List of works by Marian Beekman

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots

scientific article published on 23 February 2015

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

scientific article published on 02 August 2019

A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels

scientific article

A meta-analysis of genome-wide association studies identifies multiple longevity genes

scientific article published on 14 August 2019

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

scientific article

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

scientific article published on 20 August 2019

A mixture model with random-effects components for classifying sibling pairs.

scientific article published on 9 September 2011

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

article by Sven J. van der Lee et al published 27 May 2019 in Acta Neuropathologica

A powerful and rapid approach to human genome scanning using small quantities of genomic DNA

scientific article published on 01 April 2001

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

scientific article published on 22 September 2016

Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

scientific article

Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age.

scientific article published on 15 August 2016

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

scientific article

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.

scientific article

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants

scientific article

Association of common genetic variants with brain microbleeds: A Genome-wide Association Study

scientific article published on 10 September 2020

Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

scientific article published on 31 March 2020

Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes

C-reactive protein and glucose regulation in familial longevity

scientific article published on 19 January 2011

C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age.

scientific article

Cerebral small vessel disease genomics and its implications across the lifespan

scientific article published on 08 December 2020

Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies

scientific article

Classification for Longevity Potential: The Use of Novel Biomarkers ⬇️

scientific article published on 28 October 2016

Combined association and linkage analysis applied to the APOE locus

scientific article published in May 2004

Copulas in QTL mapping.

scientific article published in March 2004

Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment

scientific article

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

scientific article published on 18 January 2020

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 7 July 2017

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

scientific article published on 10 May 2012

DNA methylation signatures of educational attainment

scientific article published on 23 March 2018

Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity

scientific article

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

scientific article (publication date: November 2011)

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

scientific article

Disease variants alter transcription factor levels and methylation of their binding sites

scientific article published on 5 December 2016

Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis

scientific article (publication date: 15 March 1999)

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

scientific article published on 29 June 2016

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

scientific article published on 21 December 2016

Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population.

scientific article published in November 2003

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

scientific article published on 12 January 2012

Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study.

scientific article published in January 2006

Exome and whole genome sequencing in aging and longevity.

scientific article published on January 2015

Familial longevity is associated with decreased thyroid function

scientific article published on 25 August 2010

Familial resemblance for serum metabolite concentrations

scientific article published on 28 August 2013

Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum

scientific article published on 26 August 2019

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

scientific article published in March 2010

Fibroblast growth factor 21 reflects liver fat accumulation and dysregulation of signalling pathways in the liver of C57BL/6J mice.

scientific article published on 29 July 2016

Gene expression analysis of mTOR pathway: association with human longevity

scientific article published on 23 November 2012

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

scientific article

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

scientific article published on 30 October 2017

Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data

scientific article published on 01 June 2020

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

scientific article published in November 2018

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

scientific article

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

scientific article published on 27 February 2020

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

scientific article published in Nature Communications

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

scientific article

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

scientific article

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

scientific article

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

scientific article

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

scientific article published on 17 January 2018

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

scientific article published on 06 February 2013

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

scientific article published on February 2016

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

scientific article published on 23 March 2016

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits ⬇️

scientific article published on 21 June 2016

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

scientific article

Genomic structure of the human PLZF gene

scientific article (publication date: 5 August 1999)

Genomic studies in ageing research: the need to integrate genetic and gene expression approaches

article

Genomics of human longevity.

scientific article

Genotype-Based Score Test for Association Testing in Families

scientific article

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

scientific article published on 19 February 2020

Heritabilities of apolipoprotein and lipid levels in three countries

scientific article

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

scientific article published on 07 January 2020

High Liver Enzyme Concentrations are Associated with Higher Glycemia, but not with Glycemic Variability, in Individuals without Diabetes Mellitus

scientific article published on 13 September 2017

Historical demography and longevity genetics: Back to the future

scientific article

Homocysteine and familial longevity: the Leiden Longevity Study

scientific article

How to deal with the early GWAS data when imputing and combining different arrays is necessary

scientific article

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health ⬇️

scientific article

Human insulin/IGF-1 and familial longevity at middle age.

scientific article

Human longevity and 11p15.5: a study in 1321 centenarians

scientific article

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies

scientific article

IL7R gene expression network associates with human healthy ageing

scientific article

Identification of context-dependent expression quantitative trait loci in whole blood

scientific article published on 5 December 2016

Identification of seven loci affecting mean telomere length and their association with disease

scientific article published on April 2013

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges

scientific article published on 19 February 2013

IgG glycosylation and DNA methylation are interconnected with smoking

scientific article

Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis

scientific article published on 16 December 2011

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

scientific article published on 13 January 2020

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

scientific article published on 03 April 2019

Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers

scientific article

Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study

scientific article

Lipid metabolism in long-lived families: the Leiden Longevity Study

scientific article

Lipidomics of familial longevity

scientific article published on 02 April 2013

Lipoprotein particle profiles mark familial and sporadic human longevity

scientific article

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

scientific article

Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies

scientific article published on 30 April 2020

Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait

scientific article published in Nature Communications

Longevity defined as top 10% survivors is transmitted as a quantitative genetic trait: results from large three-generation datasets

Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study

scientific article

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study

scientific article published on 16 December 2009

Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance

scientific article published on 23 July 2014

Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions

scientific article published in October 2005

Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

scientific article published on 16 January 2013

Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging

scientific article

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

scientific article published on 14 August 2020

Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles

scientific article published on 27 October 2012

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

scientific article published on 12 August 2019

Molecular epidemiology, candidate genes versus genome-wide scans

scientific article published on October 2007

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

scientific article published on 7 February 2015

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

No causal association between 25-hydroxyvitamin D and features of skin aging: evidence from a bidirectional Mendelian Randomization Study

scientific article

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

scientific article published on 17 July 2009

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Paragangliomas of the head and neck region show complete loss of heterozygosity at 11 q22-q23 in chief cells and the flow-sorted dna aneuploid fraction

article

Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health.

scientific article published on 23 February 2011

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

scientific article

Reduced insulin/IGF-1 signalling and human longevity.

scientific article

Relationship between the functional exon 3 deleted growth hormone receptor polymorphism and symptomatic osteoarthritis in women

scientific article published on 5 June 2013

Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study.

scientific article published on 07 June 2013

Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.

scientific article published on 13 April 2014

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

scientific article

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.

scientific article

Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?

scientific article

Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health

scientific article published on 26 September 2017

The Genome of the Netherlands: design, and project goals

scientific article (publication date: February 2014)

The MC1R Gene and Youthful Looks

scientific article published on 27 April 2016

The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 10 January 2017

The effect of standardized food intake on the association between BMI and 1H-NMR metabolites.

scientific article published on 14 December 2016

The impact of low-frequency and rare variants on lipid levels

scientific article published on 11 May 2015

Thyroid status and mortality in nonagenarians from long-lived families and the general population

scientific article published on 25 October 2017

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

scientific article (publication date: 2012)

Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels

article

Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2.

scientific article published on 29 January 2016

Variation in the SHC1 gene and longevity in humans

scientific article (publication date: February 2004)

Variation in the human TP53 gene affects old age survival and cancer mortality.

scientific article

Weighted statistics for aggregation and linkage analysis of human longevity in selected families: the Leiden Longevity Study.

scientific article published in January 2009

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