List of works - Marco Racchi

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

scientific article published on 14 July 2015

5alpha-Reductase activity in Lycopersicon esculentum: cloning and functional characterization of LeDET2 and evidence of the presence of two isoenzymes.

scientific article published in August 2005

Acetylcholinesterase inhibitors: novel activities of old molecules.

scientific article published in October 2004

Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP.

scientific article published in September 2005

Activity of alpha-secretase as the common final effector of protein kinase C-dependent and -independent modulation of amyloid precursor protein metabolism

scientific article published on 01 June 1999

Acute beta-amyloid administration disrupts the cholinergic control of dopamine release in the nucleus accumbens

scientific article published on 20 June 2007

Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone.

scientific article published on 17 November 2004

Alzheimer's disease: new diagnostic and therapeutic tools

scientific article published on 13 August 2008

Amyloid precursor protein metabolism in fibroblasts from individuals with one, two or three copies of the amyloid precursor protein (APP) gene

scientific article published in March 1999

Antiradical activity of water soluble components in common diet vegetables

scientific article published in February 2002

Association of the estrogen receptor alpha gene polymorphisms with sporadic Alzheimer's disease.

scientific article published in November 1999

AβPP intracellular C-terminal domain function is related to its degradation processes

scientific article published in January 2012

Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families

scientific article published in July 1998

Capillary electrophoresis studies on the aggregation process of beta-amyloid 1-42 and 1-40 peptides

scientific article published on 01 October 2004

Changes in beta amyloid precursor protein secretion associated with the proliferative status of CNS derived progenitor cells

scientific article published on July 1996

Characterization and distribution of protein kinase C isoforms in human skin fibroblasts

scientific article published on 01 October 1994

Characterization of the effect of ganstigmine (CHF2819) on amyloid precursor protein metabolism in SH-SY5Y neuroblastoma cells

scientific article published in August 2003

Cognition enhancers between treating and doping the mind

scientific article

Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression.

scientific article published on 07 February 2013

Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease

scientific article

Conformationally altered p53: a novel Alzheimer's disease marker?

scientific article published on 7 August 2007

Conformationally altered p53: a putative peripheral marker for Alzheimer's disease.

scientific article published on 06 March 2008

Corticosteroids modulate the expression of the PKC-anchoring protein RACK-1 and cytokine release in THP-1 cells.

scientific article published on 22 January 2014

Curcumin in Alzheimer's disease: Can we think to new strategies and perspectives for this molecule?

scientific article published on 12 August 2017

DHEA modulates the effect of cortisol on RACK1 expression via interference with the splicing of the glucocorticoid receptor

scientific article

Dangerous liaisons between beta-amyloid and cholinergic neurotransmission.

scientific article published on January 2014

Defective DNA repair and increased chromatin binding of DNA repair factors in Down syndrome fibroblasts.

scientific article

Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts

scientific article

Dehydroepiandrosterone and the relationship with aging and memory: a possible link with protein kinase C functional machinery

scientific article published on 01 November 2001

Development of the first Gateway firefly luciferase vector and use of reverse transcriptase in FLOE (Fluorescently Labeled Oligonucleotide Extension) reactions

scientific article published on 20 August 2007

Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein.

scientific article published on July 2004

Do we need pharmacogenetics to personalize antidepressant therapy?

scientific article published on 28 December 2012

Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.

scientific article published in October 2005

Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells.

scientific article published on August 1997

Endocrine-Disrupting Chemicals' (EDCs) Effects on Tumour Microenvironment and Cancer Progression: Emerging Contribution of RACK1

scientific article published on 03 December 2020

Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts.

scientific article published in March 1999

Estrogen receptor alpha and APOEepsilon4 polymorphisms interact to increase risk for sporadic AD in Italian females

scientific article published in June 2006

Expression and phosphorylation of delta-CaM kinase II in cultured Alzheimer fibroblasts

scientific article

Expression and regulation of calcium-independent protein kinase C in NG 108-15 cell differentiation.

scientific article published in September 1994

Familial migraine with aura: association study with 5-HT1B/1D, 5-HT2C, and hSERT polymorphisms

scientific article published in April 2004

Fibroblast glutamate transport in aging and in AD: correlations with disease severity

scientific article

Fibroblasts from Alzheimer's disease donors do not differ from controls in response to heat shock

scientific article published on 01 October 1998

Functional mapping of the promoter region of the GNB2L1 human gene coding for RACK1 scaffold protein

scientific article

High interleukin-10 production is associated with low antibody response to influenza vaccination in the elderly.

scientific article published on 17 May 2006

Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival

scientific article

Identification of a mutant-like conformation of p53 in fibroblasts from sporadic Alzheimer's disease patients.

scientific article

Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea

article

Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors

scientific article published on March 2015

In vitro and ex vivo antihydroxyl radical activity of green and roasted coffee

scientific article published in March 2004

Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients

scientific article

Insights into the definition of terms in European medical device regulation

scientific article

Menopause and estrogen deficiency as a risk factor in dementing illness: hypothesis on the biological basis.

scientific article

Modulation of Rack-1/PKCβII signalling by soluble AβPPα in SH-SY5Y cells

scientific article published on September 2013

Mucoadhesive microspheres for nasal administration of cyclodextrins

scientific article published on 01 February 2009

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors

scientific article published on 11 December 2014

New evidence of similarity between human and plant steroid metabolism: 5alpha-reductase activity in Solanum malacoxylon.

scientific article

Nicotinic component of galantamine in the regulation of amyloid precursor protein processing

scientific article published on December 2006

Ontogenesis of protein kinase C betaII and its anchoring protein RACK1 in the maturation of alveolar macrophage functional responses

scientific article

Opposing effects of cortisol and dehydroepiandrosterone on the expression of the receptor for Activated C Kinase 1: implications in immunosenescence

scientific article

Over-expression of amyloid precursor protein in HEK cells alters p53 conformational state and protects against doxorubicin

scientific article

Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients

scientific article published on October 1997

Peripheral cells as an investigational tool for Alzheimer's disease.

scientific article

Pharmacogenetics and pharmagenomics, trends in normal and pathological aging studies: focus on p53.

scientific article published in January 2008

Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role--relevance for Alzheimer pathology

scientific article

Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases

scientific article published on 01 March 1999

RACK-1 expression and cytokine production in leukocytes obtained from AD patients

scientific article published on 01 April 2006

Rationalizing a pharmacological intervention on the amyloid precursor protein metabolism.

scientific article

Recruitment of casein kinase 2 is involved in AbetaPP processing following cholinergic stimulation

scientific article published on January 2010

Role of Hormones in the Regulation of RACK1 Expression as a Signaling Checkpoint in Immunosenescence

scientific article

Role of PKC-β in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells.

scientific article published on 18 October 2013

Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes.

scientific article published on 29 May 2016

Role of protein kinase Calpha in the regulated secretion of the amyloid precursor protein

scientific article

Role of spliceosome proteins in the regulation of glucocorticoid receptor isoforms by cortisol and dehydroepiandrosterone.

scientific article

Searching for predictive blood biomarkers: misfolded p53 in mild cognitive impairment

scientific article published in December 2012

Serotonin transporter polymorphism modifies the association between depressive symptoms and sleep onset latency complaint in elderly people: results from the 'InveCe.Ab' study

scientific article published on 9 October 2014

Short- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein

scientific article published in September 2001

Specific role for protein kinase C alpha in the constitutive and regulated secretion of amyloid precursor protein in human skin fibroblasts

scientific article published on January 1998

Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819).

scientific article published in August 2006

Targeting the Nrf2/Amyloid-Beta Liaison in Alzheimer's Disease: A Rational Approach.

scientific article

The Peptidyl-prolyl Isomerase Pin1 in Neuronal Signaling: from Neurodevelopment to Neurodegeneration

scientific article published on 21 October 2020

The expanding universe of neurotrophic factors: therapeutic potential in aging and age-associated disorders.

scientific article published on January 2010

The pharmacology of amyloid precursor protein processing.

scientific article

The role of HSP27 in RACK1-mediated PKC activation in THP-1 cells

scientific article published on 13 May 2016

The scaffold protein RACK1 is a target of endocrine disrupting chemicals (EDCs) with important implication in immunity

scientific article

Transcriptional regulation of RACK1 and modulation of its expression: Role of steroid hormones and significance in health and aging.

scientific article published on 9 February 2017

Unfolded p53 in blood as a predictive signature signature of the transition from mild cognitive impairment to Alzheimer's disease.

scientific article

Unfolded p53 in the pathogenesis of Alzheimer's disease: is HIPK2 the link?

scientific article

Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53.

scientific article published on 13 January 2009

Wild type but not mutant APP is involved in protective adaptive responses against oxidants

article

Zyxin is a novel target for β-amyloid peptide: characterization of its role in Alzheimer's pathogenesis

scientific article published on 13 February 2013

beta amyloid-induced disruption of ionic balance: studies on the isolated frog labyrinth

scientific article published in August 2001

nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing

scientific article

p53 at the crossroads between cancer and neurodegeneration

scientific article published on 03 March 2012

List of works by Marco Racchi

3,4-Dihydro-1,3,5-triazin-2(1H)-ones as the First Dual BACE-1/GSK-3β Fragment Hits against Alzheimer's Disease

5alpha-Reductase activity in Lycopersicon esculentum: cloning and functional characterization of LeDET2 and evidence of the presence of two isoenzymes.

Acetylcholinesterase inhibitors: novel activities of old molecules.

Activation of the Notch pathway in Down syndrome: cross-talk of Notch and APP.

Activity of alpha-secretase as the common final effector of protein kinase C-dependent and -independent modulation of amyloid precursor protein metabolism

Acute beta-amyloid administration disrupts the cholinergic control of dopamine release in the nucleus accumbens

Age-related decline in RACK-1 expression in human leukocytes is correlated to plasma levels of dehydroepiandrosterone.

Alzheimer's disease: new diagnostic and therapeutic tools

Amyloid precursor protein metabolism in fibroblasts from individuals with one, two or three copies of the amyloid precursor protein (APP) gene

Antiradical activity of water soluble components in common diet vegetables

Association of the estrogen receptor alpha gene polymorphisms with sporadic Alzheimer's disease.

AβPP intracellular C-terminal domain function is related to its degradation processes

Calcium responses in fibroblasts from asymptomatic members of Alzheimer's disease families

Capillary electrophoresis studies on the aggregation process of beta-amyloid 1-42 and 1-40 peptides

Changes in beta amyloid precursor protein secretion associated with the proliferative status of CNS derived progenitor cells

Characterization and distribution of protein kinase C isoforms in human skin fibroblasts

Characterization of the effect of ganstigmine (CHF2819) on amyloid precursor protein metabolism in SH-SY5Y neuroblastoma cells

Cognition enhancers between treating and doping the mind

Conformational altered p53 affects neuronal function: relevance for the response to toxic insult and growth-associated protein 43 expression.

Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease

Conformationally altered p53: a novel Alzheimer's disease marker?

Conformationally altered p53: a putative peripheral marker for Alzheimer's disease.

Corticosteroids modulate the expression of the PKC-anchoring protein RACK-1 and cytokine release in THP-1 cells.

Curcumin in Alzheimer's disease: Can we think to new strategies and perspectives for this molecule?

DHEA modulates the effect of cortisol on RACK1 expression via interference with the splicing of the glucocorticoid receptor

Dangerous liaisons between beta-amyloid and cholinergic neurotransmission.

Defective DNA repair and increased chromatin binding of DNA repair factors in Down syndrome fibroblasts.

Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts

Dehydroepiandrosterone and the relationship with aging and memory: a possible link with protein kinase C functional machinery

Development of the first Gateway firefly luciferase vector and use of reverse transcriptase in FLOE (Fluorescently Labeled Oligonucleotide Extension) reactions

Differential involvement of protein kinase C alpha and epsilon in the regulated secretion of soluble amyloid precursor protein.

Do we need pharmacogenetics to personalize antidepressant therapy?

Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.

Effect of energy shortage and oxidative stress on amyloid precursor protein metabolism in COS cells.

Endocrine-Disrupting Chemicals' (EDCs) Effects on Tumour Microenvironment and Cancer Progression: Emerging Contribution of RACK1

Energy metabolism inhibition impairs amyloid precursor protein secretion from Alzheimer's fibroblasts.

Estrogen receptor alpha and APOEepsilon4 polymorphisms interact to increase risk for sporadic AD in Italian females

Expression and phosphorylation of delta-CaM kinase II in cultured Alzheimer fibroblasts

Expression and regulation of calcium-independent protein kinase C in NG 108-15 cell differentiation.

Familial migraine with aura: association study with 5-HT1B/1D, 5-HT2C, and hSERT polymorphisms

Fibroblast glutamate transport in aging and in AD: correlations with disease severity

Fibroblasts from Alzheimer's disease donors do not differ from controls in response to heat shock

Functional mapping of the promoter region of the GNB2L1 human gene coding for RACK1 scaffold protein

High interleukin-10 production is associated with low antibody response to influenza vaccination in the elderly.

Homeodomain interacting protein kinase 2: a target for Alzheimer's beta amyloid leading to misfolded p53 and inappropriate cell survival

Identification of a mutant-like conformation of p53 in fibroblasts from sporadic Alzheimer's disease patients.

Immunomodulators Inspired by Nature: A Review on Curcumin and Echinacea

Immunostimulatory effects of RACK1 pseudosubstrate in human leukocytes obtained from young and old donors

In vitro and ex vivo antihydroxyl radical activity of green and roasted coffee

Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients

Insights into the definition of terms in European medical device regulation

Menopause and estrogen deficiency as a risk factor in dementing illness: hypothesis on the biological basis.

Modulation of Rack-1/PKCβII signalling by soluble AβPPα in SH-SY5Y cells

Mucoadhesive microspheres for nasal administration of cyclodextrins

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors

New evidence of similarity between human and plant steroid metabolism: 5alpha-reductase activity in Solanum malacoxylon.

Nicotinic component of galantamine in the regulation of amyloid precursor protein processing

Ontogenesis of protein kinase C betaII and its anchoring protein RACK1 in the maturation of alveolar macrophage functional responses

Opposing effects of cortisol and dehydroepiandrosterone on the expression of the receptor for Activated C Kinase 1: implications in immunosenescence

Over-expression of amyloid precursor protein in HEK cells alters p53 conformational state and protects against doxorubicin

Oxidative metabolism in cultured fibroblasts derived from sporadic Alzheimer's disease (AD) patients

Peripheral cells as an investigational tool for Alzheimer's disease.

Pharmacogenetics and pharmagenomics, trends in normal and pathological aging studies: focus on p53.

Phosphorylation of APP-CTF-AICD domains and interaction with adaptor proteins: signal transduction and/or transcriptional role--relevance for Alzheimer pathology

Protein kinase C and amyloid precursor protein processing in skin fibroblasts from sporadic and familial Alzheimer's disease cases

RACK-1 expression and cytokine production in leukocytes obtained from AD patients

Rationalizing a pharmacological intervention on the amyloid precursor protein metabolism.

Recruitment of casein kinase 2 is involved in AbetaPP processing following cholinergic stimulation

Role of Hormones in the Regulation of RACK1 Expression as a Signaling Checkpoint in Immunosenescence

Role of PKC-β in chemical allergen-induced CD86 expression and IL-8 release in THP-1 cells.

Role of androgens in dhea-induced rack1 expression and cytokine modulation in monocytes.

Role of protein kinase Calpha in the regulated secretion of the amyloid precursor protein

Role of spliceosome proteins in the regulation of glucocorticoid receptor isoforms by cortisol and dehydroepiandrosterone.

Searching for predictive blood biomarkers: misfolded p53 in mild cognitive impairment

Serotonin transporter polymorphism modifies the association between depressive symptoms and sleep onset latency complaint in elderly people: results from the 'InveCe.Ab' study

Short- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein

Specific role for protein kinase C alpha in the constitutive and regulated secretion of amyloid precursor protein in human skin fibroblasts

Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819).

Targeting the Nrf2/Amyloid-Beta Liaison in Alzheimer's Disease: A Rational Approach.