List of works - Adrienne L. Edkins

A Trypanosoma cruzi heat shock protein 40 is able to stimulate the adenosine triphosphate hydrolysis activity of heat shock protein 70 and can substitute for a yeast heat shock protein 40.

scientific article published on August 2004

Analysis of the CD23-αv integrin interaction: a study with model peptides

scientific article published on 27 April 2012

Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay ⬇️

scientific article published on May 2013

Author Correction: LRP1 is required for novobiocin-mediated fibronectin turnover

scientific article published on 15 May 2020

CD23/FcεRII: molecular multi-tasking

scientific article (publication date: October 2010)

CHIP: a co-chaperone for degradation by the proteasome

scientific article published on January 2015

Cancer stem cells in breast cancer and metastasis

scientific article

Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean

Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells.

scientific article published on 5 January 2013

Differential regulation of monocyte cytokine release by αV and β(2) integrins that bind CD23.

scientific article

Dynamic Mitochondrial Localisation of STAT3 in the Cellular Adipogenesis Model 3T3-L1.

scientific article published on July 2015

Expanding the SAR of Nontoxic Antiplasmodial Indolyl-3-ethanone Ethers and Thioethers

scientific article published on 07 June 2018

Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model

scientific article

Facile synthesis and biological evaluation of assorted indolyl-3-amides and esters from a single, stable carbonyl nitrile intermediate

Ferrocenyl and organic novobiocin derivatives: Synthesis and their in vitro biological activity

scientific article

Fibronectin is a stress responsive gene regulated by HSF1 in response to geldanamycin.

scientific article

General Structural and Functional Features of Molecular Chaperones

HOP expression is regulated by p53 and RAS and characteristic of a cancer gene signature

scientific article published on 16 December 2016

HSP90 Interacts with the Fibronectin N-terminal Domains and Increases Matrix Formation

scientific article published on 22 January 2020

Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective.

scientific article published in January 2018

Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression

scientific article published on 08 March 2018

Hop/STIP1 depletion alters nuclear structure via depletion of nuclear structural protein emerin

scientific article published on 16 November 2018

Hsp40 Co-chaperones as Drug Targets: Towards the Development of Specific Inhibitors

article

Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins

scientific article published on January 2015

Hsp90 Co-chaperones as Drug Targets in Cancer: Current Perspectives

Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells

scientific article

Hsp90α/β associates with the GSK3β/axin1/phospho-β-catenin complex in the human MCF-7 epithelial breast cancer model

scientific article

Human DNAJ in cancer and stem cells

scientific article published on 27 August 2011

In vitro analysis of putative cancer stem cell populations and chemosensitivity in the SW480 and SW620 colon cancer metastasis model.

scientific article

Isolation, Characterization and Antiproliferative Activity of New Metabolites from the South African Endemic Red Algal Species Laurencia alfredensis.

scientific article

Knockdown of Hop downregulates RhoC expression, and decreases pseudopodia formation and migration in cancer cell lines

scientific article

LRP1 is required for novobiocin-mediated fibronectin turnover

scientific article published in Scientific Reports

Localisation of Theiler's murine encephalomyelitis virus protein 2C to the Golgi apparatus using antibodies generated against a peptide region

scientific article

Management of chemically contaminated bodies.

scientific article published in April 2005

Metal nanoparticles caused death of metastatic MDA-MB-231 breast cancer cells

scholarly article by Oluyomi S. Adeyemi et al published August 2013 in Toxicology Letters

NMR structural elucidation of channaine, an unusual alkaloid from Sceletium tortuosum

article published in 2018

Novobiocin-ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition

scientific article published on 12 December 2018

Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum

scientific article published in February 2019

Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro

scientific article published on 17 January 2012

Real-time monitoring of 3T3-L1 preadipocyte differentiation using a commercially available electric cell-substrate impedance sensor system

scientific article published on 3 January 2014

Regulation of the Extracellular Matrix by Heat Shock Proteins and Molecular Chaperones

SDF-1 and PDGF enhance alphavbeta5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines.

scientific article published on 16 July 2009

STAT3 interacts directly with Hsp90.

scientific article

STIP1/HOP Regulates the Actin Cytoskeleton through Interactions with Actin and Changes in Actin-Binding Proteins Cofilin and Profilin

scientific article published on 30 April 2020

Semi-Synthesis and Evaluation of Sargahydroquinoic Acid Derivatives as Potential Antimalarial Agents

scientific article published on 01 April 2019

Sequence and domain conservation of the coelacanth Hsp40 and Hsp90 chaperones suggests conservation of function

scientific article published on 17 September 2013

Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors.

scientific article published on 9 May 2016

Targeting Conserved Pathways as a Strategy for Novel Drug Development: Disabling the Cellular Stress Response

article

The African coelacanth genome provides insights into tetrapod evolution

scientific article

The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells

scientific article

Theiler's murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin

scientific article

Use of a non-hepatic cell line highlights limitations associated with cell-based assessment of metabolically induced toxicity

scientific article published on 18 March 2019

αvβ5 Integrin Sustains Growth of Human Pre-B Cells through an RGD-independent Interaction with a Basic Domain of the CD23 Protein

scientific article published in Journal of Biological Chemistry

List of works by Adrienne L. Edkins

A Trypanosoma cruzi heat shock protein 40 is able to stimulate the adenosine triphosphate hydrolysis activity of heat shock protein 70 and can substitute for a yeast heat shock protein 40.

Analysis of the CD23-αv integrin interaction: a study with model peptides

Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay ⬇️

Author Correction: LRP1 is required for novobiocin-mediated fibronectin turnover

CD23/FcεRII: molecular multi-tasking

CHIP: a co-chaperone for degradation by the proteasome

Cancer stem cells in breast cancer and metastasis

Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean

Cytotoxicity of lapachol, β-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells.

Differential regulation of monocyte cytokine release by αV and β(2) integrins that bind CD23.

Dynamic Mitochondrial Localisation of STAT3 in the Cellular Adipogenesis Model 3T3-L1.

Expanding the SAR of Nontoxic Antiplasmodial Indolyl-3-ethanone Ethers and Thioethers

Extracellular Hsp90 and TGFβ regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model

Facile synthesis and biological evaluation of assorted indolyl-3-amides and esters from a single, stable carbonyl nitrile intermediate

Ferrocenyl and organic novobiocin derivatives: Synthesis and their in vitro biological activity

Fibronectin is a stress responsive gene regulated by HSF1 in response to geldanamycin.

General Structural and Functional Features of Molecular Chaperones

HOP expression is regulated by p53 and RAS and characteristic of a cancer gene signature

HSP90 Interacts with the Fibronectin N-terminal Domains and Increases Matrix Formation

Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective.

Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression

Hop/STIP1 depletion alters nuclear structure via depletion of nuclear structural protein emerin

Hsp40 Co-chaperones as Drug Targets: Towards the Development of Specific Inhibitors

Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins

Hsp90 Co-chaperones as Drug Targets in Cancer: Current Perspectives

Hsp90 binds directly to fibronectin (FN) and inhibition reduces the extracellular fibronectin matrix in breast cancer cells

Hsp90α/β associates with the GSK3β/axin1/phospho-β-catenin complex in the human MCF-7 epithelial breast cancer model

Human DNAJ in cancer and stem cells

In vitro analysis of putative cancer stem cell populations and chemosensitivity in the SW480 and SW620 colon cancer metastasis model.

Isolation, Characterization and Antiproliferative Activity of New Metabolites from the South African Endemic Red Algal Species Laurencia alfredensis.

Knockdown of Hop downregulates RhoC expression, and decreases pseudopodia formation and migration in cancer cell lines

LRP1 is required for novobiocin-mediated fibronectin turnover

Localisation of Theiler's murine encephalomyelitis virus protein 2C to the Golgi apparatus using antibodies generated against a peptide region

Management of chemically contaminated bodies.

Metal nanoparticles caused death of metastatic MDA-MB-231 breast cancer cells

NMR structural elucidation of channaine, an unusual alkaloid from Sceletium tortuosum

Novobiocin-ferrocene conjugates possessing anticancer and antiplasmodial activity independent of HSP90 inhibition

Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum

Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro

Real-time monitoring of 3T3-L1 preadipocyte differentiation using a commercially available electric cell-substrate impedance sensor system

Regulation of the Extracellular Matrix by Heat Shock Proteins and Molecular Chaperones

SDF-1 and PDGF enhance alphavbeta5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines.

STAT3 interacts directly with Hsp90.

STIP1/HOP Regulates the Actin Cytoskeleton through Interactions with Actin and Changes in Actin-Binding Proteins Cofilin and Profilin

Semi-Synthesis and Evaluation of Sargahydroquinoic Acid Derivatives as Potential Antimalarial Agents

Sequence and domain conservation of the coelacanth Hsp40 and Hsp90 chaperones suggests conservation of function

Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors.

Targeting Conserved Pathways as a Strategy for Novel Drug Development: Disabling the Cellular Stress Response

The African coelacanth genome provides insights into tetrapod evolution

The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells

Theiler's murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin

Use of a non-hepatic cell line highlights limitations associated with cell-based assessment of metabolically induced toxicity

αvβ5 Integrin Sustains Growth of Human Pre-B Cells through an RGD-independent Interaction with a Basic Domain of the CD23 Protein