List of works - Lasse Folkersen

12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms

scientific article published on 21 January 2011

A Genome-Wide Association Study Identifies KNG1 as a Genetic Determinant of Plasma Factor XI Level and Activated Partial Thromboplastin Time

article by Maria Sabater-Lleal et al published August 2012 in Arteriosclerosis, Thrombosis, and Vascular Biology

A gene-centric study of common carotid artery remodelling

scientific article published on 23 November 2012

A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima–media thickness)

article

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

scientific article

AllelicImbalance: an R/bioconductor package for detecting, managing, and visualizing allele expression imbalance data from RNA sequencing

scientific article

Aneurysm Development in Patients With Bicuspid Aortic Valve (BAV): Possible Connection to Repair Deficiency?

scientific article

Applying genetics in inflammatory disease drug discovery.

scientific article published on 04 June 2015

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

scientific article

Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease

scientific article published on 12 December 2013

Association of genetic risk variants with expression of proximal genes identifies novel susceptibility genes for cardiovascular disease

scientific article

CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation.

scientific article published in October 2013

CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin

scientific article

Characterization of shear-sensitive genes in the normal rat aorta identifies Hand2 as a major flow-responsive transcription factor

scientific article published on 20 December 2012

Chemokine expression in retinal pigment epithelial ARPE-19 cells in response to coculture with activated T cells

scientific article

ClusterSignificance: a bioconductor package facilitating statistical analysis of class cluster separations in dimensionality reduced data

scientific article published in October 2017

Combined chromatin and expression analysis reveals specific regulatory mechanisms within cytokine genes in the macrophage early immune response

scientific article

Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease

scientific article

Correlations Between Clinical Variables and Gene-expression Profiles in Carotid Plaque Instability

article

Correlations between clinical variables and gene-expression profiles in carotid plaque instability

scientific article

Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Dickkopf-1 Enhances Inflammatory Interaction Between Platelets and Endothelial Cells and Shows Increased Expression in Atherosclerosis

Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis

scientific article

Diverging alternative splicing fingerprints in the transforming growth factor-β signaling pathway identified in thoracic aortic aneurysms

scientific article

Dual roles of heparanase in human carotid plaque calcification

scientific article published on 05 January 2019

EBI3 regulates the NK cell response to mouse cytomegalovirus infection

scientific article published on 31 January 2017

Endogenous control genes in complex vascular tissue samples

scientific article

Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA.

scientific article published on 2 July 2016

Expression of fatty acid-binding protein 4/aP2 is correlated with plaque instability in carotid atherosclerosis

Functional Analysis of a Carotid Intima-Media Thickness Locus Implicates BCAR1 and Suggests a Causal Variant

scientific article published on 14 August 2015

Functional Analysis of a Novel Genome-Wide Association Study Signal in SMAD3 That Confers Protection From Coronary Artery Disease.

scientific article published on 10 March 2016

Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22.

scientific article

Functional analysis of the chromosome 21q22 (gene desert) variant associated with CHD risk

article

Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels

scientific article

GLP-1 Induces Barrier Protective Expression in Brunner's Glands and Regulates Colonic Inflammation.

scientific article published on September 2016

Gene expression signatures, pathways and networks in carotid atherosclerosis

article

GeneRegionScan: a Bioconductor package for probe-level analysis of specific, small regions of the genome.

scientific article published on 27 April 2009

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects

scientific article

Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis

scientific article

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

scientific article

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

scientific article

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

scientific article

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

scientific journal article

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

scientific article published on 16 October 2020

H1N1 vaccination in Sjögren's syndrome triggers polyclonal B cell activation and promotes autoantibody production

scientific article published on 31 July 2017

High plasma adiponectin concentration is associated with all-cause mortality in patients with carotid atherosclerosis

scientific article published on 8 October 2012

Human Genetic Evidence that Common Variants near PIK3CG are Associated with Atherosclerotic Plaque Hemorrhage and Vessel Density

Human genetic evidence for involvement of CD137 in atherosclerosis

scientific article

Human mediastinal adipose tissue displays certain characteristics of brown fat.

scientific article published on 13 May 2013

Identification of a novel flow-mediated gene expression signature in patients with bicuspid aortic valve

scientific article published on 18 August 2012

Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk

scientific article

Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene

scientific article

Impact of common variation in bone-related genes on type 2 diabetes and related traits

scientific article

Impaired splicing of fibronectin is associated with thoracic aortic aneurysm formation in patients with bicuspid aortic valve

scientific article

Increased expression of heparanase in symptomatic carotid atherosclerosis

Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis – Potential role in plaque stabilization

Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice.

scientific article

Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip

scientific article published on 8 November 2012

Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study

scientific article published on 15 August 2016

Interleukin-6 receptor pathways in abdominal aortic aneurysm

scientific article published on 30 October 2012

KLF12 Regulates Mouse NK Cell Proliferation

scientific article published on 12 July 2019

Ketamine reduce left ventricular systolic and diastolic function in patients with ischaemic heart disease

scientific article published on 5 August 2010

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events

scientific article

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

scientific article

Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms.

scientific article

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ⬇️

scientific article

Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism

scientific article

MicroRNA 486-3P as a stability marker in acute coronary syndrome

scientific article published on 17 May 2016

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

scientific article (publication date: 17 September 2013)

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

scientific article published on 20 May 2016

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice

scientific article published on 22 June 2016

Network-based analysis of genome wide association data provides novel candidate genes for lipid and lipoprotein traits

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

Novel Mutations in a Chinese Pedigree of Limb Girdle Muscular Dystrophy

article

Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels

scientific article

PDE1A inhibition elicits cGMP-dependent relaxation of rat mesenteric arteries.

scientific article published on 14 September 2017

PLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk

scientific article published on 12 January 2015

Photochemotherapy Induces Interferon Type III Expression via STING Pathway

scientific article published on 10 November 2020

Prediction of ischemic events on the basis of transcriptomic and genomic profiling in patients undergoing carotid endarterectomy

scientific article

Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis

scientific article published in August 2013

Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve

scientific article

Raised MCP-4 levels in symptomatic carotid atherosclerosis: an inflammatory link between platelet and monocyte activation

scientific article

Reduced expression of TRIM21/Ro52 predicts poor prognosis in diffuse large B-cell lymphoma patients with and without rheumatic disease

scientific article published on 29 May 2015

Regulation and gene expression profiling of NKG2D positive human cytomegalovirus-primed CD4+ T-cells

scientific article

Relationship between CAD risk genotype in the chromosome 9p21 locus and gene expression. Identification of eight new ANRIL splice variants

scientific article

Retinal pigment epithelial cells upregulate expression of complement factors after co-culture with activated T cells

scientific article published on 19 January 2011

SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes

scientific article

Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study

scientific article published on 31 July 2013

The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues

scientific article

The collagen cross-linking enzyme lysyl oxidase is associated with the healing of human atherosclerotic lesions

scientific article published on 24 March 2014

The expression of IGFs and IGF binding proteins in human carotid atherosclerosis, and the possible role of IGF binding protein-1 in the regulation of smooth muscle cell proliferation

scientific article

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The hunt for fatal myocardial infarction biomarkers: predictive circulating microRNAs

scientific article published on October 2016

The role of innate immune receptor nod2 in atherosclerosis

Thromboxane synthase expression and thromboxane A2 production in the atherosclerotic lesion

scientific article published on 12 April 2010

Tissue factor pathway inhibitor-2 is induced by fluid shear stress in vascular smooth muscle cells and affects cell proliferation and survival

scientific journal article

Toll-Like Receptor 7 Protects From Atherosclerosis by Constraining “Inflammatory” Macrophage Activation

scientific article published on 11 July 2012

Transfusion Requirements in 811 Patients During and After Cardiac Surgery: A Prospective Observational Study ⬇️

scientific article published on July 31, 2010

Ubiquitin-specific peptidase 2 as a potential link between microRNA-125b and psoriasis

scientific article published on August 2016

Unraveling divergent gene expression profiles in bicuspid and tricuspid aortic valve patients with thoracic aortic dilatation: the ASAP study

scientific article published on 27 September 2011

Use of allele-specific FAIRE to determine functional regulatory polymorphism using large-scale genotyping arrays

scientific article

List of works by Lasse Folkersen

12- and 15-lipoxygenases in human carotid atherosclerotic lesions: associations with cerebrovascular symptoms

A Genome-Wide Association Study Identifies KNG1 as a Genetic Determinant of Plasma Factor XI Level and Activated Partial Thromboplastin Time

A gene-centric study of common carotid artery remodelling

A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima–media thickness)

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

AllelicImbalance: an R/bioconductor package for detecting, managing, and visualizing allele expression imbalance data from RNA sequencing

Aneurysm Development in Patients With Bicuspid Aortic Valve (BAV): Possible Connection to Repair Deficiency?

Applying genetics in inflammatory disease drug discovery.

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease

Association of genetic risk variants with expression of proximal genes identifies novel susceptibility genes for cardiovascular disease

CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation.

CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin

Characterization of shear-sensitive genes in the normal rat aorta identifies Hand2 as a major flow-responsive transcription factor

Chemokine expression in retinal pigment epithelial ARPE-19 cells in response to coculture with activated T cells

ClusterSignificance: a bioconductor package facilitating statistical analysis of class cluster separations in dimensionality reduced data

Combined chromatin and expression analysis reveals specific regulatory mechanisms within cytokine genes in the macrophage early immune response

Common genetic determinants of lung function, subclinical atherosclerosis and risk of coronary artery disease

Correlations Between Clinical Variables and Gene-expression Profiles in Carotid Plaque Instability

Correlations between clinical variables and gene-expression profiles in carotid plaque instability

Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease

Defining the role of common variation in the genomic and biological architecture of adult human height

Dickkopf-1 Enhances Inflammatory Interaction Between Platelets and Endothelial Cells and Shows Increased Expression in Atherosclerosis

Discovery of new candidate genes for rheumatoid arthritis through integration of genetic association data with expression pathway analysis

Diverging alternative splicing fingerprints in the transforming growth factor-β signaling pathway identified in thoracic aortic aneurysms

Dual roles of heparanase in human carotid plaque calcification

EBI3 regulates the NK cell response to mouse cytomegalovirus infection

Endogenous control genes in complex vascular tissue samples

Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA.

Expression of fatty acid-binding protein 4/aP2 is correlated with plaque instability in carotid atherosclerosis

Functional Analysis of a Carotid Intima-Media Thickness Locus Implicates BCAR1 and Suggests a Causal Variant

Functional Analysis of a Novel Genome-Wide Association Study Signal in SMAD3 That Confers Protection From Coronary Artery Disease.

Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22.

Functional analysis of the chromosome 21q22 (gene desert) variant associated with CHD risk

Functional analysis of two PLA2G2A variants associated with secretory phospholipase A2-IIA levels

GLP-1 Induces Barrier Protective Expression in Brunner's Glands and Regulates Colonic Inflammation.

Gene expression signatures, pathways and networks in carotid atherosclerosis

GeneRegionScan: a Bioconductor package for probe-level analysis of specific, small regions of the genome.

Genetic studies of body mass index yield new insights for obesity biology

Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects

Genome-wide association analysis of self-reported events in 6135 individuals and 252 827 controls identifies 8 loci associated with thrombosis

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

H1N1 vaccination in Sjögren's syndrome triggers polyclonal B cell activation and promotes autoantibody production

High plasma adiponectin concentration is associated with all-cause mortality in patients with carotid atherosclerosis

Human Genetic Evidence that Common Variants near PIK3CG are Associated with Atherosclerotic Plaque Hemorrhage and Vessel Density

Human genetic evidence for involvement of CD137 in atherosclerosis

Human mediastinal adipose tissue displays certain characteristics of brown fat.

Identification of a novel flow-mediated gene expression signature in patients with bicuspid aortic valve

Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk

Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene

Impact of common variation in bone-related genes on type 2 diabetes and related traits

Impaired splicing of fibronectin is associated with thoracic aortic aneurysm formation in patients with bicuspid aortic valve

Increased expression of heparanase in symptomatic carotid atherosclerosis

Increased levels of the homeostatic chemokine CXCL13 in human atherosclerosis – Potential role in plaque stabilization

Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice.

Integration of genetics into a systems model of electrocardiographic traits using HumanCVD BeadChip

Integration of known DNA, RNA and protein biomarkers provides prediction of anti-TNF response in rheumatoid arthritis: results from the COMBINE study

Interleukin-6 receptor pathways in abdominal aortic aneurysm

KLF12 Regulates Mouse NK Cell Proliferation

Ketamine reduce left ventricular systolic and diastolic function in patients with ischaemic heart disease

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Large-scale association analysis identifies new risk loci for coronary artery disease

Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms.

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci ⬇️

Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism

MicroRNA 486-3P as a stability marker in acute coronary syndrome

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice

Network-based analysis of genome wide association data provides novel candidate genes for lipid and lipoprotein traits

New genetic loci link adipose and insulin biology to body fat distribution

Novel Mutations in a Chinese Pedigree of Limb Girdle Muscular Dystrophy

Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels