List of works by Ko Willems van Dijk

A Diurnal Rhythm in Brown Adipose Tissue Causes Rapid Clearance and Combustion of Plasma Lipids at Wakening.

scientific article published in March 2018

A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose and Type 2 Diabetes

scientific article

A Novel Role for CETP as Immunological Gatekeeper: Raising HDL to Cure Sepsis?

scientific article published on 04 February 2020

A Workflow for Missing Values Imputation of Untargeted Metabolomics Data

scientific article published on 26 November 2020

A genome-wide association search for type 2 diabetes genes in African Americans

scientific article published on 4 January 2012

A single night of sleep curtailment increases plasma acylcarnitines: Novel insights in the relationship between sleep and insulin resistance

scientific article

AAV1-LPL(S447X) gene therapy reduces hypertriglyceridemia in apoE2 knock in mice

scientific article published on 16 August 2006

Adenovirus-Mediated Gene Transfer ⬇️

scientific article published on 01 January 2011

Adenovirus-mediated gene transfer

scientific article published on 01 January 2003

Akkermansia muciniphila Exerts Lipid-Lowering and Immunomodulatory Effects without Affecting Neointima Formation in Hyperlipidemic APOE*3-Leiden.CETP Mice

scientific article published on 06 August 2019

An 8-week high-fat diet induces obesity and insulin resistance with small changes in the muscle transcriptome of C57BL/6J mice

scientific article published in January 2009

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.

scientific article published on 13 June 2019

Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9.

scientific article

Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin

scientific article

Angptl4 upregulates cholesterol synthesis in liver via inhibition of LPL- and HL-dependent hepatic cholesterol uptake

scientific article (publication date: November 2007)

ApoAV reduces plasma triglycerides by inhibiting very low density lipoprotein-triglyceride (VLDL-TG) production and stimulating lipoprotein lipase-mediated VLDL-TG hydrolysis

scientific article

ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression

scientific article published in May 2005

ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency

scientific article published on 10 February 2008

Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake

scientific article published on 6 May 2013

Apolipoprotein AV: low concentration, high impact

scientific article published on 01 December 2005

Apolipoprotein CI causes hypertriglyceridemia independent of the very-low-density lipoprotein receptor and apolipoprotein CIII in mice

scientific article published on 27 January 2006

Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo

scientific article

Assessment of reproducibility and biological variability of fasting and postprandial plasma metabolite concentrations using 1H NMR spectroscopy

scientific article published on 20 June 2019

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants

scientific article

Association of metabolic syndrome and electrocardiographic markers of subclinical cardiovascular disease

scientific article

Associations between Lifestyle Factors and Vitamin E Metabolites in the General Population

scientific article published on 15 December 2020

Associations between outdoor temperature and bright sunlight with metabolites in two population-based European cohorts

scientific article published on 28 July 2020

Associations of Outdoor Temperature, Bright Sunlight, and Cardiometabolic Traits in Two European Population-Based Cohorts.

scientific article published in July 2019

Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

scientific article published on 31 March 2020

Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles

scientific article (publication date: 9 December 2013)

BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality

scientific article

BMT decreases HFD-induced weight gain associated with decreased preadipocyte number and insulin secretion.

scientific article published on 26 April 2017

Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

scientific article published on 03 February 2014

Body fat distribution, in particular visceral fat, is associated with cardiometabolic risk factors in obese women

scientific article published on 28 September 2017

Bone marrow transplantation induces changes in the gut microbiota that chronically increase the cytokine response pattern of splenocytes

scientific article published in 2022

Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

scientific article published on 3 November 2017

Butyrate via the gut-brain neuronal circuit reduces appetite and activates brown adipose tissue

scientific article

CD36 is important for adipocyte recruitment and affects lipolysis

scientific article published on 29 May 2013

CETP (Cholesteryl Ester Transfer Protein) Concentration: A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease

scientific article published on 01 May 2018

CETP does not affect triglyceride production or clearance in APOE*3-Leiden mice

scientific article published on January 2010

COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking.

scientific article published on 15 March 2018

Calorie Restriction is a Major Determinant of the Short-Term Metabolic Effects of Gastric Bypass Surgery in Obese Type 2 Diabetic Patients

scientific article published on 20 June 2013

Calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects

scientific article published on 12 June 2014

Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression

scientific article published on 14 October 2011

Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion

scientific article published on 17 November 2012

Chromosomal organization of the heavy chain variable region gene segments comprising the human fetal antibody repertoire ⬇️

scientific article published on November 1, 1992

Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice

scientific article published on 7 April 2015

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

scientific article

Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals

scientific article

Clearance of coagulation factor VIII in very low-density lipoprotein receptor knockout mice

scientific article published on 01 September 2004

Correction to: Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes

scientific article published on 04 November 2020

Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity

scientific article published on 9 January 2013

Differential insulin sensitivity of NMR-based metabolomic measures in a two-step hyperinsulinemic euglycemic clamp study

scientific article published on 09 June 2021

Disruption of circadian rhythm by alternating light-dark cycles aggravates atherosclerosis development in APOE*3-Leiden.CETP mice

scientific article published on 10 October 2019

Downregulation of the acetyl-CoA metabolic network in adipose tissue of obese diabetic individuals and recovery after weight loss.

scientific article published on 7 August 2014

Effect of plasma triglyceride metabolism on lipid storage in adipose tissue: studies using genetically engineered mouse models

scientific article published on 08 January 2009

Effects of low-stearate palm oil and high-stearate lard high-fat diets on rat liver lipid metabolism and glucose tolerance

scientific article

Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes

scientific article published on 5 August 2015

Effects of prolonged fasting on AMPK signaling, gene expression, and mitochondrial respiratory chain content in skeletal muscle from lean and obese individuals

scientific article

Efficient in vivo knock-down of estrogen receptor alpha: application of recombinant adenovirus vectors for delivery of short hairpin RNA.

scientific article

Energy restriction and Roux-en-Y gastric bypass reduce postprandial α-dicarbonyl stress in obese women with type 2 diabetes

scientific article published on 16 June 2016

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article published in May 2010

Estimation of activity related energy expenditure and resting metabolic rate in freely moving mice from indirect calorimetry data

scientific article (publication date: 2012)

European Lipoprotein Club: Report of the 27th ELC Annual Conference, Tutzing, 6–9 September 2004

European Lipoprotein Club: Report of the 28th ELC Annual Conference, Tutzing, 12–15 September 2005

European Lipoprotein Club: Report of the 29th ELC Annual Conference, Tutzing, 4-7 September 2006.

scientific article published on 3 January 2007

European Lipoprotein Club: Report of the 30th ELC annual conference, Tutzing, 3-6 September 2007.

scientific article published in March 2008

Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice

scientific article published on 03 May 2007

Fasting in diabetes treatment (FIT) trial: study protocol for a randomised, controlled, assessor-blinded intervention trial on the effects of intermittent use of a fasting-mimicking diet in patients with type 2 diabetes

scientific article published on 24 June 2020

FcRγ-chain deficiency reduces the development of diet-induced obesity.

scientific article published on 2 November 2015

Fenofibrate increases very low density lipoprotein triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden.CETP mice

scientific article published on 25 May 2010

Fiber-type-specific sensitivities and phenotypic adaptations to dietary fat overload differentially impact fast- versus slow-twitch muscle contractile function in C57BL/6J mice.

scientific article published on 25 October 2014

FluxModeCalculator: an efficient tool for large-scale flux mode computation

scientific article published on 18 December 2015

GC-MS Analysis of Medium- and Long-Chain Fatty Acids in Blood Samples.

scientific article published in January 2018

GC-MS Analysis of Short-Chain Fatty Acids in Feces, Cecum Content, and Blood Samples.

scientific article published in January 2018

Gender-dependent effects of high-fat lard diet on cardiac function in C57Bl/6J mice

scientific article published in March 2012

Generation of a recombinant apolipoprotein E variant with improved biological functions: hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia

scientific article published on 2 December 2004

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity

scientific article published on 11 September 2020

Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache

scientific article published on 14 July 2021

Genetic architecture of plasma adiponectin overlaps with the genetics of metabolic syndrome-related traits

scientific article

Genetic insights into biological mechanisms governing human ovarian ageing

scientific article

Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data

scientific article published on 01 June 2020

Genetics of the human metabolome, what is next?

scientific article published in October 2014

Genome-Wide Association Study on the Early-Phase Insulin Response to a Liquid Mixed Meal: Results From the NEO Study

scientific article published on 19 September 2019

Genome-wide Association Study of the Postprandial Triglyceride Response Yields Common Genetic Variation in Hepatic Lipase (LIPC)

scientific article published on 30 June 2020

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

scientific article

Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program

scientific article

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol

scientific article

Hepatic triglyceride content does not affect circulating CETP: lessons from a liraglutide intervention trial and a population-based cohort

scientific article published on 10 July 2019

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

scientific article published on 07 January 2020

Heritability of dietary food intake patterns

scientific article published on 15 March 2012

High fat diet-induced changes in mouse muscle mitochondrial phospholipids do not impair mitochondrial respiration despite insulin resistance

scientific article

High levels of dietary stearate promote adiposity and deteriorate hepatic insulin sensitivity

scientific article

High levels of whole-body energy expenditure are associated with a lower coupling of skeletal muscle mitochondria in C57Bl/6 mice

article published in 2010

High-fat diets rich in medium- versus long-chain fatty acids induce distinct patterns of tissue specific insulin resistance

scholarly article by Johan De Vogel-van den Bosch et al published April 2011 in Journal of Nutritional Biochemistry

Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profiling

scientific article published on 03 November 2021

Hyperlipidemia in APOE2 transgenic mice is ameliorated by a truncated apoE variant lacking the C-terminal domain.

scientific article published on 16 October 2002

Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation

scientific article

Improving the analysis of designed studies by combining statistical modelling with study design information

scientific article

In vivo and in silico dynamics of the development of Metabolic Syndrome.

scientific article

Increased PUFA Content and 5-Lipoxygenase Pathway Expression Are Associated with Subcutaneous Adipose Tissue Inflammation in Obese Women with Type 2 Diabetes.

scientific article

Increased systemic and adipose tissue inflammation differentiates obese women with T2DM from obese women with normal glucose tolerance.

scientific article published on 10 December 2013

Inhibition of neointima formation by local delivery of estrogen receptor alpha and beta specific agonists

scientific article published on 10 November 2006

Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses

scientific article

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

scientific article published on 13 January 2020

Intrauterine exposure to maternal atherosclerotic risk factors increases the susceptibility to atherosclerosis in adult life

scientific article published on 26 July 2007

Investigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses

scientific article published on 18 March 2021

Local Cre-mediated gene recombination in vascular smooth muscle cells in mice

scientific article published in February 2006

Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B.

scientific article published on 28 January 2014

LysoPC-acyl C16:0 is associated with brown adipose tissue activity in men

scientific article published on 03 March 2017

META060 protects against diet-induced obesity and insulin resistance in a high-fat-diet fed mouse

scientific article published on 15 September 2012

MIF deficiency reduces chronic inflammation in white adipose tissue and impairs the development of insulin resistance, glucose intolerance, and associated atherosclerotic disease

scientific article published on 28 May 2009

Macrophage-specific inhibition of NF-kappaB activation reduces foam-cell formation

scientific article

Male apoE*3-Leiden.CETP mice on high-fat high-cholesterol diet exhibit a biphasic dyslipidemic response, mimicking the changes in plasma lipids observed through life in men.

scientific article published on 16 October 2017

Mannose-Binding Lectin Is Required for the Effective Clearance of Apoptotic Cells by Adipose Tissue Macrophages During Obesity

scientific article published on 09 July 2014

Maternal transmission of risk for atherosclerosis

scientific article published on August 2008

Mendelian randomization analysis of cholesteryl ester transfer protein and subclinical atherosclerosis: A population-based study.

scientific article published on 2 November 2017

Mendelian randomization reveals unexpected effects of CETP on the lipoprotein profile

scientific article published on 12 November 2018

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels

scientific article

Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls

scientific article published on 29 August 2019

Metabolomics Profiling of Visceral Adipose Tissue: Results From MESA and the NEO Study

scientific article published on 01 May 2019

Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity

scientific article published on 02 March 2020

Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study

scientific article published on 28 July 2017

Metabolomics: a search for biomarkers of visceral fat and liver fat content

scientific article published on 05 October 2019

Modulation of the gut microbiota impacts nonalcoholic fatty liver disease: a potential role for bile acids

scientific article published on 22 May 2017

Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype

scientific article published in August 2003

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

scientific article published on 12 November 2019

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Perfluoroalkyl sulfonates cause alkyl chain length-dependent hepatic steatosis and hypolipidemia mainly by impairing lipoprotein production in APOE*3-Leiden CETP mice

scientific article published on 24 June 2011

Physiological changes due to mild cooling in healthy lean males of white Caucasian and South Asian descent: A metabolomics study.

scientific article published on 15 September 2015

Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism

scientific article published on 13 June 2006

Plasma cholesteryl ester transfer protein is predominantly derived from Kupffer cells.

scientific article published on 14 July 2015

Plasma metabolomics identifies markers of impaired renal function: A meta-analysis of 3,089 persons with type 2 diabetes

scientific article published on 09 April 2020

Postprandial metabolite profiles associated with type 2 diabetes clearly stratify individuals with impaired fasting glucose

scientific article published on 12 December 2017

Practical aspects of estimating energy components in rodents

scientific article published on May 2013

Preclinical studies on intestinal administration of antisense oligonucleotides as a model for oral delivery for treatment of duchenne muscular dystrophy

scientific article published on 18 November 2014

Prenatal exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature

scientific article

Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile.

scientific article

Proteoglycan 4 deficiency protects against glucose intolerance and fatty liver disease in diet-induced obese mice

scientific article published on 15 November 2018

Proteomic analysis in type 2 diabetes patients before and after a very low calorie diet reveals potential disease state and intervention specific biomarkers

scientific article

Reanalysis of mGWAS results and in vitro validation show that lactate dehydrogenase interacts with branched-chain amino acid metabolism

scientific article published on 27 May 2015

Regulation of skeletal muscle energy/nutrient-sensing pathways during metabolic adaptation to fasting in healthy humans.

scientific article published on 23 September 2014

Relation of Overall and Abdominal Adiposity With Electrocardiogram Parameters of Subclinical Cardiovascular Disease in Individuals Aged 45 to 65 Years (from the Netherlands Epidemiology of Obesity Study).

scientific article

Repeat length variations in polyglutamine disease-associated genes affect body mass index

scientific article published on 17 August 2018

Role of Rare and Low-Frequency Variants in Gene-Alcohol Interactions on Plasma Lipid Levels

scientific article published on 08 June 2020

Role of the macrophage very-low-density lipoprotein receptor in atherosclerotic lesion development.

scientific article

Roux-en-Y gastric bypass surgery, but not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the presence of type 2 diabetes

scientific article published on 14 October 2014

Selective targeting of liposomes to macrophages using a ligand with high affinity for the macrophage scavenger receptor class A.

scientific article published on June 2006

Serum CETP concentration is not associated with measures of body fat: The NEO study

scientific article published on 19 January 2016

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects.

scientific article published on January 2015

Skeletal muscle mitochondrial uncoupling, adaptive thermogenesis and energy expenditure.

scientific article published on May 2011

Smoking is associated with increased resting energy expenditure in the general population: The NEO study

scientific article published on 18 August 2015

Study design of the Fasting In diabetes Treatment (FIT) trial: a randomised, controlled, assessor blinded intervention trial which examines the effect of intermittent use of a fasting mimicking diet in patients with type 2 diabetes

scientific article published on 01 June 2020

Targeted sequencing by proximity ligation for comprehensive variant detection and local haplotyping.

scientific article published on 17 August 2014

The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice

scientific article

The VLDL receptor plays a major role in chylomicron metabolism by enhancing LPL-mediated triglyceride hydrolysis

scientific article

The association of genetic variants in the cholesteryl ester transfer protein gene with hemostatic factors and a first venous thrombosis

scientific article published on 21 June 2019

The contribution of tissue-grouped BMI-associated gene sets to cardiometabolic-disease risk: a Mendelian randomization study

scientific article published on 04 June 2020

The effect of mirabegron on energy expenditure and brown adipose tissue in healthy lean South Asian and Europid men

scientific article published on 18 June 2020

The expression of type III hyperlipoproteinemia: involvement of lipolysis genes

scientific article

The genetics of fasting and postprandial metabolite levels are overlapping.

scientific article published on 26 January 2018

The hepatic uptake of VLDL in lrp-ldlr-/-vldlr-/- mice is regulated by LPL activity and involves proteoglycans and SR-BI

scientific article published on 26 March 2008

The limited storage capacity of gonadal adipose tissue directs the development of metabolic disorders in male C57Bl/6J mice

scientific article published on 12 May 2015

The prebiotic inulin modulates gut microbiota but does not ameliorate atherosclerosis in hypercholesterolemic APOE*3-Leiden.CETP mice

scientific article published in Scientific Reports

The prevalence of metabolic syndrome and its association with body fat distribution in middle-aged individuals from Indonesia and the Netherlands: a cross-sectional analysis of two population-based studies

scientific article published on 07 January 2020

The role and mode of action of apolipoproteins CIII and AV: synergistic actors in triglyceride metabolism?

scientific article

The role of C-reactive protein, adiponectin and leptin in the association between abdominal adiposity and insulin resistance in middle-aged individuals

scientific article published on 05 May 2020

The role of body mass index, insulin, and adiponectin in the relation between fat distribution and bone mineral density

scientific article

The suprachiasmatic nucleus controls circadian energy metabolism and hepatic insulin sensitivity

scientific article published on 28 December 2012

Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin reduces body weight by decreasing food intake and increasing fat oxidation

scientific article published on 3 August 2011

Type 2 diabetes is associated with postprandial amino acid measures

scientific article published on 10 August 2015

VLDL receptor deficiency enhances intimal thickening after vascular injury but does not affect atherosclerotic lesion area

scientific article

Very-low-density lipoprotein binding to the apolipoprotein E receptor 2 is enhanced by lipoprotein lipase, and does not require apolipoprotein E.

scientific article published on April 2000

Weight loss induced by very low calorie diet is associated with a more beneficial systemic inflammatory profile than by Roux-en-Y gastric bypass

scientific article published on 16 August 2016

Znf202 affects high density lipoprotein cholesterol levels and promotes hepatosteatosis in hyperlipidemic mice

scientific article

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