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List of works by Gianluigi Zaza

A new mechanism of action of sulodexide in diabetic nephropathy: inhibits heparanase-1 and prevents FGF-2-induced renal epithelial-mesenchymal transition.

scientific article

A specific immune transcriptomic profile discriminates chronic kidney disease patients in predialysis from hemodialyzed patients

scientific article

A type I interferon signature characterizes chronic antibody-mediated rejection in kidney transplantation

scientific article published on 04 June 2015

Aberrantly methylated DNA regions lead to low activation of CD4+ T-cells in IgA nephropathy.

scientific article published on 4 February 2016

Activated innate immunity and the involvement of CX3CR1-fractalkine in promoting hematuria in patients with IgA nephropathy.

scientific article published on 9 May 2012

Acute lymphoblastic leukemia with TEL-AML1 fusion has lower expression of genes involved in purine metabolism and lower de novo purine synthesis

scientific article

Altered modulation of WNT-beta-catenin and PI3K/Akt pathways in IgA nephropathy.

scientific article published on 19 May 2010

Assessment of physical performance and body composition in male renal transplant patients

scientific article published on 17 March 2018

Association between PNPLA3rs738409 polymorphism decreased kidney function in postmenopausal type 2 diabetic women with or without non-alcoholic fatty liver disease

scientific article published on 11 February 2019

Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

scientific article published on 01 December 2018

COVID-19 and Kidney Transplantation: Results from the TANGO International Transplant Consortium

scientific article published on 10 July 2020

COVID-19 and kidney transplantation: an Italian Survey and Consensus

scientific article published on 03 June 2020

Comparative transcriptome analysis of peripheral blood mononuclear cells in renal transplant recipients in everolimus- and tacrolimus-based immunosuppressive therapy

scientific article published on 22 June 2019

Complement and Complement Targeting Therapies in Glomerular Diseases ⬇️

scientific article published on 16 December 2019

De Novo Renal Neoplasia After Kidney Transplantation According to New 2016 WHO Classification of Renal Tumors

scientific article published on 6 December 2016

Dialysis-related systemic microinflammation is associated with specific genomic patterns.

scientific article published on 29 November 2007

Dialysis-related transcriptomic profiling: the pivotal role of heparanase

scientific article

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

scientific article published on 26 September 2016

Downregulation of nuclear-encoded genes of oxidative metabolism in dialyzed chronic kidney disease patients

scientific article (publication date: 2013)

Editorial of Special Issue "Rare Kidney Diseases: New Translational Research Approach to Improve Diagnosis and Therapy"

scientific article published on 14 June 2020

Epithelial to mesenchymal transition in the liver field: the double face of Everolimus in vitro.

scientific article published on 14 September 2015

Everolimus-induced epithelial to mesenchymal transition (EMT) in bronchial/pulmonary cells: when the dosage does matter in transplantation.

scientific article

Everolimus-induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase

scientific article published on 20 November 2013

Evidence of potent humoral immune activity in COVID19-infected kidney transplant recipients

scientific article published on 12 August 2020

Heparanase is a key player in renal fibrosis by regulating TGF-β expression and activity

scientific article

Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury.

scientific article

Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) Injury

scientific article

Heparanase: another renal player controlled by vitamin D

scientific article published on 14 November 2015

Histopathology and Long-Term Outcome of Kidneys Transplanted From Donors With Severe Acute Kidney Injury

scientific article published on 13 December 2018

How has peritoneal dialysis changed over the last 30 years: experience of the Verona dialysis center.

scientific article

How safe are organs from deceased donors with neoplasia? The results of the Italian Transplantation Network

scientific article published on 02 January 2019

Immunohistochemical characterization of glomerular and tubulointerstitial infiltrates in renal transplant patients with chronic allograft dysfunction

scientific article published on 30 June 2010

Impact of 3 Major Maintenance Immunosuppressive Protocols on Long-term Clinical Outcomes: Result of a Large Multicenter Italian Cohort Study Including 5635 Renal Transplant Recipients

scientific article published on 28 June 2018

Impact of heparanase on renal fibrosis

scientific article

Impact of maintenance immunosuppressive therapy on the fecal microbiome of renal transplant recipients: Comparison between an everolimus- and a standard tacrolimus-based regimen

scientific article

In Vitro Identification of New Transcriptomic and miRNomic Profiles Associated with Pulmonary Fibrosis Induced by High Doses Everolimus: Looking for New Pathogenetic Markers and Therapeutic Targets

scientific article published on 20 April 2018

In a retrospective international study, circulating miR-148b and let-7b were found to be serum markers for detecting primary IgA nephropathy.

scientific article published on 18 November 2015

In vitro effects of interleukin (IL)-1 beta inhibition on the epithelial-to-mesenchymal transition (EMT) of renal tubular and hepatic stellate cells

scientific article published on 07 January 2019

Incidence of primary glomerulonephritis in a large North-Eastern Italian area: a 13-year renal biopsy study

scientific article published on 6 December 2012

Interleukin-27 is a potential marker for the onset of post-transplant malignancies

scientific article published in January 2019

Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545.

scientific article published on 25 March 2017

Karyopherins: potential biological elements involved in the delayed graft function in renal transplant recipients.

scientific article

Kidney allograft fibrosis: what we learned from latest translational research studies

scientific article published on 19 March 2020

Liver Metastases From Renal Oncocytoma With Vascular Extension

scientific article published on 04 July 2017

Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms

scientific article published on 23 November 2018

Metabolic Fingerprinting of Fabry Disease: Diagnostic and Prognostic Aspects

scientific article published in 2022

Mitochondria: a new therapeutic target in chronic kidney disease

scientific article

Mitochondrial dysregulation and oxidative stress in patients with chronic kidney disease

scientific article published on 21 August 2009

NLRP3 inflammasome activation in dialyzed chronic kidney disease patients

scientific article

Naturally Occurring Compounds: New Potential Weapons against Oxidative Stress in Chronic Kidney Disease

scientific article

New non-renal congenital disorders associated with medullary sponge kidney (MSK) support the pathogenic role of GDNF and point to the diagnosis of MSK in recurrent stone formers.

scientific article published on 29 August 2016

Nonalcoholic Fatty Liver Disease Increases Risk of Incident Chronic Kidney Disease: a Systematic Review and Meta-Analysis.

scientific article

Personalization of the immunosuppressive treatment in renal transplant recipients: the great challenge in "omics" medicine

scientific article

PharmGKB summary: methotrexate pathway.

scientific article

Pharmacogenomics: a new paradigm to personalize treatments in nephrology patients.

scientific article

Predictive model for delayed graft function based on easily available pre-renal transplant variables

scientific article published on 28 August 2014

Proteomic Analysis of Urinary Extracellular Vesicles Reveals a Role for the Complement System in Medullary Sponge Kidney Disease ⬇️

scientific article published on 05 November 2019

Proteomic Analysis of Urinary Microvesicles and Exosomes in Medullary Sponge Kidney Disease and Autosomal Dominant Polycystic Kidney Disease

scientific article published on 24 April 2019

Proteomic-based research strategy identified laminin subunit alpha 2 as a potential urinary-specific biomarker for the medullary sponge kidney disease.

scientific article published on 30 November 2016

Rapamycin inhibits PAI-1 expression and reduces interstitial fibrosis and glomerulosclerosis in chronic allograft nephropathy

scientific article published on January 2008

Recent data concerning heparanase: focus on fibrosis, inflammation and cancer

scientific article published on 9 November 2015

Renal biopsy in chronic kidney disease: lessons from a large Italian registry

scientific article published on 13 March 2013

SARS-CoV-2 Pandemic and The Need for Transplant-oriented Trials

scientific article published on 25 April 2020

Safety and Efficacy of Citrate Anticoagulation for Continuous Renal Replacement Therapy for Acute Kidney Injury After Liver Transplantation: A Single-Center Experience

scientific article published on 01 May 2017

Sclerostin and Dickkopf-1 in Post-menopausal Renal Allograft Recipients

scientific article published on 01 September 2014

Serum fetuin a in hemodialysis: a link between derangement of calcium-phosphorus homeostasis and progression of atherosclerosis?

scientific article published on 23 January 2009

Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects

scientific article

Specific heparanase inhibition reverses glucose-induced mesothelial-to-mesenchymal transition.

scientific article published on 7 January 2017

Sulodexide alone or in combination with low doses of everolimus inhibits the hypoxia-mediated epithelial to mesenchymal transition in human renal proximal tubular cells.

scientific article published on 9 June 2015

Sulodexide and glycosaminoglycans in the progression of renal disease

scientific article

Systemic and nonrenal adverse effects occurring in renal transplant patients treated with mTOR inhibitors

scientific article

T helper 1, 2 and 17 cell subsets in renal transplant patients with delayed graft function.

scientific article published on 7 September 2010

TLR2 plays a role in the activation of human resident renal stem/progenitor cells

scientific article published on 20 October 2009

The Donor Action Project: a valuable tool to measure quality and efficacy of the donation process in Emilia-Romagna

scientific article

The anti-fibrotic effect of mycophenolic acid-induced neutral endopeptidase.

scientific article

The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis

scientific article published on 30 March 2020

The nephrologist of tomorrow: towards a kidney-omic future.

scientific article published on 9 March 2016

The relationship between calcium kidney stones, arterial stiffness and bone density: unraveling the stone-bone-vessel liaison

scientific article published on 30 September 2014

Transcriptomics: A Step behind the Comprehension of the Polygenic Influence on Oxidative Stress, Immune Deregulation, and Mitochondrial Dysfunction in Chronic Kidney Disease

scientific article

Tremor induced by Calcineurin inhibitor immunosuppression: a single-centre observational study in kidney transplanted patients

scientific article published on 18 May 2018

mTOR Inhibition Role in Cellular Mechanisms.

scientific article published in February 2018

mTOR inhibitors and renal allograft: Yin and Yang.

scientific article published on 08 May 2014

mTOR inhibitors effects on regulatory T cells and on dendritic cells

scientific article

miR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction.

scientific article published on 11 April 2016

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