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List of works by Laura B Creemers

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis

scientific article

A novel injectable thermoresponsive and cytocompatible gel of poly( N -isopropylacrylamide) with layered double hydroxides facilitates siRNA delivery into chondrocytes in 3D culture

article

A validated new histological classification for intervertebral disc degeneration.

scientific article published on 10 October 2013

Altered in vitro chondrogenic properties of chondrocytes harvested from unaffected cartilage in osteoarthritic joints

scientific article published on 01 June 2006

An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid

scientific article

Antimicrobial activity of platelet-leukocyte gel against Staphylococcus aureus

scientific article published in March 2008

Applicability of a newly developed bioassay for determining bioactivity of anti-inflammatory compounds in release studies--celecoxib and triamcinolone acetonide released from novel PLGA-based microspheres.

scientific article

Articular cartilage degeneration following the treatment of focal cartilage defects with ceramic metal implants and compared with microfracture

scientific article published in April 2009

Articular cartilage evaluation after TruFit plug implantation analyzed by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC).

scientific article published on 12 April 2013

Articular damage caused by metal plugs in a rabbit model for treatment of localized cartilage defects

scientific article published on 21 March 2007

Biocompatibility and intradiscal application of a thermoreversible celecoxib-loaded poly-N-isopropylacrylamide MgFe-layered double hydroxide hydrogel in a canine model

scientific article

Biomaterials for intervertebral disc regeneration: past performance and possible future strategies.

scientific article published on 12 October 2015

Bone Morphogenetic Protein-2, But Not Mesenchymal Stromal Cells, Exert Regenerative Effects on Canine and Human Nucleus Pulposus Cells

scientific article

Bone Morphogenetic Proteins for Nucleus Pulposus Regeneration

scientific article published on 14 April 2020

Cartilage damage caused by metal implants applied for the treatment of established localized cartilage defects in a rabbit model

scientific article published in January 2009

Cartilage degeneration in the goat knee caused by treating localized cartilage defects with metal implants

scientific article published on 23 October 2009

Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells

scientific article published on 15 December 2013

Chondrogenic potential of articular chondrocytes depends on their original location

scientific article

Class 3 semaphorins expression and association with innervation and angiogenesis within the degenerate human intervertebral disc.

scientific article published on July 2015

Concise review: unraveling stem cell cocultures in regenerative medicine: which cell interactions steer cartilage regeneration and how?

scientific article published on 24 April 2014

Contrast enhanced computed tomography for real-time quantification of glycosaminoglycans in cartilage tissue engineered constructs

scientific article published on 30 September 2019

Correlation of meiotic events in testis sections and microspreads of mouse spermatocytes relative to the mid-pachytene checkpoint

scientific article

Cytokine profile of autologous conditioned serum for treatment of osteoarthritis, in vitro effects on cartilage metabolism and intra-articular levels after injection.

scientific article

Cytokine profiles in the joint depend on pathology, but are different between synovial fluid, cartilage tissue and cultured chondrocytes

scientific article

Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) can be effectively applied for longitudinal cohort evaluation of articular cartilage regeneration

scientific article published on 9 April 2013

Derivatization Strategies for the Detection of Triamcinolone Acetonide in Cartilage by Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

scientific article

Development of a cryopreservation protocol for type A spermatogonia.

scientific article

Diagnostic Modalities for Diseased Articular Cartilage-From Defect to Degeneration: A Review

scientific article

Direct Cell-Cell Contact with Chondrocytes Is a Key Mechanism in Multipotent Mesenchymal Stromal Cell-Mediated Chondrogenesis.

scientific article published on 12 August 2015

Early evolving joint degeneration by cartilage trauma is primarily mechanically controlled

scientific article published on 11 February 2016

Effect of autologous bone marrow stromal cell seeding and bone morphogenetic protein-2 delivery on ectopic bone formation in a microsphere/poly(propylene fumarate) composite.

scientific article

Effect of collagen type I or type II on chondrogenesis by cultured human articular chondrocytes.

scientific article

Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration.

scientific article published on 20 February 2009

Effect of transforming growth factor-beta and growth differentiation factor-5 on proliferation and matrix production by human bone marrow stromal cells cultured on braided poly lactic-co-glycolic acid scaffolds for ligament tissue engineering

scientific article published in July 2007

Enhanced bone morphogenetic protein-2-induced ectopic and orthotopic bone formation by intermittent parathyroid hormone (1-34) administration.

scientific article

Enhanced cell-induced articular cartilage regeneration by chondrons; the influence of joint damage and harvest site

scientific article published on 20 August 2014

Establishment of cell lines with rat spermatogonial stem cell characteristics

scientific article

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

scientific article published on 18 December 2018

Focal adhesion signaling affects regeneration by human nucleus pulposus cells in collagen- but not carbohydrate-based hydrogels

scientific article published on 22 November 2017

Gelatinase A (MMP-2) and cysteine proteinases are essential for the degradation of collagen in soft connective tissue

scientific article published in April 1998

Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies.

scientific article published on 29 January 2013

Growth factor interactions in bone regeneration

scientific article

Hyperosmolar expansion medium improves nucleus pulposus cell phenotype

scientific article published in 2022

Hypertrophic differentiation and calcification during intervertebral disc degeneration.

scientific article published on 17 August 2010

Identification of cell surface-specific markers to target human nucleus pulposus cells: expression of carbonic anhydrase XII varies with age and degeneration.

scientific article published in December 2011

Impact of expansion and redifferentiation conditions on chondrogenic capacity of cultured chondrocytes

scientific article published in September 2006

In vivo matrix production by bone marrow stromal cells seeded on PLGA scaffolds for ligament tissue engineering.

scientific article published in October 2009

Increased MMP-2 activity during intervertebral disc degeneration is correlated to MMP-14 levels

scientific article published on 01 March 2008

Increased caveolin-1 in intervertebral disc degeneration facilitates repair

scientific article published on January 2015

Inflammatory mediators in posttraumatic radiocarpal osteoarthritis

scientific article published on 6 August 2013

Inflammatory profiles in canine intervertebral disc degeneration

scientific article published on 13 January 2016

Inhibition of oncostatin M in osteoarthritic synovial fluid enhances GAG production in osteoarthritic cartilage repair.

scientific article

Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model

scientific article published on 3 December 2012

International Cartilage Repair Society (ICRS) Recommended Guidelines for Histological Endpoints for Cartilage Repair Studies in Animal Models and Clinical Trials

scientific article

Intervertebral disc disease in dogs - part 1: a new histological grading scheme for classification of intervertebral disc degeneration in dogs

scientific article published on 11 July 2012

Intradiscal application of a PCLA-PEG-PCLA hydrogel loaded with celecoxib for the treatment of back pain in canines: What's in it for humans?

scientific article published on 19 May 2017

Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration

scientific article

Involvement of V-ATPases in the Digestion of Soft Connective Tissue Collagen

scientific article published on 01 October 1998

Isolation and purification of type A spermatogonia from the bovine testis.

scientific article

Link-N: The missing link towards intervertebral disc repair is species-specific

scientific article

Maintenance of adult mouse type A spermatogonia in vitro: influence of serum and growth factors and comparison with prepubertal spermatogonial cell culture

scientific article published in December 2002

Mechanisms of intervertebral disk degeneration/injury and pain: a review

scientific article published on 21 May 2013

Micro-CT quantification of subchondral endplate changes in intervertebral disc degeneration

scientific article published on 13 October 2010

Modulating endochondral ossification of multipotent stromal cells for bone regeneration

scientific article published on August 2010

Nerves are more abundant than blood vessels in the degenerate human intervertebral disc.

scientific article published on 21 December 2015

No Effects of Hyperosmolar Culture Medium on Tissue Regeneration by Human Degenerated Nucleus Pulposus Cells Despite Upregulation Extracellular Matrix Genes

scientific article published on 8 April 2015

Non-invasive screening method for simultaneous evaluation of in vivo growth factor release profiles from multiple ectopic bone tissue engineering implants.

scientific article published on 13 May 2008

Notochordal-cell derived extracellular vesicles exert regenerative effects on canine and human nucleus pulposus cells.

scientific article published on 4 October 2017

Nucleus pulposus phenotypic markers to determine stem cell differentiation: fact or fiction?

scientific article published on 28 December 2015

Of mice, men and elephants: the relation between articular cartilage thickness and body mass

scientific article

One-stage focal cartilage defect treatment with bone marrow mononuclear cells and chondrocytes leads to better macroscopic cartilage regeneration compared to microfracture in goats

scientific article published on 09 April 2013

Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: Establishment and characterization of a long-term cartilage-synovium coculture

scientific article published on 01 July 2011

Osteoarthritis treatment using autologous conditioned serum after placebo.

scientific article

Osteogenic protein 1 does not stimulate a regenerative effect in cultured human degenerated nucleus pulposus tissue.

scientific article published on 27 November 2015

Overexpression of hsa-miR-148a promotes cartilage production and inhibits cartilage degradation by osteoarthritic chondrocytes

scientific article published on 21 November 2013

Participation of intracellular cysteine proteinases, in particular cathepsin B, in degradation of collagen in periosteal tissue explants

scientific article published on 01 March 1998

Patient Profiling in Cartilage Regeneration: Prognostic Factors Determining Success of Treatment for Cartilage Defects

scientific article published on 01 November 2009

Phagocytosis and intracellular digestion of collagen, its role in turnover and remodelling.

scientific article

Prolactinoma and body weight: a retrospective study

scientific article published in October 1991

Proliferation and differentiation of bovine type A spermatogonia during long-term culture.

scientific article published in January 2003

Prolonged inhibition of inflammation in osteoarthritis by triamcinolone acetonide released from a polyester amide microsphere platform.

scientific article published on 8 March 2017

Pronounced biomaterial dependency in cartilage regeneration using nonexpanded compared with expanded chondrocytes

scientific article published in September 2013

Quality of scaffold fixation in a human cadaver knee model

scientific article published on 22 September 2009

Reliability, reproducibility and variability of the traditional Histologic/Histochemical Grading System vs the new OARSI Osteoarthritis Cartilage Histopathology Assessment System

scientific article published on 18 June 2007

Replacement of the medial tibial plateau by a metallic implant in a goat model

scientific article published on 01 April 2010

Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering.

scientific article published on 09 May 2008

Safety of intradiscal delivery of triamcinolone acetonide by a poly(esteramide) microsphere platform in a large animal model of intervertebral disc degeneration

scientific article published on 26 October 2018

Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration.

scientific article published on 21 December 2015

Single-Stage Cell-Based Cartilage Regeneration Using a Combination of Chondrons and Mesenchymal Stromal Cells

scientific article published on 05 July 2013

Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium: implications for IVD regeneration.

scientific article published on 30 August 2016

Soluble mediators in posttraumatic wrist and primary knee osteoarthritis

scientific article published on 15 September 2014

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species

scientific article published on 27 June 2018

The dog as an animal model for intervertebral disc degeneration?

scientific article published in March 2012

The effect of a cyclooxygenase 2 inhibitor on early degenerated human nucleus pulposus explants

scientific article published on 23 October 2013

The effect of synovial fluid from injured knee joints on in vitro chondrogenesis

scientific article published on October 2006

The effect of timing of mechanical stimulation on proliferation and differentiation of goat bone marrow stem cells cultured on braided PLGA scaffolds

scientific article

The fixation of a collagen type I/III membrane in the distal radioulnar joint of a human cadaver model.

scientific article published in April 2014

The presence of extracellular matrix degrading metalloproteinases during fetal development of the intervertebral disc.

scientific article published on 10 April 2010

The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs.

scientific article published on 21 September 2015

Transplantation of germ cells from glial cell line-derived neurotrophic factor-overexpressing mice to host testes depleted of endogenous spermatogenesis by fractionated irradiation

scientific article

Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration.

scientific article published in October 2009

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