and mechanism of action of active compounds from Alpinia galanga oil on Cyprinus carpio (koi carp)

In vivo evaluation of lipid-based formulations for oral delivery of apomorphine and its diester prodrugs

scientific article published on 8 September 2016

In vivo in vitro correlations for a poorly soluble drug, danazol, using the flow-through dissolution method with biorelevant dissolution media

scientific article published on 6 January 2005

Increased concentration of plasminogen activator inhibitor type-1 in plasma after intake of fish oil

Influence of Lipid Composition and Drug Load on the In Vitro Performance of Self-Nanoemulsifying Drug Delivery Systems

article

Influence of bile on the absorption of halofantrine from lipid-based formulations

scientific article published on 20 March 2012

Influence of drug load and physical form of cinnarizine in new SNEDDS dosing regimens: in vivo and in vitro evaluations

Influence of the solid form of siramesine hydrochloride on its behavior in aqueous environments

scientific article

Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats

scientific article published in August 2004

Insights into intermediate phases of human intestinal fluids visualized by atomic force microscopy and cryo-transmission electron microscopy ex vivo

scientific article published on 27 December 2011

Insights into the Early Dissolution Events of Amlodipine Using UV Imaging and Raman Spectroscopy

scientific article published on 20 June 2011

Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs

scientific article

Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80.

scientific article published on 15 July 2008

Investigating the correlation between in vivo absorption and in vitro release of fenofibrate from lipid matrix particles in biorelevant medium

scientific article published on 14 October 2013

Investigation of Mucoadhesion and Degradation of PCL and PLGA Microcontainers for Oral Drug Delivery

scientific article published on 07 November 2019

Investigation of the Intra- and Interlaboratory Reproducibility of a Small Scale Standardized Supersaturation and Precipitation Method

scientific article

Kolliphor Surfactants Affect Solubilization and Bioavailability of Fenofibrate. Studies of in Vitro Digestion and Absorption in Rats

Lipid-based formulations for danazol containing a digestible surfactant, Labrafil M2125CS: in vivo bioavailability and dynamic in vitro lipolysis

scientific article published in July 2008

Lipid-based formulations for oral administration of poorly water-soluble drugs

scientific article published on 08 April 2013

Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media

Lymphatic fatty acids in canines dosed with pharmaceutical formulations containing structured triacylglycerols

Mapping the intermediate digestion phases of human healthy intestinal contents from distal ileum and caecum at fasted and fed state conditions

scientific article published on 20 January 2017

Meeting report: applied biopharmaceutics and quality by design for dissolution/release specification setting: product quality for patient benefit

scientific article

Metabolism of emulsions containing medium- and long-chain triglycerides or interesterified triglycerides

scientific article published on 01 October 1994

Microcontainers for oral insulin delivery - In vitro studies of permeation enhancement

scientific article published on 16 August 2019

Milk osteopontin retains integrin-binding activity after in vitro gastrointestinal transit

scientific article published on 14 November 2019

Miniaturized Approach for Excipient Selection During the Development of Oral Solid Dosage Form

article

Monoacyl phosphatidylcholine inhibits the formation of lipid multilamellar structures during in vitro lipolysis of self-emulsifying drug delivery systems

scientific article published on 23 November 2016

Morphological observations on a lipid-based drug delivery system during in vitro digestion

scientific article published on 23 February 2007

New perspectives on lipid and surfactant based drug delivery systems for oral delivery of poorly soluble drugs

scientific article

Optimization of self nanoemulsifying drug delivery system for poorly water-soluble drug using response surface methodology

scientific article published on 8 August 2012

Optimizing Clinical Drug Product Performance: Applying Biopharmaceutics Risk Assessment Roadmap (BioRAM) and the BioRAM Scoring Grid

scientific article published on 19 September 2016

Oral bioavailability of cinnarizine in dogs: relation to SNEDDS droplet size, drug solubility and in vitro precipitation.

scientific article

Oral biopharmaceutics tools - time for a new initiative - an introduction to the IMI project OrBiTo

scientific article

Oral delivery of peptides and proteins using lipid-based drug delivery systems

scientific article published on 17 August 2012

Phase transformations of amlodipine besylate solid forms

scientific article published on 22 February 2011

Polymer-filled microcontainers for oral delivery loaded using supercritical impregnation

scientific article published on 2 October 2013

Polymeric Lids for Microcontainers for Oral Protein Delivery

scientific article published on 02 April 2019

Polymeric microcontainers improve oral bioavailability of furosemide

Precipitation of a poorly soluble model drug during in vitro lipolysis: characterization and dissolution of the precipitate

scientific article published on December 2010

Preparation and characterization of insulin-surfactant complexes for loading into lipid-based drug delivery systems

scientific article published on 9 July 2013

Preparation of an amorphous sodium furosemide salt improves solubility and dissolution rate and leads to a faster Tmax after oral dosing to rats

scientific article published on 27 September 2013

Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption

scientific article

Real-time dissolution behavior of furosemide in biorelevant media as determined by UV imaging

scientific article

Rhamnogalacturonan-I Based Microcapsules for Targeted Drug Release

scientific article

SEDDS for intestinal absorption of insulin: Application of Caco-2 and Caco-2/HT29 co-culture monolayers and intra-jejunal instillation in rats

scientific article published on 18 February 2019

SNEDDS Containing Poorly Water Soluble Cinnarizine; Development and in Vitro Characterization of Dispersion, Digestion and Solubilization

scientific article published on 14 December 2012

Self-microemulsifying drug delivery system and nanoemulsion for enhancing aqueous miscibility of Alpinia galanga oil.

scientific article

Self-nanoemulsifying drug delivery systems for oral insulin delivery: in vitro and in vivo evaluations of enteric coating and drug loading

scientific article published on 17 October 2014

Separation and detection of phospholipid hydroperoxides in the low nanomolar range by a high performance liquid chromatography/irothiocyanate assay

scientific article published on 01 July 1990

Solid Forms of Amlodipine Besylate: Physicochemical, Structural, and Thermodynamic Characterization

Solid Lipid Particles for Oral Delivery of Peptide and Protein Drugs II – The Digestion of Trilaurin Protects Desmopressin from Proteolytic Degradation

Solid cellulose nanofiber based foams - Towards facile design of sustained drug delivery systems

scientific article published on 12 November 2016

Solid lipid particles for oral delivery of peptide and protein drugs I--elucidating the release mechanism of lysozyme during lipolysis

scientific article published on 2 August 2013

Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin

scientific article published on 30 May 2014

Solubilisation of poorly water-soluble drugs during in vitro lipolysis of medium- and long-chain triacylglycerols

scientific article published in November 2004

Solution or suspension – Does it matter for lipid based systems? In vivo studies of chase dosing lipid vehicles with aqueous suspensions of a poorly soluble drug

Spatial confinement can lead to increased stability of amorphous indomethacin

scientific article

Stabilisation of amorphous furosemide increases the oral drug bioavailability in rats

Steric and interactive barrier properties of intestinal mucus elucidated by particle diffusion and peptide permeation

scientific article published on 23 January 2015

Structural development of self nano emulsifying drug delivery systems (SNEDDS) during in vitro lipid digestion monitored by small-angle X-ray scattering

scientific article published on 26 April 2007

Structural features of colloidal species in the human fasted upper small intestine

scientific article published on 8 January 2015

Structured triglyceride vehicles for oral delivery of halofantrine: examination of intestinal lymphatic transport and bioavailability in conscious rats

scientific article published in September 2002

Studying furosemide solubilization using an in vitro model simulating gastrointestinal digestion and drug solubilization in neonates and young infants

scientific article published on 10 August 2017

Studying the Propensity of Compounds to Supersaturate: A Practical and Broadly Applicable Approach

scientific article published on 31 July 2016

Supersaturated self-nanoemulsifying drug delivery systems (Super-SNEDDS) enhance the bioavailability of the poorly water-soluble drug simvastatin in dogs

scientific article

Supersaturation of zafirlukast in fasted and fed state intestinal media with and without precipitation inhibitors.

scientific article published on 31 May 2016

Survival of Lactobacillus acidophilus NCFM ® and Bifidobacterium lactis HN019 encapsulated in chocolate during in vitro simulated passage of the upper gastrointestinal tract

The Effect of Digestion and Drug Load on Halofantrine Absorption from Self-nanoemulsifying Drug Delivery System (SNEDDS).

scientific article published on 20 October 2015

The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

scientific article published on 21 September 2018

The ability of two in vitro lipolysis models reflecting the human and rat gastro-intestinal conditions to predict the in vivo performance of SNEDDS dosing regimens

scientific article published on 27 December 2017

The biopharmaceutics risk assessment roadmap for optimizing clinical drug product performance

scientific article published on 24 September 2014

The effect of alpha-tocopherol on the in vitro solubilisation of lipophilic drugs

scientific article

The preparation of magnetically guided lipid based nanoemulsions using self-emulsifying technology

scientific article published on 24 December 2009

Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations, Part 1: Method Parameterization and Comparison of In Vitro Digestion Profiles Across a Range of Representative Formulations

scientific article published on 29 May 2012

Toward the Establishment of Standardized in Vitro Tests for Lipid-Based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations during in Vitro Digestion

scientific article published on 22 October 2012

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations.

scientific article published on 10 May 2013

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system

scientific article published on 01 July 2014

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 6: effects of varying pancreatin and calcium levels

scientific article

Toward the establishment of standardized in vitro tests for lipid-based formulations. 5. Lipolysis of representative formulations by gastric lipase.

scientific article published on 7 October 2014

Unravelling the ultrastructure of ascending colon fluids from patients with ulcerative colitis by cryogenic transmission electron microscopy

article

Using Potentiometric Free Drug Sensors to Determine the Free Concentration of Ionizable Drugs in Colloidal Systems

scientific article published on 23 May 2017

Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound

scientific article

Using in vitro lipolysis and SPECT/CT in vivo imaging to understand oral absorption of fenofibrate from lipid-based drug delivery systems

scientific article published on 23 November 2019

Using resin to generate a non-invasive intestinal bile-depleted rat model was unsuccessful

pH-triggered drug release from biodegradable microwells for oral drug delivery

scientific article published on June 2015

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