List of works - Robert K. Bradley

<i>ZBTB33</i> is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing

scientific article published on 14 July 2021

A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy

scientific article

Alternative splicing of RNA triplets is often regulated and accelerates proteome evolution

scientific article

Binding site turnover produces pervasive quantitative changes in transcription factor binding between closely related Drosophila species

scientific article

Braveheart, a long noncoding RNA required for cardiovascular lineage commitment

scientific article published on 24 January 2013

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

scientific article published on 02 October 2019

DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade

scientific article published on 18 July 2019

Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs

scientific article published on 17 April 2018

Evolution of genes and genomes on the Drosophila phylogeny

scientific article

Evolutionary modeling and prediction of non-coding RNAs in Drosophila

scientific article

Evolutionary triplet models of structured RNA

scientific article

Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing

scientific article published in November 2018

Expression of androgen receptor splice variants in clinical breast cancers.

scientific article published on 7 November 2015

Fast statistical alignment

scientific article

Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A

scientific article published on May 2013

Horizontal transfer of expressed genes in a parasitic flowering plant

scientific article

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene

article published in the Proceedings of the National Academy of Sciences of the United States of America

Integrative Clinical Genomics of Advanced Prostate Cancer.

scientific article

Integrative clinical genomics of advanced prostate cancer

scientific article

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

scientific article published on 09 August 2021

Massive mitochondrial gene transfer in a parasitic flowering plant clade

scientific article

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

scientific article published on 12 April 2021

Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

scientific article published on 02 May 2016

Most human introns are recognized via multiple and tissue-specific branchpoints

scientific article published on 17 April 2018

Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of FSHD

article

Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy

article

RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing

scientific article published on 21 August 2019

RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons

scientific article published on 07 January 2020

RNA splicing factors as oncoproteins and tumour suppressors

scientific article published on 10 June 2016

Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations

scientific article published on 01 March 2020

Recurrent SRSF2 mutations in MDS affect both splicing and NMD

scientific article published on 30 January 2020

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

scientific article published on May 2015

Sample processing obscures cancer-specific alterations in leukemic transcriptomes.

scientific article

Short H2A histone variants are expressed in cancer

scientific article published on 20 January 2021

Specific alignment of structured RNA: stochastic grammars and sequence annealing

scientific article published on 16 September 2008

Spliceosomal disruption of the non-canonical BAF complex in cancer

scientific article published on 09 October 2019

Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis

scientific article

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

article

Systematic and functional characterization of novel androgen receptor variants arising from alternative splicing in the ligand-binding domain

scientific article published on 03 October 2016

The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity

scientific article

The TAGteam motif facilitates binding of 21 sequence-specific transcription factors in the Drosophila embryo

scientific article published on 13 January 2012

The origins and consequences of <i>UPF1</i> variants in pancreatic adenosquamous carcinoma

scientific article published on 06 January 2021

The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation

scientific article published on 06 March 2019

Tools for simulating evolution of aligned genomic regions with integrated parameter estimation

scientific article published on 8 October 2008

Transducers: an emerging probabilistic framework for modeling indels on trees

article

Translational plasticity facilitates the accumulation of nonsense genetic variants in the human population

scientific article published on 19 September 2016

Widespread intron retention diversifies most cancer transcriptomes

scientific article

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival

scientific article

XRate: a fast prototyping, training and annotation tool for phylo-grammars

scientific article

List of works by Robert K. Bradley

<i>ZBTB33</i> is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing

A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy

Alternative splicing of RNA triplets is often regulated and accelerates proteome evolution

Binding site turnover produces pervasive quantitative changes in transcription factor binding between closely related Drosophila species

Braveheart, a long noncoding RNA required for cardiovascular lineage commitment

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade

Dissecting the Contributions of Cooperating Gene Mutations to Cancer Phenotypes and Drug Responses with Patient-Derived iPSCs

Evolution of genes and genomes on the Drosophila phylogeny

Evolutionary modeling and prediction of non-coding RNAs in Drosophila

Evolutionary triplet models of structured RNA

Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing

Expression of androgen receptor splice variants in clinical breast cancers.

Fast statistical alignment

Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A

Horizontal transfer of expressed genes in a parasitic flowering plant

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene

Integrative Clinical Genomics of Advanced Prostate Cancer.

Integrative clinical genomics of advanced prostate cancer

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Massive mitochondrial gene transfer in a parasitic flowering plant clade

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

Most human introns are recognized via multiple and tissue-specific branchpoints

Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of FSHD

Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy

RNA components of the spliceosome regulate tissue- and cancer-specific alternative splicing

RNA isoform screens uncover the essentiality and tumor-suppressor activity of ultraconserved poison exons

RNA splicing factors as oncoproteins and tumour suppressors

Rare and private spliceosomal gene mutations drive partial, complete, and dual phenocopies of hotspot alterations

Recurrent SRSF2 mutations in MDS affect both splicing and NMD

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

Sample processing obscures cancer-specific alterations in leukemic transcriptomes.

Short H2A histone variants are expressed in cancer

Specific alignment of structured RNA: stochastic grammars and sequence annealing

Spliceosomal disruption of the non-canonical BAF complex in cancer

Spliceosomal gene mutations in myelodysplasia: molecular links to clonal abnormalities of hematopoiesis

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

Systematic and functional characterization of novel androgen receptor variants arising from alternative splicing in the ligand-binding domain

The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity

The TAGteam motif facilitates binding of 21 sequence-specific transcription factors in the Drosophila embryo

The origins and consequences of <i>UPF1</i> variants in pancreatic adenosquamous carcinoma

The splicing factor U2AF1 contributes to cancer progression through a noncanonical role in translation regulation

Tools for simulating evolution of aligned genomic regions with integrated parameter estimation

Transducers: an emerging probabilistic framework for modeling indels on trees

Translational plasticity facilitates the accumulation of nonsense genetic variants in the human population

Widespread intron retention diversifies most cancer transcriptomes

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival

XRate: a fast prototyping, training and annotation tool for phylo-grammars