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List of works by Marcos Malumbres

A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain

scientific article published on 23 April 2015

A GRFa2/Prop1/stem (GPS) cell niche in the pituitary

scientific article

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis

scientific article published in August 2016

A SUMOylation Motif in Aurora-A: Implications for Spindle Dynamics and Oncogenesis

scientific article published on 14 December 2011

A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy

scientific article published on 27 January 2007

A centrosomal route for cancer genome instability

scientific article published on 01 June 2014

A kinase-independent function of CDK6 links the cell cycle to tumor angiogenesis

scientific article

A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens

scientific article published on 6 February 2014

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

scientific article published on 31 August 2015

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction

scientific article

Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice.

scientific article

An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress

scientific article

Aurora A controls CD8 T cell cytotoxic activity and antiviral response

scientific article published on 18 February 2019

Aurora A drives early signalling and vesicle dynamics during T-cell activation

scientific article

Aurora B Overexpression Causes Aneuploidy and p21Cip1 Repression during Tumor Development

scientific article

Aurora B prevents delayed DNA replication and premature mitotic exit by repressing p21(Cip1).

scientific article published on 21 February 2013

Aurora kinase A inhibitors: promising agents in antitumoral therapy

scientific article published on 09 September 2014

Biochemical analyses reveal amino acid residues critical for cell cycle-dependent phosphorylation of human Cdc14A phosphatase by cyclin-dependent kinase 1

scientific article published in Scientific Reports

Brick1 is an essential regulator of actin cytoskeleton required for embryonic development and cell transformation

scientific journal article

CDK inhibitors in cancer therapy: what is next?

scientific article

CDK4/6 Inhibitors: What Is the Best Cocktail?

scientific article published on 16 August 2018

CDK6 Antagonizes p53-Induced Responses during Tumorigenesis

article

CDK6 as a key regulator of hematopoietic and leukemic stem cell activation

scientific journal article

Cannabinoid receptors as novel targets for the treatment of melanoma

scientific article

Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis

scientific article

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription

scientific article published on 12 December 2011

Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F.

scientific article

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

scientific article published on December 2011

Cdk1 is sufficient to drive the mammalian cell cycle

scientific article published on August 2007

Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1).

scientific article published in June 2005

Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis

scientific article published on 25 August 2014

Cdk4 promotes adipogenesis through PPARgamma activation

scientific article published on October 2005

Cell Cycle-Based Therapies Move Forward ⬇️

scientific article published on October 16, 2012

Cell cycle control of pituitary development and disease

scientific article

Cell cycle deregulation: a common motif in cancer

scientific article published on January 1, 2003

Cell cycle kinases in cancer

scientific article

Cell cycle, CDKs and cancer: a changing paradigm

scientific article

Combinatorial effects of microRNAs to suppress the Myc oncogenic pathway

scientific article

Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity

scientific article published in May 2005

Correction to Low Dose of Amino-Modified Nanoparticles Induces Cell Cycle Arrest

scholarly article published in ACS Nano

Crystal structure of the open conformation of the mammalian chaperonin CCT in complex with tubulin

scientific article

Cyclin C surprises in tumour suppression.

scientific article

Cyclin D-dependent kinases, INK4 inhibitors and cancer

scientific article

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

scientific article published on 17 August 2003

Cyclin-dependent kinases: a family portrait.

scientific article

Cyclins and related kinases in cancer cells.

scientific article published on September 2007

Dependency of the spindle assembly checkpoint on Cdk1 renders the anaphase transition irreversible

scientific article published on 27 February 2014

Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development.

scientific article

Driving the cell cycle to cancer.

scientific article

E2F2 represses cell cycle regulators to maintain quiescence.

scientific article

Emerging cancer therapeutic opportunities by inhibiting mitotic kinases

scientific article published on 30 July 2008

Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin.

scientific article published in January 2006

From Plk1 to Plk5: functional evolution of polo-like kinases

scientific article published on 15 July 2011

Fueling the Cell Division Cycle

scientific article

Functional reprogramming of polyploidization in megakaryocytes

scientific article

Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors.

scientific article

Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression

scientific article

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development.

scientific article published on 25 May 2011

Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number

scientific journal article

Genomic stability and tumour suppression by the APC/C cofactor Cdh1.

scientific article

Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals

scientific article

HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5.

scientific article

Hypermethylation of the Ink4b locus in murine myeloid leukemia and increased susceptibility to leukemia in p15(Ink4b)-deficient mice

scientific article published on December 2003

Is Cyclin D1-CDK4 kinase a bona fide cancer target?

scientific article published on 01 January 2006

Killing cells by targeting mitosis

scientific article published on 6 January 2012

Lineage-restricted function of the pluripotency factor NANOG in stratified epithelia.

scientific article

Loss of the actin regulator HSPC300 results in clear cell renal cell carcinoma protection in Von Hippel-Lindau patients

scientific article published on June 2007

Low dose of amino-modified nanoparticles induces cell cycle arrest

scientific article published on 19 August 2013

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

scientific article

Mammalian cyclin-dependent kinases

scientific article

Mice deficient for N-ras: impaired antiviral immune response and T-cell function

scientific article published on 01 April 2003

Mice thrive without Cdk4 and Cdk2.

scientific article

MicroRNAs and the cell cycle

scientific article published on 18 February 2011

Mitophagy in mitosis: More than a myth

scientific article published on 13 November 2015

Mitosis-targeting therapies: a troubleshooting guide

scientific article published on 12 April 2013

Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2 ⬇️

scientific article published on November 1, 2012

Mouse p10, an alternative spliced form of p15INK4b, inhibits cell cycle progression and malignant transformation

scientific article published on April 2005

Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling.

scientific article

Non-mitotic functions of the Anaphase-Promoting Complex

scientific article published on 23 March 2011

Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner

scientific article

Nucleotide sequence of the threonine synthase (thrC) gene of Brevibacterium lactofermentum

scientific article published on October 1988

Oncogene-induced mitotic stress: p53 and pRb get mad too.

scientific article published in June 2011

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis

scientific article

Physiological Relevance of Cell Cycle Kinases ⬇️

scientific article published on July 1, 2011

Plk1 overexpression induces chromosomal instability and suppresses tumor development

scientific article published in Nature Communications

Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis

scientific article

Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression

scientific article

Preclinical models for cell cycle-targeted therapies.

scientific article published on January 2006

Preparing a cell for nuclear envelope breakdown: Spatio-temporal control of phosphorylation during mitotic entry.

scientific article

Programmed mitophagy is essential for the glycolytic switch during cell differentiation

scientific article published on 2 May 2017

RAS oncogenes: the first 30 years.

scientific article

RAS pathways to cell cycle control and cell transformation ⬇️

scientific article published on August 6, 1998

RINGO C is required to sustain the spindle-assembly checkpoint

scientific article

Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals

scientific article published in November 2013

Revisiting the "Cdk-centric" view of the mammalian cell cycle

scientific article published on 03 February 2005

SUMOylation modulates the function of Aurora-B kinase

scientific article

Splicing together sister chromatids

scientific article

Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice.

scientific article

Squamous differentiation requires G2/mitosis slippage to avoid apoptosis

scientific article published on 20 February 2020

Suppressor of cytokine signaling 1 blocks mitosis in human melanoma cells.

scientific article

TRF1 controls telomere length and mitotic fidelity in epithelial homeostasis.

scientific article published on 05 January 2009

Targeting aneuploidy for cancer therapy

scientific article published in February 2011

Targeting cell cycle kinases for cancer therapy

scientific article published on January 2007

Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase

scientific article published on December 2010

The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors

scientific article published in January 2013

The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway

scientific article

The E3 ligase APC/C-Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult mice

scientific article

The European dimension for the mouse genome mutagenesis program

scientific article

The Greatwall-PP2A axis in cell cycle control

scientific article

The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene

scientific article published on 01 August 2002

The Rgr oncogene (homologous to RalGDS) induces transformation and gene expression by activating Ras, Ral and Rho mediated pathways

scientific article

The TGF-beta co-receptor endoglin modulates the expression and transforming potential of H-Ras

scientific article published on 30 September 2010

The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites

scientific article

The anaphase-promoting complex/cyclosome (APC/C): cell-cycle-dependent and -independent functions

scientific article

The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes

scientific journal article

The bleomycin resistance gene of transposon Tn5 is an excellent marker for transformation of corynebacteria

scientific article

The cell proliferation antigen Ki-67 organises heterochromatin

scientific journal article

The functional relevance of polyploidization in the skin

scientific article published on 30 December 2013

Therapeutic opportunities to control tumor cell cycles

scientific article published on June 2006

Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancer.

scientific article published on 11 December 2017

To cycle or not to cycle: a critical decision in cancer.

scientific article

Tpx2 controls spindle integrity, genome stability, and tumor development

scientific article published on 20 January 2012

Transient exposure to miR-203 enhances the differentiation capacity of established pluripotent stem cells

scientific article published on 02 July 2020

USP7 limits CDK1 activity throughout the cell cycle

scientific article published on 15 April 2021

c-JUN promotes BCR-ABL-induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6.

scientific article published on 7 February 2011

miRNAs and cancer: An epigenetics view ⬇️

scientific article published on July 4, 2012

miRNAs versus oncogenes: the power of social networking ⬇️

scientific article published on February 14, 2012

microRNAs regulate TAL1 expression in T-cell acute lymphoblastic leukemia

scientific article published on 23 January 2016

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