List of works - Lee Moir

2-Arylbenzo[d]oxazole phosphinate esters as second-generation modulators of utrophin for the treatment of Duchenne Muscular Dystrophy

scientific article published on 18 June 2020

A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice

scientific article

A genetic modifier suggests that endurance exercise exacerbates Huntington's disease

scientific article published on 2 March 2018

A missense mutation in the non-neural G-protein alpha-subunit isoforms modulates susceptibility to obesity.

scientific article published on 24 February 2009

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

scientific article

A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene

scientific article

Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid

scientific article published on 03 January 2020

Comprehensive Energy Balance Measurements in Mice

scientific article

Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31

scientific journal article

Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety

scientific article

Embryonic myosin is a regeneration marker to monitor utrophin based therapies for DMD

article

From Mice to Humans ⬇️

scientific article published on December 1, 2012

Micro-utrophin Improves Cardiac and Skeletal Muscle Function of Severely Affected D2/ Mice

scientific article published on 16 October 2018

Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice

scientific article (publication date: 2013)

New mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism but not in suckling

scientific article published on 3 January 2012

Novel phenotypes identified by plasma biochemical screening in the mouse

scientific article published in October 2002

Overexpression of Fto leads to increased food intake and results in obesity

scientific article

Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model

scientific article published on 01 January 2020

The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophy.

scientific article

Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle

scientific article published on 24 October 2017

List of works by Lee Moir

2-Arylbenzo[d]oxazole phosphinate esters as second-generation modulators of utrophin for the treatment of Duchenne Muscular Dystrophy

A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice

A genetic modifier suggests that endurance exercise exacerbates Huntington's disease

A missense mutation in the non-neural G-protein alpha-subunit isoforms modulates susceptibility to obesity.

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene

A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene

Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid

Comprehensive Energy Balance Measurements in Mice

Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31

Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety

Embryonic myosin is a regeneration marker to monitor utrophin based therapies for DMD

From Mice to Humans ⬇️

Micro-utrophin Improves Cardiac and Skeletal Muscle Function of Severely Affected D2/ Mice

Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice

New mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism but not in suckling

Novel phenotypes identified by plasma biochemical screening in the mouse

Overexpression of Fto leads to increased food intake and results in obesity

Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model

The potential of utrophin and dystrophin combination therapies for Duchenne muscular dystrophy.

Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle