List of works - Rona J Strawbridge

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.

scientific article

A gene-centric study of common carotid artery remodelling

scientific article published on 23 November 2012

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

scientific article published on 13 May 2012

A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima–media thickness)

article

Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study

scientific article published on 14 January 2020

Analysis of the role of interleukin 6 receptor haplotypes in the regulation of circulating levels of inflammatory biomarkers and risk of coronary heart disease

scientific article

Analysis with the exome array identifies multiple new independent variants in lipid loci

scientific article published on 27 July 2016

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

scientific article published in August 2012

Assessing for interaction between APOE ε4, sex, and lifestyle on cognitive abilities.

scientific article published on 26 April 2019

Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity

scientific article published on 22 March 2019

Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank

scientific article published on 15 May 2018

Associations of autozygosity with a broad range of human phenotypes

scientific article published on 31 October 2019

CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation.

scientific article published in October 2013

Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis

scientific article published on 28 December 2012

Characterisation and Genetic Architecture of Major Depressive Disorder Subgroups Defined by Weight and Sleep Changes

scientific article published in September 2022

Common and Low-Frequency Genetic Variants in the PCSK9 Locus Influence Circulating PCSK9 Levels

article

Common variants associated with plasma triglycerides and risk for coronary artery disease

scientific article

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

scientific article

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

Correction: The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

scientific article published on 30 July 2019

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Directional dominance on stature and cognition in diverse human populations

scientific article published in July 2015

Discovery and refinement of loci associated with lipid levels

scientific article

Duffy antigen receptor genetic variant and the association with Interleukin 8 levels

scientific article published on 31 January 2015

Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis

scientific article

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article published in November 2011

Exome sequencing followed by genotyping suggests SYPL2 as a susceptibility gene for morbid obesity

scientific article

Exploring the Role of Contactins across Psychological, Psychiatric and Cardiometabolic Traits within UK Biobank

scientific article published on 10 November 2020

F11 is associated with recurrent VTE in women. A prospective cohort study

scientific article published in October 2015

FAM13A and POM121C are candidate genes for fasting insulin: functional follow-up analysis of a genome-wide association study.

scientific article published on 27 February 2018

Fast and general tests of genetic interaction for genome-wide association studies ⬇️

scientific article

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

scientific article published in Nature Communications

GWAS-identified loci for coronary heart disease are associated with intima-media thickness and plaque presence at the carotid artery bulb

scientific article

Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease Do Not Associate with Measures of Sub-Clinical Atherosclerosis: Results from the IMPROVE Study

scientific article published on 22 October 2020

Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology

scientific article published in 2021

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scientific article published on 17 September 2018

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank

scientific article published in 2022

Genetic evidence of assortative mating in humans

article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article

Genetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variation in CADM2 as a link between psychological traits and obesity

scientific article published on 14 May 2019

Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression

article

Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability

scientific article published on 14 August 2018

Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia

scientific article published on 30 November 2017

Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort.

scientific article published on 2 February 2018

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

scientific article

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

scientific article

Genome-wide association study of multisite chronic pain in UK Biobank

scientific article published on 13 June 2019

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

scientific journal article

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

scientific article

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

scientific article

Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

scientific article published on 28 September 2017

Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5

scientific article published on 20 November 2019

Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide

scientific article published on 08 February 2019

Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk

scientific article

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

scientific article published on 12 September 2017

Influence of MUC1 genetic variation on prostate cancer risk and survival

Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism

scientific article

LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes

scientific article published on 19 January 2021

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

scientific article

Large-scale association analysis identifies new risk loci for coronary artery disease

scientific article published on 02 December 2012

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

scientific article

Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

scientific article

MUC1 as a Putative Prognostic Marker for Prostate Cancer

scientific article published on 14 May 2008

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

scientific article

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

scientific article

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

scientific article (publication date: 17 September 2013)

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

scientific article published on 20 May 2016

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects

scientific article

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

scientific article

Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure

scientific article published on 04 December 2019

Numerous Genes in Loci Associated With Body Fat Distribution Are Linked to Adipose Function

scientific article published on February 2016

PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study.

scientific article published on 14 October 2016

Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank

scientific article published on 19 July 2021

Plasma IL-5 concentration and subclinical carotid atherosclerosis

scientific article

Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosis

scientific article

Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: Meta-analysis of three treatment cohorts

scientific article published in PLoS ONE

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

scholarly article published in Nature Genetics

Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

erratum

Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF

scientific article

Serum 25-Hydroxyvitamin D Concentration in Subclinical Carotid Atherosclerosis

article

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease

scientific article

Sex-Stratified Genome-Wide Association Study of Multisite Chronic Pain in UK Biobank

scientific article published on 26 June 2020

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

Sex-stratified genome-wide association study of multisite chronic pain in UK Biobank

scientific article published in April 2021

Shared Genetic Contribution of Type 2 Diabetes and Cardiovascular Disease: Implications for Prognosis and Treatment.

scientific article published on 25 June 2018

Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness

scientific article published on October 2016

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

scientific article

The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

scientific article published on 12 September 2016

The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

scientific article published on 05 June 2019

Toll-Like Receptor 3 Influences Glucose Homeostasis and β-Cell Insulin Secretion

scientific article published on 27 April 2015

List of works by Rona J Strawbridge

A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE.

A gene-centric study of common carotid artery remodelling

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima–media thickness)

Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study

Analysis of the role of interleukin 6 receptor haplotypes in the regulation of circulating levels of inflammatory biomarkers and risk of coronary heart disease

Analysis with the exome array identifies multiple new independent variants in lipid loci

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism

Assessing for interaction between APOE ε4, sex, and lifestyle on cognitive abilities.

Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity

Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank

Associations of autozygosity with a broad range of human phenotypes

CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation.

Causal relevance of blood lipid fractions in the development of carotid atherosclerosis: Mendelian randomization analysis

Characterisation and Genetic Architecture of Major Depressive Disorder Subgroups Defined by Weight and Sleep Changes

Common and Low-Frequency Genetic Variants in the PCSK9 Locus Influence Circulating PCSK9 Levels

Common variants associated with plasma triglycerides and risk for coronary artery disease

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways ⬇️

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

Correction: The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

Defining the role of common variation in the genomic and biological architecture of adult human height

Directional dominance on stature and cognition in diverse human populations

Discovery and refinement of loci associated with lipid levels

Duffy antigen receptor genetic variant and the association with Interleukin 8 levels

Effects of Genetic Loci Associated with Central Obesity on Adipocyte Lipolysis

Erratum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Exome sequencing followed by genotyping suggests SYPL2 as a susceptibility gene for morbid obesity

Exploring the Role of Contactins across Psychological, Psychiatric and Cardiometabolic Traits within UK Biobank

F11 is associated with recurrent VTE in women. A prospective cohort study

FAM13A and POM121C are candidate genes for fasting insulin: functional follow-up analysis of a genome-wide association study.

Fast and general tests of genetic interaction for genome-wide association studies ⬇️

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

GWAS-identified loci for coronary heart disease are associated with intima-media thickness and plaque presence at the carotid artery bulb

Genetic Variants Associated with Non-Alcoholic Fatty Liver Disease Do Not Associate with Measures of Sub-Clinical Atherosclerosis: Results from the IMPROVE Study

Genetic Variation in the ASTN2 Locus in Cardiovascular, Metabolic and Psychiatric Traits: Evidence for Pleiotropy Rather Than Shared Biology

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Genetic analysis of over one million people identifies 535 novel loci for blood pressure

Genetic analysis of the PCSK9 locus in psychological, psychiatric, metabolic and cardiovascular traits in UK Biobank

Genetic evidence of assortative mating in humans

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Genetic loci on chromosome 5 are associated with circulating levels of interleukin-5 and eosinophil count in a European population with high risk for cardiovascular disease

Genetic studies of body mass index yield new insights for obesity biology

Genetic variation in CADM2 as a link between psychological traits and obesity

Genetics of self-reported risk-taking behaviour, trans-ethnic consistency and relevance to brain gene expression

Genome-Wide Association Study of Circadian Rhythmicity in 71,500 UK Biobank Participants and Polygenic Association with Mood Instability

Genome-wide analysis in UK Biobank identifies four loci associated with mood instability and genetic correlation with major depressive disorder, anxiety disorder and schizophrenia

Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort.

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

Genome-wide association study of multisite chronic pain in UK Biobank

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Identification of novel common variants associated with chronic pain using conditional false discovery rate analysis with major depressive disorder and assessment of pleiotropic effects of LRFN5

Identification of novel genome-wide associations for suicidality in UK Biobank, genetic correlation with psychiatric disorders and polygenic association with completed suicide

Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

Influence of MUC1 genetic variation on prostate cancer risk and survival

Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism

LRIG proteins regulate lipid metabolism via BMP signaling and affect the risk of type 2 diabetes

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Large-scale association analysis identifies new risk loci for coronary artery disease

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility

MUC1 as a Putative Prognostic Marker for Prostate Cancer

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease

NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis

New genetic loci link adipose and insulin biology to body fat distribution

No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney

Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure

Numerous Genes in Loci Associated With Body Fat Distribution Are Linked to Adipose Function

PDGFB, a new candidate plasma biomarker for venous thromboembolism: results from the VEREMA affinity proteomics study.

Phenotypic and genetic associations between anhedonia and brain structure in UK Biobank

Plasma IL-5 concentration and subclinical carotid atherosclerosis