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List of works by Antonio Bertoletti

A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors

scientific article

A Dynamic Immune Response Shapes COVID-19 Progression

scientific article published on 30 April 2020

A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures.

scientific article

A longitudinal analysis of innate and adaptive immune profile during hepatic flares in chronic hepatitis B

article

A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus

scientific article published on 13 August 2013

A whole recombinant yeast-based therapeutic vaccine elicits HBV X, S and Core specific T cells in mice and activates human T cells recognizing epitopes linked to viral clearance

scientific article

Activated macrophages promote hepatitis C virus entry in a tumor necrosis factor-dependent manner.

scientific article published on 25 February 2014

Adaptive immunity in HBV infection

scientific article published on April 2016

Advanced Design of Dumbbell-shaped Genetic Minimal Vectors Improves Non-coding and Coding RNA Expression.

scientific article published on 30 June 2016

Advances in therapeutics for chronic hepatitis B.

scientific article published on 12 September 2015

Age-Dependent Immune Events during HBV Infection from Birth to Adulthood: An Alternative Interpretation

scientific article

Alpha-fetoprotein impairs APC function and induces their apoptosis

article

An accelerated rabies vaccine schedule based on toll-like receptor 3 (TLR3) agonist PIKA adjuvant augments rabies virus specific antibody and T cell response in healthy adult volunteers

scientific article published on 21 January 2017

Analysis of CD4+ T-Cell Responses to a Novel -Fetoprotein-Derived Epitope in Hepatocellular Carcinoma Patients

article

Author Correction: Therapeutic strategies for hepatitis B virus infection: towards a cure

scientific article published on 01 April 2020

Bim-mediated deletion of antigen-specific CD8 T cells in patients unable to control HBV infection

scientific article published on May 2008

Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes

scientific article

Building and optimizing a virus-specific T cell receptor library for targeted immunotherapy in viral infections

scientific article

CD137L dendritic cells induce potent response against cancer-associated viruses and polarize human CD8+ T cells to Tc1 phenotype.

scientific article published on 5 March 2018

CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes

scientific article

CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut.

scientific article

CRISPR-Mediated Base Conversion Allows Discriminatory Depletion of Endogenous T Cell Receptors for Enhanced Synthetic Immunity

scientific article published on 11 September 2020

Cancer immunotherapy: targeting the difference

scientific article published on 30 June 2014

Challenges of CAR- and TCR-T cell-based therapy for chronic infections

scientific article published on 01 May 2020

Characterization of CD8+ T-cell response in acute and resolved hepatitis A virus infection

scientific article

Characterization of hepatitis B virus (HBV)-specific T-cell dysfunction in chronic HBV infection

scientific article published on 7 February 2007

Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model

scientific article

Circumventing failed antiviral immunity in chronic hepatitis B virus infection: triggering virus-specific or innate-like T cell response?

scientific article published on 16 December 2014

Clinical Trial Design for Immune-Based Therapy of Hepatitis B Virus

scientific article published on 31 May 2017

Comparative characterization of B cells specific for HBV nucleocapsid and envelope proteins in patients with chronic hepatitis B

scientific article published on 23 July 2019

Conditional ligands for Asian HLA variants facilitate the definition of CD8+ T-cell responses in acute and chronic viral diseases

scientific article

Contribution of herpesvirus specific CD8 T cells to anti-viral T cell response in humans.

scientific article

Control or persistence of hepatitis B virus: the critical role of initial host-virus interactions

scientific article

Corrigendum: CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes

scientific article published on 7 April 2017

Corrigendum: Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model.

scientific article

Cross-Reactivity and Anti-viral Function of Dengue Capsid and NS3-Specific Memory T Cells Toward Zika Virus

scientific article published on 01 October 2018

Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage

scientific article

Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope.

scientific article

Defining CD8+ T cell determinants during human viral infection in populations of Asian ethnicity.

scientific article published on 20 September 2013

Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection.

scientific article

Distinct, cross-reactive epitope specificities of CD8 T cell responses are induced by natural hepatitis B surface antigen variants of different hepatitis B virus genotypes

scientific article published on April 2006

Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming

scientific article published on 02 October 2019

E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.

scientific article

Early treatment of chronic hepatitis B in children: Everything to play for?

scientific article published on 14 February 2020

Editorial overview: Antiviral strategies: Virological and immunological basis for HBV cure

scientific article published on 01 June 2018

Effect of HIV infection and antiretroviral therapy on hepatitis B virus (HBV)-specific T cell responses in patients who have resolved HBV infection

scientific article published on 28 February 2005

Effects of Hepatitis B Surface Antigen on Virus-specific and Global T Cells in Patients With Chronic HBV infection

scientific article published on 14 April 2020

Engineering T cells specific for a dominant severe acute respiratory syndrome coronavirus CD8 T cell epitope

scientific article

Engineering virus-specific T cells that target HBV infected hepatocytes and hepatocellular carcinoma cell lines

scientific article published on 23 November 2010

Erratum: Corrigendum: Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire

scientific article published in Nature Communications

Erratum: E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.

scientific article published on 18 August 2017

Escaping high viral load exhaustion: CD8 cells with altered tetramer binding in chronic hepatitis B virus infection

scientific article

Evolution of hepatitis B virus during primary infection in humans: transient generation of cytotoxic T-cell mutants

scientific article published in October 2004

Excellent safety and effectiveness of high-dose myrcludex-B monotherapy administered for 48 weeks in HDV-related compensated cirrhosis: A case report of 3 patients

scientific article published on 11 July 2019

Fine specificity of the human T-cell response to the hepatitis B virus preS1 antigen

scientific article published on July 1, 1992

Fine-Tuning TLR-7-Based Therapy for Functional HBV Cure

scientific article published on 01 October 2019

Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection

scientific article published on 11 August 2008

Greater CD8+ TCR heterogeneity and functional flexibility in HIV-2 compared to HIV-1 infection

scientific article published in July 2003

HBV DNA Integration and Clonal Hepatocyte Expansion in Chronic Hepatitis B Patients Considered Immune Tolerant

scientific article published on 21 July 2016

HBV antiviral immunity: not all CD8 T cells are born equal

scientific article published on 30 January 2019

HBV as a target for CAR or TCR-T cell therapy

scientific article published on 30 April 2020

HBV in 2016: Global and immunotherapeutic insights into hepatitis B.

scientific article published on 5 January 2017

HBV infection and HCC: the 'dangerous liaisons'.

scientific article

HBV-Specific Adaptive Immunity

scientific article

Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation.

scientific article published on 8 January 2018

Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg+/HBeAg- mothers

scientific article published on 26 July 2010

Hepatitis B: future curative strategies

scientific article

Hepatitis C Virus-Specific T Cell Receptor mRNA-Engineered Human T Cells: Impact of Antigen Specificity on Functional Properties.

scientific article published on 22 February 2017

Hepatitis Delta Virus Acts as an Immunogenic Adjuvant in Hepatitis B Virus-Infected Hepatocytes

scientific article published on 21 July 2020

Heterologous T cell immunity in severe hepatitis C virus infection

scientific article

Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire.

scientific article published on 17 September 2008

Host factor-targeted hepatitis B virus therapies

scientific article published on 15 July 2014

Human liver-resident CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways

scientific article

Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells

scientific article

IFN-α Suppresses Myeloid Cytokine Production, Impairing IL-12 Production and the Ability to Support T cell Proliferation

scientific article published on 12 February 2020

IL-1β production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease

scientific article

IL-7 Licenses Activation of Human Liver Intrasinusoidal Mucosal-Associated Invariant T Cells

scientific article published on 27 February 2013

ImmTAV, a new Immunotherapy targeting the source of HBV infection

scientific article published on 31 August 2020

Immune Response in Hepatitis B Virus Infection

scientific article published on July 2015

Immune Tolerant Chronic Hepatitis B: The Unrecognized Risks

scientific article

Immune response and tolerance during chronic hepatitis B virus infection

scientific article

Immune therapeutic strategies in chronic hepatitis B virus infection: virus or inflammation control?

scientific article

Immunological aspects of antiviral therapy of chronic hepatitis B virus and hepatitis C virus infections

scientific article

Immunoprevalence and immunodominance of HLA-Cw*0801-restricted T cell response targeting the hepatitis B virus envelope transmembrane region

scientific article

Immunosuppressive Drug Resistant Armored TCR T cells for immune-therapy of HCC in liver transplant patients

scientific article published on 29 November 2020

Immunotherapy for Chronic Hepatitis B Virus Infection

scientific article published on 11 January 2018

Immunotherapy of HCC metastases with autologous T cell receptor redirected T cells, targeting HBsAg in a liver transplant patient

scientific article published on 13 October 2014

Increased Levels of Arginase in Patients With Acute Hepatitis B Suppress Antiviral T Cells

scientific article published on 01 April 2012

Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection

scientific article published on 09 December 2011

Intrahepatic CD206+ macrophages contribute to inflammation in advanced viral-related liver disease

scientific article published on 5 May 2017

Is antigenic variability a strategy adopted by hepatitis B virus to escape cytotoxic T-lymphocyte surveillance?

Kinetics of the immune response during HBV and HCV infection.

scientific article

Lamivudine treatment can overcome cytotoxic T-cell hyporesponsiveness in chronic hepatitis B: new perspectives for immune therapy.

scientific article published in April 2001

Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection

scientific article

Liver fibrosis and CD206+ macrophage accumulation are suppressed by anti-GM-CSF therapy

scientific article published on 06 December 2019

Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy

scientific article

Lymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection

scientific article

Memory T cell responses targeting the SARS coronavirus persist up to 11 years post-infection

scientific article

Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells.

scientific article published on 11 May 2015

Microfluidic models for adoptive cell-mediated cancer immunotherapies

scientific article published on 13 May 2016

Mobilizing monocytes to cross-present circulating viral antigen in chronic infection.

scientific article published on August 2013

Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with hepatitis B virus infection

scientific article

Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver

scientific article published on 16 August 2018

Multifactorial heterogeneity of virus-specific T cells and association with the progression of human chronic hepatitis B infection

scientific article published on 01 February 2019

Non-lytic Lymphocytes Engineered to Express Virus-specific T-cell Receptors Limit HBV Infection by Activating APOBEC3.

scientific article

Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.

scientific article published on 13 July 2018

Overview of the special issue on HBV immunity

scientific article published on 13 April 2015

PD-1 blockade partially recovers dysfunctional virus-specific B cells in chronic hepatitis B infection

article

PD-1/PD-L1 pathway and T-cell exhaustion in chronic hepatitis virus infection

scientific article published on 10 May 2010

Parallel T-cell cloning and deep sequencing of human MAIT cells reveal stable oligoclonal TCRβ repertoire.

scientific article published on 15 May 2014

Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B.

scientific article published on April 1997

Preserved T-cell function in children and young adults with immune-tolerant chronic hepatitis B.

scientific article

Profile of tumor antigen-specific CD8 T cells in patients with hepatitis B virus-related hepatocellular carcinoma

scientific article published on 23 April 2009

Protection or damage: a dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection?

scientific article published in August 2000

Protection or damage: a dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection?

article

Quantity and quality of virus-specific CD8 cell response: relevance to the design of a therapeutic vaccine for chronic HBV infection.

scientific article

Reconstitution of hepatitis B virus (HBV)-specific T cell responses with treatment of human immunodeficiency virus/HBV coinfection

scientific article published on 8 December 2003

Redirecting T Cell Specificity Using T Cell Receptor Messenger RNA Electroporation

scientific article published on January 2016

Reduction of HBV replication prolongs the early immunological response to IFNα therapy

scientific article published on 29 August 2013

Reply

Reply to: "To target or not to target viral antigens in HBV related HCC?".

scientific article published on 21 February 2015

Republished: Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection ⬇️

scientific article published on May 1, 2013

Resistance to lamivudine therapy: is there more than meets the eye?

scientific article

Role of hepatitis B virus specific cytotoxic T cells in liver damage and viral control

scientific article published in October 2003

Role of the Immune Response in Hepatitis B

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

scientific article published on 15 July 2020

Sources of diversity in T cell epitope discovery

scientific article published on June 2011

Spatio-temporal differences in presentation of CD8 T cell epitopes during HBV infection

article published in 2018

Stability screening of arrays of major histocompatibility complexes on combinatorially encoded flow cytometry beads

scientific article

Sustained and focused hepatitis B virus nucleocapsid-specific T-cell immunity in liver transplant recipients compared to individuals with chronic and self-limited hepatitis B virus infection

scientific article published in April 2008

T cell fitness in the liver: How can T cells keep it up?

scientific article published in March 2016

T cell receptor-therapy in HBV-related hepatocellularcarcinoma

scientific article published on 19 March 2015

TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity

scientific article

Targeted Therapy of Hepatitis B Virus-Related Hepatocellular Carcinoma: Present and Future

scientific article published on 15 February 2016

Targeted delivery of interferon-α to hepatitis B virus-infected cells using T-cell receptor-like antibodies

scientific article published on 12 July 2012

Targeting hepatitis B virus-infected cells with a T-cell receptor-like antibody

scientific article

The Effects of Pathogens on the Immune System: Viral Hepatitis

The expression and function of NKG2D molecule on intrahepatic CD8+ T cells in chronic viral hepatitis

scientific article

The host-pathogen interaction during HBV infection: immunological controversies

scientific article published on January 2010

The immune response during hepatitis B virus infection

scientific article

The immune tolerant phase of chronic HBV infection: new perspectives on an old concept

scientific article published on September 2014

The impact of HBV-DNA fluctuations on virus-specific CD8+ T cells in HBeAg+ chronic hepatitis B patients treated with a steroid and lamivudine

scientific article published in June 2006

The influence of T cell cross-reactivity on HCV-peptide specific human T cell response.

scientific article published in March 2006

The level of viral antigen presented by hepatocytes influences CD8 T-cell function.

scientific article published on 3 January 2007

The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection

scientific article

Therapeutic strategies for hepatitis B virus infection: towards a cure

scientific article published on 27 August 2019

Therapeutic vaccination and novel strategies to treat chronic HBV infection

scientific article published on October 2009

Tolerance and immunity to pathogens in early life: insights from HBV infection.

scientific article

Toll-like receptor 8 agonist and bacteria trigger potent activation of innate immune cells in human liver

scientific article

Tracking the source of the hepatitis B virus-specific CD8 T cells during lamivudine treatment

scientific article published on 29 January 2003

Trained immunity in newborn infants of HBV-infected mothers

scientific article

Transient restoration of anti-viral T cell responses induced by lamivudine therapy in chronic hepatitis B.

scientific article published in October 2003

Translation from cryptic reading frames of DNA vaccines generates an extended repertoire of immunogenic, MHC class I-restricted epitopes

scientific article published on 01 April 2005

Translation of immunological knowledge into better treatments of chronic hepatitis B.

scientific article

Type I IFN negatively regulates CD8+ T cell responses through IL-10-producing CD4+ T regulatory 1 cells

article

Understanding the T cell immune response in SARS coronavirus infection

scientific article published on 5 September 2012

Understanding the immunopathogenesis of chronic hepatitis B virus: an Asian prospective.

scientific article published on June 2008

Underwhelming the Immune Response: Effect of Slow Virus Growth on CD8+-T-Lymphocyte Responses.

scientific article published in June 2004

Underwhelming the immune response: effect of slow virus growth on CD8+-T-lymphocyte responses

scientific article published on March 2004

Use of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy

scientific article published on 31 January 2019

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

scientific article published on 28 February 2019

Using microfluidics to investigate tumor cell extravasation and T-cell immunotherapies

scientific article published in August 2015

Viral hepatitis and serotonin: altering cytotoxic T-lymphocyte function in the liver

scientific article

Virus-specific T lymphocytes home to the skin during natural dengue infection

scientific article published on March 2015

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