List of works - Adam E Locke

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

scientific article published on 24 March 2017

A novel procedure for genotyping of single nucleotide polymorphisms in trisomy with genomic DNA and the invader assay

scientific article published on 21 October 2008

Across-cohort QC analyses of GWAS summary statistics from complex traits

scientific article

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences

scientific article published on 11 September 2020

Altered patterns of multiple recombinant events are associated with nondisjunction of chromosome 21.

scientific article published on 09 December 2011

An excess of deleterious variants in VEGF-A pathway genes in Down-syndrome-associated atrioventricular septal defects

scientific article published in October 2012

Combining microarray-based genomic selection (MGS) with the Illumina Genome Analyzer platform to sequence diploid target regions

scientific article

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

scientific article published on 30 October 2017

Contribution of copy-number variation to Down syndrome-associated atrioventricular septal defects.

scientific article published on 23 October 2014

Defining the role of common variation in the genomic and biological architecture of adult human height

scientific article

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 23 January 2018

Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project

article

Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees

scientific article

Exome Sequencing of Familial Bipolar Disorder

scientific article

Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans

scientific article published in Nature Communications

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

scientific article published on 08 October 2018

Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity

scientific article

Genetic evidence of assortative mating in humans

article

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

scientific article

Genetic studies of body mass index yield new insights for obesity biology

scientific article

Genome-Wide Association Study of Down Syndrome-Associated Atrioventricular Septal Defects.

scientific article

Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci

scientific article published on 28 March 2022

Getting to precision psychopharmacology: Combining clinical and genetic information to predict fat gain from aripiprazole

scientific article published on 23 April 2019

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

scientific article

Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.

scientific article published on 21 February 2018

In search of rare variants: preliminary results from whole genome sequencing of 1,325 individuals with psychophysiological endophenotypes

scientific article

Lack of maternal folic acid supplementation is associated with heart defects in Down syndrome: a report from the National Down Syndrome Project

scientific article published on 24 August 2011

Mendelian Randomization Study of Body Mass Index and Colorectal Cancer Risk

scientific article published on 14 May 2015

New genetic loci link adipose and insulin biology to body fat distribution

scientific article

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

scientific article published on February 2016

Next-generation genotype imputation service and methods

scientific article published on 29 August 2016

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

article

Population genetic differentiation of height and body mass index across Europe

scientific article

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

article

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

scientific article published on 01 July 2019

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article published on 16 March 2018

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

scientific article

Quality control and conduct of genome-wide association meta-analyses

scientific article

Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

Rare and low-frequency coding variants alter human adult height

scientific article (publication date: February 2017)

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

scientific article published on 19 December 2017

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

scientific article

The genetic architecture of type 2 diabetes

scientific article (publication date: 11 July 2016)

Validity of self-reported sunscreen use by parents, children, and lifeguards

scientific article published on 21 October 2008

Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome

scientific article

Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

scientific article published on 23 May 2017

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol

scientific article

List of works by Adam E Locke

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

A novel procedure for genotyping of single nucleotide polymorphisms in trisomy with genomic DNA and the invader assay

Across-cohort QC analyses of GWAS summary statistics from complex traits

Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences

Altered patterns of multiple recombinant events are associated with nondisjunction of chromosome 21.

An excess of deleterious variants in VEGF-A pathway genes in Down-syndrome-associated atrioventricular septal defects

Combining microarray-based genomic selection (MGS) with the Illumina Genome Analyzer platform to sequence diploid target regions

Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

Contribution of copy-number variation to Down syndrome-associated atrioventricular septal defects.

Defining the role of common variation in the genomic and biological architecture of adult human height

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project

Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees

Exome Sequencing of Familial Bipolar Disorder

Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans

Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps

Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity

Genetic evidence of assortative mating in humans

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Genetic studies of body mass index yield new insights for obesity biology

Genome-Wide Association Study of Down Syndrome-Associated Atrioventricular Septal Defects.

Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci

Getting to precision psychopharmacology: Combining clinical and genetic information to predict fat gain from aripiprazole

Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus

Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.

In search of rare variants: preliminary results from whole genome sequencing of 1,325 individuals with psychophysiological endophenotypes

Lack of maternal folic acid supplementation is associated with heart defects in Down syndrome: a report from the National Down Syndrome Project

Mendelian Randomization Study of Body Mass Index and Colorectal Cancer Risk

New genetic loci link adipose and insulin biology to body fat distribution

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk ⬇️

Next-generation genotype imputation service and methods

PROTEIN-CODING VARIANTS IMPLICATE NOVEL GENES RELATED TO LIPID HOMEOSTASIS CONTRIBUTING TO BODY FAT DISTRIBUTION

Population genetic differentiation of height and body mass index across Europe

Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Quality control and conduct of genome-wide association meta-analyses

Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

Rare and low-frequency coding variants alter human adult height

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits

The genetic architecture of type 2 diabetes

Validity of self-reported sunscreen use by parents, children, and lifeguards

Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome

Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol