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List of works by Marcus E Kleber

A catalog of genetic loci associated with kidney function from analyses of a million individuals

scientific article published on 31 May 2019

A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration

scientific article published on January 2015

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

scientific article

A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease

scientific article

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

scientific article

A variant in the ABO gene explains the variation in soluble E-selectin levels-results from dense genotyping in two independent populations

scientific article

Additional use of glycated hemoglobin for diagnosis of type 2 diabetes in people undergoing coronary angiography reveals a subgroup at increased cardiovascular risk

scientific article

Adiponectin and Mortality in Smokers and Non-Smokers of the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study

scientific article published on 30 June 2016

Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis

scientific article published in December 2016

Alterations in the coagulation system of active smokers from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

scientific article

Apolipoprotein E genotypes, circulating C-reactive protein and angiographic coronary artery disease: The Ludwigshafen Risk and Cardiovascular Health Study

article

Area-based socioeconomic status and mortality: the Ludwigshafen Risk and Cardiovascular Health study

scientific article published on 29 May 2019

Assessment of the Relationship Between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study

article published in 2019

Association between a gene variant near ataxia telangiectasia mutated and coronary artery disease in men.

scientific article published on 26 November 2013

Association of 25-hydroxyvitamin D with type 2 diabetes among patients undergoing coronary angiography: cross-sectional findings from the LUdwigshafen Risk and Cardiovascular Health (LURIC) Study

scientific article published on April 2013

Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

scientific article published on 04 September 2019

Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events

scientific article published on 21 March 2019

Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk

Association of Factor V Leiden with Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data

scientific article published on 13 July 2020

Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.

scientific article published in July 2011

Association of double product and pulse pressure with cardiovascular and all-cause mortality in the LURIC study

scientific article published on 09 October 2020

Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography--the LURIC study

scientific article

Association of soluble CD40L with short-term and long-term cardiovascular and all-cause mortality: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study

scientific article published on 14 September 2019

Association of the novel single-nucleotide polymorphism which increases oxidized low-density lipoprotein levels with cerebrovascular disease events

Association of the single nucleotide polymorphism rs599839 in the vicinity of the sortilin 1 gene with LDL and triglyceride metabolism, coronary heart disease and myocardial infarction. The Ludwigshafen Risk and Cardiovascular Health Study

scientific article published on 2 October 2009

Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study

scientific article

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke

scientific article published on 17 March 2016

Author Correction: Cardiovascular risk algorithms in primary care: Results from the DETECT study

scientific article published on 31 March 2020

Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency

scientific article published on 6 April 2013

Bile Acids in Patients with Uncontrolled Type 2 Diabetes Mellitus - The Effect of Two Days of Oatmeal Treatment

scientific article published on 02 January 2020

Biomarker-Based Risk Model to Predict Cardiovascular Mortality in Patients With Stable Coronary Disease

scientific article published on August 2017

C-Reactive Protein and Lipoprotein-Associated Phospholipase A2 in Smokers and Nonsmokers of the Ludwigshafen Risk and Cardiovascular Health Study

article

C-peptide levels are associated with mortality and cardiovascular mortality in patients undergoing angiography: the LURIC study

scientific article published on 30 November 2012

C-reactive protein predicts mortality in patients referred for coronary angiography and symptoms of heart failure with preserved ejection fraction

scientific article

Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

scientific article (publication date: 2013)

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

scientific article

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study

scientific article

Correction: Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 23 August 2017

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Cotinine as a marker for risk prediction in the Ludwigshafen Risk and Cardiovascular Health Study

article

Cystatin C is independently associated with total and cardiovascular mortality in individuals undergoing coronary angiography. The Ludwigshafen Risk and Cardiovascular Health (LURIC) study

scientific article

Data on gender and subgroup specific analyses of omega-3 fatty acids in the Ludwigshafen Risk and Cardiovascular Health Study

scientific article

Decreased cholesterol efflux capacity in patients with low cholesteryl ester transfer protein plasma levels

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps

scientific article published on 26 September 2016

Discovery and refinement of loci associated with lipid levels

scientific article

Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals

scientific article published on 24 July 2017

Duration of type 2 diabetes strongly predicts all-cause and cardiovascular mortality in people referred for coronary angiography

scientific article published on 11 January 2012

EPIQ-efficient detection of SNP-SNP epistatic interactions for quantitative traits

scientific article

ERRATUM: Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

article by Matthew B. Lanktree et al published June 2012 in American Journal of Human Genetics

Effect of Genetically Low 25-Hydroxyvitamin D on Mortality Risk: Mendelian Randomization Analysis in 3 Large European Cohorts

Effect of the rs2259816 polymorphism in the HNF1A gene on circulating levels of c-reactive protein and coronary artery disease (the ludwigshafen risk and cardiovascular health study).

scientific article

Erratum: Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation

scientific article published in July 2017

Evaluation of 9 biomarkers for predicting 10-year cardiovascular risk in patients undergoing coronary angiography: Findings from the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study

article

Evidence of a synergistic association between heart rate, inflammation, and cardiovascular mortality in patients undergoing coronary angiography.

scientific article published on 23 November 2012

Evolving biomarkers improve prediction of long-term mortality in patients with stable coronary artery disease: the BIO-VILCAD score

scientific article published on August 2014

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

scientific article

Familial hypercholesterolemia in primary care in Germany. Diabetes and cardiovascular risk evaluation: Targets and Essential Data for Commitment of Treatment (DETECT) study

scientific article

Fast and Accurate Construction of Confidence Intervals for Heritability

scientific article published on June 2016

Fibroblast Growth Factor 23 Is an Independent and Specific Predictor of Mortality in Patients With Heart Failure and Reduced Ejection Fraction

scientific article published on 13 August 2015

Fibroblast growth factor 23 (FGF23) and mortality: The Ludwigshafen Risk and Cardiovascular Health Study

article

Galectin-3, Renal Function, and Clinical Outcomes: Results from the LURIC and 4D Studies

scientific article

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

scientific article published on 20 February 2014

Gene-gene Interaction Analyses for Atrial Fibrillation

scientific article

Genetic Determinants of Circulating Estrogen Levels, and Evidence of a Causal Effect of Estradiol on Bone Density in Men.

scientific article published on 9 January 2018

Genetic Interactions with Age, Sex, Body Mass Index, and Hypertension in Relation to Atrial Fibrillation: The AFGen Consortium

scientific article published on 12 September 2017

Genetic Variants Associated with Circulating Parathyroid Hormone

scientific article published on 07 December 2016

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

scientific article

Genetic determinants of major blood lipids in Pakistanis compared with Europeans

scientific article published on 22 June 2010

Genetic evidence of assortative mating in humans

scholarly article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Genome-Wide Association Analysis for Severity of Coronary Artery Disease Using the Gensini Scoring System

scientific article

Genome-Wide Association Study Pinpoints a New Functional Apolipoprotein B Variant Influencing Oxidized Low-Density Lipoprotein Levels But Not Cardiovascular Events

scholarly article by Kari-Matti Mäkelä et al published February 2013 in Circulation: Cardiovascular Genetics

Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci

scientific article published on 14 July 2016

Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia

scientific article published on 24 April 2013

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

scientific article published in February 2013

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

scientific article published on 09 January 2020

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

scientific article

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

scientific article

Genome-wide association study identifies 3 genomic loci significantly associated with serum levels of homoarginine: the AtheroRemo Consortium.

scientific article

Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.

scientific article

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

scientific article published on 17 January 2018

Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality

scientific article

Genome-wide mapping identifies beta-1,4-N-acetyl-galactosaminyl-transferase as a novel determinant of sclerostin levels and bone mineral density

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

scientific article

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults

scientific article published on 27 April 2017

Glycerophospholipid and sphingolipid species and mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

scientific article published on 17 January 2014

HDL cholesterol is not associated with lower mortality in patients with kidney dysfunction

scientific article published on 07 March 2014

Hemoglobin, iron metabolism and angiographic coronary artery disease (The Ludwigshafen Risk and Cardiovascular Health Study).

scientific article

High intestinal cholesterol absorption is associated with cardiovascular disease and risk alleles in ABCG8 and ABO: evidence from the LURIC and YFS cohorts and from a meta-analysis

scientific article published on 22 May 2013

High-density lipoprotein cholesterol, coronary artery disease, and cardiovascular mortality

scholarly article by Guenther Silbernagel et al published December 2013 in European Heart Journal

High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide predict mortality in stable coronary artery disease: results from the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

scientific article published in October 2013

High-sensitivity troponin T improves the prognostic value of N-terminal pro-B-type natriuretic peptide in patients with stable coronary artery disease: results from the LURIC Study

scientific article published on 17 May 2011

Homoarginine, cardiovascular risk, and mortality

scientific article

Homoarginine, kidney function and cardiovascular mortality risk

scientific article published on 06 January 2014

Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias ⬇️

scientific article (publication date: February 2012)

Immune activation and inflammation in patients with cardiovascular disease are associated with higher phenylalanine to tyrosine ratios: the ludwigshafen risk and cardiovascular health study

scientific article published on 10 February 2014

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

scientific article published on 12 September 2017

Increased Soluble ST2 Predicts Long-term Mortality in Patients with Stable Coronary Artery Disease: Results from the Ludwigshafen Risk and Cardiovascular Health Study

article

Independent associations of vitamin D metabolites with anemia in patients referred to coronary angiography: the LURIC study

scientific article published on 8 January 2016

Individual omega-9 monounsaturated fatty acids and mortality—The Ludwigshafen Risk and Cardiovascular Health Study

article

Influence of Resting Heart Rate on Mortality in Patients Undergoing Coronary Angiography (from the Ludwigshafen Risk and Cardiovascular Health [LURIC] Study)

article

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

scientific article published on 14 March 2012

Interrelated aldosterone and parathyroid hormone mutually modify cardiovascular mortality risk

scientific article published on 4 March 2015

Intronic Variants in OCT1 are Associated with All-Cause and Cardiovascular Mortality in Metformin Users with Type 2 Diabetes

scientific article published on 18 June 2020

Inverse association of the endogenous thrombin potential (ETP) with cardiovascular death: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study

article

Investigating the associations of self-rated health: heart rate variability is more strongly associated than inflammatory and other frequently used biomarkers in a cross sectional occupational sample

scientific article

Investigation of 95 variants identified in a genome-wide study for association with mortality after acute coronary syndrome

scientific article

Isolated post-challenge hyperglycaemia predicts increased cardiovascular mortality

scientific article published on 27 August 2012

LDL receptor traffic: in the fast lane

scientific article published on 01 March 2020

LDL triglycerides, hepatic lipase activity, and coronary artery disease: An epidemiologic and Mendelian randomization study

scholarly article by Günther Silbernagel et al published March 2019 in Atherosclerosis

Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.

scientific article

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci

scientific article

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci

scientific article

Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function

scientific article published on 10 April 2017

Letter by Scharnagl et al Regarding Article, “Elevated Remnant Cholesterol Causes Both Low-Grade Inflammation and Ischemic Heart Disease, Whereas Elevated Low-Density Lipoprotein Cholesterol Causes Ischemic Heart Disease Without Inflammation”

Lipopolysaccharide-binding protein (LBP) is associated with total and cardiovascular mortality in individuals with or without stable coronary artery disease--results from the Ludwigshafen Risk and Cardiovascular Health Study (LURIC).

scientific article published on 13 June 2011

Loci influencing blood pressure identified using a cardiovascular gene-centric array

scientific article published on 8 January 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

scientific article

Low serum tryptophan predicts higher mortality in cardiovascular disease

scientific article

Low serum zinc levels in patients undergoing coronary angiography correlate with immune activation and inflammation

scientific article published in 2012

Low-density lipoprotein particle diameter and mortality: the Ludwigshafen Risk and Cardiovascular Health Study

article

Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures

scientific article published on 02 August 2019

Mendelian randomization analysis does not support causal associations of birth weight with hypertension risk and blood pressure in adulthood

scientific article published on 07 May 2020

Mendelian randomization evaluation of causal effects of fibrinogen on incident coronary heart disease

scientific article published on 10 May 2019

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

scientific article

Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations

scientific article

Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

scientific article published on 30 October 2020

Molecular lipids identify cardiovascular risk and are efficiently lowered by simvastatin and PCSK9 deficiency

scientific article published on 20 December 2013

Multi-ethnic genome-wide association study for atrial fibrillation

article

NFAT5 and SLC4A10 Loci Associate with Plasma Osmolality

scientific article published on 30 March 2017

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis ⬇️

scientific article published on 12 October 2016

Novel genetic markers associate with atrial fibrillation risk in Europeans and Japanese

scientific article published on 30 January 2014

Omega-3 fatty acids and mortality in patients referred for coronary angiography. The Ludwigshafen Risk and Cardiovascular Health Study

article

PCSK9 Plasma Concentrations Are Independent of GFR and Do Not Predict Cardiovascular Events in Patients with Decreased GFR

scientific article published on 22 January 2016

Plasma Fibrinolysis Parameters in Smokers and Non-smokers of the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study

scientific article

Predicting sudden cardiac death using common genetic risk variants for coronary artery disease

scientific article published on 23 April 2015

Recurrent tendosynovitis as a rare manifestation of a lipid disorder

scientific article published on 24 October 2018

Refining Long-Term Prediction of Cardiovascular Risk in Diabetes - The VILDIA Score

scientific article

Relation of genetic profile and novel circulating biomarkers with coronary plaque phenotype as determined by intravascular ultrasound: rationale and design of the ATHEROREMO-IVUS study

article

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study

scientific article published on 26 May 2017

Reply

Residual risk: The roles of triglycerides and high density lipoproteins

scientific article

Routinely available biomarkers improve prediction of long-term mortality in stable coronary artery disease: the Vienna and Ludwigshafen Coronary Artery Disease (VILCAD) risk score

scientific article published on 28 June 2012

SOD3 R231G polymorphism associated with coronary artery disease and myocardial infarction. The Ludwigshafen Risk and Cardiovascular Health (LURIC) study.

scientific article

Saturated fatty acids are not off the hook

scientific article published on 9 October 2015

Serum amyloid A: high-density lipoproteins interaction and cardiovascular risk

scientific article published on 6 August 2015

Seventy-five genetic loci influencing the human red blood cell

scientific article published on 5 December 2012

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Smoking, apolipoprotein E genotypes, and mortality (the Ludwigshafen RIsk and Cardiovascular Health study)

article

Soluble klotho and mortality: the Ludwigshafen Risk and Cardiovascular Health Study

scientific article published on 13 August 2015

Soluble urokinase plasminogen activation receptor and long-term outcomes in persons undergoing coronary angiography

scientific article published in Scientific Reports

Subsequent Event Risk in Individuals With Established Coronary Heart Disease

scientific article published on 21 March 2019

Symmetric dimethylarginine, high-density lipoproteins and cardiovascular disease

scientific article published on 31 March 2017

Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels

scientific article published on 02 October 2019

The European Collaborative Project on Inflammation and Vascular Wall Remodeling in Atherosclerosis - Intravascular Ultrasound (ATHEROREMO-IVUS) Study

scientific article published on 26 September 2017

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The Renin-Angiotensin-Aldosterone System in Smokers and Non-Smokers of the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study

scientific article published on 23 June 2016

The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism

scientific article published on November 2014

The association of high-normal international-normalized-ratio (INR) with mortality in patients referred for coronary angiography

scientific article published on 15 August 2019

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

scientific article

Trans-fatty acids and mortality in patients referred for coronary angiography: the Ludwigshafen Risk and Cardiovascular Health Study

scientific article

Uric Acid and Cardiovascular Events: A Mendelian Randomization Study

scientific article

Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium

scientific article

Vitamin D deficiency parallels inflammation and immune activation, the Ludwigshafen Risk and Cardiovascular Health (LURIC) study

scholarly article by Christian Murr et al published December 2012 in Clinical Chemistry and Laboratory Medicine

Vitamin D levels predict all-cause and cardiovascular disease mortality in subjects with the metabolic syndrome: the Ludwigshafen Risk and Cardiovascular Health (LURIC) Study

scientific article published on 7 March 2012

Von Willebrand factor improves risk prediction in addition to N-terminal pro-B-type natriuretic peptide in patients referred to coronary angiography and signs and symptoms of heart failure and preserved ejection fraction

scientific article published on 23 October 2014

Which leukocyte subsets predict cardiovascular mortality? From the LUdwigshafen RIsk and Cardiovascular Health (LURIC) Study

article

Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

scientific article published on 23 May 2017

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