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List of works by Alan R. Prescott

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

scientific article

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

scientific article

A GDSL-motif Esterase/Lipase Affects Wax and Cutin Deposition and Controls Hull-Caryopsis Attachment in Barley

scientific article published in 2024

A comparative map of macroautophagy and mitophagy in the vertebrate eye

scientific article published on 20 February 2019

A lateral protrusion latticework connects neuroepithelial cells and is regulated during neurogenesis

scientific article published on 30 March 2022

A proteomic approach to identify early molecular targets of oxidative stress in human epithelial lens cells

scientific article

A role for ARF6 in dendritic cell podosome formation and migration

scientific article published in March 2008

A role for PP1/NIPP1 in steering migration of human cancer cells

scientific article (publication date: 2012)

A synthetic system for expression of components of a bacterial microcompartment

scientific article published on 06 September 2013

A systemic lupus erythematosus-associated R77H substitution in the CD11b chain of the Mac-1 integrin compromises leukocyte adhesion and phagocytosis

scientific article published on 25 March 2011

Activated cAMP receptors switch encystation into sporulation

scientific article

An intranucleolar body associated with rDNA.

scientific article

Analysis of the LKB1-STRAD-MO25 complex

scientific article

Bfsp2 mutation found in mouse 129 strains causes the loss of CP49 and induces vimentin-dependent changes in the lens fibre cell cytoskeleton

scientific article published on 01 January 2004

BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm.

scientific article

Burkholderia phymatum is a highly effective nitrogen-fixing symbiont of Mimosa spp. and fixes nitrogen ex planta

scientific article published in January 2007

Cajal body proteins SMN and Coilin show differential dynamic behaviour in vivo

scientific article (publication date: 15 May 2003)

Cellular responses to the metal-binding properties of metformin.

scientific article

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

scientific article published on January 2014

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

scientific article published on 6 March 2011

Cholesterol oxides mediated changes in cytoskeletal organisation involves Rho GTPases.

scientific article published on December 2003

DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double-stranded RNA.

scientific article published on 11 July 2013

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

scientific article

Deletion of the GPIdeAc gene alters the location and fate of glycosylphosphatidylinositol precursors in Trypanosoma brucei.

scientific article

Dendritic cell podosomes are protrusive and invade the extracellular matrix using metalloproteinase MMP-14.

scientific article published on 31 March 2010

Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases

scientific article

Desmin aggregate formation by R120G alphaB-crystallin is caused by altered filament interactions and is dependent upon network status in cells

scientific article

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.

scientific article published on January 2013

ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa

scientific article published on February 2011

Endocytosis of DNA-Hsp65 alters the pH of the late endosome/lysosome and interferes with antigen presentation

scientific article

Enhanced Dendritic Cell Antigen Capture via Toll-Like Receptor-Induced Actin Remodeling

scientific article published in Science

Evolution of the vertebrate beaded filament protein, Bfsp2; comparing the in vitro assembly properties of a "tailed" zebrafish Bfsp2 to its "tailless" human orthologue

scientific article published on 11 December 2011

Expression and localisation of apical junctional complex proteins in lens epithelial cells

scientific article

Expression of limb initiation genes and clues to the morphological diversification of threespine stickleback

scientific article

FGF-2 release from the lens capsule by MMP-2 maintains lens epithelial cell viability.

scientific article published on 15 August 2007

Fate of glycosylphosphatidylinositol (GPI)-less procyclin and characterization of sialylated non-GPI-anchored surface coat molecules of procyclic-form Trypanosoma brucei

scientific article published on 24 July 2009

Fin development in a cartilaginous fish and the origin of vertebrate limbs

scientific article published in April 2002

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

scientific article published on 26 November 2019

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1

scientific article published on 12 November 2021

Homeostasis in the vertebrate lens: mechanisms of solute exchange

scientific article published in April 2011

Identification of a Novel Intercellular Structure in Late-Stage Differentiating Lens Cells

scientific article published on 01 January 2003

Increased SK3 expression in DM1 lens cells leads to impaired growth through a greater calcium-induced fragility

scientific article

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

scientific article published on September 2010

Inhibition of autophagy in mitotic animal cells

scientific journal article

Inositol phospholipids regulate the guanine-nucleotide-exchange factor Tiam1 by facilitating its binding to the plasma membrane and regulating GDP/GTP exchange on Rac1

scientific article published on September 2004

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

scientific article

Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract

scientific journal article

Loss of kindlin-1, a human homolog of the Caenorhabditis elegans actin-extracellular-matrix linker protein UNC-112, causes Kindler syndrome

scientific article

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

scientific article

Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase

scientific article

Molecular mechanisms of kinetochore capture by spindle microtubules

scientific article published in April 2005

Morphological Changes and Nuclear Pore Clustering during Nuclear Degradation in Differentiating Bovine Lens Fibre Cells

scientific article published on 01 September 2002

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

scientific article

Ninein is released from the centrosome and moves bi-directionally along microtubules

scientific article published on 14 August 2007

Novel MHC class I structures on exosomes.

scientific article published on 13 July 2009

Nuclear speckle localisation of the small heat shock protein alpha B-crystallin and its inhibition by the R120G cardiomyopathy-linked mutation

scientific article (publication date: 15 July 2003)

Observation of keratin particles showing fast bidirectional movement colocalized with microtubules

scientific article published on April 2003

PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.

scientific article published on 14 December 2012

Proof that Burkholderia strains form effective symbioses with legumes: a study of novel Mimosa-nodulating strains from South America.

scientific article

Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin

scientific article published on 2 August 2013

Proximal effects of Toll-like receptor activation in dendritic cells

scientific article published on 4 December 2006

Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2

scientific article published on 21 December 2023

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

scientific article

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

scientific article published on March 2011

Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation

scientific article

Reorganization of centrosomal marker proteins coincides with epithelial cell differentiation in the vertebrate lens

scientific article published on 15 August 2007

Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling

scientific article published on 11 January 2013

Sigma receptor antagonists inhibit human lens cell growth and induce pigmentation

scientific article published in April 2005

Small molecule antagonists of the sigma-1 receptor cause selective release of the death program in tumor and self-reliant cells and inhibit tumor growth in vitro and in vivo

scientific article published on July 2004

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

scientific article published on 30 September 2004

TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent

scientific article published on September 2008

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF in LPS-stimulated macrophages

scientific article published on 01 January 2008

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

scientific article

The Alexander disease-causing glial fibrillary acidic protein mutant, R416W, accumulates into Rosenthal fibers by a pathway that involves filament aggregation and the association of alpha B-crystallin and HSP27

scientific article

The C Terminus of Lens Aquaporin 0 Interacts with the Cytoskeletal Proteins Filensin and CP49

article

The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation

scientific article

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells

scientific article

The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a.

scientific article

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

scientific article published on 29 April 2004

The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability

scientific article

The spontaneously adhesive leukocyte function-associated antigen-1 (LFA-1) integrin in effector T cells mediates rapid actin- and calmodulin-dependent adhesion strengthening to ligand under shear flow

scientific article published on 12 April 2013

The suppression of galactose metabolism in procylic form Trypanosoma brucei causes cessation of cell growth and alters procyclin glycoprotein structure and copy number.

scientific article

The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation.

scientific article published on April 2008

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

scientific article published on March 2006

The β2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo

scientific article published on 3 July 2013

Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle

scientific article

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

scientific journal article

Trypanosoma brucei glycoproteins contain novel giant poly-N-acetyllactosamine carbohydrate chains

scientific article published on 27 October 2004

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

scientific article

YuaB functions synergistically with the exopolysaccharide and TasA amyloid fibers to allow biofilm formation by Bacillus subtilis

scientific article

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase

scientific article

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

scientific article

p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase

scientific journal article

p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia

scientific article published on 3 October 2013

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