List of works - Aris Economides

A lymphatic defect causes ocular hypertension and glaucoma in mice

scientific article (publication date: October 2014)

A shared, non-canonical DNA conformation detected at DNA/protein contact sites and bent DNA in the absence of supercoiling or cognate protein binding

scientific article published on October 1996

A sweat gland-derived differentiation activity acts through known cytokine signaling pathways.

scientific article published in November 1997

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

scientific article

Abstract 09: Changing The Paradigm For A Rare Genetic Disease That Is Currently Contraindicated For Surgery and Lacks Alternative Treatments.

scientific article published in April 2018

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

scientific article published on 09 June 2020

Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone.

scientific article published in March 2004

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

scientific article

Apoptosis in cord blood T lymphocytes from infants of human immunodeficiency virus-infected mothers

scientific article

Application of a novel strategy of engineering conditional alleles to a single exon gene, Sox2.

scientific article

Author Correction: The bone marrow microenvironment at single-cell resolution

scientific article published on 01 August 2019

BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b.

scientific article published on 10 November 2011

Biochemical and biophysical characterization of refolded Drosophila DPP, a homolog of bone morphogenetic proteins 2 and 4.

scientific article published in October 1998

Bmp7 maintains undifferentiated kidney progenitor population and determines nephron numbers at birth

scientific article

Bone Morphogenetic Protein 2 Coordinates Early Tooth Mineralization.

scientific article published in February 2018

Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts

scientific article

Bone morphogenetic proteins, their antagonists, and the skeleton

scientific article

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors.

scientific article

Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression

scholarly article by Aimy Sebastian published in September 2018

Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression

scientific article published on 14 August 2018

Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy

scientific article

Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair

scientific article published on March 2010

Conditional deletion of gremlin causes a transient increase in bone formation and bone mass

scientific article

Conditionals by inversion provide a universal method for the generation of conditional alleles

scientific journal article

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis

scientific article

Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells

scientific article

Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice

scientific article

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.

scientific article

Control of digit formation by activin signalling

scientific article published on 01 May 1999

Cooperative activity of noggin and gremlin 1 in axial skeleton development

scientific article

Cytokine traps: multi-component, high-affinity blockers of cytokine action

scientific article (publication date: 2003)

Designer cytokines: targeting actions to cells of choice

scientific article

Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2.

scientific article published in May 2009

Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways

scientific article

Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study

scientific article published on December 2016

Effects of BMP7 Produced by Group 2 Innate Lymphoid Cells on Adipogenesis

scientific article published on 09 March 2020

Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age.

scientific article

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

scientific article

Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway

scientific article published on 29 March 2019

Exome sequencing and characterization of 49,960 individuals in the UK Biobank

scientific article published on 21 October 2020

Expression and function of Gdf-5 during digit skeletogenesis in the embryonic chick leg bud.

scientific article

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury

article

Follistatin and noggin are excluded from the zebrafish organizer.

scientific article published on December 1998

Functional biology of the Steel syndrome founder allele and evidence for clan genomics derivation of COL27A1 pathogenic alleles worldwide

scientific article published on 06 May 2020

Generation and functional characterization of mice with a conditional BMP7 allele.

scientific article published in January 2009

Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism

scientific article published on September 2011

Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis

scientific article published on 18 April 2016

Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients

scientific article (publication date: 18 January 2002)

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

scientific article (publication date: June 2003)

Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding

scientific article

Identification of mammalian noggin and its expression in the adult nervous system

scientific article

In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased Mouse Model

scientific article (publication date: 2016)

In vivo somatic cell gene transfer of an engineered Noggin mutein prevents BMP4-induced heterotopic ossification

scientific article published in December 2003

Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function

scientific article

Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease

scientific article

Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis.

scientific article published on 12 March 2018

Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts

scientific article

Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations

scientific article

Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice

scientific article published on 10 August 2011

Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.

scientific article

MAPPIN: a method for annotating, predicting pathogenicity and mode of inheritance for nonsynonymous variants

scientific article published on 25 August 2017

Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling

scientific article published on August 1998

Multifunctional Alleles: A novel method for the generation of "All-In-One" null and conditional alleles

scientific article published on 27 April 2019

Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis

scientific article

Neural induction by the secreted polypeptide noggin

scientific article published in October 1993

New horizons at the caudal embryos: coordinated urogenital/reproductive organ formation by growth factor signaling.

scientific article published on 16 September 2009

Noggin arrests stromal cell differentiation in vitro☆☆This work was supported by Grant AR21707 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and Grant DK45227 from the National Institute of Diabetes, Digestive an

scientific article published on 01 February 2003

Noggin gene delivery inhibits cementoblast-induced mineralization.

scientific article published on January 2004

Noncoding RNA transcription targets AID to divergently transcribed loci in B cells.

scientific article

Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury

Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation

scientific article published on 20 February 2016

Podocyte-derived BMP7 is critical for nephron development

scientific article published on 15 October 2008

RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity.

scientific article published on May 2015

Reactivation of a developmental signaling center is required for therapeutic control of the murine periosteal niche

scientific article published on 08 February 2019

Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region

scientific journal article

Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia

scientific article

Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model

scientific article published on 10 March 2015

Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5

scientific article

Response to "Mutations of the NOGGIN and of the activin A type I receptor genes in fibrodysplasia ossificans progressiva (FOP)" by Lucotte et al.

scientific article

SOST/Sclerostin Improves Post Traumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury.

scientific article published on 26 January 2018

Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model

scientific article

Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis

scientific article published on 23 December 2015

Skeletal Overexpression of Noggin Results in Osteopenia and Reduced Bone Formation

scientific article published on 01 May 2003

Skeletal overexpression of gremlin impairs bone formation and causes osteopenia

scientific article

Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner.

scientific article published on 29 August 2013

Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells

scientific article

Sox2 acts as a rheostat of epithelial to mesenchymal transition during neural crest development.

scientific article

Structural basis of BMP signaling inhibition by Noggin, a novel twelve-membered cystine knot protein.

scientific article published in January 2003

Structural basis of BMP signalling inhibition by the cystine knot protein Noggin

scientific article

Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity

scientific article published on 17 July 2019

Sustained Notch2 signaling in osteoblasts, but not in osteoclasts, is linked to osteopenia in a mouse model of Hajdu-Cheney syndrome

scientific article published on 7 June 2017

Sustained induction of neuronal addition to the adult rat neostriatum by AAV4-delivered noggin and BDNF.

scientific article

Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease

scientific article

Sydenham's chorea and seizures. Clinical and electroencephalographic studies

scientific article published on 01 June 1978

Targeted deletion of Sost distal enhancer increases bone formation and bone mass

scientific article

The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb

scientific article (published 1999-12-01)

The BMP antagonist noggin regulates cranial suture fusion

scientific article

The Bone Morphogenetic Proteins Antagonist Noggin Inhibits Membranous Ossification

article

The Bulk of Autotaxin Activity Is Dispensable for Adult Mouse Life

scientific article

The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow.

scientific article published on 15 April 2011

The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A-Dependent

scientific article published on 7 August 2017

The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities

scientific article

The bone marrow microenvironment at single-cell resolution

scientific article published on 10 April 2019

The effects of variations in end-expiratory inflation pressure on cardiorespiratory function in normo-, hypo-and hypervolaemic dogs ⬇️

scientific article published on 01 August 1970

The mammalian gene function resource: the International Knockout Mouse Consortium

scientific article

The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome

article

The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry

scientific article published on September 1999

The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva.

scientific article published on 16 June 2017

Twisted gastrulation, a BMP antagonist, exacerbates podocyte injury

scientific article

Twisted gastrulation, a bone morphogenetic protein agonist/antagonist, is not required for post-natal skeletal function

scientific article published on 24 August 2006

Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.

scientific article published on November 2016

Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts

scientific article published on 27 November 2017

Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2

scientific article

microTSS: accurate microRNA transcription start site identification reveals a significant number of divergent pri-miRNAs.

scientific article published on 10 December 2014

List of works by Aris Economides

A lymphatic defect causes ocular hypertension and glaucoma in mice

A shared, non-canonical DNA conformation detected at DNA/protein contact sites and bent DNA in the absence of supercoiling or cognate protein binding

A sweat gland-derived differentiation activity acts through known cytokine signaling pathways.

ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.

Abstract 09: Changing The Paradigm For A Rare Genetic Disease That Is Currently Contraindicated For Surgery and Lacks Alternative Treatments.

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop

Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone.

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor.

Apoptosis in cord blood T lymphocytes from infants of human immunodeficiency virus-infected mothers

Application of a novel strategy of engineering conditional alleles to a single exon gene, Sox2.

Author Correction: The bone marrow microenvironment at single-cell resolution

BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b.

Biochemical and biophysical characterization of refolded Drosophila DPP, a homolog of bone morphogenetic proteins 2 and 4.

Bmp7 maintains undifferentiated kidney progenitor population and determines nephron numbers at birth

Bone Morphogenetic Protein 2 Coordinates Early Tooth Mineralization.

Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts

Bone morphogenetic proteins, their antagonists, and the skeleton

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors.

Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression

Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression

Conditional activation of akt in adult skeletal muscle induces rapid hypertrophy

Conditional deletion of BMP7 from the limb skeleton does not affect bone formation or fracture repair

Conditional deletion of gremlin causes a transient increase in bone formation and bone mass

Conditionals by inversion provide a universal method for the generation of conditional alleles

Connective tissue growth factor (CTGF) inactivation leads to defects in islet cell lineage allocation and beta-cell proliferation during embryogenesis

Connective tissue growth factor acts within both endothelial cells and beta cells to promote proliferation of developing beta cells

Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male mice

Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP.

Control of digit formation by activin signalling

Cooperative activity of noggin and gremlin 1 in axial skeleton development

Cytokine traps: multi-component, high-affinity blockers of cytokine action

Designer cytokines: targeting actions to cells of choice

Direct hematological toxicity and illegitimate chromosomal recombination caused by the systemic activation of CreERT2.

Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways

Distribution and clinical impact of functional variants in 50,726 whole-exome sequences from the DiscovEHR study

Effects of BMP7 Produced by Group 2 Innate Lymphoid Cells on Adipogenesis

Elimination of BMP7 from the developing limb mesenchyme leads to articular cartilage degeneration and synovial inflammation with increased age.

Essential requirement of BMPs-2/4 for both osteoblast and osteoclast formation in murine bone marrow cultures from adult mice: antagonism by noggin

Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway

Exome sequencing and characterization of 49,960 individuals in the UK Biobank

Expression and function of Gdf-5 during digit skeletogenesis in the embryonic chick leg bud.

Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury

Follistatin and noggin are excluded from the zebrafish organizer.

Functional biology of the Steel syndrome founder allele and evidence for clan genomics derivation of COL27A1 pathogenic alleles worldwide

Generation and functional characterization of mice with a conditional BMP7 allele.

Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism

Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis

Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients

High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

Human disease-causing NOG missense mutations: effects on noggin secretion, dimer formation, and bone morphogenetic protein binding

Identification of mammalian noggin and its expression in the adult nervous system

In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased Mouse Model

In vivo somatic cell gene transfer of an engineered Noggin mutein prevents BMP4-induced heterotopic ossification

Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function

Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease

Induction of the Hajdu-Cheney Syndrome Mutation in CD19 B Cells in Mice Alters B-Cell Allocation but Not Skeletal Homeostasis.

Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts

Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations

Loss of gremlin delays primordial follicle assembly but does not affect female fertility in mice

Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome.

MAPPIN: a method for annotating, predicting pathogenicity and mode of inheritance for nonsynonymous variants

Morphogenesis of digits in the avian limb is controlled by FGFs, TGFbetas, and noggin through BMP signaling

Multifunctional Alleles: A novel method for the generation of "All-In-One" null and conditional alleles

Nephroblastoma overexpressed (Nov) inactivation sensitizes osteoblasts to bone morphogenetic protein-2, but nov is dispensable for skeletal homeostasis

Neural induction by the secreted polypeptide noggin

New horizons at the caudal embryos: coordinated urogenital/reproductive organ formation by growth factor signaling.

Noggin arrests stromal cell differentiation in vitro☆☆This work was supported by Grant AR21707 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, and Grant DK45227 from the National Institute of Diabetes, Digestive an

Noggin gene delivery inhibits cementoblast-induced mineralization.

Noncoding RNA transcription targets AID to divergently transcribed loci in B cells.

Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury

Odd skipped-related 1 (Osr1) identifies muscle-interstitial fibro-adipogenic progenitors (FAPs) activated by acute injury

Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1(R206H) Fibrodysplasia Ossificans Progressiva (FOP) Mutation

Podocyte-derived BMP7 is critical for nephron development

RNA exosome-regulated long non-coding RNA transcription controls super-enhancer activity.

Reactivation of a developmental signaling center is required for therapeutic control of the murine periosteal niche

Receptor tyrosine kinase-like orphan receptor 2 (ROR2) and Indian hedgehog regulate digit outgrowth mediated by the phalanx-forming region

Reduced BMP signaling results in hindlimb fusion with lethal pelvic/urogenital organ aplasia: a new mouse model of sirenomelia

Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model

Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5