List of works - Carmen Ortiz Mellet

(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties.

scientific article published on 22 February 2010

6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase

scientific article

A Fluorescent sp2-iminosugar with pharmacological chaperone activity for gaucher disease: synthesis and intracellular distribution studies

scientific article published on November 2010

A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.

scientific article published on 22 January 2013

A general entry to linear, dendritic and branched thiourea-linked glycooligomers as new motifs for phosphate ester recognition in water.

scientific article

A mild and efficient procedure to remove acetal and dithioacetal protecting groups in carbohydrate derivatives using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone

scientific article published on 01 September 1995

Amphiphilic 1-Deoxynojirimycin Derivatives through Click Strategies for Chemical Chaperoning in N370S Gaucher Cells

scientific article published on 29 August 2011

Bicyclic derivatives of L-idonojirimycin as pharmacological chaperones for neuronopathic forms of Gaucher disease.

scientific article published on 18 April 2013

Carbohydrate Microarrays

scientific article published on 01 September 2002

Carbohydrate supramolecular chemistry: beyond the multivalent effect

scientific article published on 23 April 2020

Carbohydrate-Derived Spiroketals: Stereoselective Synthesis of Di-d-fructose Dianhydrides via Intramolecular Aglycon Delivery

scientific article published on 01 March 2003

Carbohydrate-based receptors with multiple thiourea binding sites. Multipoint hydrogen bond recognition of dicarboxylates and monosaccharides.

scientific article published in February 2001

Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties.

scientific article

Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin

scientific article published in November 2009

Click Synthesis of Size- and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery

scientific article published on 21 October 2020

Conformationally-Locked N-Glycosides with Selective β-Glucosidase Inhibitory Activity: Identification of a New Non-Iminosugar-Type Pharmacological Chaperone for Gaucher Disease

scientific article published on 18 July 2012

Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts

scientific article published in 2016

Cyclodextrin-Based Functional Glyconanomaterials

scientific article published on 15 December 2020

Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis

scientific article published on 06 December 2020

Cyclodextrin-based facial amphiphiles: assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities

scientific article

Cyclodextrin-based gene delivery systems.

scientific article

Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate-protein interactions.

scientific article published on 23 January 2013

Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues

scientific article

Cyclotrehalins: cyclooligosaccharide receptors featuring a hydrophobic cavity

scientific article

Di-D-fructose dianhydride-enriched caramels: effect on colon microbiota, inflammation, and tissue damage in trinitrobenzenesulfonic acid-induced colitic rats.

scientific article published in May 2010

Di-D-fructose dianhydride-enriched products by acid ion-exchange resin-promoted caramelization of D-fructose: chemical analyses.

scientific article published in February 2010

Dynamic self-assembly of polycationic clusters based on cyclodextrins for pH-sensitive DNA nanocondensation and delivery by component design.

scientific article published on 16 April 2014

Effects of inulin and di-D-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens

scientific article

Fluorescent-tagged sp2-iminosugars with potent β-glucosidase inhibitory activity.

scientific article published on 7 September 2010

Fullerene-sp2-iminosugar balls as multimodal ligands for lectins and glycosidases: a mechanistic hypothesis for the inhibitory multivalent effect.

scientific article

Functional evaluation of carbohydrate-centred glycoclusters by enzyme-linked lectin assay: ligands for concanavalin A.

scientific article

Generalized Anomeric Effect in Action: Synthesis and Evaluation of Stable Reducing Indolizidine Glycomimetics as Glycosidase Inhibitors

article

Generalized Anomeric Effect ingem-Diamines: Stereoselective Synthesis of α-N-Linked Disaccharide Mimics

scientific article published on 01 August 2009

Giant Glycosidase Inhibitors: First- and Second-Generation Fullerodendrimers with a Dense Iminosugar Shell.

scientific article published on 27 December 2017

Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers.

scientific article published in July 2014

Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring

scientific article

Glycosidase inhibition with fullerene iminosugar balls: a dramatic multivalent effect.

scientific article

Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

scientific article published on 01 March 2014

Influence of the macroring size on the self-association thermodynamics of cyclodextrins with a double-linked naphthalene at the secondary face.

scientific article

Insights in cellular uptake mechanisms of pDNA-polycationic amphiphilic cyclodextrin nanoparticles (CDplexes).

scientific article published on 20 January 2010

Intramolecular Benzyl Protection Delivery: A Practical Synthesis of DMDP and DGDP fromd-Fructose

scientific article published on 01 January 2006

Molecular basis for beta-glucosidase inhibition by ring-modified calystegine analogues

scientific article

Monodisperse nanoparticles from self-assembling amphiphilic cyclodextrins: modulable tools for the encapsulation and controlled release of pharmaceuticals

scientific article

Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies.

scientific article published on June 2013

Multivalent cyclooligosaccharides: versatile carbohydrate clusters with dual role as molecular receptors and lectin ligands

scientific article published in May 2002

Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

scientific article published on 09 October 2019

Multivalent iminosugars to modulate affinity and selectivity for glycosidases.

scientific article

N-Thiocarbonyl Iminosugars: Synthesis and Evaluation of Castanospermine Analogues Bearing Oxazole-2(3H)-thione Moieties

Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds

scientific article

New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells

scientific article

Novel Therapies for Orphan Diseases

scientific article published on 18 June 2019

One-step synthesis of non-anomeric sugar isothiocyanates from sugar azides.

scientific article published in November 2002

Optimizing saccharide-directed molecular delivery to biological receptors: design, synthesis, and biological evaluation of glycodendrimer-cyclodextrin conjugates

scientific article

Pharmacological Chaperones for the Treatment of α-Mannosidosis

scientific article published on 02 May 2019

Pharmacological chaperone therapy for Gaucher disease: a patent review.

scientific article published on 04 April 2011

Plasmid-Templated Control of DNA-Cyclodextrin Nanoparticle Morphology Through Molecular Vector Design for Effective Gene Delivery

scientific article published on 17 January 2018

Polycationic amphiphilic cyclodextrin-based nanoparticles for therapeutic gene delivery.

scientific article

Polycationic amphiphilic cyclodextrins as gene vectors: effect of the macrocyclic ring size on the DNA complexing and delivery properties

scientific article published on 26 June 2012

Polycationic amphiphilic cyclodextrins for gene delivery: synthesis and effect of structural modifications on plasmid DNA complex stability, cytotoxicity, and gene expression

scientific article published on November 2009

Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition.

scientific article published on 4 July 2016

Preorganized macromolecular gene delivery systems: amphiphilic beta-cyclodextrin "click clusters".

scientific article

Preorganized, macromolecular, gene-delivery systems

scientific article published on June 2010

Probing carbohydrate-lectin recognition in heterogeneous environments with monodisperse cyclodextrin-based glycoclusters

scientific article

Probing secondary carbohydrate-protein interactions with highly dense cyclodextrin-centered heteroglycoclusters: the heterocluster effect

scientific article

Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

scientific article published on 17 April 2018

Probing the Nature of the Cluster Effect Observed with Synthetic Multivalent Galactosides and Peanut Agglutinin Lectin

scientific article published on 21 November 2012

Rational design of cationic cyclooligosaccharides as efficient gene delivery systems

article

Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.

scientific article published on 26 June 2012

Size-tunable trehalose-based nanocavities: synthesis, structure, and inclusion properties of large-ring cyclotrehalans

scientific article published in April 2009

Spacer-mediated synthesis of contra-thermodynamic spiroacetals: stereoselective synthesis of C2-symmetric difructose dianhydrides

scientific article published in March 2006

Stereocontrolled synthesis of sulfur-linked analogues of the branched tetrasaccharide repeating-unit of the immunostimulant polysaccharide schizophyllan and of its β-(1 → 3)-branched, β-(1 → 6)-linked isomer

scientific article published on 01 February 1996

Stereoselective Synthesis of 2-Acetamido-1,2-dideoxyallonojirimycin (DAJNAc), a New Potent Hexosaminidase Inhibitor

scientific article published on 26 June 2013

Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis

scientific article published on 23 March 2020

Stereoselective synthesis of nonsymmetrical difructose dianhydrides from xylylene-tethered d-fructose precursors

Structural basis of pharmacological chaperoning for human β-galactosidase.

scientific article

Symmetry complementarity-guided design of anthrax toxin inhibitors based on β-cyclodextrin: Synthesis and relative activities of face-selective functionalized polycationic clusters.

scientific article published on January 2011

Synthesis and Comparative Glycosidase Inhibitory Properties of Reducing Castanospermine Analogues

Synthesis and evaluation of calystegine B2 analogues as glycosidase inhibitors

scientific article published in November 2001

Synthesis and evaluation of isourea-type glycomimetics related to the indolizidine and trehazolin glycosidase inhibitor families

scientific article published in November 2003

Synthesis and evaluation of sulfamide-type indolizidines as glycosidase inhibitors

scientific article

Synthesis and glycosidase inhibitory activity of isourea-type bicyclic sp2-iminosugars related to galactonojirimycin and allonojirimycin

Synthesis of 6,7-dideoxy-7-isothiocyanatoheptoses: stable fully unprotected monosaccharide isothiocyanates

scientific article published on 01 January 2000

Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents.

scientific article published on 15 June 2010

Synthesis of glycosyl(thio)ureido sugars via carbodiimides and their conformational behaviour in water.

scientific article published in June 2000

Synthesis of substituted exo-glucals via a modified Julia olefination and identification as selective β-glucosidase inhibitors

scientific article published on 01 January 2014

Synthesis of sulfur-linked analogues of nigerose, laminarabiose, laminaratriose, gentiobiose, gentiotriose, and laminaran trisaccharide Y

scientific article published on 01 February 1996

Synthesis, conformational analysis and in vivo assays of an anti-cancer vaccine that features an unnatural antigen based on an sp2-iminosugar fragment

scientific article published on 27 March 2020

Targeted delivery of pharmacological chaperones for Gaucher disease to macrophages by a mannosylated cyclodextrin carrier.

scientific article published in April 2014

Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanocomplexes in vitro and in vivo.

scientific article published on 27 June 2013

The Impact of Heteromultivalency in Lectin Recognition and Glycosidase Inhibition: An Integrated Mechanistic Study

scientific article published on 27 February 2017

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Architectural Parameters with Cyclodextrin-based Iminosugar Click Clusters

scientific article published on 03 November 2011

The multivalent effect in glycosidase inhibition: probing the influence of valency, peripheral ligand structure, and topology with cyclodextrin-based iminosugar click clusters.

scientific article

The o-xylylene protecting group as an element of conformational control of remote stereochemistry in the synthesis of spiroketals

scientific article published on 10 May 2006

Thermodynamics of the dimer formation of 2(I),3(I)-O-(o-xylylene)-per-O-Me-gamma-cyclodextrin: fluorescence, molecular mechanics and molecular dynamics.

scientific article published on 14 July 2009

Thiol-ene "Click" Synthesis and Pharmacological Evaluation of C-Glycoside sp2-Iminosugar Glycolipids

scientific article published on 08 August 2019

Topological effects and binding modes operating with multivalent iminosugar-based glycoclusters and mannosidases.

scientific article

Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties

scientific article published on 01 July 2019

Tuning glycosidase inhibition through aglycone interactions: pharmacological chaperones for Fabry disease and GM1 gangliosidosis

scientific article published on 23 May 2012

o-Xylylene protecting group in carbohydrate chemistry: application to the regioselective protection of a single vic-diol segment in cyclodextrins.

scientific article published on 4 February 2013

sp2-Iminosugar O-, S-, and N-glycosides as conformational mimics of α-linked disaccharides; implications for glycosidase inhibition

scientific article

sp2-Iminosugar glycolipids as inhibitors of lipopolysaccharide-mediated human dendritic cell activation in vitro and of acute inflammation in mice in vivo

scientific article published on 05 March 2019

sp2-Iminosugars targeting human lysosomal β-hexosaminidase as pharmacological chaperone candidates for late-onset Tay-Sachs disease

scientific article published on 01 December 2022

β-Cyclodextrin-based polycationic amphiphilic "click" clusters: effect of structural modifications in their DNA complexing and delivery properties

scientific article published on July 6, 2011

List of works by Carmen Ortiz Mellet

(Pseudo)amide-linked oligosaccharide mimetics: molecular recognition and supramolecular properties.

6-Amino-6-deoxy-5,6-di-N-(N'-octyliminomethylidene)nojirimycin: synthesis, biological evaluation, and crystal structure in complex with acid beta-glucosidase

A Fluorescent sp2-iminosugar with pharmacological chaperone activity for gaucher disease: synthesis and intracellular distribution studies

A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.

A general entry to linear, dendritic and branched thiourea-linked glycooligomers as new motifs for phosphate ester recognition in water.

A mild and efficient procedure to remove acetal and dithioacetal protecting groups in carbohydrate derivatives using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone

Amphiphilic 1-Deoxynojirimycin Derivatives through Click Strategies for Chemical Chaperoning in N370S Gaucher Cells

Bicyclic derivatives of L-idonojirimycin as pharmacological chaperones for neuronopathic forms of Gaucher disease.

Carbohydrate Microarrays

Carbohydrate supramolecular chemistry: beyond the multivalent effect

Carbohydrate-Derived Spiroketals: Stereoselective Synthesis of Di-d-fructose Dianhydrides via Intramolecular Aglycon Delivery

Carbohydrate-based receptors with multiple thiourea binding sites. Multipoint hydrogen bond recognition of dicarboxylates and monosaccharides.

Castanospermine-trehazolin hybrids: a new family of glycomimetics with tuneable glycosidase inhibitory properties.

Chaperone activity of bicyclic nojirimycin analogues for Gaucher mutations in comparison with N-(n-nonyl)deoxynojirimycin

Click Synthesis of Size- and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery

Conformationally-Locked N-Glycosides with Selective β-Glucosidase Inhibitory Activity: Identification of a New Non-Iminosugar-Type Pharmacological Chaperone for Gaucher Disease

Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts

Cyclodextrin-Based Functional Glyconanomaterials

Cyclodextrin-Based Nanostructure Efficiently Delivers siRNA to Glioblastoma Cells Preferentially via Macropinocytosis

Cyclodextrin-based facial amphiphiles: assessing the impact of the hydrophilic-lipophilic balance in the self-assembly, DNA complexation and gene delivery capabilities

Cyclodextrin-based gene delivery systems.

Cyclodextrin-based multivalent glycodisplays: covalent and supramolecular conjugates to assess carbohydrate-protein interactions.

Cyclodextrin-mediated crystallization of acid β-glucosidase in complex with amphiphilic bicyclic nojirimycin analogues

Cyclotrehalins: cyclooligosaccharide receptors featuring a hydrophobic cavity

Di-D-fructose dianhydride-enriched caramels: effect on colon microbiota, inflammation, and tissue damage in trinitrobenzenesulfonic acid-induced colitic rats.

Di-D-fructose dianhydride-enriched products by acid ion-exchange resin-promoted caramelization of D-fructose: chemical analyses.

Dynamic self-assembly of polycationic clusters based on cyclodextrins for pH-sensitive DNA nanocondensation and delivery by component design.

Effects of inulin and di-D-fructose dianhydride-enriched caramels on intestinal microbiota composition and performance of broiler chickens

Fluorescent-tagged sp2-iminosugars with potent β-glucosidase inhibitory activity.

Fullerene-sp2-iminosugar balls as multimodal ligands for lectins and glycosidases: a mechanistic hypothesis for the inhibitory multivalent effect.

Functional evaluation of carbohydrate-centred glycoclusters by enzyme-linked lectin assay: ligands for concanavalin A.

Generalized Anomeric Effect in Action: Synthesis and Evaluation of Stable Reducing Indolizidine Glycomimetics as Glycosidase Inhibitors

Generalized Anomeric Effect ingem-Diamines: Stereoselective Synthesis of α-N-Linked Disaccharide Mimics

Giant Glycosidase Inhibitors: First- and Second-Generation Fullerodendrimers with a Dense Iminosugar Shell.

Glycoligand-targeted core-shell nanospheres with tunable drug release profiles from calixarene-cyclodextrin heterodimers.

Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring

Glycosidase inhibition with fullerene iminosugar balls: a dramatic multivalent effect.

Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies

Influence of the macroring size on the self-association thermodynamics of cyclodextrins with a double-linked naphthalene at the secondary face.

Insights in cellular uptake mechanisms of pDNA-polycationic amphiphilic cyclodextrin nanoparticles (CDplexes).

Intramolecular Benzyl Protection Delivery: A Practical Synthesis of DMDP and DGDP fromd-Fructose

Molecular basis for beta-glucosidase inhibition by ring-modified calystegine analogues

Monodisperse nanoparticles from self-assembling amphiphilic cyclodextrins: modulable tools for the encapsulation and controlled release of pharmaceuticals

Multivalency in heterogeneous glycoenvironments: hetero-glycoclusters, -glycopolymers and -glycoassemblies.

Multivalent cyclooligosaccharides: versatile carbohydrate clusters with dual role as molecular receptors and lectin ligands

Multivalent glycoligands with lectin/enzyme dual specificity: self-deliverable glycosidase regulators

Multivalent iminosugars to modulate affinity and selectivity for glycosidases.

N-Thiocarbonyl Iminosugars: Synthesis and Evaluation of Castanospermine Analogues Bearing Oxazole-2(3H)-thione Moieties

Neuronopathic Gaucher's disease: induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds

New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cells

Novel Therapies for Orphan Diseases

One-step synthesis of non-anomeric sugar isothiocyanates from sugar azides.

Optimizing saccharide-directed molecular delivery to biological receptors: design, synthesis, and biological evaluation of glycodendrimer-cyclodextrin conjugates

Pharmacological Chaperones for the Treatment of α-Mannosidosis

Pharmacological chaperone therapy for Gaucher disease: a patent review.

Plasmid-Templated Control of DNA-Cyclodextrin Nanoparticle Morphology Through Molecular Vector Design for Effective Gene Delivery

Polycationic amphiphilic cyclodextrin-based nanoparticles for therapeutic gene delivery.

Polycationic amphiphilic cyclodextrins as gene vectors: effect of the macrocyclic ring size on the DNA complexing and delivery properties

Polycationic amphiphilic cyclodextrins for gene delivery: synthesis and effect of structural modifications on plasmid DNA complex stability, cytotoxicity, and gene expression

Potent Glycosidase Inhibition with Heterovalent Fullerenes: Unveiling the Binding Modes Triggering Multivalent Inhibition.

Preorganized macromolecular gene delivery systems: amphiphilic beta-cyclodextrin "click clusters".

Preorganized, macromolecular, gene-delivery systems

Probing carbohydrate-lectin recognition in heterogeneous environments with monodisperse cyclodextrin-based glycoclusters

Probing secondary carbohydrate-protein interactions with highly dense cyclodextrin-centered heteroglycoclusters: the heterocluster effect

Probing the Inhibitor versus Chaperone Properties of sp2-Iminosugars towards Human β-Glucocerebrosidase: A Picomolar Chaperone for Gaucher Disease

Probing the Nature of the Cluster Effect Observed with Synthetic Multivalent Galactosides and Peanut Agglutinin Lectin

Rational design of cationic cyclooligosaccharides as efficient gene delivery systems

Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.

Size-tunable trehalose-based nanocavities: synthesis, structure, and inclusion properties of large-ring cyclotrehalans

Spacer-mediated synthesis of contra-thermodynamic spiroacetals: stereoselective synthesis of C2-symmetric difructose dianhydrides

Stereocontrolled synthesis of sulfur-linked analogues of the branched tetrasaccharide repeating-unit of the immunostimulant polysaccharide schizophyllan and of its β-(1 → 3)-branched, β-(1 → 6)-linked isomer

Stereoselective Synthesis of 2-Acetamido-1,2-dideoxyallonojirimycin (DAJNAc), a New Potent Hexosaminidase Inhibitor

Stereoselective Synthesis of Iminosugar 2-Deoxy(thio)glycosides from Bicyclic Iminoglycal Carbamates Promoted by Cerium(IV) Ammonium Nitrate and Cooperative Brønsted Acid-Type Organocatalysis

Stereoselective synthesis of nonsymmetrical difructose dianhydrides from xylylene-tethered d-fructose precursors

Structural basis of pharmacological chaperoning for human β-galactosidase.

Symmetry complementarity-guided design of anthrax toxin inhibitors based on β-cyclodextrin: Synthesis and relative activities of face-selective functionalized polycationic clusters.

Synthesis and Comparative Glycosidase Inhibitory Properties of Reducing Castanospermine Analogues

Synthesis and evaluation of calystegine B2 analogues as glycosidase inhibitors

Synthesis and evaluation of isourea-type glycomimetics related to the indolizidine and trehazolin glycosidase inhibitor families