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List of works by Themistocles L Assimes

A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium

scientific journal article

A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease

scientific article

A genome-wide scan for circulating vascular adhesion protein-1 (VAP-1) levels: MACROD2 as a potential transcriptional regulator of adipogenesis

scientific article published on 24 January 2018

A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

scientific article

A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease

scientific article published on 23 October 2007

A systems biology framework identifies molecular underpinnings of coronary heart disease

scientific article published on 28 March 2013

Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1

scientific article

Age at incident treatment of hypertension and risk of cancer: a population study

scientific article published on December 2009

Age-related somatic structural changes in the nuclear genome of human blood cells

scientific article published on 2 February 2012

An "almost exhaustive" search-based sequential permutation method for detecting epistasis in disease association studies

scientific article published on July 2010

An epigenetic biomarker of aging for lifespan and healthspan

scientific article published on 18 April 2018

An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease

scientific article

An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis.

scientific article published on 13 June 2019

Association Between Heart Failure and Postoperative Mortality Among Patients Undergoing Ambulatory Noncardiac Surgery

scientific article published on 10 July 2019

Association analyses based on false discovery rate implicate new loci for coronary artery disease

scientific article published on 17 July 2017

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

scientific article (publication date: November 2010)

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels

scientific article

Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies

scientific article published on 23 December 2011

Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis

scientific article published on 23 January 2013

Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program

scientific article published on 24 July 2019

Association of Left Ventricular Ejection Fraction and Symptoms With Mortality After Elective Noncardiac Surgery Among Patients With Heart Failure

scientific article published on 01 February 2019

Associations among multiple markers and complex disease: models, algorithms, and applications

scientific article published on January 2008

Associations between a Genetic Risk Score for Clinical CAD and Early Stage Lesions in the Coronary Artery and the Aorta

scientific article

Associations of Genetically Predicted Lp(a) (Lipoprotein [a]) Levels With Cardiovascular Traits in Individuals of European and African Ancestry

scientific article published in 2021

Biological, clinical and population relevance of 95 loci for blood lipids

scientific article

Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease

scientific article published on 19 August 2019

Breastfeeding Duration and the Risk of Coronary Artery Disease

scientific article published on 05 December 2018

Call to action: cardiovascular disease in Asian Americans: a science advisory from the American Heart Association

scientific article

Cardiac outcomes occurred more frequently with PCI than CABG or medical therapy in coronary artery disease.

scientific article

Cardioinformatics: the nexus of bioinformatics and precision cardiology

scientific article published on 04 December 2019

Central obesity is important but not essential component of the metabolic syndrome for predicting diabetes mellitus in a hypertensive family-based cohort. Results from the Stanford Asia-pacific program for hypertension and insulin resistance (SAPPHI

scientific article

Characterization of TCF21 Downstream Target Regions Identifies a Transcriptional Network Linking Multiple Independent Coronary Artery Disease Loci

scientific article

Characterizing the admixed African ancestry of African Americans

scientific article published in 2009

Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction

scientific article published on 04 September 2020

Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

scientific article

Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community

scientific article

Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease

scientific article

Clinical interpretation and implications of whole-genome sequencing

scientific article published in March 2014

Clonal hematopoiesis associated with epigenetic aging and clinical outcomes

scientific article published on 29 May 2021

Coffee consumption is associated with DNA methylation levels of human blood

scientific article published on 15 February 2017

Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease

scientific article

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Comprehensive Investigation of Circulating Biomarkers and their Causal Role in Atherosclerosis-related Risk Factors and Clinical Events

scientific article published on 30 October 2020

Contemporary Considerations for Constructing a Genetic Risk Score: An Empirical Approach.

scientific article

Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation

scientific article

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Corrigendum: Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example

scientific article published on 7 July 2015

Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache

scientific article published on 19 April 2020

DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation

scientific article published on 30 November 2017

DNA methylation GrimAge strongly predicts lifespan and healthspan

DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative

scientific article

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

scientific article published on 12 December 2016

DNA methylation-based estimator of telomere length

scientific article published on 18 August 2019

DNA methylation-based measures of biological age: meta-analysis predicting time to death

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls

scientific article

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans

scientific article

Detecting clinically meaningful biomarkers with repeated measurements: An illustration with electronic health records

scientific article published on 4 February 2015

Digital ischemia

scientific article published on December 2008

Discovery and refinement of loci associated with lipid levels

scientific article

Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis

scientific article published on 15 June 2020

Discovery, fine-mapping, and conditional analyses of genetic variants associated with C-reactive protein in multiethnic populations using the Metabochip in the Population Architecture using Genomics and Epidemiology (PAGE) study

scientific article published on 01 August 2018

Disease-related growth factor and embryonic signaling pathways modulate an enhancer of TCF21 expression at the 6q23.2 coronary heart disease locus

scientific article

Dissecting the causal genetic mechanisms of coronary heart disease

scientific article published on May 2014

Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses

scientific article

Effect of Common Genetic Variants of Growth Arrest-Specific 6 Gene on Insulin Resistance, Obesity and Type 2 Diabetes in an Asian Population

scientific article published on 18 August 2015

Effects of Genetic Variants Associated with Familial Hypercholesterolemia on Low-Density Lipoprotein-Cholesterol Levels and Cardiovascular Outcomes in the Million Veteran Program

scientific article published on 01 December 2018

Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study

scientific article

Epigenetic clock analysis of diet, exercise, education, and lifestyle factors

scientific article

Epigenome-wide Association Study of Diet Quality in the Women's Health Initiative (OR31-06-19)

Epigenome-wide association study of diet quality in the Women's Health Initiative and TwinsUK cohort

scientific article published on 23 December 2020

Erratum to: Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache

scientific article published on 06 December 2020

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article published in November 2011

Evaluation of 71 Coronary Artery Disease Risk Variants in a Multiethnic Cohort.

scientific article

Evaluation of the metabochip genotyping array in African Americans and implications for fine mapping of GWAS-identified loci: the PAGE study

scientific article

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

scientific article

Exome-wide association study of plasma lipids in >300,000 individuals

scientific article published on 30 October 2017

FTO genotype is associated with phenotypic variability of body mass index

scientific article published on 16 September 2012

Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD

scientific article

Family History of Heart Disease

Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

scientific article published on 22 May 2017

Fine-mapping of lipid regions in global populations discovers ethnic-specific signals and refines previously identified lipid loci

scientific article

GWAS of epigenetic aging rates in blood reveals a critical role for TERT.

scientific article published on 26 January 2018

Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans

scientific article published on 11 January 2016

Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program

scientific article published on 28 September 2020

Genetic Predisposition to Higher Blood Pressure Increases Coronary Artery Disease Risk

scientific article published on March 11, 2013

Genetic Risk Scores in Premature Coronary Artery Disease: Still Only One Piece of the Prevention Puzzle

scientific article published on 01 January 2018

Genetic analysis for a shared biological basis between migraine and coronary artery disease

scientific article published on June 2015

Genetic cardiovascular risk prediction: are we already there?

Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes risk but not coronary artery disease

scientific article published on 24 August 2020

Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium

scientific article published on 2 February 2012

Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-associated adverse health outcomes

scientific article published in 2022

Genetic evidence of assortative mating in humans

scholarly article

Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits

scientific article published in 2022

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology

scientific article

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes

scientific article published on February 2013

Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk

scientific article

Genetically determined height and coronary artery disease

scientific article

Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the American Heart Association

scientific article published on 02 December 2013

Genetics of 35 blood and urine biomarkers in the UK Biobank

Genetics of Coronary Artery Disease in Taiwan: A Cardiometabochip Study by the Taichi Consortium

scientific article

Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program

article

Genetics: Implications for Prevention and Management of Coronary Artery Disease

scientific article published on December 2016

Genome-Wide Association Studies of Coronary Artery Disease: Recent Progress and Challenges Ahead

scientific article published on 18 July 2018

Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease

scientific article published on 01 November 2019

Genome-wide association study of peripheral artery disease in the Million Veteran Program

scientific article published on 08 July 2019

Genome-wide linkage analysis and regional fine mapping identified variants in the RYR3 gene as a novel quantitative trait locus for circulating adiponectin in Chinese population

scientific article published on November 2016

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genotyping Array Design and Data Quality Control in the Million Veteran Program

scientific article published on 01 April 2020

Harmonizing Genetic Ancestry and Self-identified Race/Ethnicity in Genome-wide Association Studies

scientific article published on 26 September 2019

HeartBioPortal

scientific article published on 16 April 2019

Heritability of left ventricular mass in Japanese families living in Hawaii: the SAPPHIRe Study

scientific article published on May 2007

Homocysteine and Coronary Heart Disease: Meta-analysis of MTHFR Case-Control Studies, Avoiding Publication Bias

scientific article (publication date: February 2012)

Hundreds of variants clustered in genomic loci and biological pathways affect human height

scientific article

Hypermetabolic macrophages in rheumatoid arthritis and coronary artery disease due to glycogen synthase kinase 3b inactivation.

scientific article published on 3 February 2018

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

scientific article published on 23 March 2015

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

scientific article published on 4 January 2016

Identification of 22 novel loci associated with urinary biomarkers of albumin, sodium, and potassium excretion

scientific article published on 12 March 2019

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies

scientific article

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders

scientific article published on 14 April 2013

Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease

scientific article published on 4 September 2017

Immortal person time bias in pharmacoepidemiological studies of antihypertensive drugs

scientific article

Impact of a Genetic Risk Score for Coronary Artery Disease on Reducing Cardiovascular Risk: A Pilot Randomized Controlled Study

scientific article published on 14 August 2017

Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity

scientific article

Imputation of coding variants in African Americans: better performance using data from the exome sequencing project

scientific article

Inactivating mutations in NPC1L1 and protection from coronary heart disease

scientific article

Inhaled corticosteroid use in asthma and the prevention of myocardial infarction

scientific article published on October 2003

Insulin resistance: regression and clustering

scientific article (publication date: 2014)

Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

scientific article published on 08 July 2016

Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.

scientific article

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

scientific article published on 14 March 2012

Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies

scientific article

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

scientific article

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Lean body mass and risk of incident atrial fibrillation in post-menopausal women

scientific article published on 14 September 2015

Leukocyte Telomere Length and Risks of Incident Coronary Heart Disease and Mortality in a Racially Diverse Population of Postmenopausal Women

scientific article

Leukocyte Traits and Exposure to Ambient Particulate Matter Air Pollution in the Women's Health Initiative and Atherosclerosis Risk in Communities Study

scientific article published on 06 January 2020

Leukocyte telomere length, T cell composition and DNA methylation age.

scientific article

Leveraging Multi-ethnic Evidence for Risk Assessment of Quantitative Traits in Minority Populations

scientific article

Leveraging Multi-ethnic Evidence for Risk Assessment of Quantitative Traits in Minority Populations

scientific article published on 01 October 2017

Leveraging information from genetic risk scores of coronary atherosclerosis

scientific article published on 14 February 2017

Leveraging linkage evidence to identify low-frequency and rare variants on 16p13 associated with blood pressure using TOPMed whole genome sequencing data

scientific article published on 22 January 2019

Leveraging population admixture to characterize the heritability of complex traits

scientific article

Long-term use of angiotensin receptor blockers and the risk of cancer

scientific article

Long-term use of antihypertensive drugs and risk of cancer

Loss-of-function mutations in APOC3, triglycerides, and coronary disease

scientific article published on 18 June 2014

Low lifetime recreational activity is a risk factor for peripheral arterial disease

scientific article

Making the Most out of Mendel's Laws in Complex Coronary Artery Disease

scientific article published on 09 July 2018

Measurement of insulin-mediated glucose uptake: direct comparison of the modified insulin suppression test and the euglycemic, hyperinsulinemic clamp

scientific article

Melanoma risk prediction using a multilocus genetic risk score in the Women's Health Initiative cohort.

scientific article published in March 2018

Mendelian Randomization Analysis of Hemostatic Factors and Their Contribution to Peripheral Artery Disease

scientific article published on 27 August 2020

Menopause accelerates biological aging

scientific article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

scientific article

Methylome-wide association study provides evidence of particulate matter air pollution-associated DNA methylation

scientific article published on 14 June 2019

Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study

scientific article published on 30 March 2020

Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians

scientific article

Near-term prediction of sudden cardiac death in older hemodialysis patients using electronic health records

scientific article published on 31 October 2013

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis

scientific article published on 12 October 2016

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Obesity, physical activity, and their interaction in incident atrial fibrillation in postmenopausal women

scientific article

PCSK9 loss of function is protective against extra-coronary atherosclerotic cardiovascular disease in a large multi-ethnic cohort

scientific article published on 09 November 2020

Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease

article

Quantifying rare, deleterious variation in 12 human cytochrome P450 drug-metabolism genes in a large-scale exome dataset

scientific article

RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies

scientific article

Randomized trial of personal genomics for preventive cardiology: design and challenges

scientific article

Sex differences in the prevalence of peripheral artery disease in patients undergoing coronary catheterization

scientific article published on December 2010

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants

scientific article

Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example

scientific article

Study of exonic variation identifies incremental information regarding lipid-related and coronary heart disease genes

scientific article published on August 2014

Susceptibility Loci for Clinical Coronary Artery Disease and Subclinical Coronary Atherosclerosis Throughout the Life-Course

scientific article published on 28 September 2015

Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study

scientific article published on 28 April 2008

Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease

scientific article published on 14 May 2015

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The Project Baseline Health Study: a step towards a broader mission to map human health

scientific article published on 05 June 2020

The associations of leptin, adiponectin and resistin with incident atrial fibrillation in women

scientific article

The combination of 9p21.3 genotype and biomarker profile improves a peripheral artery disease risk prediction model

scientific article

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

scientific article published on 29 February 2016

The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease

scientific article

The power of genetic diversity in genome-wide association studies of lipids

The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study

scientific article published on 11 September 2020

The relationship of lipoprotein(a), C-reactive protein and homocysteine with metabolic syndrome in South Asians

article

The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women

scientific article published on 06 February 2019

The shared allelic architecture of adiponectin levels and coronary artery disease

scientific article published on April 22, 2013

The use of perioperative corticosteroids in craniomaxillofacial surgery

scientific article published on January 1999

Trans-ethnic fine mapping identifies a novel independent locus at the 3' end of CDKAL1 and novel variants of several susceptibility loci for type 2 diabetes in a Han Chinese population

scientific article published on 08 September 2013

Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE) Study reveals evidence for multiple signals at established loci

scientific article published on 8 April 2017

Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained

scientific article

Transcriptomic signatures across human tissues identify functional rare genetic variation

scientific article

Urinary Albumin, Sodium, and Potassium and Cardiovascular Outcomes in the UK Biobank: Observational and Mendelian Randomization Analyses

scientific article published on 03 February 2020

Use of Medicare data to identify coronary heart disease outcomes in the Women's Health Initiative.

scientific article

Use of venlafaxine compared with other antidepressants and the risk of sudden cardiac death or near death: a nested case-control study

scientific article

Validating a non-invasive, ALT-based non-alcoholic fatty liver phenotype in the million veteran program

scientific article published on 25 August 2020

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

scientific article