List of works - Rudolf Fehrmann

A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer.

scientific article published on 10 January 2011

A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD.

scientific article published on 2 July 2014

A large pooled analysis refines gene expression-based molecular subclasses in cutaneous melanoma

article

A new perspective on transcriptional system regulation (TSR): towards TSR profiling.

scientific article

A retrospective analysis of clinical outcome of patients with chemo-refractory metastatic breast cancer treated in a single institution phase I unit

scientific article

ATR inhibition preferentially targets homologous recombination-deficient tumor cells.

scientific article published in September 2014

Application of a comprehensive subtelomere array in clinical diagnosis of mental retardation

scientific article published in July 2005

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

scientific article published on 09 January 2019

CD47 Expression Defines Efficacy of Rituximab with CHOP in Non-Germinal Center B-cell (Non-GCB) Diffuse Large B-cell Lymphoma Patients (DLBCL), but Not in GCB DLBCL

scientific article published on 13 August 2019

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

scientific article

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

scientific article

Consideration of breast cancer subtype in targeting the androgen receptor

scientific article published on 08 May 2019

Considering the biology of late recurrences in selecting patients for extended endocrine therapy in breast cancer

scientific article published on 26 July 2018

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

scientific article published on 28 February 2022

Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer

scientific article

Current state and prospects of artificial intelligence in allergy

scientific article published in 2023

Cyclin E expression is associated with high levels of replication stress in triple-negative breast cancer

scientific article published on 07 September 2020

Data-Driven Prioritization and Review of Targets for Molecular-Based Theranostic Approaches in Pancreatic Cancer.

scientific article

Data-Driven prioritisation of antibody-drug conjugate targets in head and neck squamous cell carcinoma

scientific article published on 27 March 2018

Defining the risk of toxicity in phase I oncology trials of novel molecularly targeted agents: a single centre experience

scientific article published on 9 March 2012

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Erratum: Corrigendum: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scholarly article published in Nature Genetics

Extraintestinal manifestations and complications in inflammatory bowel disease: from shared genetics to shared biological pathways

scientific article published on June 2014

Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets.

scientific article published on 06 January 2017

Functional genomic mRNA profiling of a large cancer data base demonstrates mesothelin overexpression in a broad range of tumor types.

scientific article

GWAS for executive function and processing speed suggests involvement of the CADM2 gene.

scientific article

Gene expression analysis identifies global gene dosage sensitivity in cancer.

scientific article published on 12 January 2015

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genetic variants in RBFOX3 are associated with sleep latency

scientific article

Glypican 3 Overexpression across a Broad Spectrum of Tumor Types Discovered with Functional Genomic mRNA Profiling of a Large Cancer Database

scientific article published on 21 June 2018

Growth differentiation factor 15 (GDF-15) plasma levels increase during bleomycin- and cisplatin-based treatment of testicular cancer patients and relate to endothelial damage

scientific article

Human disease-associated genetic variation impacts large intergenic non-coding RNA expression

scientific article

Identification of genes and pathways associated with cytotoxic T lymphocyte infiltration of serous ovarian cancer

scientific article

Identification of novel therapeutic targets in anaplastic thyroid carcinoma using functional genomic mRNA-profiling: Paving the way for new avenues?

scientific article published on 16 November 2016

Identification of relevant drugable targets in diffuse large B-cell lymphoma using a genome-wide unbiased CD20 guilt-by association approach.

scientific article published on 28 February 2018

Immune microenvironment composition in non-small cell lung cancer and its association with survival

scientific article published on 12 June 2020

Improving gene function predictions using independent transcriptional components

scientific article published on 05 March 2021

Indispensable benefit of independent investigator-driven research in a changing clinical trial landscape.

scientific article

Integrative kinome profiling identifies mTORC1/2 inhibition as treatment strategy in ovarian clear cell carcinoma.

scientific article published on 23 April 2018

Involvement of the TGF-β and β-Catenin Pathways in Pelvic Lymph Node Metastasis in Early-Stage Cervical Cancer

scientific article published on 08 March 2011

MAPK pathway activity plays a key role in PD-L1 expression of lung adenocarcinoma cells

scientific article published on 21 May 2019

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling

scientific article published in 2022

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scientific journal article

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

scientific journal article

MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects

scientific article published on 7 June 2011

Multiple common variants for celiac disease influencing immune gene expression

scientific article

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

P04.22 Data-driven prioritization and evaluation of novel therapeutic targets in glioblastoma

Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parralel-group, phase II-III, r

scientific article published on 25 April 2019

Quantitative proteomics analysis identifies MUC1 as an effect sensor of EGFR inhibition

scientific article published on 10 October 2018

Regulators of homologous recombination repair as novel targets for cancer treatment.

scientific article

Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer.

scientific article published on 13 October 2016

Serotonin and Dopamine Receptor Expression in Solid Tumours Including Rare Cancers

scientific article published on 02 September 2019

Survival-related profile, pathways, and transcription factors in ovarian cancer

scientific article published on February 2009

TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells

scientific article published on 03 September 2018

The antibody-drug conjugate target landscape across a broad range of tumour types.

scientific article

Theranostics Using Antibodies and Antibody-Related Therapeutics.

scientific article published on September 2017

Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9

scientific article

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA

scientific article

Transcriptional effects of copy number alterations in a large set of human cancers

scientific article published on 05 February 2020

Transcriptional regulators CITED2 and PU.1 cooperate in maintaining hematopoietic stem cells

scientific article published on 13 April 2019

Treatment with high-dose simvastatin inhibits geranylgeranylation in AML blast cells in a subset of AML patients.

scientific article published on 25 November 2011

Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression

scientific article

List of works by Rudolf Fehrmann

A bioinformatical and functional approach to identify novel strategies for chemoprevention of colorectal cancer.

A large lung gene expression study identifying fibulin-5 as a novel player in tissue repair in COPD.

A large pooled analysis refines gene expression-based molecular subclasses in cutaneous melanoma

A new perspective on transcriptional system regulation (TSR): towards TSR profiling.

A retrospective analysis of clinical outcome of patients with chemo-refractory metastatic breast cancer treated in a single institution phase I unit

ATR inhibition preferentially targets homologous recombination-deficient tumor cells.

Application of a comprehensive subtelomere array in clinical diagnosis of mental retardation

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

CD47 Expression Defines Efficacy of Rituximab with CHOP in Non-Germinal Center B-cell (Non-GCB) Diffuse Large B-cell Lymphoma Patients (DLBCL), but Not in GCB DLBCL

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

Consideration of breast cancer subtype in targeting the androgen receptor

Considering the biology of late recurrences in selecting patients for extended endocrine therapy in breast cancer

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer

Current state and prospects of artificial intelligence in allergy

Cyclin E expression is associated with high levels of replication stress in triple-negative breast cancer

Data-Driven Prioritization and Review of Targets for Molecular-Based Theranostic Approaches in Pancreatic Cancer.

Data-Driven prioritisation of antibody-drug conjugate targets in head and neck squamous cell carcinoma

Defining the risk of toxicity in phase I oncology trials of novel molecularly targeted agents: a single centre experience

Defining the role of common variation in the genomic and biological architecture of adult human height

Erratum: Corrigendum: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Extraintestinal manifestations and complications in inflammatory bowel disease: from shared genetics to shared biological pathways

Functional Genomic mRNA Profiling of Colorectal Adenomas: Identification and in vivo Validation of CD44 and Splice Variant CD44v6 as Molecular Imaging Targets.

Functional genomic mRNA profiling of a large cancer data base demonstrates mesothelin overexpression in a broad range of tumor types.

GWAS for executive function and processing speed suggests involvement of the CADM2 gene.

Gene expression analysis identifies global gene dosage sensitivity in cancer.

Genetic studies of body mass index yield new insights for obesity biology

Genetic variants in RBFOX3 are associated with sleep latency

Glypican 3 Overexpression across a Broad Spectrum of Tumor Types Discovered with Functional Genomic mRNA Profiling of a Large Cancer Database

Growth differentiation factor 15 (GDF-15) plasma levels increase during bleomycin- and cisplatin-based treatment of testicular cancer patients and relate to endothelial damage

Human disease-associated genetic variation impacts large intergenic non-coding RNA expression

Identification of genes and pathways associated with cytotoxic T lymphocyte infiltration of serous ovarian cancer

Identification of novel therapeutic targets in anaplastic thyroid carcinoma using functional genomic mRNA-profiling: Paving the way for new avenues?

Identification of relevant drugable targets in diffuse large B-cell lymphoma using a genome-wide unbiased CD20 guilt-by association approach.

Immune microenvironment composition in non-small cell lung cancer and its association with survival

Improving gene function predictions using independent transcriptional components

Indispensable benefit of independent investigator-driven research in a changing clinical trial landscape.

Integrative kinome profiling identifies mTORC1/2 inhibition as treatment strategy in ovarian clear cell carcinoma.

Involvement of the TGF-β and β-Catenin Pathways in Pelvic Lymph Node Metastasis in Early-Stage Cervical Cancer

MAPK pathway activity plays a key role in PD-L1 expression of lung adenocarcinoma cells

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci

MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects

Multiple common variants for celiac disease influencing immune gene expression

New genetic loci link adipose and insulin biology to body fat distribution

P04.22 Data-driven prioritization and evaluation of novel therapeutic targets in glioblastoma

Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parralel-group, phase II-III, r

Quantitative proteomics analysis identifies MUC1 as an effect sensor of EGFR inhibition

Regulators of homologous recombination repair as novel targets for cancer treatment.

Relevance of Tumor-Infiltrating Immune Cell Composition and Functionality for Disease Outcome in Breast Cancer.

Serotonin and Dopamine Receptor Expression in Solid Tumours Including Rare Cancers

Survival-related profile, pathways, and transcription factors in ovarian cancer

TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells

The antibody-drug conjugate target landscape across a broad range of tumour types.

Theranostics Using Antibodies and Antibody-Related Therapeutics.

Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9

Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA

Transcriptional effects of copy number alterations in a large set of human cancers

Transcriptional regulators CITED2 and PU.1 cooperate in maintaining hematopoietic stem cells

Treatment with high-dose simvastatin inhibits geranylgeranylation in AML blast cells in a subset of AML patients.

Unraveling the regulatory mechanisms underlying tissue-dependent genetic variation of gene expression