List of works - Chris Wallace

A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes

scientific article

A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples

scientific article

A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations

scientific article

A method for identifying genetic heterogeneity within phenotypically defined disease subgroups

scientific article published on 26 December 2016

A pleiotropy-informed Bayesian false discovery rate adapted to a shared control design finds new disease associations from GWAS summary statistics.

scientific article published on 6 February 2015

A rareIL2RAhaplotype identifies SNP rs61839660 as causal for autoimmunity

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

scientific article published on 8 September 2010

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.

scientific article

An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes ⬇️

scientific article

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

scientific article

Author Correction: Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

scientific article published in Nature Communications

Bayesian test for colocalisation between pairs of genetic association studies using summary statistics

scientific article (publication date: May 2014)

Blood pressure loci identified with a gene-centric array

scientific article

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

scientific article published on 23 July 2017

Chromosome 2p Shows Significant Linkage to Antihypertensive Response in the British Genetics of Hypertension Study

article

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

scientific article published on 4 September 2017

Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies

scientific article

Common variants near MC4R are associated with fat mass, weight and risk of obesity

scientific article

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration

scientific article published on 30 July 2011

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

scientific article

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

scientific article

Detecting chromosomal interactions in Capture Hi-C data with CHiCAGO and companion tools

scientific article published on 09 August 2021

Detection of quantitative trait loci from RNA-seq data with or without genotypes using BaseQTL

scientific article published on 24 June 2021

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

scientific article

Dissection of a complex disease susceptibility region using a Bayesian stochastic search approach to fine mapping

Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing.

scientific article published on 7 September 2015

Estimating the relative recurrence risk ratio for leprosy in Karonga District, Malawi.

scientific article published on June 2003

Estimating the relative recurrence risk ratio using a global cross-ratio model

scientific article published on December 2003

Extra-binomial variation approach for analysis of pooled DNA sequencing data

scientific article

Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses

scientific article

Fine mapping chromatin contacts in capture Hi-C data

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

scientific article

Functional effects of variation in transcription factor binding highlight long-range gene regulation by epromoters

scientific article published on 01 April 2020

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes

scientific article

Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension

scientific article published on 8 June 2007

Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases

scientific article published on 25 November 2020

Genetic loci influencing kidney function and chronic kidney disease

scientific article

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

scientific article

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

scientific article published in June 2009

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia

scientific article

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

scientific article published on 16 October 2011

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

scientific article

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

scientific article

Glutathione S-transferase variants and hypertension

scientific article published in July 2008

Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study

article

Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study

scientific article published on 01 March 2006

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

scientific article

Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait loci by selective genotyping

scientific article published on 5 January 2006

Improving the coverage of credible sets in Bayesian genetic fine-mapping ⬇️

scientific article published on 13 April 2020

Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study

article

Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates

scientific article published on 25 September 2007

Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes

scientific article published on 25 March 2011

Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases

scientific article

Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR

scientific article published on 20 October 2021

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

scientific article

Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension

scientific article

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations

scientific article published in June 2009

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

scientific article

Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes

scientific article

Multi-tissue transcriptome-wide association studies

scientific article published on 28 December 2020

Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes

scientific article published on 29 July 2015

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

scientific article published on 17 August 2017

Pervasive sharing of genetic effects in autoimmune disease

scientific article

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.

scientific article

Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion

scientific article

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors

scientific article published on 15 February 2013

Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.

scientific article

Reduced expression of IFIH1 is protective for type 1 diabetes

scientific article

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

scientific article

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

scientific article

SLC2A9 is a high-capacity urate transporter in humans

scientific article

Seven newly identified loci for autoimmune thyroid disease

scientific article

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

scientific article

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

scientific article published on 8 June 2015

Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes

scientific article

Statistical testing of shared genetic control for potentially related traits.

scientific article

Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

scientific article published on 19 July 2019

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.

scientific article

The flashfm approach for fine-mapping multiple quantitative traits

scientific article published in 2021

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

scientific article

Trends in drug overdose deaths in England and Wales 1993-98: methadone does not kill more people than heroin

scientific article published in April 2003

Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension

article

VSEAMS: a pipeline for variant set enrichment analysis using summary GWAS data identifies IKZF3, BATF and ESRRA as key transcription factors in type 1 diabetes ⬇️

scientific article

Widespread seasonal gene expression reveals annual differences in human immunity and physiology

scientific article published on 12 May 2015

fcfdr: an R package to leverage continuous and binary functional genomic data in GWAS

scientific article published in 2022

simGWAS: a fast method for simulation of large scale case-control GWAS summary statistics

scientific article published in June 2019

List of works by Chris Wallace

A genome-wide assessment of the role of untagged copy number variants in type 1 diabetes

A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples

A method for gene-based pathway analysis using genomewide association study summary statistics reveals nine new type 1 diabetes associations

A method for identifying genetic heterogeneity within phenotypically defined disease subgroups

A pleiotropy-informed Bayesian false discovery rate adapted to a shared control design finds new disease associations from GWAS summary statistics.

A rareIL2RAhaplotype identifies SNP rs61839660 as causal for autoimmunity

A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.

An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes ⬇️

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Author Correction: Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks

Bayesian test for colocalisation between pairs of genetic association studies using summary statistics

Blood pressure loci identified with a gene-centric array

Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity

Chromosome 2p Shows Significant Linkage to Antihypertensive Response in the British Genetics of Hypertension Study

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis

Detecting chromosomal interactions in Capture Hi-C data with CHiCAGO and companion tools

Detection of quantitative trait loci from RNA-seq data with or without genotypes using BaseQTL

Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping

Dissection of a complex disease susceptibility region using a Bayesian stochastic search approach to fine mapping

Epigenetic analysis of regulatory T cells using multiplex bisulfite sequencing.

Estimating the relative recurrence risk ratio for leprosy in Karonga District, Malawi.

Estimating the relative recurrence risk ratio using a global cross-ratio model

Extra-binomial variation approach for analysis of pooled DNA sequencing data

Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses

Fine mapping chromatin contacts in capture Hi-C data

Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers

Functional effects of variation in transcription factor binding highlight long-range gene regulation by epromoters

Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes

Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension

Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases

Genetic loci influencing kidney function and chronic kidney disease

Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

Glutathione S-transferase variants and hypertension

Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study

Haplotypes of the beta-2 adrenergic receptor associate with high diastolic blood pressure in the Caerphilly prospective study

IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients

Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait loci by selective genotyping

Improving the coverage of credible sets in Bayesian genetic fine-mapping ⬇️

Increased Support for Linkage of a Novel Locus on Chromosome 5q13 for Essential Hypertension in the British Genetics of Hypertension Study

Information capture using SNPs from HapMap and whole-genome chips differs in a sample of inflammatory and cardiovascular gene-centric regions from genome-wide estimates

Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes

Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases

Leveraging auxiliary data from arbitrary distributions to boost GWAS discovery with Flexible cFDR

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters

Linkage analysis using co-phenotypes in the BRIGHT study reveals novel potential susceptibility loci for hypertension

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations

Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height

Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes

Multi-tissue transcriptome-wide association studies

Natural Variation in Interleukin-2 Sensitivity Influences Regulatory T-Cell Frequency and Function in Individuals With Long-standing Type 1 Diabetes

Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2.

Pervasive sharing of genetic effects in autoimmune disease

Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.

Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion

Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors

Promoter interactome of human embryonic stem cell-derived cardiomyocytes connects GWAS regions to cardiac gene networks.

Reduced expression of IFIH1 is protective for type 1 diabetes

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

SLC2A9 is a high-capacity urate transporter in humans

Seven newly identified loci for autoimmune thyroid disease

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes

Statistical testing of shared genetic control for potentially related traits.

Stochastic search and joint fine-mapping increases accuracy and identifies previously unreported associations in immune-mediated diseases

The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.

The flashfm approach for fine-mapping multiple quantitative traits