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List of works by Rachel M Freathy

A Common Allele in FGF21 Associated with Sugar Intake Is Associated with Body Shape, Lower Total Body-Fat Percentage, and Higher Blood Pressure

scientific article published in April 2018

A common allele in FGF21 associated with preference for sugar consumption lowers body fat in the lower body and increases blood pressure

scholarly article published 6 November 2017

A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy

scientific article published on 09 May 2009

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

scientific article

A common variant of HMGA2 is associated with adult and childhood height in the general population

scientific article

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

scientific article

A novel common variant in DCST2 is associated with length in early life and height in adulthood

scientific article published on 3 October 2014

A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population

scientific article

Adult height variants affect birth length and growth rate in children

scientific article

Association analysis of 29,956 individuals confirms that a low-frequency variant at CCND2 halves the risk of type 2 diabetes by enhancing insulin secretion

scientific article published on 20 January 2015

Association of COMT Val(108/158)Met genotype and cigarette smoking in pregnant women

scientific article

Association of maternal circulating 25(OH)D and calcium with birth weight: A mendelian randomisation analysis.

scientific article published on 18 June 2019

Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome

scientific article published on 14 May 2008

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

scientific article

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

scientific article published on 29 September 2017

Can genetic evidence help us to understand the fetal origins of type 2 diabetes?

scientific article published on 19 July 2016

Common maternal and fetal genetic variants show expected polygenic effects on risk of small- or large-for-gestational-age (SGA or LGA), except in the smallest 3% of babies

scientific article published on 07 December 2020

Common variants at 12q15 and 12q24 are associated with infant head circumference

scientific article published on 15 April 2012

Common variants near MC4R are associated with fat mass, weight and risk of obesity

scientific article

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

scientific article

Dissecting maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes, and adult phenotypes: A mendelian-randomization and haplotype-based genetic score analysis in 10,734 mother-infant pairs

scientific article published on 25 August 2020

Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference

scholarly article published in Nature Genetics

Evidence that low socioeconomic position accentuates genetic susceptibility to obesity

article published in 2016

FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians.

scientific article

Fetal Genotype and Maternal Glucose have Independent and Additive Effects on Birth Weight.

scientific article published on 20 February 2018

Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population

scientific article published on 09 May 2006

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

scientific article published on 04 September 2019

Gene-obesogenic environment interactions in the UK Biobank study

scientific article published on 10 January 2017

Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight

scientific article published on March 2016

Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease

scientific article published on 26 April 2016

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health

scientific article

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

article

Genetic influences on the association between fetal growth and susceptibility to type 2 diabetes

scientific article

Genetic origins of low birth weight

scientific article published on May 2012

Genetic studies of accelerometer-based sleep measures in 85,670 individuals yield new insights into human sleep behaviour

article published in 2018

Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour

scientific article published on 05 April 2019

Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

scientific article published on 18 May 2011

Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight

scientific article

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci.

scientific article

Genome-Wide and Abdominal MRI-Imaging Data Provides Evidence that a Genetically Determined Favourable Adiposity Phenotype is Characterized by Lower Ectopic Liver Fat and Lower Risk of Type 2 Diabetes, Heart Disease and Hypertension

scientific article published on 23 October 2018

Genome-wide association analyses in >119,000 individuals identifies thirteen morningness and two sleep duration loci

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms

scientific article published in Nature Communications

Genome-wide association analyses of chronotype in 697,828 individuals provides new insights into circadian rhythms in humans and links to disease

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

scientific article

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

scientific article

Genome-wide association study of offspring birth weight in 86,577 women highlights maternal genetic effects that are independent of fetal genetics

article

Genome-wide association study of offspring birth weight in 86,577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics

scientific article published on 3 January 2018

Genome-wide associations for birth weight and correlations with adult disease

scientific article

Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank

scientific article

How Can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes?

scientific article

Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants

scientific article published on 23 March 2016

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchallenge glucose levels in pregnancy and with the new consensus definition of gestational diabetes mellitus from

scientific article

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease

scientific article

Maternal and fetal genetic contribution to gestational weight gain

article

Maternal and fetal genetic contribution to gestational weight gain.

scientific article published on 9 October 2017

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

scientific article published on 01 May 2019

Mendelian randomization studies do not support a role for raised circulating triglyceride levels influencing type 2 diabetes, glucose levels, or insulin resistance

scientific article

Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort

scientific article published on 26 October 2020

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

scientific article

Mosaic Turner syndrome shows reduced penetrance in an adult population study

scientific article published on 05 September 2018

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

scientific article published on 2 December 2012

Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits

scientific article published on 12 October 2020

Parental diabetes and birthweight in 236 030 individuals in the UK biobank study

scientific article published on 11 December 2013

Quantifying the extent to which index event biases influence large genetic association studies

scientific article published on 30 December 2016

Quantifying the extent to which index event biases influence large genetic association studies

article

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

scientific article (publication date: June 2007)

Response to Prakash et al

scientific article published on 21 December 2018

Smoking is associated with, but does not cause, depressed mood in pregnancy--a mendelian randomization study

scientific article

The Effect of Genetic Variation on the Placental Transcriptome in Humans.

scientific article

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians

scientific article published on 5 June 2006

The impact of the angiotensin-converting enzyme insertion/deletion polymorphism on severe hypoglycemia in Type 2 diabetes

scientific article published on 10 August 2006

The influence of transmitted and non-transmitted parental BMI-associated alleles on the risk of overweight in childhood

scientific article published on 16 March 2020

The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy

scientific article (publication date: 2012)

Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals

scientific article published on 23 April 2007

Type 2 diabetes risk alleles are associated with reduced size at birth

scientific article published on 19 February 2009

Using a two-sample Mendelian randomization design to investigate a possible causal effect of maternal lipid concentrations on offspring birth weight

scientific article published on 01 October 2019

Using genetics to understand the causal influence of higher BMI on depression

article

Using structural equation modelling to jointly estimate maternal and fetal effects on birthweight in the UK Biobank

scientific article published on 13 February 2018

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

scientific article

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes respectively

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively

scientific article published on 10 March 2016

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 are associated with gestational duration

article

Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration

scientific article published on 02 September 2019

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